YGR008C / STF2

Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR008C / STF2

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-3.70|P-value:7.48E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.33|P-value:4.49E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.14|P-value:1.10E-5 ID:SGTC_162|Compound:k030-0015|FD-Score:4.64|P-value:1.19E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:-4.01|P-value:1.98E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:5.73|P-value:2.69E-9 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.28|P-value:3.81E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.59|P-value:1.31E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.30|P-value:3.61E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.49|P-value:1.71E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-4.14|P-value:1.09E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.17|P-value:6.46E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.10|P-value:8.12E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.32|P-value:3.69E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.25|P-value:4.31E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-4.55|P-value:1.60E-6 ID:SGTC_1810|Compound:st050138|FD-Score:4.27|P-value:7.06E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.63|P-value:4.27E-9 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.08|P-value:8.63E-4 ID:SGTC_2063|Compound:5246145|FD-Score:-4.29|P-value:5.45E-6 ID:SGTC_2368|Compound:9071271|FD-Score:3.33|P-value:3.63E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.29|P-value:4.09E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.60|P-value:1.28E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.85|P-value:4.43E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.50|P-value:1.70E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-3.55|P-value:1.39E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.19|P-value:5.36E-4 ID:SGTC_2947|Compound:9072639|FD-Score:4.79|P-value:5.57E-7 ID:SGTC_3194|Compound:9111903|FD-Score:3.07|P-value:9.18E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.28|P-value:3.92E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.20|P-value:5.68E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.20|P-value:5.08E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.70|P-value:7.48E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.33|P-value:4.49E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.14|P-value:1.10E-5 ID:SGTC_162|Compound:k030-0015|FD-Score:4.64|P-value:1.19E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:-4.01|P-value:1.98E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:5.73|P-value:2.69E-9 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.28|P-value:3.81E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.59|P-value:1.31E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.30|P-value:3.61E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.49|P-value:1.71E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-4.14|P-value:1.09E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.17|P-value:6.46E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.10|P-value:8.12E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.32|P-value:3.69E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.25|P-value:4.31E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-4.55|P-value:1.60E-6 ID:SGTC_1810|Compound:st050138|FD-Score:4.27|P-value:7.06E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.63|P-value:4.27E-9 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.08|P-value:8.63E-4 ID:SGTC_2063|Compound:5246145|FD-Score:-4.29|P-value:5.45E-6 ID:SGTC_2368|Compound:9071271|FD-Score:3.33|P-value:3.63E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.29|P-value:4.09E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.60|P-value:1.28E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.85|P-value:4.43E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.50|P-value:1.70E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-3.55|P-value:1.39E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.19|P-value:5.36E-4 ID:SGTC_2947|Compound:9072639|FD-Score:4.79|P-value:5.57E-7 ID:SGTC_3194|Compound:9111903|FD-Score:3.07|P-value:9.18E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.28|P-value:3.92E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.20|P-value:5.68E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.20|P-value:5.08E-4

Top fitness defect scores for YGR008C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_170 4197-0004 5.73 226.0 µM 2.69E-9 3 5.00E-9
2 SGTC_2947 9072639 4.79 7.7 µM 5.57E-7 tubulin folding & SWR complex 23 8.52E-7
3 SGTC_162 k030-0015 4.64 37.8 µM 1.19E-6 iron homeostasis 14 1.78E-6
4 SGTC_1810 st050138 4.27 53.0 µM 7.06E-6 PDR1 7 9.85E-6
5 SGTC_2487 5918373 3.85 44.0 µM 4.43E-5 18 5.80E-5
6 SGTC_2482 5981709 3.60 142.7 µM 1.28E-4 PDR1 48 1.61E-4
7 SGTC_429 1112-0049 3.59 25.5 µM 1.31E-4 DNA damage response 49 1.65E-4
8 SGTC_2368 9071271 3.33 200.0 µM 3.63E-4 63 4.41E-4
9 SGTC_1546 5-methoxyflavanone 3.32 78.7 µM 3.69E-4 22 4.48E-4
10 SGTC_2480 5767542 3.29 37.2 µM 4.09E-4 29 4.95E-4
11 SGTC_3296 9122258 3.20 64.0 µM 5.68E-4 redox potentiating 46 6.80E-4
12 SGTC_1294 1000-1494 3.17 117.0 µM 6.46E-4 50 7.71E-4
13 SGTC_1512 0259-0544 3.10 12.2 µM 8.12E-4 61 9.61E-4
14 SGTC_2039 Aminomethylbenzodioxan 3.08 200.0 µM 8.63E-4 25 0.00102
15 SGTC_3194 9111903 3.07 49.5 µM 9.18E-4 63 0.00108
16 SGTC_2359 9039622 2.98 200.0 µM 0.00123 endomembrane recycling 70 0.00144
17 SGTC_521 r062-0005 2.94 13.8 µM 0.00143 54 0.00166
18 SGTC_1152 3909-8331 2.89 15.9 µM 0.00165 55 0.00191
19 SGTC_2755 lomerizine 2.86 42.7 µM 0.00182 83 0.00210
20 SGTC_1990 st072050 2.79 59.8 µM 0.00229 67 0.00262

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.300 6.44E-71 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.244 1.21E-46 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.206 1.49E-33 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.183 1.03E-26 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.183 1.41E-26 YFR026C ULI1 hom Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response
0.182 2.13E-26 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.180 9.88E-26 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.166 3.27E-22 YJR108W ABM1 hom Protein of unknown function, required for normal microtubule organization
0.162 3.45E-21 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.159 2.68E-20 YKL164C PIR1 hom O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
0.154 3.51E-19 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.151 1.53E-18 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.150 2.31E-18 YGR042W YGR042W hom Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress
0.147 1.24E-17 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.144 5.70E-17 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication