YGL225W / VRG4

Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL225W / VRG4

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:3.84|P-value:3.24E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.88|P-value:2.87E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.26|P-value:7.75E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:4.33|P-value:6.03E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:3.60|P-value:7.09E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-4.00|P-value:1.91E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:5.06|P-value:3.51E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:3.69|P-value:5.23E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:4.26|P-value:7.91E-5 ID:SGTC_297|Compound:0986-0032|FD-Score:3.65|P-value:5.93E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.93|P-value:2.45E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-4.05|P-value:1.60E-4 ID:SGTC_443|Compound:clozapine|FD-Score:-4.03|P-value:1.68E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.51|P-value:9.32E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:4.42|P-value:4.44E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:5.26|P-value:1.51E-6 ID:SGTC_695|Compound:3505-6186|FD-Score:4.00|P-value:1.92E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:5.63|P-value:2.84E-7 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.08|P-value:1.49E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.82|P-value:3.53E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.93|P-value:2.41E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.73|P-value:4.61E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.93|P-value:2.48E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.81|P-value:3.65E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.13|P-value:1.26E-4 ID:SGTC_1740|Compound:st038286|FD-Score:4.38|P-value:5.06E-5 ID:SGTC_1744|Compound:st037937|FD-Score:5.16|P-value:2.32E-6 ID:SGTC_1843|Compound:st055809|FD-Score:-4.03|P-value:1.68E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.82|P-value:3.55E-4 ID:SGTC_1857|Compound:st056007|FD-Score:3.65|P-value:6.04E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-4.17|P-value:1.05E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:4.00|P-value:1.92E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.68|P-value:5.47E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.80|P-value:3.72E-4 ID:SGTC_2351|Compound:9026858|FD-Score:4.37|P-value:5.34E-5 ID:SGTC_2434|Compound:5670830|FD-Score:-3.48|P-value:9.97E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.41|P-value:4.51E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.84|P-value:3.19E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:6.54|P-value:3.29E-9 ID:SGTC_2684|Compound:capsaicin|FD-Score:5.04|P-value:3.88E-6 ID:SGTC_2691|Compound:st077356|FD-Score:3.50|P-value:9.58E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.88|P-value:2.86E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.75|P-value:4.31E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.24|P-value:8.07E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.77|P-value:4.08E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.85|P-value:3.18E-4 ID:SGTC_2962|Compound:9082311|FD-Score:4.36|P-value:5.48E-5 ID:SGTC_2963|Compound:9082507|FD-Score:4.03|P-value:1.76E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.93|P-value:2.46E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.89|P-value:2.78E-4 ID:SGTC_3107|Compound:9121808|FD-Score:5.11|P-value:2.90E-6 ID:SGTC_3133|Compound:9127736|FD-Score:-3.67|P-value:5.46E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-4.08|P-value:1.41E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.52|P-value:8.88E-4 ID:SGTC_3335|Compound:9143315|FD-Score:5.62|P-value:3.05E-7 ID:SGTC_22|Compound:0964-0034|FD-Score:3.84|P-value:3.24E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.88|P-value:2.87E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.26|P-value:7.75E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:4.33|P-value:6.03E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:3.60|P-value:7.09E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-4.00|P-value:1.91E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:5.06|P-value:3.51E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:3.69|P-value:5.23E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:4.26|P-value:7.91E-5 ID:SGTC_297|Compound:0986-0032|FD-Score:3.65|P-value:5.93E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.93|P-value:2.45E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-4.05|P-value:1.60E-4 ID:SGTC_443|Compound:clozapine|FD-Score:-4.03|P-value:1.68E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.51|P-value:9.32E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:4.42|P-value:4.44E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:5.26|P-value:1.51E-6 ID:SGTC_695|Compound:3505-6186|FD-Score:4.00|P-value:1.92E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:5.63|P-value:2.84E-7 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.08|P-value:1.49E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.82|P-value:3.53E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.93|P-value:2.41E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.73|P-value:4.61E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.93|P-value:2.48E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.81|P-value:3.65E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.13|P-value:1.26E-4 ID:SGTC_1740|Compound:st038286|FD-Score:4.38|P-value:5.06E-5 ID:SGTC_1744|Compound:st037937|FD-Score:5.16|P-value:2.32E-6 ID:SGTC_1843|Compound:st055809|FD-Score:-4.03|P-value:1.68E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.82|P-value:3.55E-4 ID:SGTC_1857|Compound:st056007|FD-Score:3.65|P-value:6.04E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-4.17|P-value:1.05E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:4.00|P-value:1.92E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.68|P-value:5.47E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.80|P-value:3.72E-4 ID:SGTC_2351|Compound:9026858|FD-Score:4.37|P-value:5.34E-5 ID:SGTC_2434|Compound:5670830|FD-Score:-3.48|P-value:9.97E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.41|P-value:4.51E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.84|P-value:3.19E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:6.54|P-value:3.29E-9 ID:SGTC_2684|Compound:capsaicin|FD-Score:5.04|P-value:3.88E-6 ID:SGTC_2691|Compound:st077356|FD-Score:3.50|P-value:9.58E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.88|P-value:2.86E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.75|P-value:4.31E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.24|P-value:8.07E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.77|P-value:4.08E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.85|P-value:3.18E-4 ID:SGTC_2962|Compound:9082311|FD-Score:4.36|P-value:5.48E-5 ID:SGTC_2963|Compound:9082507|FD-Score:4.03|P-value:1.76E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.93|P-value:2.46E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.89|P-value:2.78E-4 ID:SGTC_3107|Compound:9121808|FD-Score:5.11|P-value:2.90E-6 ID:SGTC_3133|Compound:9127736|FD-Score:-3.67|P-value:5.46E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-4.08|P-value:1.41E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.52|P-value:8.88E-4 ID:SGTC_3335|Compound:9143315|FD-Score:5.62|P-value:3.05E-7

Top fitness defect scores for YGL225W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2597 laccaic acid a 6.54 100.0 µM 3.29E-9 1 3.17E-11 1.62
2 SGTC_824 1304-0008 5.63 100.0 µM 2.84E-7 DNA damage response 2 8.77E-9 0.81
3 SGTC_3335 9143315 5.62 29.6 µM 3.05E-7 fatty acid desaturase (OLE1) 3 9.56E-9 0.95
4 SGTC_690 glyoxal 5.26 20.3 µM 1.51E-6 15 7.16E-8 0.16
5 SGTC_1744 st037937 5.16 38.9 µM 2.32E-6 1 1.23E-7 0.40
6 SGTC_3107 9121808 5.11 49.5 µM 2.90E-6 1 1.63E-7 0.66
7 SGTC_137 0438-0332 5.06 85.4 µM 3.51E-6 ubiquinone biosynthesis & proteasome 28 2.07E-7 0.23
8 SGTC_2684 capsaicin 5.04 100.0 µM 3.88E-6 1 2.35E-7 0.80
9 SGTC_524 r073-0010 4.42 27.8 µM 4.44E-5 10 5.03E-6 0.02
10 SGTC_1740 st038286 4.38 13.2 µM 5.06E-5 5 5.92E-6 0.30
11 SGTC_2351 9026858 4.37 72.3 µM 5.34E-5 RNA processing & uracil transport 9 6.33E-6 0.12
12 SGTC_2962 9082311 4.36 13.2 µM 5.48E-5 7 6.54E-6 0.19
13 SGTC_76 0433-0009 4.33 400.3 µM 6.03E-5 7 7.37E-6 0.53
14 SGTC_68 0986-0284 4.26 82.8 µM 7.75E-5 7 1.01E-5 0.06
15 SGTC_214 4373-3496 4.26 70.0 µM 7.91E-5 13 1.04E-5 0.06
16 SGTC_1728 st035614 4.13 33.8 µM 1.26E-4 5 1.85E-5 0.19
17 SGTC_1035 k081-0041 4.08 55.2 µM 1.49E-4 Golgi 7 2.29E-5 0.53
18 SGTC_2963 9082507 4.03 9.0 µM 1.76E-4 7 2.83E-5 0.05
19 SGTC_695 3505-6186 4.00 243.0 µM 1.92E-4 7 3.15E-5 0.14
20 SGTC_1928 4'-methoxychalcone 4.00 40.3 µM 1.92E-4 3 3.15E-5 0.62

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.45E-12 YJL066C MPM1 hom Mitochondrial intermembrane space protein of unknown function
0.102 3.20E-9 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.100 6.35E-9 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.096 2.89E-8 YFR050C PRE4 het Beta 7 subunit of the 20S proteasome
0.089 2.87E-7 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.082 1.78E-6 YPL107W_p YPL107W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene
0.082 1.81E-6 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.078 5.65E-6 YDR142C PEX7 hom Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)
0.078 6.07E-6 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.078 6.59E-6 YGL011C SCL1 het Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
0.078 6.84E-6 YGR146C ECL1 hom Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.078 7.07E-6 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.077 7.17E-6 YDR329C PEX3 hom Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p
0.076 9.36E-6 YOR364W_d YOR364W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.072 3.05E-5 YNR031C SSK2 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress