YGL243W / TAD1

tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL243W / TAD1

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:2.94|P-value:6.59E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.49|P-value:6.65E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.47|P-value:7.41E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:2.86|P-value:9.14E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-5.53|P-value:7.14E-10 ID:SGTC_750|Compound:4073-0104|FD-Score:-6.60|P-value:2.51E-13 ID:SGTC_752|Compound:1896-0090|FD-Score:-2.83|P-value:9.58E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:6.08|P-value:1.53E-11 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.36|P-value:1.15E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-4.06|P-value:4.48E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:3.36|P-value:1.24E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-3.94|P-value:8.15E-6 ID:SGTC_1089|Compound:terbinafine|FD-Score:2.87|P-value:8.60E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.63|P-value:3.63E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.15|P-value:2.88E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:2.96|P-value:6.09E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.19|P-value:2.50E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.97|P-value:7.50E-6 ID:SGTC_1603|Compound:st002045|FD-Score:-3.34|P-value:1.27E-4 ID:SGTC_1617|Compound:st002906|FD-Score:-3.58|P-value:4.50E-5 ID:SGTC_1764|Compound:st044502|FD-Score:3.00|P-value:5.25E-4 ID:SGTC_1886|Compound:st057356|FD-Score:4.42|P-value:6.84E-7 ID:SGTC_2015|Compound:5119600|FD-Score:3.88|P-value:1.12E-5 ID:SGTC_2027|Compound:5150920|FD-Score:3.81|P-value:1.57E-5 ID:SGTC_2031|Compound:5180455|FD-Score:3.14|P-value:3.08E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-3.51|P-value:6.17E-5 ID:SGTC_2329|Compound:6138490|FD-Score:2.98|P-value:5.65E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.32|P-value:1.44E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.76|P-value:1.98E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-3.74|P-value:2.11E-5 ID:SGTC_2602|Compound:kawain|FD-Score:3.50|P-value:6.63E-5 ID:SGTC_2623|Compound:humulene|FD-Score:-3.78|P-value:1.73E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.57|P-value:4.94E-5 ID:SGTC_2708|Compound:st078559|FD-Score:2.89|P-value:8.09E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.31|P-value:1.51E-4 ID:SGTC_2|Compound:0422-0095|FD-Score:2.94|P-value:6.59E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.49|P-value:6.65E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.47|P-value:7.41E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:2.86|P-value:9.14E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-5.53|P-value:7.14E-10 ID:SGTC_750|Compound:4073-0104|FD-Score:-6.60|P-value:2.51E-13 ID:SGTC_752|Compound:1896-0090|FD-Score:-2.83|P-value:9.58E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:6.08|P-value:1.53E-11 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.36|P-value:1.15E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-4.06|P-value:4.48E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:3.36|P-value:1.24E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-3.94|P-value:8.15E-6 ID:SGTC_1089|Compound:terbinafine|FD-Score:2.87|P-value:8.60E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.63|P-value:3.63E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.15|P-value:2.88E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:2.96|P-value:6.09E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.19|P-value:2.50E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.97|P-value:7.50E-6 ID:SGTC_1603|Compound:st002045|FD-Score:-3.34|P-value:1.27E-4 ID:SGTC_1617|Compound:st002906|FD-Score:-3.58|P-value:4.50E-5 ID:SGTC_1764|Compound:st044502|FD-Score:3.00|P-value:5.25E-4 ID:SGTC_1886|Compound:st057356|FD-Score:4.42|P-value:6.84E-7 ID:SGTC_2015|Compound:5119600|FD-Score:3.88|P-value:1.12E-5 ID:SGTC_2027|Compound:5150920|FD-Score:3.81|P-value:1.57E-5 ID:SGTC_2031|Compound:5180455|FD-Score:3.14|P-value:3.08E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-3.51|P-value:6.17E-5 ID:SGTC_2329|Compound:6138490|FD-Score:2.98|P-value:5.65E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.32|P-value:1.44E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.76|P-value:1.98E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-3.74|P-value:2.11E-5 ID:SGTC_2602|Compound:kawain|FD-Score:3.50|P-value:6.63E-5 ID:SGTC_2623|Compound:humulene|FD-Score:-3.78|P-value:1.73E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.57|P-value:4.94E-5 ID:SGTC_2708|Compound:st078559|FD-Score:2.89|P-value:8.09E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.31|P-value:1.51E-4

Top fitness defect scores for YGL243W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_784 4579-0127 6.08 173.0 µM 1.53E-11 4 5.91E-10
2 SGTC_1886 st057356 4.42 49.9 µM 6.84E-7 60S ribosome export 8 4.86E-6
3 SGTC_1493 4348-0038 3.97 111.0 µM 7.50E-6 RSC complex & mRNA processing 27 3.67E-5
4 SGTC_2015 5119600 3.88 184.0 µM 1.12E-5 33 5.16E-5
5 SGTC_2027 5150920 3.81 200.0 µM 1.57E-5 14 6.86E-5
6 SGTC_2563 tomatine 3.76 8.5 µM 1.98E-5 56 8.33E-5
7 SGTC_2638 epoxomicin 3.57 18.0 µM 4.94E-5 45 1.81E-4
8 SGTC_2602 kawain 3.50 100.0 µM 6.63E-5 41 2.32E-4
9 SGTC_997 3996-0078 3.36 137.0 µM 1.24E-4 49 3.92E-4
10 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 3.32 19.9 µM 1.44E-4 redox potentiating 22 4.46E-4
11 SGTC_3334 9142812 3.31 21.9 µM 1.51E-4 51 4.65E-4
12 SGTC_1390 3413-2614 3.19 145.0 µM 2.50E-4 fatty acid desaturase (OLE1) 52 7.12E-4
13 SGTC_1176 0848-0131 3.15 83.3 µM 2.88E-4 Golgi 47 8.05E-4
14 SGTC_2031 5180455 3.14 200.0 µM 3.08E-4 39 8.51E-4
15 SGTC_1764 st044502 3.00 93.5 µM 5.25E-4 83 0.00134
16 SGTC_2329 6138490 2.98 200.0 µM 5.65E-4 94 0.00142
17 SGTC_1334 1486-0610 2.96 236.0 µM 6.09E-4 60S ribosome export 62 0.00152
18 SGTC_2 0422-0095 2.94 29.0 µM 6.59E-4 redox potentiating 20 0.00162
19 SGTC_2708 st078559 2.89 56.0 µM 8.09E-4 33 0.00193
20 SGTC_1089 terbinafine 2.87 2.2 µM 8.60E-4 65 0.00203

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.241 1.44E-45 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.208 4.58E-34 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.182 1.90E-26 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.151 1.24E-18 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.145 2.74E-17 YOR083W WHI5 hom Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
0.143 6.60E-17 YJR056C YJR056C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress
0.136 2.11E-15 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.133 9.36E-15 YER053C PIC2 hom Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
0.133 1.02E-14 YDR399W HPT1 hom Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
0.131 3.04E-14 YEL038W UTR4 hom Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus
0.128 1.20E-13 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.123 8.74E-13 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.121 1.67E-12 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.120 3.27E-12 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.119 4.16E-12 YHL040C ARN1 hom ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress