YGL242C_p

Putative protein of unknown function; deletion mutant is viable

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL242C / YGL242C

Click on Significant Values for Screen Details ID:SGTC_199|Compound:4063-0024|FD-Score:-3.60|P-value:4.02E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:-3.47|P-value:6.08E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.40|P-value:8.52E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.81|P-value:2.21E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.87|P-value:1.80E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.91|P-value:1.52E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.77|P-value:2.54E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:4.40|P-value:2.48E-5 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.96|P-value:1.29E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:5.83|P-value:3.60E-8 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.47|P-value:6.78E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.70|P-value:3.16E-4 ID:SGTC_1753|Compound:st043925|FD-Score:5.81|P-value:3.95E-8 ID:SGTC_1777|Compound:st045864|FD-Score:3.76|P-value:2.65E-4 ID:SGTC_1944|Compound:st076371|FD-Score:5.68|P-value:7.70E-8 ID:SGTC_1955|Compound:wogonin|FD-Score:3.77|P-value:2.53E-4 ID:SGTC_1981|Compound:st071826|FD-Score:4.57|P-value:1.24E-5 ID:SGTC_2015|Compound:5119600|FD-Score:-4.41|P-value:2.07E-5 ID:SGTC_2027|Compound:5150920|FD-Score:-3.63|P-value:3.67E-4 ID:SGTC_2295|Compound:7971645|FD-Score:-3.68|P-value:3.04E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-5.41|P-value:2.42E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.12|P-value:7.67E-9 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.52|P-value:5.12E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:6.05|P-value:1.13E-8 ID:SGTC_2767|Compound:sibutramine|FD-Score:6.51|P-value:8.69E-10 ID:SGTC_2777|Compound:climbazole|FD-Score:5.61|P-value:1.11E-7 ID:SGTC_2942|Compound:9052777|FD-Score:4.35|P-value:2.97E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.66|P-value:3.74E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.50|P-value:6.34E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.89|P-value:1.63E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:-3.60|P-value:4.02E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:-3.47|P-value:6.08E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.40|P-value:8.52E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.81|P-value:2.21E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.87|P-value:1.80E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.91|P-value:1.52E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.77|P-value:2.54E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:4.40|P-value:2.48E-5 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.96|P-value:1.29E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:5.83|P-value:3.60E-8 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.47|P-value:6.78E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.70|P-value:3.16E-4 ID:SGTC_1753|Compound:st043925|FD-Score:5.81|P-value:3.95E-8 ID:SGTC_1777|Compound:st045864|FD-Score:3.76|P-value:2.65E-4 ID:SGTC_1944|Compound:st076371|FD-Score:5.68|P-value:7.70E-8 ID:SGTC_1955|Compound:wogonin|FD-Score:3.77|P-value:2.53E-4 ID:SGTC_1981|Compound:st071826|FD-Score:4.57|P-value:1.24E-5 ID:SGTC_2015|Compound:5119600|FD-Score:-4.41|P-value:2.07E-5 ID:SGTC_2027|Compound:5150920|FD-Score:-3.63|P-value:3.67E-4 ID:SGTC_2295|Compound:7971645|FD-Score:-3.68|P-value:3.04E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-5.41|P-value:2.42E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.12|P-value:7.67E-9 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.52|P-value:5.12E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:6.05|P-value:1.13E-8 ID:SGTC_2767|Compound:sibutramine|FD-Score:6.51|P-value:8.69E-10 ID:SGTC_2777|Compound:climbazole|FD-Score:5.61|P-value:1.11E-7 ID:SGTC_2942|Compound:9052777|FD-Score:4.35|P-value:2.97E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.66|P-value:3.74E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.50|P-value:6.34E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.89|P-value:1.63E-4

Top fitness defect scores for YGL242C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2767 sibutramine 6.51 71.5 µM 8.69E-10 2 3.67E-11
2 SGTC_2582 agaric acid 6.12 100.0 µM 7.67E-9 redox potentiating 153 4.62E-10
3 SGTC_2762 leflunomide 6.05 42.1 µM 1.13E-8 1 7.21E-10
4 SGTC_1439 4092-1168 5.83 46.0 µM 3.60E-8 1 2.79E-9
5 SGTC_1753 st043925 5.81 64.0 µM 3.95E-8 1 3.11E-9
6 SGTC_1944 st076371 5.68 56.9 µM 7.70E-8 5 6.75E-9
7 SGTC_2777 climbazole 5.61 1.5 µM 1.11E-7 iron homeostasis 16 1.03E-8
8 SGTC_1981 st071826 4.57 47.0 µM 1.24E-5 7 2.46E-6
9 SGTC_1412 3909-8563 4.40 178.0 µM 2.48E-5 3 5.53E-6
10 SGTC_2942 9052777 4.35 62.2 µM 2.97E-5 26 6.82E-6
11 SGTC_1431 4049-0260 3.96 9.1 µM 1.29E-4 3 3.73E-5
12 SGTC_965 1291-5240 3.91 308.0 µM 1.52E-4 31 4.53E-5
13 SGTC_3191 9110352 3.89 49.5 µM 1.63E-4 11 4.91E-5
14 SGTC_783 0848-0141 3.87 92.7 µM 1.80E-4 RSC & ERG11 16 5.49E-5
15 SGTC_776 4476-4378 3.81 112.0 µM 2.21E-4 ERG2 23 6.96E-5
16 SGTC_1955 wogonin 3.77 32.4 µM 2.53E-4 21 8.17E-5
17 SGTC_996 3970-0799 3.77 1.8 µM 2.54E-4 88 8.22E-5
18 SGTC_1777 st045864 3.76 34.8 µM 2.65E-4 13 8.63E-5
19 SGTC_1548 st061468 3.70 90.8 µM 3.16E-4 10 1.06E-4
20 SGTC_2966 9084041 3.66 48.0 µM 3.74E-4 43 1.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 1.69E-21 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.145 3.90E-17 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.143 7.40E-17 YDR234W LYS4 hom Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
0.143 7.77E-17 YGL254W FZF1 hom Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress
0.136 3.09E-15 YMR251W GTO3 hom Omega class glutathione transferase; putative cytosolic localization
0.134 5.23E-15 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.132 1.81E-14 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.129 6.14E-14 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.125 3.22E-13 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.124 4.68E-13 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.122 1.08E-12 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.117 1.11E-11 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.115 2.52E-11 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.115 2.80E-11 YDR100W TVP15 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
0.108 3.40E-10 YNR013C PHO91 hom Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth