YGL238W / CSE1

Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL238W / CSE1

Click on Significant Values for Screen Details ID:SGTC_85|Compound:0868-0259|FD-Score:4.19|P-value:5.28E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.88|P-value:1.65E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.59|P-value:4.37E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.78|P-value:2.34E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:7.80|P-value:2.27E-13 ID:SGTC_948|Compound:3448-0295|FD-Score:8.50|P-value:1.57E-15 ID:SGTC_963|Compound:1269-2853|FD-Score:4.09|P-value:7.59E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.50|P-value:5.98E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.22|P-value:4.63E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.64|P-value:3.76E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.42|P-value:7.65E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.68|P-value:3.25E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:-3.44|P-value:6.69E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:6.20|P-value:4.43E-9 ID:SGTC_1715|Compound:st032160|FD-Score:4.07|P-value:8.13E-5 ID:SGTC_1717|Compound:st033143|FD-Score:5.54|P-value:1.38E-7 ID:SGTC_1784|Compound:st039334|FD-Score:3.40|P-value:8.31E-4 ID:SGTC_1796|Compound:st049173|FD-Score:3.71|P-value:2.97E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:-3.54|P-value:4.95E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.48|P-value:5.98E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-4.12|P-value:6.30E-5 ID:SGTC_1975|Compound:st070967|FD-Score:6.01|P-value:1.29E-8 ID:SGTC_2018|Compound:5133068|FD-Score:3.53|P-value:5.32E-4 ID:SGTC_2080|Compound:5212524|FD-Score:4.15|P-value:5.95E-5 ID:SGTC_2108|Compound:5365811|FD-Score:3.73|P-value:2.74E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-3.49|P-value:5.72E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.48|P-value:6.28E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.40|P-value:8.20E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.31|P-value:3.30E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.69|P-value:3.15E-4 ID:SGTC_2836|Compound:9010338|FD-Score:4.01|P-value:1.03E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.46|P-value:6.89E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.56|P-value:4.91E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.76|P-value:2.45E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.04|P-value:9.08E-5 ID:SGTC_3033|Compound:9090887|FD-Score:4.04|P-value:8.94E-5 ID:SGTC_3072|Compound:9116419|FD-Score:3.55|P-value:5.02E-4 ID:SGTC_3111|Compound:9122088|FD-Score:-3.46|P-value:6.27E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.52|P-value:5.50E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.95|P-value:1.17E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:4.19|P-value:5.28E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.88|P-value:1.65E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.59|P-value:4.37E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.78|P-value:2.34E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:7.80|P-value:2.27E-13 ID:SGTC_948|Compound:3448-0295|FD-Score:8.50|P-value:1.57E-15 ID:SGTC_963|Compound:1269-2853|FD-Score:4.09|P-value:7.59E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.50|P-value:5.98E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.22|P-value:4.63E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.64|P-value:3.76E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.42|P-value:7.65E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.68|P-value:3.25E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:-3.44|P-value:6.69E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:6.20|P-value:4.43E-9 ID:SGTC_1715|Compound:st032160|FD-Score:4.07|P-value:8.13E-5 ID:SGTC_1717|Compound:st033143|FD-Score:5.54|P-value:1.38E-7 ID:SGTC_1784|Compound:st039334|FD-Score:3.40|P-value:8.31E-4 ID:SGTC_1796|Compound:st049173|FD-Score:3.71|P-value:2.97E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:-3.54|P-value:4.95E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.48|P-value:5.98E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-4.12|P-value:6.30E-5 ID:SGTC_1975|Compound:st070967|FD-Score:6.01|P-value:1.29E-8 ID:SGTC_2018|Compound:5133068|FD-Score:3.53|P-value:5.32E-4 ID:SGTC_2080|Compound:5212524|FD-Score:4.15|P-value:5.95E-5 ID:SGTC_2108|Compound:5365811|FD-Score:3.73|P-value:2.74E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-3.49|P-value:5.72E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.48|P-value:6.28E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.40|P-value:8.20E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.31|P-value:3.30E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.69|P-value:3.15E-4 ID:SGTC_2836|Compound:9010338|FD-Score:4.01|P-value:1.03E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.46|P-value:6.89E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.56|P-value:4.91E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.76|P-value:2.45E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.04|P-value:9.08E-5 ID:SGTC_3033|Compound:9090887|FD-Score:4.04|P-value:8.94E-5 ID:SGTC_3072|Compound:9116419|FD-Score:3.55|P-value:5.02E-4 ID:SGTC_3111|Compound:9122088|FD-Score:-3.46|P-value:6.27E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.52|P-value:5.50E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.95|P-value:1.17E-4

Top fitness defect scores for YGL238W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_948 3448-0295 8.50 75.3 µM 1.57E-15 1 9.36E-18 1.71
2 SGTC_827 3253-0474 7.80 693.0 µM 2.27E-13 1 2.98E-15 2.26
3 SGTC_1450 4112-4260 6.20 37.6 µM 4.43E-9 calcium & mitochondrial duress 2 2.77E-10 1.56
4 SGTC_1975 st070967 6.01 30.8 µM 1.29E-8 2 9.50E-10 0.06
5 SGTC_1717 st033143 5.54 58.0 µM 1.38E-7 2 1.48E-8 0.64
6 SGTC_2679 rapamycin 4.31 1.0 nM 3.30E-5 47 8.28E-6 0.11
7 SGTC_1060 3448-7350 4.22 82.0 µM 4.63E-5 Golgi 14 1.22E-5 0.58
8 SGTC_85 0868-0259 4.19 160.1 µM 5.28E-5 60S ribosome export 5 1.43E-5 0.10
9 SGTC_2080 5212524 4.15 12.4 µM 5.95E-5 copper-dependent oxidative stress 6 1.64E-5 0.02
10 SGTC_963 1269-2853 4.09 151.0 µM 7.59E-5 3 2.17E-5 0.45
11 SGTC_1715 st032160 4.07 10.2 µM 8.13E-5 4 2.34E-5 0.08
12 SGTC_3033 9090887 4.04 49.5 µM 8.94E-5 fatty acid desaturase (OLE1) 13 2.62E-5 0.04
13 SGTC_2951 9072950 4.04 58.1 µM 9.08E-5 ERG2 4 2.66E-5 0.26
14 SGTC_2836 9010338 4.01 19.5 µM 1.03E-4 RPP1 & pyrimidine depletion 3 3.09E-5 0.12
15 SGTC_151 3013-0144 3.88 2.3 µM 1.65E-4 iron homeostasis 10 5.31E-5 0.01
16 SGTC_660 4031-1742 3.78 102.0 µM 2.34E-4 redox potentiating 16 7.92E-5 0.05
17 SGTC_2943 9068529 3.76 45.3 µM 2.45E-4 12 8.35E-5 0.13
18 SGTC_2108 5365811 3.73 200.0 µM 2.74E-4 8 9.53E-5 0.15
19 SGTC_1796 st049173 3.71 110.4 µM 2.97E-4 4 1.04E-4 0.34
20 SGTC_2725 haloperidol 3.69 53.2 µM 3.15E-4 plasma membrane duress 22 1.12E-4 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.32E-18 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.131 2.23E-14 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.128 8.61E-14 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.125 3.71E-13 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.107 4.73E-10 YJR135C MCM22 hom Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4
0.106 8.17E-10 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.104 1.51E-9 YLR093C NYV1 hom v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane
0.103 2.39E-9 YLL030C_d RRT7_d hom Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.100 6.24E-9 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.094 4.50E-8 YDR059C UBC5 hom Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication
0.092 8.48E-8 YGL215W CLG1 hom Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
0.091 1.45E-7 YLR036C_p YLR036C_p hom Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein
0.090 1.82E-7 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.089 2.41E-7 YOR322C LDB19 hom Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye
0.089 2.53E-7 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae