YGL249W / ZIP2

Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL249W / ZIP2

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:3.14|P-value:2.13E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.90|P-value:3.48E-8 ID:SGTC_148|Compound:3253-0744|FD-Score:-4.23|P-value:1.62E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:-8.60|P-value:1.02E-21 ID:SGTC_165|Compound:k038-0023|FD-Score:-4.76|P-value:8.13E-8 ID:SGTC_166|Compound:k072-0058|FD-Score:-7.68|P-value:1.14E-17 ID:SGTC_167|Compound:3672-0051|FD-Score:-6.09|P-value:9.48E-12 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.00|P-value:3.78E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.34|P-value:1.26E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.32|P-value:9.47E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:4.59|P-value:1.42E-7 ID:SGTC_551|Compound:k048-0028|FD-Score:4.18|P-value:1.41E-6 ID:SGTC_761|Compound:k216-0224|FD-Score:3.03|P-value:3.26E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.25|P-value:9.90E-7 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.95|P-value:6.08E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.32|P-value:1.38E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.41|P-value:9.22E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:2.75|P-value:9.75E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.94|P-value:1.61E-8 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.14|P-value:2.94E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.81|P-value:3.70E-8 ID:SGTC_1101|Compound:ebselen|FD-Score:3.11|P-value:2.35E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.15|P-value:2.01E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.02|P-value:3.48E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.28|P-value:1.58E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.86|P-value:7.70E-6 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.52|P-value:3.84E-5 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.40|P-value:6.66E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.25|P-value:1.30E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-5.07|P-value:1.17E-8 ID:SGTC_1731|Compound:st035964|FD-Score:-3.41|P-value:9.19E-5 ID:SGTC_1732|Compound:st034308|FD-Score:2.92|P-value:5.14E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.87|P-value:1.09E-5 ID:SGTC_1889|Compound:st059080|FD-Score:3.38|P-value:7.50E-5 ID:SGTC_1902|Compound:st060212|FD-Score:-3.45|P-value:7.64E-5 ID:SGTC_1915|Compound:st067105|FD-Score:3.09|P-value:2.52E-4 ID:SGTC_2050|Compound:5263056|FD-Score:2.89|P-value:5.66E-4 ID:SGTC_2160|Compound:5660466|FD-Score:2.92|P-value:5.18E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.47|P-value:4.89E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.14|P-value:2.85E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-2.86|P-value:8.65E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.82|P-value:9.40E-6 ID:SGTC_2323|Compound:6148992|FD-Score:-2.97|P-value:5.69E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.00|P-value:3.73E-4 ID:SGTC_2374|Compound:9071832|FD-Score:2.78|P-value:8.73E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-2.94|P-value:6.39E-4 ID:SGTC_2394|Compound:5221648|FD-Score:2.93|P-value:4.96E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-3.21|P-value:2.15E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.07|P-value:2.58E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:4.43|P-value:3.47E-7 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.99|P-value:3.93E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-4.13|P-value:2.78E-6 ID:SGTC_2616|Compound:abietic acid|FD-Score:5.11|P-value:5.64E-9 ID:SGTC_2855|Compound:9016525|FD-Score:-3.49|P-value:6.48E-5 ID:SGTC_2918|Compound:7977171|FD-Score:3.10|P-value:2.42E-4 ID:SGTC_2921|Compound:7974240|FD-Score:2.82|P-value:7.67E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.41|P-value:9.16E-5 ID:SGTC_2989|Compound:9073649|FD-Score:2.91|P-value:5.40E-4 ID:SGTC_3065|Compound:9113888|FD-Score:2.78|P-value:8.73E-4 ID:SGTC_3150|Compound:9097574|FD-Score:2.91|P-value:5.25E-4 ID:SGTC_3157|Compound:9099274|FD-Score:2.82|P-value:7.52E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.32|P-value:9.85E-5 ID:SGTC_3247|Compound:9135149|FD-Score:2.82|P-value:7.64E-4 ID:SGTC_3258|Compound:9138477|FD-Score:-3.88|P-value:1.04E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:3.14|P-value:2.13E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.90|P-value:3.48E-8 ID:SGTC_148|Compound:3253-0744|FD-Score:-4.23|P-value:1.62E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:-8.60|P-value:1.02E-21 ID:SGTC_165|Compound:k038-0023|FD-Score:-4.76|P-value:8.13E-8 ID:SGTC_166|Compound:k072-0058|FD-Score:-7.68|P-value:1.14E-17 ID:SGTC_167|Compound:3672-0051|FD-Score:-6.09|P-value:9.48E-12 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.00|P-value:3.78E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.34|P-value:1.26E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.32|P-value:9.47E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:4.59|P-value:1.42E-7 ID:SGTC_551|Compound:k048-0028|FD-Score:4.18|P-value:1.41E-6 ID:SGTC_761|Compound:k216-0224|FD-Score:3.03|P-value:3.26E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.25|P-value:9.90E-7 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.95|P-value:6.08E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.32|P-value:1.38E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.41|P-value:9.22E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:2.75|P-value:9.75E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.94|P-value:1.61E-8 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.14|P-value:2.94E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.81|P-value:3.70E-8 ID:SGTC_1101|Compound:ebselen|FD-Score:3.11|P-value:2.35E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.15|P-value:2.01E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.02|P-value:3.48E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.28|P-value:1.58E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.86|P-value:7.70E-6 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.52|P-value:3.84E-5 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.40|P-value:6.66E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.25|P-value:1.30E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-5.07|P-value:1.17E-8 ID:SGTC_1731|Compound:st035964|FD-Score:-3.41|P-value:9.19E-5 ID:SGTC_1732|Compound:st034308|FD-Score:2.92|P-value:5.14E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.87|P-value:1.09E-5 ID:SGTC_1889|Compound:st059080|FD-Score:3.38|P-value:7.50E-5 ID:SGTC_1902|Compound:st060212|FD-Score:-3.45|P-value:7.64E-5 ID:SGTC_1915|Compound:st067105|FD-Score:3.09|P-value:2.52E-4 ID:SGTC_2050|Compound:5263056|FD-Score:2.89|P-value:5.66E-4 ID:SGTC_2160|Compound:5660466|FD-Score:2.92|P-value:5.18E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.47|P-value:4.89E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.14|P-value:2.85E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-2.86|P-value:8.65E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.82|P-value:9.40E-6 ID:SGTC_2323|Compound:6148992|FD-Score:-2.97|P-value:5.69E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.00|P-value:3.73E-4 ID:SGTC_2374|Compound:9071832|FD-Score:2.78|P-value:8.73E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-2.94|P-value:6.39E-4 ID:SGTC_2394|Compound:5221648|FD-Score:2.93|P-value:4.96E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-3.21|P-value:2.15E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.07|P-value:2.58E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:4.43|P-value:3.47E-7 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.99|P-value:3.93E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-4.13|P-value:2.78E-6 ID:SGTC_2616|Compound:abietic acid|FD-Score:5.11|P-value:5.64E-9 ID:SGTC_2855|Compound:9016525|FD-Score:-3.49|P-value:6.48E-5 ID:SGTC_2918|Compound:7977171|FD-Score:3.10|P-value:2.42E-4 ID:SGTC_2921|Compound:7974240|FD-Score:2.82|P-value:7.67E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.41|P-value:9.16E-5 ID:SGTC_2989|Compound:9073649|FD-Score:2.91|P-value:5.40E-4 ID:SGTC_3065|Compound:9113888|FD-Score:2.78|P-value:8.73E-4 ID:SGTC_3150|Compound:9097574|FD-Score:2.91|P-value:5.25E-4 ID:SGTC_3157|Compound:9099274|FD-Score:2.82|P-value:7.52E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.32|P-value:9.85E-5 ID:SGTC_3247|Compound:9135149|FD-Score:2.82|P-value:7.64E-4 ID:SGTC_3258|Compound:9138477|FD-Score:-3.88|P-value:1.04E-5

Top fitness defect scores for YGL249W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2616 abietic acid 5.11 100.0 µM 5.64E-9 17 1.64E-7
2 SGTC_996 3970-0799 4.94 1.8 µM 1.61E-8 57 3.85E-7
3 SGTC_1066 ketoconazole 4.81 628.0 nM 3.70E-8 8 7.56E-7
4 SGTC_536 3852-0578 4.59 10.6 µM 1.42E-7 15 2.25E-6
5 SGTC_2605 digitonin 4.43 300.0 nM 3.47E-7 15 4.65E-6
6 SGTC_769 0302-0231 4.25 76.0 µM 9.90E-7 29 1.09E-5
7 SGTC_551 k048-0028 4.18 34.9 µM 1.41E-6 10 1.45E-5
8 SGTC_2410 aloe-emodin-8-o-glycoside 4.07 46.3 µM 2.58E-6 mitochondrial processes 26 2.37E-5
9 SGTC_265 mycophenolic acid 4.00 32.9 µM 3.78E-6 RPP1 & pyrimidine depletion 17 3.23E-5
10 SGTC_1284 0929-0043 3.86 16.0 µM 7.70E-6 25 5.77E-5
11 SGTC_2316 5844804 3.82 197.4 µM 9.40E-6 37 6.78E-5
12 SGTC_1290 0986-0249 3.52 10.2 µM 3.84E-5 DNA intercalators 32 2.13E-4
13 SGTC_2239 6685329 3.47 187.6 µM 4.89E-5 48 2.59E-4
14 SGTC_1307 1187-1599 3.40 12.2 µM 6.66E-5 PDR1 22 3.33E-4
15 SGTC_1889 st059080 3.38 5.2 µM 7.50E-5 42 3.67E-4
16 SGTC_527 4476-4215 3.32 268.0 µM 9.47E-5 PDR1 61 4.44E-4
17 SGTC_3188 9110789 3.32 49.5 µM 9.85E-5 iron homeostasis 45 4.58E-4
18 SGTC_1309 pyrazolanthrone 3.25 13.4 µM 1.30E-4 46 5.75E-4
19 SGTC_1112 tnp00069 3.15 1.2 µM 2.01E-4 61 8.20E-4
20 SGTC_71 0417-1750 3.14 47.8 µM 2.13E-4 Golgi 93 8.58E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.209 1.85E-34 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.207 7.18E-34 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.190 1.18E-28 YDR133C_d YDR133C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
0.186 2.25E-27 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.162 4.85E-21 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.159 2.79E-20 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.154 3.98E-19 YOL055C THI20 hom Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p
0.141 2.40E-16 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.137 1.89E-15 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.134 8.50E-15 YKL164C PIR1 hom O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
0.132 1.77E-14 YDR330W UBX5 hom UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
0.131 2.28E-14 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.126 2.35E-13 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.123 7.10E-13 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.121 2.31E-12 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p