YGL261C_p / PAU11

Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL261C / PAU11

Click on Significant Values for Screen Details ID:SGTC_359|Compound:0081-0058|FD-Score:4.15|P-value:1.17E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.13|P-value:7.20E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.67|P-value:9.22E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:5.14|P-value:8.20E-8 ID:SGTC_535|Compound:2293-4129|FD-Score:3.31|P-value:3.72E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.06|P-value:9.11E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.69|P-value:7.69E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:4.11|P-value:1.40E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:4.44|P-value:3.07E-6 ID:SGTC_891|Compound:0929-0073|FD-Score:3.66|P-value:9.85E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:6.86|P-value:1.29E-12 ID:SGTC_1052|Compound:3253-3998|FD-Score:10.70|P-value:8.02E-28 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.62|P-value:1.14E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.89|P-value:3.69E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:-6.32|P-value:5.02E-11 ID:SGTC_1124|Compound:fisetin|FD-Score:3.81|P-value:5.35E-5 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.12|P-value:7.53E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.46|P-value:2.15E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-4.14|P-value:1.09E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.07|P-value:8.22E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.12|P-value:7.47E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.32|P-value:3.64E-4 ID:SGTC_2094|Compound:5332512|FD-Score:-3.04|P-value:9.14E-4 ID:SGTC_2258|Compound:7960471|FD-Score:7.10|P-value:2.20E-13 ID:SGTC_2346|Compound:9031566|FD-Score:-3.68|P-value:8.18E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-3.02|P-value:9.76E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.24|P-value:4.89E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:4.99|P-value:1.82E-7 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.20|P-value:5.75E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.57|P-value:1.64E-6 ID:SGTC_2920|Compound:7982904|FD-Score:4.73|P-value:7.05E-7 ID:SGTC_2925|Compound:9010536|FD-Score:5.03|P-value:1.51E-7 ID:SGTC_2927|Compound:9011802|FD-Score:-3.24|P-value:4.44E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.57|P-value:1.38E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.07|P-value:9.03E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-3.30|P-value:3.62E-4 ID:SGTC_3134|Compound:9127454|FD-Score:-3.11|P-value:7.21E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-3.25|P-value:4.22E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-4.09|P-value:1.37E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:4.15|P-value:1.17E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.13|P-value:7.20E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.67|P-value:9.22E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:5.14|P-value:8.20E-8 ID:SGTC_535|Compound:2293-4129|FD-Score:3.31|P-value:3.72E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.06|P-value:9.11E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.69|P-value:7.69E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:4.11|P-value:1.40E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:4.44|P-value:3.07E-6 ID:SGTC_891|Compound:0929-0073|FD-Score:3.66|P-value:9.85E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:6.86|P-value:1.29E-12 ID:SGTC_1052|Compound:3253-3998|FD-Score:10.70|P-value:8.02E-28 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.62|P-value:1.14E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.89|P-value:3.69E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:-6.32|P-value:5.02E-11 ID:SGTC_1124|Compound:fisetin|FD-Score:3.81|P-value:5.35E-5 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.12|P-value:7.53E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.46|P-value:2.15E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-4.14|P-value:1.09E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.07|P-value:8.22E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.12|P-value:7.47E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.32|P-value:3.64E-4 ID:SGTC_2094|Compound:5332512|FD-Score:-3.04|P-value:9.14E-4 ID:SGTC_2258|Compound:7960471|FD-Score:7.10|P-value:2.20E-13 ID:SGTC_2346|Compound:9031566|FD-Score:-3.68|P-value:8.18E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-3.02|P-value:9.76E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.24|P-value:4.89E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:4.99|P-value:1.82E-7 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.20|P-value:5.75E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.57|P-value:1.64E-6 ID:SGTC_2920|Compound:7982904|FD-Score:4.73|P-value:7.05E-7 ID:SGTC_2925|Compound:9010536|FD-Score:5.03|P-value:1.51E-7 ID:SGTC_2927|Compound:9011802|FD-Score:-3.24|P-value:4.44E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.57|P-value:1.38E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.07|P-value:9.03E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-3.30|P-value:3.62E-4 ID:SGTC_3134|Compound:9127454|FD-Score:-3.11|P-value:7.21E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-3.25|P-value:4.22E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-4.09|P-value:1.37E-5

Top fitness defect scores for YGL261C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1052 3253-3998 10.70 198.0 µM 8.02E-28 1 8.49E-27
2 SGTC_2258 7960471 7.10 200.0 µM 2.20E-13 1 6.15E-13
3 SGTC_996 3970-0799 6.86 1.8 µM 1.29E-12 27 3.35E-12
4 SGTC_522 1273-0010 5.14 11.6 µM 8.20E-8 60S ribosome export 8 1.39E-7
5 SGTC_2925 9010536 5.03 32.5 µM 1.51E-7 azole & statin 23 2.50E-7
6 SGTC_2754 granisetron 4.99 64.0 µM 1.82E-7 17 2.98E-7
7 SGTC_2920 7982904 4.73 15.8 µM 7.05E-7 7 1.10E-6
8 SGTC_2823 7987624 4.57 58.4 µM 1.64E-6 13 2.47E-6
9 SGTC_810 3825-7150 4.44 143.0 µM 3.07E-6 60S ribosome export 5 4.52E-6
10 SGTC_359 0081-0058 4.15 15.9 µM 1.17E-5 60S ribosome export 37 1.64E-5
11 SGTC_715 0868-0130 4.11 184.0 µM 1.40E-5 7 1.95E-5
12 SGTC_1104 tacrolimus 3.89 29.8 µM 3.69E-5 33 4.95E-5
13 SGTC_1124 fisetin 3.81 1.2 µM 5.35E-5 40 7.09E-5
14 SGTC_474 dl-dihydrosphingosine 3.67 5.0 µM 9.22E-5 30 1.20E-4
15 SGTC_891 0929-0073 3.66 133.0 µM 9.85E-5 31 1.28E-4
16 SGTC_1058 3448-5425 3.62 97.3 µM 1.14E-4 40 1.47E-4
17 SGTC_2928 9011484 3.57 9.8 µM 1.38E-4 heme biosynthesis & mitochondrial translocase 49 1.77E-4
18 SGTC_1326 1431-2094 3.46 10.8 µM 2.15E-4 tubulin folding & SWR complex 49 2.71E-4
19 SGTC_1879 gemcitabine 3.32 100.0 µM 3.64E-4 38 4.49E-4
20 SGTC_535 2293-4129 3.31 48.2 µM 3.72E-4 NEO1 99 4.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.230 1.87E-41 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.210 8.48E-35 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.163 2.24E-21 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.161 5.09E-21 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.149 4.86E-18 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.147 1.11E-17 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.146 2.39E-17 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.140 3.28E-16 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.139 5.18E-16 YLR326W_p YLR326W_p hom Putative protein of unknown function, predicted to be palmitoylated
0.137 1.75E-15 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.127 1.89E-13 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.127 1.95E-13 YHR109W CTM1 hom Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
0.123 8.09E-13 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.120 2.72E-12 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.118 6.88E-12 YBR177C EHT1 hom Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication