YGL224C / SDT1

Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL224C / SDT1

Click on Significant Values for Screen Details ID:SGTC_115|Compound:0527-0192|FD-Score:3.10|P-value:7.17E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.95|P-value:1.82E-7 ID:SGTC_264|Compound:promethazine|FD-Score:3.09|P-value:7.67E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.03|P-value:9.22E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.34|P-value:3.00E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.06|P-value:8.32E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.07|P-value:8.13E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.62|P-value:9.04E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:3.83|P-value:4.09E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:-3.12|P-value:6.28E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.51|P-value:1.57E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.48|P-value:1.63E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:-3.67|P-value:7.43E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:4.10|P-value:1.26E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.87|P-value:3.50E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:-4.38|P-value:3.11E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.16|P-value:5.95E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.04|P-value:8.86E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.85|P-value:3.75E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.65|P-value:8.05E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.24|P-value:4.45E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.99|P-value:2.08E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:4.35|P-value:3.87E-6 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.83|P-value:3.47E-7 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.35|P-value:3.89E-6 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.23|P-value:4.56E-4 ID:SGTC_1521|Compound:st012942|FD-Score:4.70|P-value:6.67E-7 ID:SGTC_1676|Compound:st018489|FD-Score:3.15|P-value:6.02E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.42|P-value:2.19E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.12|P-value:6.75E-4 ID:SGTC_1806|Compound:st050005|FD-Score:4.05|P-value:1.57E-5 ID:SGTC_1854|Compound:st056233|FD-Score:-3.76|P-value:5.08E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.39|P-value:2.49E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-3.68|P-value:7.18E-5 ID:SGTC_2121|Compound:5257820|FD-Score:3.51|P-value:1.56E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.95|P-value:2.48E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.95|P-value:2.47E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.39|P-value:2.49E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.99|P-value:1.90E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.66|P-value:7.85E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:4.55|P-value:1.44E-6 ID:SGTC_2811|Compound:7967822|FD-Score:-3.21|P-value:4.59E-4 ID:SGTC_2860|Compound:9025725|FD-Score:4.16|P-value:9.50E-6 ID:SGTC_2944|Compound:9067346|FD-Score:4.06|P-value:1.51E-5 ID:SGTC_2946|Compound:9065502|FD-Score:5.10|P-value:7.71E-8 ID:SGTC_2953|Compound:9074162|FD-Score:5.70|P-value:2.25E-9 ID:SGTC_3101|Compound:9120531|FD-Score:3.12|P-value:6.72E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.86|P-value:3.67E-5 ID:SGTC_3292|Compound:9120825|FD-Score:3.64|P-value:9.27E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.10|P-value:7.17E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.95|P-value:1.82E-7 ID:SGTC_264|Compound:promethazine|FD-Score:3.09|P-value:7.67E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.03|P-value:9.22E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.34|P-value:3.00E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.06|P-value:8.32E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.07|P-value:8.13E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.62|P-value:9.04E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:3.83|P-value:4.09E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:-3.12|P-value:6.28E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.51|P-value:1.57E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.48|P-value:1.63E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:-3.67|P-value:7.43E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:4.10|P-value:1.26E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.87|P-value:3.50E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:-4.38|P-value:3.11E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.16|P-value:5.95E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.04|P-value:8.86E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.85|P-value:3.75E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.65|P-value:8.05E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.24|P-value:4.45E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.99|P-value:2.08E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:4.35|P-value:3.87E-6 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.83|P-value:3.47E-7 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.35|P-value:3.89E-6 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.23|P-value:4.56E-4 ID:SGTC_1521|Compound:st012942|FD-Score:4.70|P-value:6.67E-7 ID:SGTC_1676|Compound:st018489|FD-Score:3.15|P-value:6.02E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.42|P-value:2.19E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.12|P-value:6.75E-4 ID:SGTC_1806|Compound:st050005|FD-Score:4.05|P-value:1.57E-5 ID:SGTC_1854|Compound:st056233|FD-Score:-3.76|P-value:5.08E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.39|P-value:2.49E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-3.68|P-value:7.18E-5 ID:SGTC_2121|Compound:5257820|FD-Score:3.51|P-value:1.56E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.95|P-value:2.48E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.95|P-value:2.47E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.39|P-value:2.49E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.99|P-value:1.90E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.66|P-value:7.85E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:4.55|P-value:1.44E-6 ID:SGTC_2811|Compound:7967822|FD-Score:-3.21|P-value:4.59E-4 ID:SGTC_2860|Compound:9025725|FD-Score:4.16|P-value:9.50E-6 ID:SGTC_2944|Compound:9067346|FD-Score:4.06|P-value:1.51E-5 ID:SGTC_2946|Compound:9065502|FD-Score:5.10|P-value:7.71E-8 ID:SGTC_2953|Compound:9074162|FD-Score:5.70|P-value:2.25E-9 ID:SGTC_3101|Compound:9120531|FD-Score:3.12|P-value:6.72E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.86|P-value:3.67E-5 ID:SGTC_3292|Compound:9120825|FD-Score:3.64|P-value:9.27E-5

Top fitness defect scores for YGL224C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2953 9074162 5.70 66.5 µM 2.25E-9 7 5.93E-9
2 SGTC_2946 9065502 5.10 71.4 µM 7.71E-8 2 1.67E-7
3 SGTC_145 3737-0113 4.95 38.4 µM 1.82E-7 DNA intercalators 46 3.76E-7
4 SGTC_1330 1469-0054 4.83 61.8 µM 3.47E-7 iron homeostasis 5 6.93E-7
5 SGTC_1521 st012942 4.70 49.4 µM 6.67E-7 19 1.29E-6
6 SGTC_2739 tacrine 4.55 100.9 µM 1.44E-6 heme requiring 9 2.66E-6
7 SGTC_1320 1313-0481 4.35 95.3 µM 3.87E-6 17 6.78E-6
8 SGTC_1445 4239-0156 4.35 97.7 µM 3.89E-6 21 6.82E-6
9 SGTC_2860 9025725 4.16 39.0 µM 9.50E-6 RPP1 & pyrimidine depletion 6 1.59E-5
10 SGTC_819 1013-0258 4.10 27.7 µM 1.26E-5 35 2.08E-5
11 SGTC_2944 9067346 4.06 25.6 µM 1.51E-5 20 2.46E-5
12 SGTC_1806 st050005 4.05 60.3 µM 1.57E-5 6 2.56E-5
13 SGTC_1317 1273-0028 3.99 910.0 nM 2.08E-5 azole & statin 53 3.33E-5
14 SGTC_2406 ethylparaben 3.95 405.7 µM 2.47E-5 40 3.92E-5
15 SGTC_2401 5128683 3.95 200.0 µM 2.48E-5 39 3.94E-5
16 SGTC_1052 3253-3998 3.87 198.0 µM 3.50E-5 21 5.46E-5
17 SGTC_3179 9107801 3.86 49.5 µM 3.67E-5 10 5.70E-5
18 SGTC_1173 0443-0020 3.85 122.0 µM 3.75E-5 TSC3-RPN4 37 5.83E-5
19 SGTC_633 0437-0093 3.83 97.7 µM 4.09E-5 DNA intercalators 14 6.32E-5
20 SGTC_3292 9120825 3.64 59.8 µM 9.27E-5 17 1.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.28E-10 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.105 1.20E-9 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.102 2.88E-9 YDR304C CPR5 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
0.095 3.07E-8 YLR060W FRS1 het Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control
0.094 4.44E-8 YBR057C MUM2 hom Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex
0.094 4.57E-8 YER121W_p YER121W_p hom Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
0.093 6.24E-8 YPL197C_d YPL197C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.090 1.96E-7 YOR149C SMP3 het Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
0.081 2.48E-6 YJL083W TAX4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication
0.078 6.29E-6 YBR167C POP7 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.077 7.01E-6 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.077 8.49E-6 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.077 9.14E-6 YDR155C CPR1 hom Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress
0.076 1.10E-5 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.076 1.14E-5 YOR077W RTS2 het Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication