YGL230C_p

Putative protein of unknown function; non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL230C / YGL230C

Click on Significant Values for Screen Details ID:SGTC_163|Compound:1327-0036|FD-Score:3.21|P-value:1.83E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:2.91|P-value:6.33E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.08|P-value:3.18E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:-2.99|P-value:4.17E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.12|P-value:2.65E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-3.12|P-value:2.46E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.06|P-value:3.09E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.28|P-value:1.26E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:-5.84|P-value:3.80E-11 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.95|P-value:4.93E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.01|P-value:4.17E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.82|P-value:8.09E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.11|P-value:2.77E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.77|P-value:9.68E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.08|P-value:3.18E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-2.78|P-value:9.49E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.87|P-value:8.81E-6 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.29|P-value:1.31E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.28|P-value:1.37E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.40|P-value:8.06E-5 ID:SGTC_1321|Compound:1326-2144|FD-Score:2.91|P-value:6.26E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.22|P-value:1.80E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.21|P-value:1.83E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.69|P-value:2.17E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.00|P-value:4.45E-4 ID:SGTC_1996|Compound:st072960|FD-Score:4.41|P-value:4.96E-7 ID:SGTC_2045|Compound:5106652|FD-Score:3.34|P-value:1.05E-4 ID:SGTC_2099|Compound:5377090|FD-Score:2.90|P-value:6.41E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.44|P-value:6.81E-5 ID:SGTC_2121|Compound:5257820|FD-Score:4.66|P-value:1.12E-7 ID:SGTC_2125|Compound:5246583|FD-Score:2.90|P-value:6.55E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.17|P-value:2.17E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-2.85|P-value:7.15E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.14|P-value:2.52E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-7.16|P-value:6.88E-16 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-6.66|P-value:5.79E-14 ID:SGTC_2755|Compound:lomerizine|FD-Score:-6.63|P-value:7.15E-14 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.25|P-value:1.16E-6 ID:SGTC_3155|Compound:9099265|FD-Score:-2.80|P-value:8.68E-4 ID:SGTC_3231|Compound:9132313|FD-Score:-2.97|P-value:4.60E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.21|P-value:1.83E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:2.91|P-value:6.33E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.08|P-value:3.18E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:-2.99|P-value:4.17E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.12|P-value:2.65E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-3.12|P-value:2.46E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.06|P-value:3.09E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.28|P-value:1.26E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:-5.84|P-value:3.80E-11 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.95|P-value:4.93E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.01|P-value:4.17E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.82|P-value:8.09E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.11|P-value:2.77E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.77|P-value:9.68E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.08|P-value:3.18E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-2.78|P-value:9.49E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.87|P-value:8.81E-6 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.29|P-value:1.31E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.28|P-value:1.37E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.40|P-value:8.06E-5 ID:SGTC_1321|Compound:1326-2144|FD-Score:2.91|P-value:6.26E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.22|P-value:1.80E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.21|P-value:1.83E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.69|P-value:2.17E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.00|P-value:4.45E-4 ID:SGTC_1996|Compound:st072960|FD-Score:4.41|P-value:4.96E-7 ID:SGTC_2045|Compound:5106652|FD-Score:3.34|P-value:1.05E-4 ID:SGTC_2099|Compound:5377090|FD-Score:2.90|P-value:6.41E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.44|P-value:6.81E-5 ID:SGTC_2121|Compound:5257820|FD-Score:4.66|P-value:1.12E-7 ID:SGTC_2125|Compound:5246583|FD-Score:2.90|P-value:6.55E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.17|P-value:2.17E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-2.85|P-value:7.15E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.14|P-value:2.52E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-7.16|P-value:6.88E-16 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-6.66|P-value:5.79E-14 ID:SGTC_2755|Compound:lomerizine|FD-Score:-6.63|P-value:7.15E-14 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.25|P-value:1.16E-6 ID:SGTC_3155|Compound:9099265|FD-Score:-2.80|P-value:8.68E-4 ID:SGTC_3231|Compound:9132313|FD-Score:-2.97|P-value:4.60E-4

Top fitness defect scores for YGL230C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2121 5257820 4.66 149.6 µM 1.12E-7 4 1.55E-6
2 SGTC_1996 st072960 4.41 66.8 µM 4.96E-7 7 5.22E-6
3 SGTC_2757 clomiphene 4.25 4.2 µM 1.16E-6 fatty acid desaturase (OLE1) 30 1.05E-5
4 SGTC_1111 tnp00062 3.87 510.7 nM 8.81E-6 9 5.47E-5
5 SGTC_1452 4194-0072 3.69 190.0 µM 2.17E-5 17 1.14E-4
6 SGTC_2116 5511452 3.44 16.9 µM 6.81E-5 29 2.91E-4
7 SGTC_1261 0712-0010 3.40 12.7 µM 8.06E-5 RNA processing & uracil transport 43 3.35E-4
8 SGTC_2045 5106652 3.34 78.0 µM 1.05E-4 35 4.17E-4
9 SGTC_1173 0443-0020 3.29 122.0 µM 1.31E-4 TSC3-RPN4 74 5.00E-4
10 SGTC_1255 0566-0045 3.28 221.0 µM 1.37E-4 excess fatty acid 55 5.18E-4
11 SGTC_1369 1866-0067 3.22 208.0 µM 1.80E-4 RPP1 & pyrimidine depletion 70 6.49E-4
12 SGTC_1451 4152-0210 3.21 104.0 µM 1.83E-4 57 6.55E-4
13 SGTC_163 1327-0036 3.21 7.5 µM 1.83E-4 166 6.57E-4
14 SGTC_2429 5902844 3.17 64.4 µM 2.17E-4 64 7.55E-4
15 SGTC_2700 st077718 3.14 96.8 µM 2.52E-4 37 8.53E-4
16 SGTC_394 menadione 3.12 8.3 µM 2.65E-4 superoxide 62 8.90E-4
17 SGTC_789 1309-1135 3.11 70.6 µM 2.77E-4 ERG2 68 9.21E-4
18 SGTC_317 4495-0002 3.08 170.0 µM 3.18E-4 34 0.00103
19 SGTC_1020 4335-0961 3.08 93.3 µM 3.18E-4 45 0.00103
20 SGTC_627 1391-0720 3.01 175.0 µM 4.17E-4 44 0.00129

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.186 1.99E-27 YDR524C AGE1 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif
0.169 8.41E-23 YLR211C_p YLR211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
0.147 9.02E-18 YGL132W_d YGL132W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C
0.144 6.38E-17 YNL076W MKS1 hom Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling
0.132 1.83E-14 YGR117C_p YGR117C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.123 8.06E-13 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.110 2.04E-10 YLL034C RIX7 het Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions
0.109 2.19E-10 YGR177C ATF2 hom Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking
0.100 7.45E-9 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.092 8.75E-8 YLR348C DIC1 hom Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
0.091 1.29E-7 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.091 1.31E-7 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.089 2.59E-7 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.085 8.95E-7 YEL066W HPA3 hom D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
0.084 1.01E-6 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M