YGL235W_p

Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL235W / YGL235W

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.59|P-value:7.19E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:2.97|P-value:7.21E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.42|P-value:1.50E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-6.09|P-value:5.26E-11 ID:SGTC_189|Compound:3970-0742|FD-Score:3.00|P-value:6.46E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:3.46|P-value:1.07E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.80|P-value:2.91E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:-2.94|P-value:9.48E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-2.97|P-value:8.59E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.08|P-value:7.72E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-6.15|P-value:3.57E-11 ID:SGTC_716|Compound:1683-5115|FD-Score:3.12|P-value:4.13E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.10|P-value:4.48E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.42|P-value:1.15E-6 ID:SGTC_886|Compound:0866-0150|FD-Score:3.64|P-value:5.04E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:2.92|P-value:8.78E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.09|P-value:4.69E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.34|P-value:1.78E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:2.93|P-value:8.52E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.03|P-value:6.73E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.02|P-value:7.17E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.45|P-value:1.33E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.91|P-value:8.99E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.14|P-value:4.42E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.12|P-value:4.14E-4 ID:SGTC_1563|Compound:conessine|FD-Score:2.97|P-value:7.35E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.01|P-value:6.37E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-4.12|P-value:6.28E-6 ID:SGTC_2243|Compound:6634756|FD-Score:-3.51|P-value:1.03E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-3.23|P-value:3.13E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.21|P-value:3.46E-6 ID:SGTC_2259|Compound:7964009|FD-Score:-3.08|P-value:5.64E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.03|P-value:8.09E-6 ID:SGTC_2407|Compound:paclitaxel|FD-Score:2.91|P-value:8.97E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-4.40|P-value:1.61E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:2.99|P-value:6.93E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.30|P-value:2.04E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-6.77|P-value:3.49E-13 ID:SGTC_2591|Compound:skatole|FD-Score:-4.18|P-value:4.83E-6 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.39|P-value:1.40E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:2.98|P-value:7.08E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.42|P-value:1.51E-4 ID:SGTC_3342|Compound:9147791|FD-Score:4.71|P-value:2.40E-7 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.59|P-value:7.19E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:2.97|P-value:7.21E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.42|P-value:1.50E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-6.09|P-value:5.26E-11 ID:SGTC_189|Compound:3970-0742|FD-Score:3.00|P-value:6.46E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:3.46|P-value:1.07E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.80|P-value:2.91E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:-2.94|P-value:9.48E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-2.97|P-value:8.59E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.08|P-value:7.72E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-6.15|P-value:3.57E-11 ID:SGTC_716|Compound:1683-5115|FD-Score:3.12|P-value:4.13E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.10|P-value:4.48E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.42|P-value:1.15E-6 ID:SGTC_886|Compound:0866-0150|FD-Score:3.64|P-value:5.04E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:2.92|P-value:8.78E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.09|P-value:4.69E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.34|P-value:1.78E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:2.93|P-value:8.52E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.03|P-value:6.73E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.02|P-value:7.17E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.45|P-value:1.33E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.91|P-value:8.99E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.14|P-value:4.42E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.12|P-value:4.14E-4 ID:SGTC_1563|Compound:conessine|FD-Score:2.97|P-value:7.35E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.01|P-value:6.37E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-4.12|P-value:6.28E-6 ID:SGTC_2243|Compound:6634756|FD-Score:-3.51|P-value:1.03E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-3.23|P-value:3.13E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.21|P-value:3.46E-6 ID:SGTC_2259|Compound:7964009|FD-Score:-3.08|P-value:5.64E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.03|P-value:8.09E-6 ID:SGTC_2407|Compound:paclitaxel|FD-Score:2.91|P-value:8.97E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-4.40|P-value:1.61E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:2.99|P-value:6.93E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.30|P-value:2.04E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-6.77|P-value:3.49E-13 ID:SGTC_2591|Compound:skatole|FD-Score:-4.18|P-value:4.83E-6 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.39|P-value:1.40E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:2.98|P-value:7.08E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.42|P-value:1.51E-4 ID:SGTC_3342|Compound:9147791|FD-Score:4.71|P-value:2.40E-7

Top fitness defect scores for YGL235W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3342 9147791 4.71 14.5 µM 2.40E-7 4 1.23E-6
2 SGTC_798 1287-0182 4.42 476.0 µM 1.15E-6 12 4.90E-6
3 SGTC_2257 7960413 4.21 200.0 µM 3.46E-6 NEO1-PIK1 48 1.30E-5
4 SGTC_2401 5128683 4.03 200.0 µM 8.09E-6 35 2.75E-5
5 SGTC_886 0866-0150 3.64 153.0 µM 5.04E-5 29 1.39E-4
6 SGTC_193 1273-0060 3.46 1.6 µM 1.07E-4 ergosterol biosynthesis 17 2.71E-4
7 SGTC_2616 abietic acid 3.39 100.0 µM 1.40E-4 49 3.44E-4
8 SGTC_1008 4106-0037 3.34 6.0 µM 1.78E-4 PDR1 34 4.24E-4
9 SGTC_2586 curcumin 3.30 80.0 µM 2.04E-4 iron homeostasis 90 4.78E-4
10 SGTC_716 1683-5115 3.12 658.0 µM 4.13E-4 55 8.95E-4
11 SGTC_1435 4092-0789 3.12 56.7 µM 4.14E-4 plasma membrane duress 42 8.97E-4
12 SGTC_759 3486-0358 3.10 89.3 µM 4.48E-4 51 9.61E-4
13 SGTC_998 3996-0085 3.09 177.0 µM 4.69E-4 52 0.00100
14 SGTC_2239 6685329 3.01 187.6 µM 6.37E-4 78 0.00131
15 SGTC_189 3970-0742 3.00 2.1 µM 6.46E-4 25 0.00133
16 SGTC_2584 androsterone 2.99 48.7 µM 6.93E-4 cell wall 218 0.00142
17 SGTC_2629 bisabolol 2.98 100.0 µM 7.08E-4 70 0.00144
18 SGTC_39 0986-0283 2.97 58.4 µM 7.21E-4 calcium & mitochondrial duress 85 0.00147
19 SGTC_1563 conessine 2.97 56.1 µM 7.35E-4 55 0.00149
20 SGTC_1012 4112-3522 2.93 18.0 µM 8.52E-4 60 0.00170

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.192 3.72E-29 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.178 2.52E-25 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.152 9.58E-19 YGL217C_d YGL217C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W
0.141 2.67E-16 YNL042W-B_p YNL042W-B_p hom Putative protein of unknown function
0.138 1.25E-15 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.126 2.38E-13 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.123 1.01E-12 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.121 1.89E-12 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.119 5.06E-12 YGR003W CUL3 hom Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3
0.117 1.13E-11 YGL134W PCL10 hom Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
0.115 2.13E-11 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.114 3.13E-11 YKL050C YKL050C hom Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p
0.112 6.75E-11 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.112 8.75E-11 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.111 1.11E-10 YDR286C_p YDR286C_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site