YGR007W / ECT1

Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR007W / ECT1

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:3.86|P-value:8.44E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.47|P-value:3.62E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.78|P-value:1.17E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.84|P-value:9.25E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:3.19|P-value:9.53E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:4.53|P-value:5.18E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.83|P-value:9.51E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:9.59|P-value:4.75E-21 ID:SGTC_426|Compound:0988-0037|FD-Score:3.60|P-value:2.31E-4 ID:SGTC_448|Compound:monastrol|FD-Score:3.59|P-value:2.32E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.40|P-value:4.64E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.30|P-value:6.60E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:-3.53|P-value:2.89E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.39|P-value:9.69E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:3.63|P-value:2.06E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:6.85|P-value:1.24E-11 ID:SGTC_753|Compound:1322-0200|FD-Score:4.22|P-value:1.99E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:3.43|P-value:4.24E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.76|P-value:1.25E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.30|P-value:6.55E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.62|P-value:3.42E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.18|P-value:9.81E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.81|P-value:1.44E-6 ID:SGTC_1626|Compound:st003712|FD-Score:4.76|P-value:1.78E-6 ID:SGTC_1629|Compound:st005085|FD-Score:5.06|P-value:4.16E-7 ID:SGTC_1635|Compound:st007035|FD-Score:-4.47|P-value:6.63E-6 ID:SGTC_1663|Compound:st014140|FD-Score:-3.19|P-value:9.59E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.63|P-value:2.07E-4 ID:SGTC_1774|Compound:st048371|FD-Score:-3.82|P-value:9.94E-5 ID:SGTC_1937|Compound:st074714|FD-Score:3.18|P-value:9.71E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.44|P-value:3.98E-4 ID:SGTC_2241|Compound:6772625|FD-Score:9.70|P-value:1.70E-21 ID:SGTC_2307|Compound:7538926|FD-Score:-3.29|P-value:6.76E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.76|P-value:1.23E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.24|P-value:7.89E-4 ID:SGTC_2398|Compound:5228213|FD-Score:4.48|P-value:6.34E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.92|P-value:6.75E-5 ID:SGTC_2445|Compound:5742597|FD-Score:-3.54|P-value:2.83E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-4.39|P-value:9.64E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.26|P-value:1.70E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.32|P-value:6.21E-4 ID:SGTC_2694|Compound:st077685|FD-Score:3.89|P-value:7.65E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.91|P-value:7.13E-5 ID:SGTC_2817|Compound:7995342|FD-Score:-3.98|P-value:5.32E-5 ID:SGTC_2825|Compound:7998094|FD-Score:-3.54|P-value:2.80E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.45|P-value:3.92E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-4.83|P-value:1.26E-6 ID:SGTC_2874|Compound:9043904|FD-Score:3.28|P-value:6.89E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-3.42|P-value:4.40E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.52|P-value:3.01E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.85|P-value:1.14E-6 ID:SGTC_3110|Compound:9122132|FD-Score:-4.21|P-value:2.07E-5 ID:SGTC_3112|Compound:9123419|FD-Score:-3.38|P-value:4.96E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.46|P-value:3.72E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.50|P-value:3.23E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.49|P-value:3.42E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.86|P-value:8.44E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.47|P-value:3.62E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.78|P-value:1.17E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.84|P-value:9.25E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:3.19|P-value:9.53E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:4.53|P-value:5.18E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.83|P-value:9.51E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:9.59|P-value:4.75E-21 ID:SGTC_426|Compound:0988-0037|FD-Score:3.60|P-value:2.31E-4 ID:SGTC_448|Compound:monastrol|FD-Score:3.59|P-value:2.32E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.40|P-value:4.64E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.30|P-value:6.60E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:-3.53|P-value:2.89E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.39|P-value:9.69E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:3.63|P-value:2.06E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:6.85|P-value:1.24E-11 ID:SGTC_753|Compound:1322-0200|FD-Score:4.22|P-value:1.99E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:3.43|P-value:4.24E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.76|P-value:1.25E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.30|P-value:6.55E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.62|P-value:3.42E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.18|P-value:9.81E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.81|P-value:1.44E-6 ID:SGTC_1626|Compound:st003712|FD-Score:4.76|P-value:1.78E-6 ID:SGTC_1629|Compound:st005085|FD-Score:5.06|P-value:4.16E-7 ID:SGTC_1635|Compound:st007035|FD-Score:-4.47|P-value:6.63E-6 ID:SGTC_1663|Compound:st014140|FD-Score:-3.19|P-value:9.59E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.63|P-value:2.07E-4 ID:SGTC_1774|Compound:st048371|FD-Score:-3.82|P-value:9.94E-5 ID:SGTC_1937|Compound:st074714|FD-Score:3.18|P-value:9.71E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.44|P-value:3.98E-4 ID:SGTC_2241|Compound:6772625|FD-Score:9.70|P-value:1.70E-21 ID:SGTC_2307|Compound:7538926|FD-Score:-3.29|P-value:6.76E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.76|P-value:1.23E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.24|P-value:7.89E-4 ID:SGTC_2398|Compound:5228213|FD-Score:4.48|P-value:6.34E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.92|P-value:6.75E-5 ID:SGTC_2445|Compound:5742597|FD-Score:-3.54|P-value:2.83E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-4.39|P-value:9.64E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.26|P-value:1.70E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.32|P-value:6.21E-4 ID:SGTC_2694|Compound:st077685|FD-Score:3.89|P-value:7.65E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.91|P-value:7.13E-5 ID:SGTC_2817|Compound:7995342|FD-Score:-3.98|P-value:5.32E-5 ID:SGTC_2825|Compound:7998094|FD-Score:-3.54|P-value:2.80E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.45|P-value:3.92E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-4.83|P-value:1.26E-6 ID:SGTC_2874|Compound:9043904|FD-Score:3.28|P-value:6.89E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-3.42|P-value:4.40E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.52|P-value:3.01E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.85|P-value:1.14E-6 ID:SGTC_3110|Compound:9122132|FD-Score:-4.21|P-value:2.07E-5 ID:SGTC_3112|Compound:9123419|FD-Score:-3.38|P-value:4.96E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.46|P-value:3.72E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.50|P-value:3.23E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.49|P-value:3.42E-4

Top fitness defect scores for YGR007W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2241 6772625 9.70 37.8 µM 1.70E-21 1 1.46E-22
2 SGTC_310 1273-0058 9.59 1.1 µM 4.75E-21 mitochondrial stress 48 4.32E-22
3 SGTC_733 4069-0007 6.85 56.1 µM 1.24E-11 ERAD & cell cycle 30 3.61E-12
4 SGTC_1629 st005085 5.06 44.9 µM 4.16E-7 RPP1 & pyrimidine depletion 13 2.10E-7
5 SGTC_3078 9116413 4.85 49.5 µM 1.14E-6 unfolded protein response 20 6.05E-7
6 SGTC_1568 digitonin 4.81 820.0 nM 1.44E-6 sphingolipid biosynthesis & PDR1 19 7.74E-7
7 SGTC_1626 st003712 4.76 1.8 µM 1.78E-6 12 9.71E-7
8 SGTC_1268 0828-0275 4.62 2.5 µM 3.42E-6 10 1.93E-6
9 SGTC_279 1273-0055 4.53 2.9 µM 5.18E-6 azole & statin 29 2.98E-6
10 SGTC_2398 5228213 4.48 48.8 µM 6.34E-6 iron homeostasis 23 3.69E-6
11 SGTC_639 0833-0042 4.39 114.0 µM 9.69E-6 33 5.76E-6
12 SGTC_2630 antimycin a 4.26 100.0 µM 1.70E-5 mitochondrial processes 31 1.04E-5
13 SGTC_753 1322-0200 4.22 289.0 µM 1.99E-5 12 1.23E-5
14 SGTC_2406 ethylparaben 3.92 405.7 µM 6.75E-5 41 4.44E-5
15 SGTC_2694 st077685 3.89 81.9 µM 7.65E-5 endomembrane recycling 31 5.06E-5
16 SGTC_22 0964-0034 3.86 14.5 µM 8.44E-5 unfolded protein response 48 5.62E-5
17 SGTC_2331 7980721 3.76 200.0 µM 1.23E-4 29 8.37E-5
18 SGTC_847 0342-0274 3.76 5.5 µM 1.25E-4 22 8.52E-5
19 SGTC_669 0108-0021 3.63 26.2 µM 2.06E-4 fatty acid desaturase (OLE1) 102 1.43E-4
20 SGTC_1715 st032160 3.63 10.2 µM 2.07E-4 53 1.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.00E-11 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.110 1.43E-10 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.109 2.13E-10 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.108 3.29E-10 YNL073W MSK1 hom Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)
0.107 5.54E-10 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.107 5.59E-10 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.104 1.56E-9 YLL031C GPI13 het ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein
0.103 2.14E-9 YPR099C_d YPR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W
0.102 3.47E-9 YJR073C OPI3 hom Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
0.100 7.57E-9 YDR347W MRP1 hom Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
0.098 1.26E-8 YDR003W RCR2 hom Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
0.097 1.70E-8 YNL276C_d YNL276C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W
0.096 2.29E-8 YDR519W FPR2 hom Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress
0.096 2.65E-8 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.094 4.76E-8 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability