YGL226W / MTC3

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL226W / MTC3

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.22|P-value:3.10E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.06|P-value:5.36E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-5.43|P-value:3.34E-9 ID:SGTC_76|Compound:0433-0009|FD-Score:4.78|P-value:1.79E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.09|P-value:4.84E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.10|P-value:4.97E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:4.35|P-value:1.89E-6 ID:SGTC_321|Compound:4534-3890|FD-Score:3.92|P-value:1.51E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-2.93|P-value:8.50E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.61|P-value:6.29E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:3.54|P-value:8.48E-5 ID:SGTC_446|Compound:go6976|FD-Score:4.76|P-value:2.00E-7 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.49|P-value:9.46E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.74|P-value:3.56E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:3.91|P-value:1.59E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.29|P-value:2.17E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.03|P-value:8.98E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.54|P-value:8.40E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:-2.93|P-value:8.80E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.65|P-value:5.12E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.22|P-value:3.10E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.09|P-value:5.11E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.37|P-value:1.68E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.53|P-value:7.19E-7 ID:SGTC_1247|Compound:0448-0043|FD-Score:2.95|P-value:8.67E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.16|P-value:3.95E-4 ID:SGTC_1745|Compound:st081495|FD-Score:5.77|P-value:4.23E-10 ID:SGTC_1762|Compound:st045503|FD-Score:3.75|P-value:3.30E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.75|P-value:3.40E-5 ID:SGTC_1966|Compound:st070145|FD-Score:3.41|P-value:1.42E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.64|P-value:5.35E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.95|P-value:1.30E-5 ID:SGTC_2111|Compound:5486399|FD-Score:3.10|P-value:4.99E-4 ID:SGTC_2121|Compound:5257820|FD-Score:4.21|P-value:3.72E-6 ID:SGTC_2122|Compound:5258151|FD-Score:3.92|P-value:1.51E-5 ID:SGTC_2183|Compound:6420625|FD-Score:-3.19|P-value:3.29E-4 ID:SGTC_2184|Compound:6075246|FD-Score:2.95|P-value:8.45E-4 ID:SGTC_2204|Compound:7233102|FD-Score:-4.14|P-value:4.94E-6 ID:SGTC_2206|Compound:7254556|FD-Score:3.21|P-value:3.16E-4 ID:SGTC_2274|Compound:7947094|FD-Score:2.98|P-value:7.71E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.17|P-value:3.73E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-3.06|P-value:5.25E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-2.94|P-value:8.28E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.27|P-value:2.51E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.30|P-value:2.28E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:4.54|P-value:6.79E-7 ID:SGTC_2764|Compound:methyldopa|FD-Score:8.17|P-value:1.70E-18 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.12|P-value:4.28E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.35|P-value:1.88E-6 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.55|P-value:6.58E-7 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.22|P-value:3.14E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.87|P-value:1.97E-5 ID:SGTC_2850|Compound:9015429|FD-Score:-3.57|P-value:6.83E-5 ID:SGTC_2939|Compound:9044578|FD-Score:2.97|P-value:8.08E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.53|P-value:8.76E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.55|P-value:7.90E-5 ID:SGTC_3017|Compound:9080681|FD-Score:5.58|P-value:1.47E-9 ID:SGTC_3062|Compound:9077494|FD-Score:3.08|P-value:5.40E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.35|P-value:1.83E-6 ID:SGTC_3197|Compound:9113331|FD-Score:4.12|P-value:5.90E-6 ID:SGTC_3214|Compound:9129694|FD-Score:3.31|P-value:2.13E-4 ID:SGTC_3278|Compound:9139605|FD-Score:4.25|P-value:3.11E-6 ID:SGTC_3326|Compound:9140064|FD-Score:3.81|P-value:2.50E-5 ID:SGTC_3340|Compound:9146634|FD-Score:-3.32|P-value:1.96E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.78|P-value:2.85E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.22|P-value:3.10E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.06|P-value:5.36E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-5.43|P-value:3.34E-9 ID:SGTC_76|Compound:0433-0009|FD-Score:4.78|P-value:1.79E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.09|P-value:4.84E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.10|P-value:4.97E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:4.35|P-value:1.89E-6 ID:SGTC_321|Compound:4534-3890|FD-Score:3.92|P-value:1.51E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-2.93|P-value:8.50E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.61|P-value:6.29E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:3.54|P-value:8.48E-5 ID:SGTC_446|Compound:go6976|FD-Score:4.76|P-value:2.00E-7 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.49|P-value:9.46E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.74|P-value:3.56E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:3.91|P-value:1.59E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.29|P-value:2.17E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.03|P-value:8.98E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.54|P-value:8.40E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:-2.93|P-value:8.80E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.65|P-value:5.12E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.22|P-value:3.10E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.09|P-value:5.11E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.37|P-value:1.68E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.53|P-value:7.19E-7 ID:SGTC_1247|Compound:0448-0043|FD-Score:2.95|P-value:8.67E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.16|P-value:3.95E-4 ID:SGTC_1745|Compound:st081495|FD-Score:5.77|P-value:4.23E-10 ID:SGTC_1762|Compound:st045503|FD-Score:3.75|P-value:3.30E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.75|P-value:3.40E-5 ID:SGTC_1966|Compound:st070145|FD-Score:3.41|P-value:1.42E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.64|P-value:5.35E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.95|P-value:1.30E-5 ID:SGTC_2111|Compound:5486399|FD-Score:3.10|P-value:4.99E-4 ID:SGTC_2121|Compound:5257820|FD-Score:4.21|P-value:3.72E-6 ID:SGTC_2122|Compound:5258151|FD-Score:3.92|P-value:1.51E-5 ID:SGTC_2183|Compound:6420625|FD-Score:-3.19|P-value:3.29E-4 ID:SGTC_2184|Compound:6075246|FD-Score:2.95|P-value:8.45E-4 ID:SGTC_2204|Compound:7233102|FD-Score:-4.14|P-value:4.94E-6 ID:SGTC_2206|Compound:7254556|FD-Score:3.21|P-value:3.16E-4 ID:SGTC_2274|Compound:7947094|FD-Score:2.98|P-value:7.71E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.17|P-value:3.73E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-3.06|P-value:5.25E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-2.94|P-value:8.28E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.27|P-value:2.51E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.30|P-value:2.28E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:4.54|P-value:6.79E-7 ID:SGTC_2764|Compound:methyldopa|FD-Score:8.17|P-value:1.70E-18 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.12|P-value:4.28E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.35|P-value:1.88E-6 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.55|P-value:6.58E-7 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.22|P-value:3.14E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.87|P-value:1.97E-5 ID:SGTC_2850|Compound:9015429|FD-Score:-3.57|P-value:6.83E-5 ID:SGTC_2939|Compound:9044578|FD-Score:2.97|P-value:8.08E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.53|P-value:8.76E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.55|P-value:7.90E-5 ID:SGTC_3017|Compound:9080681|FD-Score:5.58|P-value:1.47E-9 ID:SGTC_3062|Compound:9077494|FD-Score:3.08|P-value:5.40E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.35|P-value:1.83E-6 ID:SGTC_3197|Compound:9113331|FD-Score:4.12|P-value:5.90E-6 ID:SGTC_3214|Compound:9129694|FD-Score:3.31|P-value:2.13E-4 ID:SGTC_3278|Compound:9139605|FD-Score:4.25|P-value:3.11E-6 ID:SGTC_3326|Compound:9140064|FD-Score:3.81|P-value:2.50E-5 ID:SGTC_3340|Compound:9146634|FD-Score:-3.32|P-value:1.96E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.78|P-value:2.85E-5

Top fitness defect scores for YGL226W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2764 methyldopa 8.17 94.7 µM 1.70E-18 1 1.56E-16
2 SGTC_1745 st081495 5.77 74.0 µM 4.23E-10 RNA processing & uracil transport 32 4.07E-9
3 SGTC_3017 9080681 5.58 49.5 µM 1.47E-9 2 1.22E-8
4 SGTC_76 0433-0009 4.78 400.3 µM 1.79E-7 2 8.57E-7
5 SGTC_446 go6976 4.76 132.0 µM 2.00E-7 7 9.46E-7
6 SGTC_2774 tamoxifen 4.55 10.9 µM 6.58E-7 8 2.72E-6
7 SGTC_2736 butenafine 4.54 14.7 µM 6.79E-7 18 2.80E-6
8 SGTC_1202 1988-0068 4.53 29.6 µM 7.19E-7 RNA processing & uracil transport 12 2.94E-6
9 SGTC_3087 9117406 4.35 49.5 µM 1.83E-6 11 6.75E-6
10 SGTC_2766 oltipraz 4.35 83.9 µM 1.88E-6 heme requiring 20 6.88E-6
11 SGTC_316 k060-0003 4.35 58.6 µM 1.89E-6 9 6.94E-6
12 SGTC_3278 9139605 4.25 49.5 µM 3.11E-6 7 1.08E-5
13 SGTC_2121 5257820 4.21 149.6 µM 3.72E-6 8 1.26E-5
14 SGTC_3197 9113331 4.12 49.5 µM 5.90E-6 29 1.90E-5
15 SGTC_996 3970-0799 4.03 1.8 µM 8.98E-6 81 2.76E-5
16 SGTC_2016 5121758 3.95 140.0 µM 1.30E-5 redox potentiating 51 3.84E-5
17 SGTC_321 4534-3890 3.92 65.3 µM 1.51E-5 RPP1 & pyrimidine depletion 4 4.36E-5
18 SGTC_2122 5258151 3.92 111.7 µM 1.51E-5 24 4.37E-5
19 SGTC_751 0833-0568 3.91 350.0 µM 1.59E-5 22 4.59E-5
20 SGTC_2800 7887935 3.87 81.8 µM 1.97E-5 RPP1 & pyrimidine depletion 37 5.55E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 6.24E-15 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.133 1.10E-14 YFR006W_p YFR006W_p hom Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene
0.126 2.38E-13 YMR136W GAT2 hom Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
0.104 1.51E-9 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.104 1.66E-9 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.102 2.90E-9 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.100 5.60E-9 YGR047C TFC4 het One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102
0.100 6.39E-9 YMR259C TRM732 hom Interacts with Trm7p for 2'-O-methylation of C32 of substrate tRNAs; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene
0.097 2.06E-8 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.094 4.31E-8 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.092 8.05E-8 YGL215W CLG1 hom Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
0.092 9.47E-8 YGL087C MMS2 hom Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress
0.087 5.01E-7 YER079W_p YER079W_p hom Putative protein of unknown function
0.086 6.80E-7 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.085 7.62E-7 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication