HIPHOP chemogenomics database

YGL243W / TAD1

tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala

Zygosity: Homozygous strain

fixedexpanded
Profile for YGL243W / TAD1

Click on Significant Values for Screen Details

Top fitness defect scores for YGL243W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_784	4579-0127	6.08	173.0 µM	1.53E-11		4	5.91E-10
2	SGTC_1886	st057356	4.42	49.9 µM	6.84E-7	60S ribosome export	8	4.86E-6
3	SGTC_1493	4348-0038	3.97	111.0 µM	7.50E-6	RSC complex & mRNA processing	27	3.67E-5
4	SGTC_2015	5119600	3.88	184.0 µM	1.12E-5		33	5.16E-5
5	SGTC_2027	5150920	3.81	200.0 µM	1.57E-5		14	6.86E-5
6	SGTC_2563	tomatine	3.76	8.5 µM	1.98E-5		56	8.33E-5
7	SGTC_2638	epoxomicin	3.57	18.0 µM	4.94E-5		45	1.81E-4
8	SGTC_2602	kawain	3.50	100.0 µM	6.63E-5		41	2.32E-4
9	SGTC_997	3996-0078	3.36	137.0 µM	1.24E-4		49	3.92E-4
10	SGTC_2548	3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin	3.32	19.9 µM	1.44E-4	redox potentiating	22	4.46E-4
11	SGTC_3334	9142812	3.31	21.9 µM	1.51E-4		51	4.65E-4
12	SGTC_1390	3413-2614	3.19	145.0 µM	2.50E-4	fatty acid desaturase (OLE1)	52	7.12E-4
13	SGTC_1176	0848-0131	3.15	83.3 µM	2.88E-4	Golgi	47	8.05E-4
14	SGTC_2031	5180455	3.14	200.0 µM	3.08E-4		39	8.51E-4
15	SGTC_1764	st044502	3.00	93.5 µM	5.25E-4		83	0.00134
16	SGTC_2329	6138490	2.98	200.0 µM	5.65E-4		94	0.00142
17	SGTC_1334	1486-0610	2.96	236.0 µM	6.09E-4	60S ribosome export	62	0.00152
18	SGTC_2	0422-0095	2.94	29.0 µM	6.59E-4	redox potentiating	20	0.00162
19	SGTC_2708	st078559	2.89	56.0 µM	8.09E-4		33	0.00193
20	SGTC_1089	terbinafine	2.87	2.2 µM	8.60E-4		65	0.00203

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.241	1.44E-45	YDR534C	FIT1	hom	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.208	4.58E-34	YLR205C	HMX1	hom	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.182	1.90E-26	YMR111C	YMR111C	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.151	1.24E-18	YMR139W	RIM11	hom	Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.145	2.74E-17	YOR083W	WHI5	hom	Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
0.143	6.60E-17	YJR056C	YJR056C	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress
0.136	2.11E-15	YHR003C	YHR003C	hom	Protein of unknown function, localized to the mitochondrial outer membrane
0.133	9.36E-15	YER053C	PIC2	hom	Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
0.133	1.02E-14	YDR399W	HPT1	hom	Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
0.131	3.04E-14	YEL038W	UTR4	hom	Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus
0.128	1.20E-13	YOR010C	TIR2	hom	Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.123	8.74E-13	YLR023C	IZH3	hom	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.121	1.67E-12	YLL046C	RNP1	hom	Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.120	3.27E-12	YEL004W	YEA4	hom	Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.119	4.16E-12	YHL040C	ARN1	hom	ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress