YGR002C / SWC4

Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR002C / SWC4

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:3.07|P-value:6.31E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:-3.36|P-value:1.72E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.78|P-value:3.64E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.15|P-value:3.99E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:4.32|P-value:2.78E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.77|P-value:2.94E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:4.04|P-value:1.07E-5 ID:SGTC_317|Compound:4495-0002|FD-Score:3.29|P-value:2.78E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.85|P-value:2.63E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.99|P-value:1.10E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:3.18|P-value:4.15E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.31|P-value:2.28E-6 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.04|P-value:5.96E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.53|P-value:8.51E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:4.32|P-value:2.77E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:2.98|P-value:8.75E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.25|P-value:3.29E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.00|P-value:8.24E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:-2.92|P-value:9.16E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.11|P-value:4.60E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.14|P-value:6.71E-6 ID:SGTC_691|Compound:1548-0686|FD-Score:2.95|P-value:9.98E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.07|P-value:6.30E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.61|P-value:7.47E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:-3.79|P-value:2.69E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.15|P-value:4.80E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.03|P-value:7.30E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-3.22|P-value:3.05E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.49|P-value:1.23E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.62|P-value:7.12E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.04|P-value:7.17E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:2.98|P-value:8.76E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:-2.95|P-value:8.36E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.07|P-value:9.22E-6 ID:SGTC_1636|Compound:st007707|FD-Score:3.20|P-value:3.85E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-3.92|P-value:1.55E-5 ID:SGTC_1744|Compound:st037937|FD-Score:2.97|P-value:9.04E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.25|P-value:3.18E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.90|P-value:2.11E-5 ID:SGTC_1861|Compound:st057647|FD-Score:3.58|P-value:8.52E-5 ID:SGTC_1917|Compound:st066507|FD-Score:4.06|P-value:1.00E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.95|P-value:1.68E-5 ID:SGTC_2066|Compound:5222451|FD-Score:3.09|P-value:5.90E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.95|P-value:1.31E-5 ID:SGTC_2243|Compound:6634756|FD-Score:-3.08|P-value:5.12E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.14|P-value:4.09E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.03|P-value:7.28E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.10|P-value:4.75E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.10|P-value:8.05E-6 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.65|P-value:6.25E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.26|P-value:3.16E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.03|P-value:7.35E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.21|P-value:3.72E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-2.94|P-value:8.47E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.78|P-value:3.49E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:3.46|P-value:1.40E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-3.29|P-value:2.32E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.25|P-value:3.19E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.15|P-value:3.96E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.62|P-value:7.29E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.55|P-value:9.59E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:3.07|P-value:6.31E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:-3.36|P-value:1.72E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.78|P-value:3.64E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.15|P-value:3.99E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:4.32|P-value:2.78E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.77|P-value:2.94E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:4.04|P-value:1.07E-5 ID:SGTC_317|Compound:4495-0002|FD-Score:3.29|P-value:2.78E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.85|P-value:2.63E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.99|P-value:1.10E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:3.18|P-value:4.15E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.31|P-value:2.28E-6 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.04|P-value:5.96E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.53|P-value:8.51E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:4.32|P-value:2.77E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:2.98|P-value:8.75E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.25|P-value:3.29E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.00|P-value:8.24E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:-2.92|P-value:9.16E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.11|P-value:4.60E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.14|P-value:6.71E-6 ID:SGTC_691|Compound:1548-0686|FD-Score:2.95|P-value:9.98E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.07|P-value:6.30E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.61|P-value:7.47E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:-3.79|P-value:2.69E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.15|P-value:4.80E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.03|P-value:7.30E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-3.22|P-value:3.05E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.49|P-value:1.23E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.62|P-value:7.12E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.04|P-value:7.17E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:2.98|P-value:8.76E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:-2.95|P-value:8.36E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.07|P-value:9.22E-6 ID:SGTC_1636|Compound:st007707|FD-Score:3.20|P-value:3.85E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-3.92|P-value:1.55E-5 ID:SGTC_1744|Compound:st037937|FD-Score:2.97|P-value:9.04E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.25|P-value:3.18E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.90|P-value:2.11E-5 ID:SGTC_1861|Compound:st057647|FD-Score:3.58|P-value:8.52E-5 ID:SGTC_1917|Compound:st066507|FD-Score:4.06|P-value:1.00E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.95|P-value:1.68E-5 ID:SGTC_2066|Compound:5222451|FD-Score:3.09|P-value:5.90E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.95|P-value:1.31E-5 ID:SGTC_2243|Compound:6634756|FD-Score:-3.08|P-value:5.12E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.14|P-value:4.09E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.03|P-value:7.28E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.10|P-value:4.75E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.10|P-value:8.05E-6 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.65|P-value:6.25E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.26|P-value:3.16E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.03|P-value:7.35E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.21|P-value:3.72E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-2.94|P-value:8.47E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.78|P-value:3.49E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:3.46|P-value:1.40E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-3.29|P-value:2.32E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.25|P-value:3.19E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.15|P-value:3.96E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.62|P-value:7.29E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.55|P-value:9.59E-5

Top fitness defect scores for YGR002C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_426 0988-0037 4.32 14.6 µM 2.77E-6 ERAD & cell cycle 9 7.80E-6 0.04
2 SGTC_140 0062-0056 4.32 502.5 µM 2.78E-6 1 7.81E-6 0.31
3 SGTC_576 1073-0113 4.14 22.7 µM 6.71E-6 redox potentiating 40 1.73E-5 0.07
4 SGTC_2520 obtusaquinone 4.10 4.7 µM 8.05E-6 3 2.04E-5 0.12
5 SGTC_1300 1094-0077 4.07 113.0 µM 9.22E-6 5 2.31E-5 0.17
6 SGTC_1917 st066507 4.06 28.5 µM 1.00E-5 Golgi 7 2.49E-5 0.06
7 SGTC_179 1273-0063 4.04 6.8 µM 1.07E-5 5 2.64E-5 0.27
8 SGTC_2003 4023581 3.95 200.0 µM 1.68E-5 cell wall signaling 7 3.96E-5 0.01
9 SGTC_1789 tunicamycin 3.90 25.0 nM 2.11E-5 unfolded protein response 15 4.87E-5 0.03
10 SGTC_326 k292-0812 3.85 17.5 µM 2.63E-5 4 5.95E-5 0.17
11 SGTC_2681 menadione 3.78 3.2 µM 3.49E-5 superoxide 6 7.69E-5 0.48
12 SGTC_39 0986-0283 3.78 58.4 µM 3.64E-5 calcium & mitochondrial duress 10 7.99E-5 0.01
13 SGTC_2587 piperic acid 3.65 92.2 µM 6.25E-5 7 1.30E-4 0.05
14 SGTC_1019 4262-0212 3.62 3.4 µM 7.12E-5 ergosterol depletion effects on membrane 16 1.47E-4 0.02
15 SGTC_3124 9127567 3.62 49.5 µM 7.29E-5 DNA damage response 7 1.50E-4 0.03
16 SGTC_765 1319-0117 3.61 244.0 µM 7.47E-5 60S ribosome export 9 1.53E-4 0.02
17 SGTC_1861 st057647 3.58 17.4 µM 8.52E-5 8 1.72E-4 0.08
18 SGTC_3304 9125678 3.55 46.1 µM 9.59E-5 32 1.92E-4 0.17
19 SGTC_1005 4092-0690 3.49 4.4 µM 1.23E-4 plasma membrane duress 15 2.40E-4 0.08
20 SGTC_2739 tacrine 3.46 100.9 µM 1.40E-4 heme requiring 10 2.70E-4 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 2.05E-15 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.132 2.21E-14 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.108 2.94E-10 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.099 8.13E-9 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.099 8.32E-9 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.080 3.75E-6 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.073 2.60E-5 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.072 3.06E-5 YMR273C ZDS1 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication
0.072 3.13E-5 YLR416C_d YLR416C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.071 3.94E-5 YLR035C MLH2 hom Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p
0.071 4.02E-5 YJL167W ERG20 het Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
0.070 4.87E-5 YHR092C HXT4 hom High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication
0.070 5.22E-5 YML048W GSF2 hom ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
0.069 5.65E-5 YOR204W DED1 het ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility
0.069 6.38E-5 YMR238W DFG5 hom Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p