YGL241W / KAP114

Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL241W / KAP114

Click on Significant Values for Screen Details ID:SGTC_368|Compound:fentichlor|FD-Score:-3.93|P-value:5.44E-5 ID:SGTC_462|Compound:ag-879|FD-Score:-3.51|P-value:2.72E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.28|P-value:1.02E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:-3.15|P-value:9.88E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:4.04|P-value:2.81E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:3.46|P-value:2.81E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.96|P-value:3.93E-7 ID:SGTC_978|Compound:1416-0512|FD-Score:-3.24|P-value:7.20E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.21|P-value:6.88E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.56|P-value:1.92E-4 ID:SGTC_1655|Compound:st012546|FD-Score:4.49|P-value:3.82E-6 ID:SGTC_1784|Compound:st039334|FD-Score:3.10|P-value:9.81E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-3.47|P-value:3.25E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.70|P-value:1.36E-4 ID:SGTC_1963|Compound:st076565|FD-Score:-3.25|P-value:6.87E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.30|P-value:5.97E-4 ID:SGTC_2153|Compound:5569715|FD-Score:3.54|P-value:2.09E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.77|P-value:8.71E-5 ID:SGTC_2480|Compound:5767542|FD-Score:3.22|P-value:6.66E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.40|P-value:3.52E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.16|P-value:8.21E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.46|P-value:2.78E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.31|P-value:5.65E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.19|P-value:7.41E-4 ID:SGTC_3067|Compound:9117431|FD-Score:4.09|P-value:2.32E-5 ID:SGTC_3074|Compound:9116018|FD-Score:4.00|P-value:3.38E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.62|P-value:1.53E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.29|P-value:9.83E-6 ID:SGTC_3285|Compound:9112818|FD-Score:5.29|P-value:7.00E-8 ID:SGTC_3288|Compound:9119690|FD-Score:4.69|P-value:1.52E-6 ID:SGTC_3294|Compound:9122953|FD-Score:4.24|P-value:1.23E-5 ID:SGTC_3300|Compound:9124615|FD-Score:3.44|P-value:2.97E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.93|P-value:5.44E-5 ID:SGTC_462|Compound:ag-879|FD-Score:-3.51|P-value:2.72E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.28|P-value:1.02E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:-3.15|P-value:9.88E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:4.04|P-value:2.81E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:3.46|P-value:2.81E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.96|P-value:3.93E-7 ID:SGTC_978|Compound:1416-0512|FD-Score:-3.24|P-value:7.20E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.21|P-value:6.88E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.56|P-value:1.92E-4 ID:SGTC_1655|Compound:st012546|FD-Score:4.49|P-value:3.82E-6 ID:SGTC_1784|Compound:st039334|FD-Score:3.10|P-value:9.81E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-3.47|P-value:3.25E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.70|P-value:1.36E-4 ID:SGTC_1963|Compound:st076565|FD-Score:-3.25|P-value:6.87E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.30|P-value:5.97E-4 ID:SGTC_2153|Compound:5569715|FD-Score:3.54|P-value:2.09E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.77|P-value:8.71E-5 ID:SGTC_2480|Compound:5767542|FD-Score:3.22|P-value:6.66E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.40|P-value:3.52E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.16|P-value:8.21E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.46|P-value:2.78E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.31|P-value:5.65E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.19|P-value:7.41E-4 ID:SGTC_3067|Compound:9117431|FD-Score:4.09|P-value:2.32E-5 ID:SGTC_3074|Compound:9116018|FD-Score:4.00|P-value:3.38E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.62|P-value:1.53E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.29|P-value:9.83E-6 ID:SGTC_3285|Compound:9112818|FD-Score:5.29|P-value:7.00E-8 ID:SGTC_3288|Compound:9119690|FD-Score:4.69|P-value:1.52E-6 ID:SGTC_3294|Compound:9122953|FD-Score:4.24|P-value:1.23E-5 ID:SGTC_3300|Compound:9124615|FD-Score:3.44|P-value:2.97E-4

Top fitness defect scores for YGL241W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3285 9112818 5.29 20.9 µM 7.00E-8 cell wall 13 6.03E-8
2 SGTC_953 1188-0045 4.96 9.7 µM 3.93E-7 60S ribosome export 9 3.48E-7
3 SGTC_3288 9119690 4.69 36.2 µM 1.52E-6 16 1.37E-6
4 SGTC_1655 st012546 4.49 55.1 µM 3.82E-6 18 3.48E-6
5 SGTC_3143 9086658 4.29 49.5 µM 9.83E-6 35 9.08E-6
6 SGTC_474 dl-dihydrosphingosine 4.28 5.0 µM 1.02E-5 20 9.47E-6
7 SGTC_3294 9122953 4.24 26.3 µM 1.23E-5 tubulin folding & SWR complex 20 1.14E-5
8 SGTC_3067 9117431 4.09 49.5 µM 2.32E-5 7 2.17E-5
9 SGTC_675 1309-0189 4.04 238.0 µM 2.81E-5 12 2.63E-5
10 SGTC_3074 9116018 4.00 49.5 µM 3.38E-5 RNA processing & uracil transport 20 3.17E-5
11 SGTC_2273 7815444 3.77 169.1 µM 8.71E-5 29 8.28E-5
12 SGTC_3140 9094243 3.62 49.5 µM 1.53E-4 35 1.46E-4
13 SGTC_1472 k841-0093 3.56 193.0 µM 1.92E-4 28 1.84E-4
14 SGTC_2153 5569715 3.54 200.0 µM 2.09E-4 iron homeostasis 22 2.01E-4
15 SGTC_2858 9025781 3.46 9.0 µM 2.78E-4 sphingolipid biosynthesis & PDR1 127 2.68E-4
16 SGTC_805 3852-0218 3.46 479.0 µM 2.81E-4 ERAD & cell cycle 90 2.71E-4
17 SGTC_3300 9124615 3.44 50.5 µM 2.97E-4 35 2.86E-4
18 SGTC_2597 laccaic acid a 3.40 100.0 µM 3.52E-4 54 3.40E-4
19 SGTC_2480 5767542 3.22 37.2 µM 6.66E-4 33 6.49E-4
20 SGTC_1460 k062-0059 3.21 9.2 µM 6.88E-4 Golgi 39 6.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 3.33E-8 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.088 3.23E-7 YMR047C NUP116 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p)
0.085 7.71E-7 YDL160C-A MHF2 hom Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2
0.081 2.85E-6 YDR293C SSD1 hom Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function
0.077 8.10E-6 YGL215W CLG1 hom Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
0.077 8.88E-6 YDR448W ADA2 hom Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
0.076 1.04E-5 YLR230W_d YLR230W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
0.073 2.35E-5 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.072 2.65E-5 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.072 3.05E-5 YGL066W SGF73 hom SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.072 3.09E-5 YOL123W HRP1 het Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
0.070 4.54E-5 YDL074C BRE1 hom E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control
0.070 5.05E-5 YLR454W_p FMP27_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.069 6.15E-5 YDR391C_p YDR391C_p hom Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.069 7.06E-5 YPL153C RAD53 het Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication