YGL259W_p / YPS5

Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL259W / YPS5

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:3.15|P-value:4.58E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.76|P-value:3.73E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:3.40|P-value:1.74E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.35|P-value:2.08E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:2.93|P-value:9.96E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.56|P-value:8.81E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:3.22|P-value:3.45E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.05|P-value:6.68E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.65|P-value:5.92E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:2.96|P-value:9.04E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-2.96|P-value:9.23E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.87|P-value:2.25E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-2.98|P-value:8.54E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.53|P-value:1.01E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.27|P-value:2.89E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.54|P-value:9.69E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:3.41|P-value:1.63E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.62|P-value:6.76E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.85|P-value:2.53E-5 ID:SGTC_1898|Compound:st060199|FD-Score:-5.04|P-value:5.84E-8 ID:SGTC_1980|Compound:st071811|FD-Score:4.38|P-value:1.98E-6 ID:SGTC_2132|Compound:5317594|FD-Score:-3.02|P-value:7.62E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-2.94|P-value:9.99E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.08|P-value:5.84E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-3.75|P-value:3.95E-5 ID:SGTC_2323|Compound:6148992|FD-Score:-4.02|P-value:1.21E-5 ID:SGTC_2326|Compound:6164455|FD-Score:-3.43|P-value:1.54E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-3.43|P-value:1.57E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-4.56|P-value:8.33E-7 ID:SGTC_2393|Compound:9031399|FD-Score:3.04|P-value:6.87E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.02|P-value:7.39E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.17|P-value:4.31E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:4.16|P-value:5.78E-6 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.06|P-value:6.53E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.16|P-value:4.29E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.15|P-value:4.67E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.15|P-value:4.58E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.76|P-value:3.73E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:3.40|P-value:1.74E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.35|P-value:2.08E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:2.93|P-value:9.96E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.56|P-value:8.81E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:3.22|P-value:3.45E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.05|P-value:6.68E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.65|P-value:5.92E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:2.96|P-value:9.04E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-2.96|P-value:9.23E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.87|P-value:2.25E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-2.98|P-value:8.54E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.53|P-value:1.01E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.27|P-value:2.89E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.54|P-value:9.69E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:3.41|P-value:1.63E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.62|P-value:6.76E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.85|P-value:2.53E-5 ID:SGTC_1898|Compound:st060199|FD-Score:-5.04|P-value:5.84E-8 ID:SGTC_1980|Compound:st071811|FD-Score:4.38|P-value:1.98E-6 ID:SGTC_2132|Compound:5317594|FD-Score:-3.02|P-value:7.62E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-2.94|P-value:9.99E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.08|P-value:5.84E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-3.75|P-value:3.95E-5 ID:SGTC_2323|Compound:6148992|FD-Score:-4.02|P-value:1.21E-5 ID:SGTC_2326|Compound:6164455|FD-Score:-3.43|P-value:1.54E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-3.43|P-value:1.57E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-4.56|P-value:8.33E-7 ID:SGTC_2393|Compound:9031399|FD-Score:3.04|P-value:6.87E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.02|P-value:7.39E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.17|P-value:4.31E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:4.16|P-value:5.78E-6 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.06|P-value:6.53E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.16|P-value:4.29E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.15|P-value:4.67E-4

Top fitness defect scores for YGL259W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1980 st071811 4.38 45.7 µM 1.98E-6 RPP1 & pyrimidine depletion 9 5.92E-6
2 SGTC_2605 digitonin 4.16 300.0 nM 5.78E-6 23 1.56E-5
3 SGTC_786 4544-0069 3.87 423.0 µM 2.25E-5 34 5.35E-5
4 SGTC_1370 2001-0092 3.85 44.6 µM 2.53E-5 39 5.94E-5
5 SGTC_288 1315-0019 3.76 35.1 µM 3.73E-5 RSC & ERG11 28 8.46E-5
6 SGTC_419 nsc-638432 3.65 893.0 µM 5.92E-5 DNA damage response 17 1.29E-4
7 SGTC_1132 3456-3614 3.62 2.5 µM 6.76E-5 tubulin folding & SWR complex 69 1.45E-4
8 SGTC_356 1634-0012 3.56 32.5 µM 8.81E-5 33 1.84E-4
9 SGTC_939 1165-0479 3.54 45.3 µM 9.69E-5 48 2.01E-4
10 SGTC_996 3970-0799 3.41 1.8 µM 1.63E-4 121 3.22E-4
11 SGTC_290 2043-6722 3.40 48.1 µM 1.74E-4 24 3.43E-4
12 SGTC_319 1348-1596 3.35 45.5 µM 2.08E-4 RSC & ERG11 34 4.02E-4
13 SGTC_924 2046-0044 3.27 21.3 µM 2.89E-4 33 5.43E-4
14 SGTC_383 2324-0395 3.22 7.4 µM 3.45E-4 azole & statin 70 6.37E-4
15 SGTC_2757 clomiphene 3.16 4.2 µM 4.29E-4 fatty acid desaturase (OLE1) 79 7.76E-4
16 SGTC_46 0329-0187a 3.15 2.2 µM 4.58E-4 119 8.24E-4
17 SGTC_2167 5876490 3.08 200.0 µM 5.84E-4 75 0.00103
18 SGTC_398 bronopol 3.05 33.3 µM 6.68E-4 RNA processing & uracil transport 60 0.00116
19 SGTC_2393 9031399 3.04 185.9 µM 6.87E-4 RNA processing & uracil transport 75 0.00119
20 SGTC_2522 biochanin a 3.02 4.9 µM 7.39E-4 RNA pol III & RNase P/MRP 37 0.00127

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.46E-21 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.144 5.80E-17 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.143 7.97E-17 YJR038C_d YJR038C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.139 7.85E-16 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.130 3.75E-14 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.118 6.39E-12 YGL255W ZRT1 hom High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
0.116 1.44E-11 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.116 1.77E-11 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.113 5.23E-11 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.108 3.69E-10 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.107 4.34E-10 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.107 4.56E-10 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.104 1.75E-9 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.101 5.19E-9 YER002W NOP16 hom Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.101 5.55E-9 YOL082W ATG19 hom Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles