YGR004W / PEX31

Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR004W / PEX31

Click on Significant Values for Screen Details ID:SGTC_143|Compound:4032-1194|FD-Score:3.19|P-value:2.83E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.38|P-value:1.29E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:6.64|P-value:5.82E-13 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.51|P-value:1.30E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:7.98|P-value:7.53E-18 ID:SGTC_528|Compound:3492-0019|FD-Score:4.16|P-value:3.77E-6 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.00|P-value:5.76E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.09|P-value:6.63E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:5.35|P-value:4.72E-9 ID:SGTC_676|Compound:falcarinol|FD-Score:5.81|P-value:2.35E-10 ID:SGTC_723|Compound:4182-0001|FD-Score:-4.15|P-value:7.50E-6 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.09|P-value:6.67E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.99|P-value:9.73E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.14|P-value:3.42E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.32|P-value:1.65E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:5.05|P-value:2.88E-8 ID:SGTC_917|Compound:harmaline|FD-Score:2.90|P-value:8.34E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.31|P-value:1.76E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.19|P-value:4.64E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.80|P-value:2.07E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-3.00|P-value:9.24E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.39|P-value:2.20E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.10|P-value:3.89E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:5.69|P-value:5.14E-10 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.66|P-value:1.28E-16 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.35|P-value:1.49E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:-4.23|P-value:4.99E-6 ID:SGTC_1591|Compound:genipin|FD-Score:2.95|P-value:6.97E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.88|P-value:2.57E-5 ID:SGTC_1619|Compound:st003326|FD-Score:3.05|P-value:4.77E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.69|P-value:3.46E-5 ID:SGTC_1678|Compound:st019265|FD-Score:4.86|P-value:8.62E-8 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.63|P-value:7.58E-10 ID:SGTC_2125|Compound:5246583|FD-Score:3.63|P-value:4.48E-5 ID:SGTC_2175|Compound:5807670|FD-Score:3.34|P-value:1.53E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.19|P-value:2.76E-4 ID:SGTC_2186|Compound:6124449|FD-Score:2.85|P-value:9.94E-4 ID:SGTC_2194|Compound:5927483|FD-Score:-3.20|P-value:4.42E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.64|P-value:4.19E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-3.65|P-value:7.29E-5 ID:SGTC_2292|Compound:7671323|FD-Score:3.39|P-value:1.25E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.20|P-value:4.50E-4 ID:SGTC_2425|Compound:5628681|FD-Score:4.28|P-value:2.03E-6 ID:SGTC_2430|Compound:5571206|FD-Score:5.07|P-value:2.66E-8 ID:SGTC_2435|Compound:5706476|FD-Score:3.52|P-value:7.20E-5 ID:SGTC_2440|Compound:5628896|FD-Score:-3.17|P-value:4.89E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-3.05|P-value:7.66E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.47|P-value:9.07E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.63|P-value:4.47E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.05|P-value:4.73E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:2.98|P-value:6.11E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.79|P-value:2.18E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:2.87|P-value:9.23E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.74|P-value:2.75E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.87|P-value:2.74E-5 ID:SGTC_2858|Compound:9025781|FD-Score:4.87|P-value:8.43E-8 ID:SGTC_2990|Compound:9074105|FD-Score:-3.73|P-value:5.03E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-3.24|P-value:3.86E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-3.01|P-value:8.78E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.19|P-value:2.83E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.38|P-value:1.29E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:6.64|P-value:5.82E-13 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.51|P-value:1.30E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:7.98|P-value:7.53E-18 ID:SGTC_528|Compound:3492-0019|FD-Score:4.16|P-value:3.77E-6 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.00|P-value:5.76E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.09|P-value:6.63E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:5.35|P-value:4.72E-9 ID:SGTC_676|Compound:falcarinol|FD-Score:5.81|P-value:2.35E-10 ID:SGTC_723|Compound:4182-0001|FD-Score:-4.15|P-value:7.50E-6 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.09|P-value:6.67E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.99|P-value:9.73E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.14|P-value:3.42E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.32|P-value:1.65E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:5.05|P-value:2.88E-8 ID:SGTC_917|Compound:harmaline|FD-Score:2.90|P-value:8.34E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.31|P-value:1.76E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.19|P-value:4.64E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.80|P-value:2.07E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-3.00|P-value:9.24E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.39|P-value:2.20E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.10|P-value:3.89E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:5.69|P-value:5.14E-10 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.66|P-value:1.28E-16 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.35|P-value:1.49E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:-4.23|P-value:4.99E-6 ID:SGTC_1591|Compound:genipin|FD-Score:2.95|P-value:6.97E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.88|P-value:2.57E-5 ID:SGTC_1619|Compound:st003326|FD-Score:3.05|P-value:4.77E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.69|P-value:3.46E-5 ID:SGTC_1678|Compound:st019265|FD-Score:4.86|P-value:8.62E-8 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.63|P-value:7.58E-10 ID:SGTC_2125|Compound:5246583|FD-Score:3.63|P-value:4.48E-5 ID:SGTC_2175|Compound:5807670|FD-Score:3.34|P-value:1.53E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.19|P-value:2.76E-4 ID:SGTC_2186|Compound:6124449|FD-Score:2.85|P-value:9.94E-4 ID:SGTC_2194|Compound:5927483|FD-Score:-3.20|P-value:4.42E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.64|P-value:4.19E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-3.65|P-value:7.29E-5 ID:SGTC_2292|Compound:7671323|FD-Score:3.39|P-value:1.25E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.20|P-value:4.50E-4 ID:SGTC_2425|Compound:5628681|FD-Score:4.28|P-value:2.03E-6 ID:SGTC_2430|Compound:5571206|FD-Score:5.07|P-value:2.66E-8 ID:SGTC_2435|Compound:5706476|FD-Score:3.52|P-value:7.20E-5 ID:SGTC_2440|Compound:5628896|FD-Score:-3.17|P-value:4.89E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-3.05|P-value:7.66E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.47|P-value:9.07E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.63|P-value:4.47E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.05|P-value:4.73E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:2.98|P-value:6.11E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.79|P-value:2.18E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:2.87|P-value:9.23E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.74|P-value:2.75E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.87|P-value:2.74E-5 ID:SGTC_2858|Compound:9025781|FD-Score:4.87|P-value:8.43E-8 ID:SGTC_2990|Compound:9074105|FD-Score:-3.73|P-value:5.03E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-3.24|P-value:3.86E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-3.01|P-value:8.78E-4

Top fitness defect scores for YGR004W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_513 4245-1575 7.98 41.7 µM 7.53E-18 unfolded protein response 28 7.52E-16
2 SGTC_1317 1273-0028 7.66 910.0 nM 1.28E-16 azole & statin 18 9.22E-15
3 SGTC_363 0455-0021 6.64 3.1 µM 5.82E-13 azole & statin 26 1.57E-11
4 SGTC_676 falcarinol 5.81 140.0 µM 2.35E-10 17 3.13E-9
5 SGTC_1237 0330-0133 5.69 46.1 µM 5.14E-10 ergosterol biosynthesis 6 6.25E-9
6 SGTC_1679 4130-1276 5.63 6.7 µM 7.58E-10 Golgi 28 8.80E-9
7 SGTC_658 3253-0951 5.35 102.0 µM 4.72E-9 calcium & mitochondrial duress 23 4.42E-8
8 SGTC_2430 5571206 5.07 200.0 µM 2.66E-8 32 2.03E-7
9 SGTC_862 0452-0056 5.05 10.2 µM 2.88E-8 azole & statin 22 2.18E-7
10 SGTC_2858 9025781 4.87 9.0 µM 8.43E-8 sphingolipid biosynthesis & PDR1 71 5.62E-7
11 SGTC_1678 st019265 4.86 80.2 µM 8.62E-8 60S ribosome export 9 5.73E-7
12 SGTC_2425 5628681 4.28 7.8 µM 2.03E-6 13 9.29E-6
13 SGTC_528 3492-0019 4.16 172.0 µM 3.77E-6 calcium & mitochondrial duress 203 1.60E-5
14 SGTC_1059 3448-6867 3.80 171.0 µM 2.07E-5 15 7.20E-5
15 SGTC_2588 indole-3-carbinol 3.79 100.0 µM 2.18E-5 52 7.53E-5
16 SGTC_2753 fluvastatin 3.74 17.1 µM 2.75E-5 azole & statin 43 9.22E-5
17 SGTC_1620 st003704 3.69 16.5 µM 3.46E-5 23 1.13E-4
18 SGTC_2249 haloperidol 3.64 116.4 µM 4.19E-5 ergosterol depletion effects on membrane 135 1.34E-4
19 SGTC_2574 2',4'-dihydroxychalcone 3.63 14.6 µM 4.47E-5 30 1.42E-4
20 SGTC_2125 5246583 3.63 200.0 µM 4.48E-5 tubulin folding & SWR complex 52 1.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.222 1.03E-38 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.181 3.35E-26 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.164 1.26E-21 YLR359W ADE13 het Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.159 2.51E-20 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.157 7.34E-20 YLR228C ECM22 hom Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication
0.152 9.59E-19 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.149 3.50E-18 YPR198W SGE1 hom Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
0.148 7.15E-18 YIL109C SEC24 het Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p
0.147 1.13E-17 YHR072W ERG7 het Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.142 1.72E-16 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.137 1.57E-15 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.134 5.75E-15 YEL031W SPF1 hom P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
0.131 2.74E-14 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.127 1.39E-13 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.125 3.28E-13 YJL085W EXO70 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress