YGL247W / BRR6

Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL247W / BRR6

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.51|P-value:3.55E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:6.61|P-value:8.07E-11 ID:SGTC_625|Compound:k213-0058|FD-Score:3.34|P-value:6.20E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.83|P-value:1.06E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.42|P-value:4.88E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.71|P-value:1.68E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:-3.46|P-value:3.77E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.41|P-value:4.96E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.25|P-value:7.79E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.20|P-value:9.89E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:-3.26|P-value:7.72E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:5.27|P-value:1.73E-7 ID:SGTC_1337|Compound:1486-1011|FD-Score:4.02|P-value:5.17E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.30|P-value:7.19E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.29|P-value:7.36E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.51|P-value:3.51E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:3.47|P-value:4.06E-4 ID:SGTC_1689|Compound:st020265|FD-Score:4.44|P-value:8.80E-6 ID:SGTC_1727|Compound:st034309|FD-Score:5.78|P-value:1.17E-8 ID:SGTC_1755|Compound:st041960|FD-Score:3.50|P-value:3.63E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.35|P-value:6.14E-4 ID:SGTC_1847|Compound:st056231|FD-Score:5.82|P-value:9.05E-9 ID:SGTC_2180|Compound:6301957|FD-Score:-3.62|P-value:2.14E-4 ID:SGTC_2195|Compound:6536160|FD-Score:-4.57|P-value:4.43E-6 ID:SGTC_2197|Compound:6588183|FD-Score:-3.85|P-value:9.27E-5 ID:SGTC_2199|Compound:6590217|FD-Score:3.66|P-value:2.05E-4 ID:SGTC_2329|Compound:6138490|FD-Score:5.04|P-value:5.54E-7 ID:SGTC_2366|Compound:9070441|FD-Score:-3.49|P-value:3.39E-4 ID:SGTC_2373|Compound:9071805|FD-Score:-3.61|P-value:2.27E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-4.60|P-value:3.88E-6 ID:SGTC_2377|Compound:9073351|FD-Score:3.39|P-value:5.38E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-4.48|P-value:6.68E-6 ID:SGTC_2380|Compound:9035439|FD-Score:-4.43|P-value:8.49E-6 ID:SGTC_2381|Compound:9035592|FD-Score:-3.67|P-value:1.76E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:7.17|P-value:2.02E-12 ID:SGTC_2413|Compound:inermin|FD-Score:-6.51|P-value:1.27E-10 ID:SGTC_2416|Compound:tofa|FD-Score:-5.26|P-value:1.63E-7 ID:SGTC_2417|Compound:cerulenin|FD-Score:5.99|P-value:3.47E-9 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-4.77|P-value:1.81E-6 ID:SGTC_2428|Compound:5615643|FD-Score:-4.46|P-value:7.42E-6 ID:SGTC_2438|Compound:5259590|FD-Score:-3.37|P-value:5.26E-4 ID:SGTC_2447|Compound:5741742|FD-Score:5.23|P-value:2.11E-7 ID:SGTC_2472|Compound:5377652|FD-Score:3.30|P-value:7.15E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.72|P-value:1.50E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.24|P-value:8.87E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.33|P-value:6.06E-4 ID:SGTC_2702|Compound:st077768|FD-Score:4.43|P-value:9.13E-6 ID:SGTC_3135|Compound:9127742|FD-Score:-4.81|P-value:1.52E-6 ID:SGTC_3218|Compound:9131285|FD-Score:3.22|P-value:9.36E-4 ID:SGTC_3219|Compound:9131112|FD-Score:5.23|P-value:2.09E-7 ID:SGTC_3322|Compound:9139058|FD-Score:3.87|P-value:9.09E-5 ID:SGTC_3341|Compound:9147222|FD-Score:4.00|P-value:5.65E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.51|P-value:3.55E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:6.61|P-value:8.07E-11 ID:SGTC_625|Compound:k213-0058|FD-Score:3.34|P-value:6.20E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.83|P-value:1.06E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.42|P-value:4.88E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.71|P-value:1.68E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:-3.46|P-value:3.77E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.41|P-value:4.96E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.25|P-value:7.79E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.20|P-value:9.89E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:-3.26|P-value:7.72E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:5.27|P-value:1.73E-7 ID:SGTC_1337|Compound:1486-1011|FD-Score:4.02|P-value:5.17E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.30|P-value:7.19E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.29|P-value:7.36E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.51|P-value:3.51E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:3.47|P-value:4.06E-4 ID:SGTC_1689|Compound:st020265|FD-Score:4.44|P-value:8.80E-6 ID:SGTC_1727|Compound:st034309|FD-Score:5.78|P-value:1.17E-8 ID:SGTC_1755|Compound:st041960|FD-Score:3.50|P-value:3.63E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.35|P-value:6.14E-4 ID:SGTC_1847|Compound:st056231|FD-Score:5.82|P-value:9.05E-9 ID:SGTC_2180|Compound:6301957|FD-Score:-3.62|P-value:2.14E-4 ID:SGTC_2195|Compound:6536160|FD-Score:-4.57|P-value:4.43E-6 ID:SGTC_2197|Compound:6588183|FD-Score:-3.85|P-value:9.27E-5 ID:SGTC_2199|Compound:6590217|FD-Score:3.66|P-value:2.05E-4 ID:SGTC_2329|Compound:6138490|FD-Score:5.04|P-value:5.54E-7 ID:SGTC_2366|Compound:9070441|FD-Score:-3.49|P-value:3.39E-4 ID:SGTC_2373|Compound:9071805|FD-Score:-3.61|P-value:2.27E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-4.60|P-value:3.88E-6 ID:SGTC_2377|Compound:9073351|FD-Score:3.39|P-value:5.38E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-4.48|P-value:6.68E-6 ID:SGTC_2380|Compound:9035439|FD-Score:-4.43|P-value:8.49E-6 ID:SGTC_2381|Compound:9035592|FD-Score:-3.67|P-value:1.76E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:7.17|P-value:2.02E-12 ID:SGTC_2413|Compound:inermin|FD-Score:-6.51|P-value:1.27E-10 ID:SGTC_2416|Compound:tofa|FD-Score:-5.26|P-value:1.63E-7 ID:SGTC_2417|Compound:cerulenin|FD-Score:5.99|P-value:3.47E-9 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-4.77|P-value:1.81E-6 ID:SGTC_2428|Compound:5615643|FD-Score:-4.46|P-value:7.42E-6 ID:SGTC_2438|Compound:5259590|FD-Score:-3.37|P-value:5.26E-4 ID:SGTC_2447|Compound:5741742|FD-Score:5.23|P-value:2.11E-7 ID:SGTC_2472|Compound:5377652|FD-Score:3.30|P-value:7.15E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.72|P-value:1.50E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.24|P-value:8.87E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.33|P-value:6.06E-4 ID:SGTC_2702|Compound:st077768|FD-Score:4.43|P-value:9.13E-6 ID:SGTC_3135|Compound:9127742|FD-Score:-4.81|P-value:1.52E-6 ID:SGTC_3218|Compound:9131285|FD-Score:3.22|P-value:9.36E-4 ID:SGTC_3219|Compound:9131112|FD-Score:5.23|P-value:2.09E-7 ID:SGTC_3322|Compound:9139058|FD-Score:3.87|P-value:9.09E-5 ID:SGTC_3341|Compound:9147222|FD-Score:4.00|P-value:5.65E-5

Top fitness defect scores for YGL247W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 7.17 200.0 µM 2.02E-12 1 3.77E-13 1.88
2 SGTC_163 1327-0036 6.61 7.5 µM 8.07E-11 28 1.91E-11 0.14
3 SGTC_2417 cerulenin 5.99 830.0 nM 3.47E-9 6 1.05E-9 0.98
4 SGTC_1847 st056231 5.82 15.0 µM 9.05E-9 1 2.92E-9 0.90
5 SGTC_1727 st034309 5.78 9.9 µM 1.17E-8 3 3.84E-9 0.45
6 SGTC_1324 1418-0026 5.27 34.4 µM 1.73E-7 2 6.77E-8 1.00
7 SGTC_3219 9131112 5.23 49.5 µM 2.09E-7 Golgi 10 8.26E-8 0.35
8 SGTC_2447 5741742 5.23 33.8 µM 2.11E-7 3 8.35E-8 0.17
9 SGTC_2329 6138490 5.04 200.0 µM 5.54E-7 4 2.34E-7 0.19
10 SGTC_1689 st020265 4.44 53.5 µM 8.80E-6 3 4.44E-6 0.84
11 SGTC_2702 st077768 4.43 96.8 µM 9.13E-6 3 4.62E-6 0.06
12 SGTC_1337 1486-1011 4.02 40.3 µM 5.17E-5 2 2.92E-5 0.54
13 SGTC_3341 9147222 4.00 25.9 µM 5.65E-5 RNA processing & uracil transport 10 3.21E-5 0.01
14 SGTC_3322 9139058 3.87 2.1 µM 9.09E-5 cell wall 17 5.33E-5 0.06
15 SGTC_682 0kpi-0099 3.83 17.0 µM 1.06E-4 30 6.28E-5 0.02
16 SGTC_1103 duloxetine 3.71 36.1 µM 1.68E-4 7 1.02E-4 0.02
17 SGTC_2199 6590217 3.66 200.0 µM 2.05E-4 mitochondrial processes 4 1.27E-4 0.23
18 SGTC_1482 3346-2049 3.51 8.5 µM 3.51E-4 8 2.24E-4 0.10
19 SGTC_58 0957-0393 3.51 9.0 µM 3.55E-4 cell wall 60 2.27E-4 0.07
20 SGTC_1755 st041960 3.50 45.2 µM 3.63E-4 12 2.33E-4 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 4.35E-13 YMR175W SIP18 hom Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress
0.116 1.39E-11 YNL071W LAT1 hom Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
0.109 2.31E-10 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.107 4.86E-10 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.105 9.02E-10 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.105 1.23E-9 YDL189W RBS1 hom Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
0.100 7.00E-9 YDR403W DIT1 hom Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure
0.096 2.58E-8 YIL003W CFD1 het Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
0.095 3.57E-8 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.093 6.60E-8 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.093 6.96E-8 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.093 7.32E-8 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.091 1.44E-7 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.090 1.94E-7 YIL061C SNP1 het Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress
0.089 2.26E-7 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate