YGL262W_p

Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL262W / YGL262W

Click on Significant Values for Screen Details ID:SGTC_802|Compound:4112-3352|FD-Score:-4.29|P-value:4.45E-6 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.37|P-value:2.51E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:-3.00|P-value:9.87E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.61|P-value:6.58E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.43|P-value:1.45E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.92|P-value:2.41E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.30|P-value:2.31E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:-3.77|P-value:4.71E-5 ID:SGTC_1900|Compound:st060200|FD-Score:-3.02|P-value:9.12E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.08|P-value:5.38E-4 ID:SGTC_1968|Compound:st069590|FD-Score:2.92|P-value:9.65E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.26|P-value:2.78E-4 ID:SGTC_1976|Compound:st070609|FD-Score:2.93|P-value:9.24E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.16|P-value:4.01E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-3.18|P-value:5.03E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.14|P-value:4.31E-4 ID:SGTC_2374|Compound:9071832|FD-Score:3.09|P-value:5.19E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-3.16|P-value:5.49E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.56|P-value:8.10E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:5.28|P-value:1.26E-8 ID:SGTC_2453|Compound:5731132|FD-Score:3.14|P-value:4.39E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.13|P-value:4.54E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.42|P-value:1.47E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.29|P-value:3.38E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.98|P-value:1.25E-5 ID:SGTC_2808|Compound:7946468|FD-Score:-2.99|P-value:9.99E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.13|P-value:4.50E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.02|P-value:6.69E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-4.08|P-value:1.19E-5 ID:SGTC_3103|Compound:9120822|FD-Score:3.51|P-value:1.00E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-3.77|P-value:4.69E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.55|P-value:8.51E-5 ID:SGTC_3229|Compound:9132204|FD-Score:2.97|P-value:8.11E-4 ID:SGTC_3231|Compound:9132313|FD-Score:-3.09|P-value:7.09E-4 ID:SGTC_3249|Compound:9135183|FD-Score:4.80|P-value:2.02E-7 ID:SGTC_802|Compound:4112-3352|FD-Score:-4.29|P-value:4.45E-6 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.37|P-value:2.51E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:-3.00|P-value:9.87E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.61|P-value:6.58E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.43|P-value:1.45E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.92|P-value:2.41E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.30|P-value:2.31E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:-3.77|P-value:4.71E-5 ID:SGTC_1900|Compound:st060200|FD-Score:-3.02|P-value:9.12E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.08|P-value:5.38E-4 ID:SGTC_1968|Compound:st069590|FD-Score:2.92|P-value:9.65E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.26|P-value:2.78E-4 ID:SGTC_1976|Compound:st070609|FD-Score:2.93|P-value:9.24E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.16|P-value:4.01E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-3.18|P-value:5.03E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.14|P-value:4.31E-4 ID:SGTC_2374|Compound:9071832|FD-Score:3.09|P-value:5.19E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-3.16|P-value:5.49E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.56|P-value:8.10E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:5.28|P-value:1.26E-8 ID:SGTC_2453|Compound:5731132|FD-Score:3.14|P-value:4.39E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.13|P-value:4.54E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.42|P-value:1.47E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.29|P-value:3.38E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.98|P-value:1.25E-5 ID:SGTC_2808|Compound:7946468|FD-Score:-2.99|P-value:9.99E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.13|P-value:4.50E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.02|P-value:6.69E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-4.08|P-value:1.19E-5 ID:SGTC_3103|Compound:9120822|FD-Score:3.51|P-value:1.00E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-3.77|P-value:4.69E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.55|P-value:8.51E-5 ID:SGTC_3229|Compound:9132204|FD-Score:2.97|P-value:8.11E-4 ID:SGTC_3231|Compound:9132313|FD-Score:-3.09|P-value:7.09E-4 ID:SGTC_3249|Compound:9135183|FD-Score:4.80|P-value:2.02E-7

Top fitness defect scores for YGL262W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2410 aloe-emodin-8-o-glycoside 5.28 46.3 µM 1.26E-8 mitochondrial processes 8 6.38E-8
2 SGTC_3249 9135183 4.80 49.5 µM 2.02E-7 60S ribosome export 5 7.96E-7
3 SGTC_1214 0358-0031 4.43 63.7 µM 1.45E-6 8 4.77E-6
4 SGTC_2780 5215298 3.98 71.4 µM 1.25E-5 36 3.38E-5
5 SGTC_1099 5-nonyloxytryptamine 3.61 2.9 µM 6.58E-5 27 1.53E-4
6 SGTC_2379 9035213 3.56 200.0 µM 8.10E-5 36 1.84E-4
7 SGTC_3215 9129942 3.55 49.5 µM 8.51E-5 16 1.92E-4
8 SGTC_3103 9120822 3.51 49.5 µM 1.00E-4 26 2.23E-4
9 SGTC_2568 diosmetin 3.42 100.0 µM 1.47E-4 39 3.16E-4
10 SGTC_1395 3486-0190 3.30 4.3 µM 2.31E-4 40 4.77E-4
11 SGTC_1975 st070967 3.26 30.8 µM 2.78E-4 64 5.64E-4
12 SGTC_2133 5320837 3.16 200.0 µM 4.01E-4 ERG2 58 7.87E-4
13 SGTC_2354 9060492 3.14 162.0 µM 4.31E-4 52 8.39E-4
14 SGTC_2453 5731132 3.14 22.2 µM 4.39E-4 60 8.55E-4
15 SGTC_2871 9038510 3.13 13.0 µM 4.50E-4 49 8.73E-4
16 SGTC_2493 resveratrol 3.13 26.1 µM 4.54E-4 26 8.80E-4
17 SGTC_2374 9071832 3.09 200.0 µM 5.19E-4 endomembrane recycling 28 9.94E-4
18 SGTC_1906 st060206 3.08 94.7 µM 5.38E-4 57 0.00103
19 SGTC_2970 9090938 3.02 41.9 µM 6.69E-4 RNA processing & uracil transport 104 0.00125
20 SGTC_3229 9132204 2.97 49.5 µM 8.11E-4 19 0.00149

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 3.88E-12 YDR059C UBC5 hom Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication
0.119 4.34E-12 YJR099W YUH1 hom Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
0.119 4.76E-12 YGR274C TAF1 het TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression
0.106 7.47E-10 YPL185W_d YPL185W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
0.099 1.00E-8 YBR222C PCS60 hom Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase
0.099 1.09E-8 YPR171W BSP1 hom Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
0.090 1.65E-7 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.088 3.20E-7 YDL239C ADY3 hom Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication
0.088 3.56E-7 YML043C RRN11 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.085 8.84E-7 YLR351C NIT3 hom Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
0.081 2.79E-6 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.080 3.09E-6 YOR304W ISW2 hom ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
0.079 4.96E-6 YGR248W SOL4 hom 6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication
0.076 9.26E-6 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.076 1.04E-5 YOR318C_d YOR318C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo