YGL256W / ADH4

Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL256W / ADH4

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:4.11|P-value:4.60E-6 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.67|P-value:3.75E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:-2.97|P-value:6.68E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.79|P-value:2.16E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:3.78|P-value:2.24E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.52|P-value:6.95E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:5.37|P-value:3.30E-9 ID:SGTC_631|Compound:k072-0230|FD-Score:5.29|P-value:5.53E-9 ID:SGTC_657|Compound:3534-0529|FD-Score:2.96|P-value:7.06E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.00|P-value:5.93E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.51|P-value:7.56E-5 ID:SGTC_837|Compound:0091-0265|FD-Score:3.17|P-value:3.08E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.01|P-value:5.72E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.08|P-value:4.44E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.23|P-value:2.47E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.60|P-value:5.04E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:2.94|P-value:7.47E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:-3.60|P-value:4.99E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.12|P-value:4.23E-6 ID:SGTC_1158|Compound:4092-0494|FD-Score:5.67|P-value:4.58E-10 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.63|P-value:4.39E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.43|P-value:1.07E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.09|P-value:4.22E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.49|P-value:8.08E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:2.93|P-value:7.69E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.08|P-value:4.41E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.16|P-value:3.49E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.25|P-value:2.22E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-3.24|P-value:2.28E-4 ID:SGTC_2168|Compound:5727979|FD-Score:2.90|P-value:8.66E-4 ID:SGTC_2174|Compound:5790901|FD-Score:4.80|P-value:1.10E-7 ID:SGTC_2175|Compound:5807670|FD-Score:3.77|P-value:2.34E-5 ID:SGTC_2240|Compound:6690706|FD-Score:-3.82|P-value:1.81E-5 ID:SGTC_2260|Compound:7964312|FD-Score:3.16|P-value:3.26E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-2.91|P-value:8.11E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.16|P-value:3.10E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:2.86|P-value:9.99E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.01|P-value:5.89E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.97|P-value:8.97E-6 ID:SGTC_2920|Compound:7982904|FD-Score:3.44|P-value:1.03E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.15|P-value:3.35E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-2.91|P-value:8.26E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.58|P-value:5.61E-5 ID:SGTC_3324|Compound:9138759|FD-Score:4.17|P-value:3.41E-6 ID:SGTC_3328|Compound:9140624|FD-Score:3.37|P-value:1.39E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.11|P-value:4.60E-6 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.67|P-value:3.75E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:-2.97|P-value:6.68E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.79|P-value:2.16E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:3.78|P-value:2.24E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.52|P-value:6.95E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:5.37|P-value:3.30E-9 ID:SGTC_631|Compound:k072-0230|FD-Score:5.29|P-value:5.53E-9 ID:SGTC_657|Compound:3534-0529|FD-Score:2.96|P-value:7.06E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.00|P-value:5.93E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.51|P-value:7.56E-5 ID:SGTC_837|Compound:0091-0265|FD-Score:3.17|P-value:3.08E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.01|P-value:5.72E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.08|P-value:4.44E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.23|P-value:2.47E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.60|P-value:5.04E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:2.94|P-value:7.47E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:-3.60|P-value:4.99E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.12|P-value:4.23E-6 ID:SGTC_1158|Compound:4092-0494|FD-Score:5.67|P-value:4.58E-10 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.63|P-value:4.39E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.43|P-value:1.07E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.09|P-value:4.22E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.49|P-value:8.08E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:2.93|P-value:7.69E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.08|P-value:4.41E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.16|P-value:3.49E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.25|P-value:2.22E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-3.24|P-value:2.28E-4 ID:SGTC_2168|Compound:5727979|FD-Score:2.90|P-value:8.66E-4 ID:SGTC_2174|Compound:5790901|FD-Score:4.80|P-value:1.10E-7 ID:SGTC_2175|Compound:5807670|FD-Score:3.77|P-value:2.34E-5 ID:SGTC_2240|Compound:6690706|FD-Score:-3.82|P-value:1.81E-5 ID:SGTC_2260|Compound:7964312|FD-Score:3.16|P-value:3.26E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-2.91|P-value:8.11E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.16|P-value:3.10E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:2.86|P-value:9.99E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.01|P-value:5.89E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.97|P-value:8.97E-6 ID:SGTC_2920|Compound:7982904|FD-Score:3.44|P-value:1.03E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.15|P-value:3.35E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-2.91|P-value:8.26E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.58|P-value:5.61E-5 ID:SGTC_3324|Compound:9138759|FD-Score:4.17|P-value:3.41E-6 ID:SGTC_3328|Compound:9140624|FD-Score:3.37|P-value:1.39E-4

Top fitness defect scores for YGL256W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1158 4092-0494 5.67 91.8 µM 4.58E-10 3 7.11E-9
2 SGTC_571 k831-0106 5.37 44.2 µM 3.30E-9 4 3.89E-8
3 SGTC_631 k072-0230 5.29 41.5 µM 5.53E-9 60S ribosome export 3 6.07E-8
4 SGTC_2174 5790901 4.80 200.0 µM 1.10E-7 tubulin folding & SWR complex 24 7.98E-7
5 SGTC_3324 9138759 4.17 60.8 µM 3.41E-6 15 1.54E-5
6 SGTC_1673 st016611 4.16 27.3 µM 3.49E-6 36 1.57E-5
7 SGTC_1149 3909-7961 4.12 23.3 µM 4.23E-6 15 1.86E-5
8 SGTC_68 0986-0284 4.11 82.8 µM 4.60E-6 65 2.00E-5
9 SGTC_2829 7992743 3.97 58.4 µM 8.97E-6 37 3.55E-5
10 SGTC_252 miconazole 3.79 1.3 nM 2.16E-5 ergosterol depletion effects on membrane 37 7.59E-5
11 SGTC_321 4534-3890 3.78 65.3 µM 2.24E-5 RPP1 & pyrimidine depletion 5 7.83E-5
12 SGTC_2175 5807670 3.77 165.3 µM 2.34E-5 23 8.12E-5
13 SGTC_219 mitoxanthrone 3.67 164.4 µM 3.75E-5 DNA intercalators 59 1.22E-4
14 SGTC_1195 1502-0147 3.63 41.1 µM 4.39E-5 36 1.40E-4
15 SGTC_976 1348-1067 3.60 47.6 µM 5.04E-5 60S ribosome export 42 1.58E-4
16 SGTC_3185 9108267 3.58 49.5 µM 5.61E-5 60S ribosome export 27 1.73E-4
17 SGTC_668 1682-0499 3.51 62.6 µM 7.56E-5 38 2.24E-4
18 SGTC_1395 3486-0190 3.49 4.3 µM 8.08E-5 25 2.37E-4
19 SGTC_2920 7982904 3.44 15.8 µM 1.03E-4 37 2.93E-4
20 SGTC_1197 1601-0112 3.43 267.0 µM 1.07E-4 34 3.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.58E-10 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.101 5.50E-9 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.099 7.95E-9 YHL042W_p YHL042W_p hom Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.088 3.81E-7 YGR287C IMA1 hom Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family
0.086 6.77E-7 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.083 1.39E-6 YDR164C SEC1 het Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function
0.083 1.51E-6 YMR056C AAC1 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.079 4.25E-6 YDR522C SPS2 hom Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component
0.079 5.05E-6 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.077 8.35E-6 YMR068W AVO2 hom Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.077 8.37E-6 YBR040W FIG1 hom Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating
0.077 9.34E-6 YFR009W GCN20 hom Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
0.073 2.30E-5 YPL126W NAN1 het U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA
0.072 2.99E-5 YBL094C_d YBL094C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W
0.070 4.76E-5 YGR245C SDA1 het Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis