YGL229C / SAP4

Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL229C / SAP4

Click on Significant Values for Screen Details ID:SGTC_196|Compound:k015-0023|FD-Score:3.24|P-value:5.88E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.05|P-value:2.45E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.29|P-value:4.36E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:3.49|P-value:2.41E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.21|P-value:5.72E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:-5.06|P-value:1.53E-7 ID:SGTC_620|Compound:0109-0052|FD-Score:-5.22|P-value:6.70E-8 ID:SGTC_638|Compound:3970-0837|FD-Score:3.68|P-value:1.14E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.41|P-value:2.78E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.45|P-value:2.39E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.52|P-value:1.80E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.76|P-value:6.88E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.70|P-value:1.06E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.80|P-value:7.04E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.44|P-value:4.22E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.36|P-value:3.79E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.30|P-value:4.74E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.27|P-value:4.59E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:-3.19|P-value:6.18E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:-3.21|P-value:5.68E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.42|P-value:3.14E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-5.90|P-value:1.25E-9 ID:SGTC_1822|Compound:st052468|FD-Score:3.58|P-value:1.69E-4 ID:SGTC_1904|Compound:st060225|FD-Score:3.39|P-value:3.51E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.95|P-value:3.21E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-3.41|P-value:2.79E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.10|P-value:9.69E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.89|P-value:4.96E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-3.85|P-value:4.76E-5 ID:SGTC_2175|Compound:5807670|FD-Score:-3.16|P-value:6.85E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.03|P-value:2.75E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:3.27|P-value:5.42E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.82|P-value:5.55E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-5.13|P-value:1.10E-7 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.18|P-value:7.37E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.51|P-value:1.63E-8 ID:SGTC_2646|Compound:retinol|FD-Score:4.05|P-value:2.45E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:3.19|P-value:7.15E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.19|P-value:7.08E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-4.11|P-value:1.58E-5 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.11|P-value:9.43E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.42|P-value:4.66E-6 ID:SGTC_3047|Compound:9092122|FD-Score:3.45|P-value:2.76E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.29|P-value:4.88E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.27|P-value:9.56E-6 ID:SGTC_196|Compound:k015-0023|FD-Score:3.24|P-value:5.88E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.05|P-value:2.45E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.29|P-value:4.36E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:3.49|P-value:2.41E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.21|P-value:5.72E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:-5.06|P-value:1.53E-7 ID:SGTC_620|Compound:0109-0052|FD-Score:-5.22|P-value:6.70E-8 ID:SGTC_638|Compound:3970-0837|FD-Score:3.68|P-value:1.14E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.41|P-value:2.78E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.45|P-value:2.39E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.52|P-value:1.80E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.76|P-value:6.88E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.70|P-value:1.06E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.80|P-value:7.04E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.44|P-value:4.22E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.36|P-value:3.79E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.30|P-value:4.74E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.27|P-value:4.59E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:-3.19|P-value:6.18E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:-3.21|P-value:5.68E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.42|P-value:3.14E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-5.90|P-value:1.25E-9 ID:SGTC_1822|Compound:st052468|FD-Score:3.58|P-value:1.69E-4 ID:SGTC_1904|Compound:st060225|FD-Score:3.39|P-value:3.51E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.95|P-value:3.21E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-3.41|P-value:2.79E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.10|P-value:9.69E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.89|P-value:4.96E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-3.85|P-value:4.76E-5 ID:SGTC_2175|Compound:5807670|FD-Score:-3.16|P-value:6.85E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.03|P-value:2.75E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:3.27|P-value:5.42E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.82|P-value:5.55E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-5.13|P-value:1.10E-7 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.18|P-value:7.37E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.51|P-value:1.63E-8 ID:SGTC_2646|Compound:retinol|FD-Score:4.05|P-value:2.45E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:3.19|P-value:7.15E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.19|P-value:7.08E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-4.11|P-value:1.58E-5 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.11|P-value:9.43E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.42|P-value:4.66E-6 ID:SGTC_3047|Compound:9092122|FD-Score:3.45|P-value:2.76E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.29|P-value:4.88E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.27|P-value:9.56E-6

Top fitness defect scores for YGL229C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2627 acetyl isogambogic acid 5.51 100.0 µM 1.63E-8 TSC3-RPN4 20 1.81E-8
2 SGTC_1027 k015-0025 4.44 8.7 µM 4.22E-6 19 4.43E-6
3 SGTC_2753 fluvastatin 4.42 17.1 µM 4.66E-6 azole & statin 21 4.90E-6
4 SGTC_3187 9109394 4.27 49.5 µM 9.56E-6 Golgi 14 9.97E-6
5 SGTC_2646 retinol 4.05 96.8 µM 2.45E-5 8 2.53E-5
6 SGTC_219 mitoxanthrone 4.05 164.4 µM 2.45E-5 DNA intercalators 51 2.53E-5
7 SGTC_2339 9000433 4.03 200.0 µM 2.75E-5 35 2.84E-5
8 SGTC_2098 5376439 3.89 882.5 nM 4.96E-5 12 5.10E-5
9 SGTC_947 3447-0010 3.80 211.0 µM 7.04E-5 16 7.22E-5
10 SGTC_944 3370-0224 3.70 231.0 µM 1.06E-4 32 1.08E-4
11 SGTC_638 3970-0837 3.68 4.1 µM 1.14E-4 49 1.17E-4
12 SGTC_1822 st052468 3.58 42.0 µM 1.69E-4 17 1.72E-4
13 SGTC_336 4111-0029 3.49 111.0 µM 2.41E-4 12 2.45E-4
14 SGTC_3047 9092122 3.45 49.5 µM 2.76E-4 39 2.79E-4
15 SGTC_1557 sumaresinolic acid 3.42 42.3 µM 3.14E-4 34 3.18E-4
16 SGTC_1904 st060225 3.39 78.0 µM 3.51E-4 35 3.55E-4
17 SGTC_1042 0350-0096 3.36 82.0 µM 3.79E-4 TSC3-RPN4 46 3.83E-4
18 SGTC_1112 tnp00069 3.30 1.2 µM 4.74E-4 52 4.78E-4
19 SGTC_3185 9108267 3.29 49.5 µM 4.88E-4 60S ribosome export 46 4.93E-4
20 SGTC_2521 angolensin 3.27 13.4 µM 5.42E-4 27 5.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.097 2.14E-8 YBR196C-A_p YBR196C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.092 1.04E-7 YHR182W YHR182W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.090 1.84E-7 YBL087C RPL23A hom Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication
0.086 5.35E-7 YNL279W PRM1 hom Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p
0.083 1.30E-6 YGR024C THG1 het tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes
0.081 3.02E-6 YBL013W FMT1 hom Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate
0.080 3.18E-6 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.078 5.98E-6 YNL297C MON2 hom Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins
0.078 6.60E-6 YLR328W NMA1 hom Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication
0.077 8.75E-6 YGR120C COG2 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.076 9.15E-6 YDL208W NHP2 het Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
0.075 1.31E-5 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.073 2.11E-5 YMR292W GOT1 hom Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition
0.072 2.80E-5 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.072 3.10E-5 YNL308C KRI1 het Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p