YGL226C-A / OST5

Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL226C-A / OST5

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:3.45|P-value:2.24E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.57|P-value:1.34E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.72|P-value:7.37E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.39|P-value:2.66E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.52|P-value:2.05E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:3.45|P-value:2.20E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:5.02|P-value:1.60E-7 ID:SGTC_179|Compound:1273-0063|FD-Score:3.12|P-value:7.42E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.09|P-value:8.28E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.58|P-value:1.35E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:3.20|P-value:5.60E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:-3.93|P-value:3.01E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:-3.32|P-value:3.47E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.43|P-value:2.34E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.99|P-value:2.33E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:-4.02|P-value:2.05E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.50|P-value:2.34E-6 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.15|P-value:6.56E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.20|P-value:5.62E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.42|P-value:2.51E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.34|P-value:3.34E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:6.30|P-value:6.78E-11 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.67|P-value:8.86E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.18|P-value:6.06E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.10|P-value:8.02E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:-3.36|P-value:2.98E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:-3.13|P-value:6.99E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.07|P-value:8.85E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:-3.12|P-value:7.17E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.67|P-value:9.29E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.31|P-value:3.81E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.07|P-value:9.07E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:-3.92|P-value:3.21E-5 ID:SGTC_1498|Compound:4478-3555|FD-Score:-3.06|P-value:8.98E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.93|P-value:3.21E-5 ID:SGTC_1607|Compound:st000305|FD-Score:3.52|P-value:1.71E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.17|P-value:6.24E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.05|P-value:9.50E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.37|P-value:3.00E-4 ID:SGTC_1749|Compound:st037932|FD-Score:6.43|P-value:2.91E-11 ID:SGTC_1793|Compound:st048256|FD-Score:3.31|P-value:3.82E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.88|P-value:3.93E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.05|P-value:9.49E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.48|P-value:2.02E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.59|P-value:1.27E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.33|P-value:3.49E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.30|P-value:3.96E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.18|P-value:5.96E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.41|P-value:2.61E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.79|P-value:5.51E-7 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.28|P-value:4.17E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.02|P-value:2.17E-5 ID:SGTC_2323|Compound:6148992|FD-Score:-3.32|P-value:3.46E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.07|P-value:8.84E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.67|P-value:9.18E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:3.45|P-value:2.22E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.65|P-value:1.04E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.69|P-value:8.50E-5 ID:SGTC_2948|Compound:9070189|FD-Score:4.00|P-value:2.33E-5 ID:SGTC_2953|Compound:9074162|FD-Score:3.27|P-value:4.41E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.51|P-value:1.76E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.45|P-value:2.24E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.57|P-value:1.34E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.72|P-value:7.37E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.39|P-value:2.66E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.52|P-value:2.05E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:3.45|P-value:2.20E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:5.02|P-value:1.60E-7 ID:SGTC_179|Compound:1273-0063|FD-Score:3.12|P-value:7.42E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.09|P-value:8.28E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.58|P-value:1.35E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:3.20|P-value:5.60E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:-3.93|P-value:3.01E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:-3.32|P-value:3.47E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.43|P-value:2.34E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.99|P-value:2.33E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:-4.02|P-value:2.05E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.50|P-value:2.34E-6 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.15|P-value:6.56E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.20|P-value:5.62E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.42|P-value:2.51E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.34|P-value:3.34E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:6.30|P-value:6.78E-11 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.67|P-value:8.86E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.18|P-value:6.06E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.10|P-value:8.02E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:-3.36|P-value:2.98E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:-3.13|P-value:6.99E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.07|P-value:8.85E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:-3.12|P-value:7.17E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.67|P-value:9.29E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.31|P-value:3.81E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.07|P-value:9.07E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:-3.92|P-value:3.21E-5 ID:SGTC_1498|Compound:4478-3555|FD-Score:-3.06|P-value:8.98E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.93|P-value:3.21E-5 ID:SGTC_1607|Compound:st000305|FD-Score:3.52|P-value:1.71E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.17|P-value:6.24E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.05|P-value:9.50E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.37|P-value:3.00E-4 ID:SGTC_1749|Compound:st037932|FD-Score:6.43|P-value:2.91E-11 ID:SGTC_1793|Compound:st048256|FD-Score:3.31|P-value:3.82E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.88|P-value:3.93E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.05|P-value:9.49E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.48|P-value:2.02E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.59|P-value:1.27E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.33|P-value:3.49E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.30|P-value:3.96E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.18|P-value:5.96E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.41|P-value:2.61E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.79|P-value:5.51E-7 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.28|P-value:4.17E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.02|P-value:2.17E-5 ID:SGTC_2323|Compound:6148992|FD-Score:-3.32|P-value:3.46E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.07|P-value:8.84E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.67|P-value:9.18E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:3.45|P-value:2.22E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.65|P-value:1.04E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.69|P-value:8.50E-5 ID:SGTC_2948|Compound:9070189|FD-Score:4.00|P-value:2.33E-5 ID:SGTC_2953|Compound:9074162|FD-Score:3.27|P-value:4.41E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.51|P-value:1.76E-4

Top fitness defect scores for YGL226C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1749 st037932 6.43 54.2 µM 2.91E-11 5 6.38E-11
2 SGTC_1132 3456-3614 6.30 2.5 µM 6.78E-11 tubulin folding & SWR complex 9 1.44E-10
3 SGTC_169 k015-0017 5.02 16.0 µM 1.60E-7 8 2.59E-7
4 SGTC_2041 5107442 4.79 45.3 µM 5.51E-7 RSC complex & mRNA processing 13 8.52E-7
5 SGTC_161 4065-0411 4.52 162.2 µM 2.05E-6 49 3.02E-6
6 SGTC_501 nsc-95397 4.50 161.0 µM 2.34E-6 8 3.44E-6
7 SGTC_2316 5844804 4.02 197.4 µM 2.17E-5 27 2.96E-5
8 SGTC_2948 9070189 4.00 9.4 µM 2.33E-5 plasma membrane duress 43 3.16E-5
9 SGTC_1597 7-benzyloxygramine 3.93 47.5 µM 3.21E-5 calcium & mitochondrial duress 124 4.31E-5
10 SGTC_1870 st057514 3.88 26.5 µM 3.93E-5 RSC & ERG11 25 5.24E-5
11 SGTC_2635 hydroquinidine 3.69 100.0 µM 8.50E-5 29 1.10E-4
12 SGTC_1335 1486-0900 3.67 202.0 µM 9.29E-5 32 1.20E-4
13 SGTC_2578 7,8-dihydroxyflavone 3.65 64.4 µM 1.04E-4 39 1.34E-4
14 SGTC_1953 st076800 3.59 12.1 µM 1.27E-4 58 1.62E-4
15 SGTC_252 miconazole 3.58 1.3 nM 1.35E-4 ergosterol depletion effects on membrane 43 1.73E-4
16 SGTC_1607 st000305 3.52 50.6 µM 1.71E-4 25 2.16E-4
17 SGTC_2976 9009005 3.51 19.5 µM 1.76E-4 38 2.23E-4
18 SGTC_1884 5633444 3.48 25.0 µM 2.02E-4 redox potentiating 73 2.54E-4
19 SGTC_163 1327-0036 3.45 7.5 µM 2.20E-4 145 2.77E-4
20 SGTC_2532 xanthone 3.45 78.9 µM 2.22E-4 43 2.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.03E-10 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.096 2.28E-8 YOR274W MOD5 hom Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis
0.094 5.08E-8 YHR105W YPT35 hom Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport
0.092 8.48E-8 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.091 1.17E-7 YGL259W_p YPS5_p hom Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p
0.090 1.67E-7 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.090 1.80E-7 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.090 2.02E-7 YHR156C LIN1 hom Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication
0.089 2.35E-7 YBR249C ARO4 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress
0.087 4.95E-7 YAL018C_p YAL018C_p hom Putative protein of unknown function
0.087 5.10E-7 YGR044C RME1 hom Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.086 7.03E-7 YHL029C_p OCA5_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.083 1.44E-6 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.082 1.72E-6 YLR249W YEF3 het Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog, HEF3, that arose from the whole genome duplication
0.081 2.81E-6 YLR107W REX3 hom RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases