YGL258W / VEL1

Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL258W / VEL1

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:-4.47|P-value:3.37E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:3.83|P-value:3.55E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:4.06|P-value:1.62E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-4.30|P-value:6.34E-5 ID:SGTC_252|Compound:miconazole|FD-Score:5.05|P-value:3.78E-6 ID:SGTC_264|Compound:promethazine|FD-Score:4.12|P-value:1.31E-4 ID:SGTC_277|Compound:nystatin|FD-Score:5.29|P-value:1.42E-6 ID:SGTC_350|Compound:k064-0020|FD-Score:4.32|P-value:6.63E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:4.67|P-value:1.80E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:3.70|P-value:5.34E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:4.22|P-value:9.47E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:-4.09|P-value:1.36E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:-4.07|P-value:1.46E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:6.02|P-value:4.79E-8 ID:SGTC_954|Compound:1189-0853|FD-Score:4.31|P-value:6.69E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:4.06|P-value:1.64E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:8.23|P-value:1.44E-13 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.66|P-value:6.05E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-4.58|P-value:2.27E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.08|P-value:1.50E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.62|P-value:2.18E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.41|P-value:4.74E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:-3.96|P-value:2.07E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-4.47|P-value:3.46E-5 ID:SGTC_1719|Compound:st032227|FD-Score:4.21|P-value:9.78E-5 ID:SGTC_1735|Compound:st034310|FD-Score:-3.83|P-value:3.19E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.61|P-value:6.41E-4 ID:SGTC_1832|Compound:st054113|FD-Score:4.34|P-value:6.02E-5 ID:SGTC_1838|Compound:st055369|FD-Score:4.44|P-value:4.18E-5 ID:SGTC_1839|Compound:st053978|FD-Score:3.86|P-value:3.13E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.78|P-value:4.13E-4 ID:SGTC_1916|Compound:st067606|FD-Score:4.34|P-value:6.19E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.28|P-value:1.47E-6 ID:SGTC_1930|Compound:st074634|FD-Score:5.08|P-value:3.40E-6 ID:SGTC_1932|Compound:st074806|FD-Score:-4.02|P-value:1.69E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-6.65|P-value:1.62E-9 ID:SGTC_1943|Compound:st076331|FD-Score:4.39|P-value:5.10E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-3.51|P-value:8.87E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.75|P-value:4.46E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.63|P-value:6.51E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.60|P-value:7.23E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.52|P-value:9.19E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.94|P-value:2.40E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.51|P-value:9.43E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.40|P-value:4.89E-5 ID:SGTC_2324|Compound:6149169|FD-Score:-3.72|P-value:4.63E-4 ID:SGTC_2450|Compound:5739737|FD-Score:5.14|P-value:2.63E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.96|P-value:2.28E-4 ID:SGTC_2717|Compound:st081029|FD-Score:-4.61|P-value:2.01E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.81|P-value:3.74E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.22|P-value:9.41E-5 ID:SGTC_3043|Compound:9092303|FD-Score:-3.89|P-value:2.61E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.79|P-value:3.93E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-4.47|P-value:3.37E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:3.83|P-value:3.55E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:4.06|P-value:1.62E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-4.30|P-value:6.34E-5 ID:SGTC_252|Compound:miconazole|FD-Score:5.05|P-value:3.78E-6 ID:SGTC_264|Compound:promethazine|FD-Score:4.12|P-value:1.31E-4 ID:SGTC_277|Compound:nystatin|FD-Score:5.29|P-value:1.42E-6 ID:SGTC_350|Compound:k064-0020|FD-Score:4.32|P-value:6.63E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:4.67|P-value:1.80E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:3.70|P-value:5.34E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:4.22|P-value:9.47E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:-4.09|P-value:1.36E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:-4.07|P-value:1.46E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:6.02|P-value:4.79E-8 ID:SGTC_954|Compound:1189-0853|FD-Score:4.31|P-value:6.69E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:4.06|P-value:1.64E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:8.23|P-value:1.44E-13 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.66|P-value:6.05E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-4.58|P-value:2.27E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.08|P-value:1.50E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.62|P-value:2.18E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.41|P-value:4.74E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:-3.96|P-value:2.07E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-4.47|P-value:3.46E-5 ID:SGTC_1719|Compound:st032227|FD-Score:4.21|P-value:9.78E-5 ID:SGTC_1735|Compound:st034310|FD-Score:-3.83|P-value:3.19E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.61|P-value:6.41E-4 ID:SGTC_1832|Compound:st054113|FD-Score:4.34|P-value:6.02E-5 ID:SGTC_1838|Compound:st055369|FD-Score:4.44|P-value:4.18E-5 ID:SGTC_1839|Compound:st053978|FD-Score:3.86|P-value:3.13E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.78|P-value:4.13E-4 ID:SGTC_1916|Compound:st067606|FD-Score:4.34|P-value:6.19E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.28|P-value:1.47E-6 ID:SGTC_1930|Compound:st074634|FD-Score:5.08|P-value:3.40E-6 ID:SGTC_1932|Compound:st074806|FD-Score:-4.02|P-value:1.69E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-6.65|P-value:1.62E-9 ID:SGTC_1943|Compound:st076331|FD-Score:4.39|P-value:5.10E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-3.51|P-value:8.87E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.75|P-value:4.46E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.63|P-value:6.51E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.60|P-value:7.23E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.52|P-value:9.19E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.94|P-value:2.40E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.51|P-value:9.43E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.40|P-value:4.89E-5 ID:SGTC_2324|Compound:6149169|FD-Score:-3.72|P-value:4.63E-4 ID:SGTC_2450|Compound:5739737|FD-Score:5.14|P-value:2.63E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.96|P-value:2.28E-4 ID:SGTC_2717|Compound:st081029|FD-Score:-4.61|P-value:2.01E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.81|P-value:3.74E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.22|P-value:9.41E-5 ID:SGTC_3043|Compound:9092303|FD-Score:-3.89|P-value:2.61E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.79|P-value:3.93E-4

Top fitness defect scores for YGL258W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 8.23 1.8 µM 1.44E-13 20 9.13E-17
2 SGTC_834 0312-0008 6.02 75.7 µM 4.79E-8 NEO1 17 8.74E-10
3 SGTC_277 nystatin 5.29 15.5 µM 1.42E-6 2 6.26E-8
4 SGTC_1926 methyl fluorone black 5.28 53.6 µM 1.47E-6 DNA intercalators 30 6.59E-8
5 SGTC_2450 5739737 5.14 12.9 µM 2.63E-6 6 1.36E-7
6 SGTC_1930 st074634 5.08 34.3 µM 3.40E-6 RNA pol III & RNase P/MRP 17 1.89E-7
7 SGTC_252 miconazole 5.05 1.3 nM 3.78E-6 ergosterol depletion effects on membrane 24 2.15E-7
8 SGTC_438 sphingosine 4.67 6.7 µM 1.80E-5 12 1.54E-6
9 SGTC_1265 0819-1001 4.62 68.8 µM 2.18E-5 11 1.95E-6
10 SGTC_1838 st055369 4.44 84.5 µM 4.18E-5 10 4.45E-6
11 SGTC_1574 spiramycin 4.41 23.7 µM 4.74E-5 16 5.21E-6
12 SGTC_2316 5844804 4.40 197.4 µM 4.89E-5 19 5.41E-6
13 SGTC_1943 st076331 4.39 65.2 µM 5.10E-5 12 5.70E-6
14 SGTC_1832 st054113 4.34 55.0 µM 6.02E-5 4 7.04E-6
15 SGTC_1916 st067606 4.34 49.2 µM 6.19E-5 25 7.28E-6
16 SGTC_350 k064-0020 4.32 19.8 µM 6.63E-5 heme requiring 20 7.93E-6
17 SGTC_954 1189-0853 4.31 2.9 µM 6.69E-5 endomembrane recycling 31 8.03E-6
18 SGTC_2927 9011802 4.22 47.9 µM 9.41E-5 22 1.23E-5
19 SGTC_655 k060-0012 4.22 42.0 µM 9.47E-5 9 1.24E-5
20 SGTC_1719 st032227 4.21 49.2 µM 9.78E-5 18 1.29E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 5.37E-31 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.157 6.81E-20 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.148 6.66E-18 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.148 7.86E-18 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.137 1.37E-15 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.127 1.41E-13 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.121 2.10E-12 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.119 3.95E-12 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.114 4.34E-11 YDL161W ENT1 hom Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.109 2.39E-10 YHR109W CTM1 hom Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
0.109 2.56E-10 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.108 3.10E-10 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.106 6.63E-10 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.105 9.27E-10 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.102 3.09E-9 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase