HIPHOP chemogenomics database
YGR009C / SEC9 
t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YGR009C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.122 | 1.30E-12 | YLR363C | NMD4 | hom | Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
| 0.118 | 6.81E-12 | YGR013W | SNU71 | het | Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart |
| 0.108 | 3.55E-10 | YLR147C | SMD3 | het | Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3 |
| 0.105 | 9.50E-10 | YGR019W | UGA1 | hom | Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress |
| 0.102 | 2.94E-9 | YDR277C | MTH1 | hom | Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation |
| 0.100 | 6.99E-9 | YKL030W_d | YKL030W_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1 |
| 0.097 | 2.03E-8 | YGL082W_p | YGL082W_p | hom | Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene |
| 0.096 | 2.78E-8 | YER067C-A_d | YER067C-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W |
| 0.089 | 2.51E-7 | YML066C | SMA2 | hom | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation |
| 0.085 | 7.51E-7 | YLR196W | PWP1 | het | Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily |
| 0.085 | 8.17E-7 | YJR133W | XPT1 | hom | Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine |
| 0.084 | 1.08E-6 | YDR517W | GRH1 | hom | Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress |
| 0.083 | 1.37E-6 | YLR311C_d | YLR311C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.083 | 1.53E-6 | YGL149W_d | YGL149W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C. |
| 0.081 | 2.34E-6 | YPR151C | SUE1 | hom | Mitochondrial protein required for degradation of unstable forms of cytochrome c |