YGL236C / MTO1

Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL236C / MTO1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.98|P-value:7.98E-5 ID:SGTC_202|Compound:3594-0513|FD-Score:3.64|P-value:3.16E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:4.27|P-value:3.00E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.41|P-value:6.15E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.56|P-value:4.10E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-6.24|P-value:1.78E-9 ID:SGTC_517|Compound:1365-0151|FD-Score:-5.15|P-value:5.51E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:3.30|P-value:9.57E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.93|P-value:1.79E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:3.80|P-value:1.78E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.46|P-value:5.16E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.94|P-value:1.06E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.51|P-value:1.10E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:5.08|P-value:8.94E-7 ID:SGTC_946|Compound:3434-1334|FD-Score:3.69|P-value:2.59E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:4.73|P-value:4.30E-6 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:-4.16|P-value:3.97E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.53|P-value:1.04E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.63|P-value:3.23E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.39|P-value:7.35E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.75|P-value:1.91E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.35|P-value:8.25E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.64|P-value:3.12E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.02|P-value:6.91E-5 ID:SGTC_1762|Compound:st045503|FD-Score:3.50|P-value:5.08E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.70|P-value:2.52E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.58|P-value:3.89E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.70|P-value:2.53E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.40|P-value:6.99E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-4.09|P-value:5.22E-5 ID:SGTC_2286|Compound:7945697|FD-Score:-4.26|P-value:2.67E-5 ID:SGTC_2289|Compound:7946404|FD-Score:-3.47|P-value:5.04E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-4.29|P-value:2.38E-5 ID:SGTC_2381|Compound:9035592|FD-Score:-4.15|P-value:4.24E-5 ID:SGTC_2385|Compound:9074692|FD-Score:4.59|P-value:7.85E-6 ID:SGTC_2429|Compound:5902844|FD-Score:3.80|P-value:1.77E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.79|P-value:1.61E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-6.15|P-value:2.85E-9 ID:SGTC_2587|Compound:piperic acid|FD-Score:6.50|P-value:4.63E-10 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.86|P-value:1.40E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.29|P-value:9.93E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.36|P-value:7.98E-4 ID:SGTC_2942|Compound:9052777|FD-Score:4.36|P-value:2.06E-5 ID:SGTC_3159|Compound:9100096|FD-Score:4.12|P-value:5.29E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.58|P-value:3.47E-4 ID:SGTC_3340|Compound:9146634|FD-Score:4.10|P-value:5.77E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.98|P-value:7.98E-5 ID:SGTC_202|Compound:3594-0513|FD-Score:3.64|P-value:3.16E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:4.27|P-value:3.00E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.41|P-value:6.15E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.56|P-value:4.10E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-6.24|P-value:1.78E-9 ID:SGTC_517|Compound:1365-0151|FD-Score:-5.15|P-value:5.51E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:3.30|P-value:9.57E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.93|P-value:1.79E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:3.80|P-value:1.78E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.46|P-value:5.16E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.94|P-value:1.06E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.51|P-value:1.10E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:5.08|P-value:8.94E-7 ID:SGTC_946|Compound:3434-1334|FD-Score:3.69|P-value:2.59E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:4.73|P-value:4.30E-6 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:-4.16|P-value:3.97E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.53|P-value:1.04E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.63|P-value:3.23E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.39|P-value:7.35E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.75|P-value:1.91E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.35|P-value:8.25E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.64|P-value:3.12E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.02|P-value:6.91E-5 ID:SGTC_1762|Compound:st045503|FD-Score:3.50|P-value:5.08E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.70|P-value:2.52E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.58|P-value:3.89E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.70|P-value:2.53E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.40|P-value:6.99E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-4.09|P-value:5.22E-5 ID:SGTC_2286|Compound:7945697|FD-Score:-4.26|P-value:2.67E-5 ID:SGTC_2289|Compound:7946404|FD-Score:-3.47|P-value:5.04E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-4.29|P-value:2.38E-5 ID:SGTC_2381|Compound:9035592|FD-Score:-4.15|P-value:4.24E-5 ID:SGTC_2385|Compound:9074692|FD-Score:4.59|P-value:7.85E-6 ID:SGTC_2429|Compound:5902844|FD-Score:3.80|P-value:1.77E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.79|P-value:1.61E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-6.15|P-value:2.85E-9 ID:SGTC_2587|Compound:piperic acid|FD-Score:6.50|P-value:4.63E-10 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.86|P-value:1.40E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.29|P-value:9.93E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.36|P-value:7.98E-4 ID:SGTC_2942|Compound:9052777|FD-Score:4.36|P-value:2.06E-5 ID:SGTC_3159|Compound:9100096|FD-Score:4.12|P-value:5.29E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.58|P-value:3.47E-4 ID:SGTC_3340|Compound:9146634|FD-Score:4.10|P-value:5.77E-5

Top fitness defect scores for YGL236C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2587 piperic acid 6.50 92.2 µM 4.63E-10 2 3.99E-11
2 SGTC_832 4083-0019 5.08 164.0 µM 8.94E-7 translation 36 1.93E-7
3 SGTC_625 k213-0058 4.93 121.0 µM 1.79E-6 translation 58 4.20E-7
4 SGTC_1092 toremifene 4.73 6.3 µM 4.30E-6 9 1.12E-6
5 SGTC_2385 9074692 4.59 200.0 µM 7.85E-6 29 2.20E-6
6 SGTC_1107 amlodipine 4.53 47.0 µM 1.04E-5 21 3.02E-6
7 SGTC_800 3448-7362 4.51 155.0 µM 1.10E-5 translation 116 3.23E-6
8 SGTC_2942 9052777 4.36 62.2 µM 2.06E-5 24 6.49E-6
9 SGTC_204 1543-0184 4.27 62.4 µM 3.00E-5 TRP & mitochondrial translation 25 9.90E-6
10 SGTC_3159 9100096 4.12 49.5 µM 5.29E-5 16 1.87E-5
11 SGTC_3340 9146634 4.10 11.1 µM 5.77E-5 9 2.06E-5
12 SGTC_771 0250-0039 3.94 27.3 µM 1.06E-4 14 4.07E-5
13 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.86 70.0 µM 1.40E-4 redox potentiating 78 5.56E-5
14 SGTC_2429 5902844 3.80 64.4 µM 1.77E-4 30 7.23E-5
15 SGTC_660 4031-1742 3.80 102.0 µM 1.78E-4 redox potentiating 54 7.27E-5
16 SGTC_1835 st008666 3.70 49.2 µM 2.52E-4 30 1.07E-4
17 SGTC_1887 st057648 3.70 70.8 µM 2.53E-4 24 1.08E-4
18 SGTC_946 3434-1334 3.69 87.4 µM 2.59E-4 38 1.10E-4
19 SGTC_1607 st000305 3.64 50.6 µM 3.12E-4 19 1.36E-4
20 SGTC_202 3594-0513 3.64 34.8 µM 3.16E-4 PDR1 15 1.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 7.42E-32 YDR516C EMI2 hom Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.169 8.25E-23 YIL039W TED1 hom Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.166 3.09E-22 YOL100W PKH2 hom Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
0.165 5.89E-22 YPL208W RKM1 hom SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)
0.151 1.63E-18 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.145 3.55E-17 YGR214W RPS0A hom Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;
0.140 4.14E-16 YGL250W RMR1 hom Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus
0.137 1.79E-15 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.133 1.08E-14 YGL251C HFM1 hom Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity
0.128 9.70E-14 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.126 2.90E-13 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.122 1.42E-12 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.118 6.62E-12 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.115 2.50E-11 YBR162C TOS1 hom Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
0.111 9.62E-11 YDR281C PHM6 hom Protein of unknown function, expression is regulated by phosphate levels