YGR009C / SEC9

t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR009C / SEC9

Click on Significant Values for Screen Details ID:SGTC_337|Compound:1315-0038|FD-Score:2.83|P-value:9.89E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.42|P-value:9.14E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:3.53|P-value:5.89E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.87|P-value:1.22E-5 ID:SGTC_493|Compound:zm226600|FD-Score:3.91|P-value:9.98E-6 ID:SGTC_626|Compound:0214-0009|FD-Score:2.95|P-value:6.47E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:4.09|P-value:3.95E-6 ID:SGTC_826|Compound:1683-5028|FD-Score:-4.14|P-value:2.97E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:5.20|P-value:7.01E-9 ID:SGTC_913|Compound:3487-1245|FD-Score:-5.03|P-value:1.90E-8 ID:SGTC_917|Compound:harmaline|FD-Score:3.58|P-value:4.61E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.10|P-value:3.57E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:2.88|P-value:8.40E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.14|P-value:3.10E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-2.84|P-value:9.51E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.20|P-value:2.28E-6 ID:SGTC_1743|Compound:st037606|FD-Score:3.37|P-value:1.17E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.31|P-value:1.50E-4 ID:SGTC_1967|Compound:st070177|FD-Score:2.86|P-value:9.05E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.49|P-value:6.85E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-3.04|P-value:4.48E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.83|P-value:1.44E-5 ID:SGTC_2144|Compound:5628481|FD-Score:-2.93|P-value:6.75E-4 ID:SGTC_2162|Compound:5663267|FD-Score:6.99|P-value:1.17E-14 ID:SGTC_2204|Compound:7233102|FD-Score:-3.33|P-value:1.34E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.11|P-value:3.47E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.69|P-value:2.77E-5 ID:SGTC_2386|Compound:9075165|FD-Score:3.90|P-value:1.01E-5 ID:SGTC_2427|Compound:5545055|FD-Score:4.36|P-value:9.74E-7 ID:SGTC_2457|Compound:5731572|FD-Score:2.96|P-value:6.07E-4 ID:SGTC_2458|Compound:5808907|FD-Score:2.90|P-value:7.77E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.49|P-value:6.85E-5 ID:SGTC_2473|Compound:5854593|FD-Score:-2.87|P-value:8.64E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-2.87|P-value:8.68E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.92|P-value:9.20E-6 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.29|P-value:1.39E-6 ID:SGTC_2646|Compound:retinol|FD-Score:3.17|P-value:2.76E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:2.91|P-value:7.35E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.40|P-value:9.95E-5 ID:SGTC_2876|Compound:9059903|FD-Score:2.89|P-value:8.02E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-2.84|P-value:9.53E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.18|P-value:2.59E-4 ID:SGTC_3233|Compound:9132340|FD-Score:2.95|P-value:6.52E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.43|P-value:9.24E-5 ID:SGTC_3318|Compound:9139014|FD-Score:-5.54|P-value:7.22E-10 ID:SGTC_3334|Compound:9142812|FD-Score:4.76|P-value:1.00E-7 ID:SGTC_3352|Compound:9151559|FD-Score:-2.90|P-value:7.56E-4 ID:SGTC_3356|Compound:9151811|FD-Score:-4.48|P-value:4.94E-7 ID:SGTC_337|Compound:1315-0038|FD-Score:2.83|P-value:9.89E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.42|P-value:9.14E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:3.53|P-value:5.89E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.87|P-value:1.22E-5 ID:SGTC_493|Compound:zm226600|FD-Score:3.91|P-value:9.98E-6 ID:SGTC_626|Compound:0214-0009|FD-Score:2.95|P-value:6.47E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:4.09|P-value:3.95E-6 ID:SGTC_826|Compound:1683-5028|FD-Score:-4.14|P-value:2.97E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:5.20|P-value:7.01E-9 ID:SGTC_913|Compound:3487-1245|FD-Score:-5.03|P-value:1.90E-8 ID:SGTC_917|Compound:harmaline|FD-Score:3.58|P-value:4.61E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.10|P-value:3.57E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:2.88|P-value:8.40E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.14|P-value:3.10E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-2.84|P-value:9.51E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.20|P-value:2.28E-6 ID:SGTC_1743|Compound:st037606|FD-Score:3.37|P-value:1.17E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.31|P-value:1.50E-4 ID:SGTC_1967|Compound:st070177|FD-Score:2.86|P-value:9.05E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.49|P-value:6.85E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-3.04|P-value:4.48E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.83|P-value:1.44E-5 ID:SGTC_2144|Compound:5628481|FD-Score:-2.93|P-value:6.75E-4 ID:SGTC_2162|Compound:5663267|FD-Score:6.99|P-value:1.17E-14 ID:SGTC_2204|Compound:7233102|FD-Score:-3.33|P-value:1.34E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.11|P-value:3.47E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.69|P-value:2.77E-5 ID:SGTC_2386|Compound:9075165|FD-Score:3.90|P-value:1.01E-5 ID:SGTC_2427|Compound:5545055|FD-Score:4.36|P-value:9.74E-7 ID:SGTC_2457|Compound:5731572|FD-Score:2.96|P-value:6.07E-4 ID:SGTC_2458|Compound:5808907|FD-Score:2.90|P-value:7.77E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.49|P-value:6.85E-5 ID:SGTC_2473|Compound:5854593|FD-Score:-2.87|P-value:8.64E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-2.87|P-value:8.68E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.92|P-value:9.20E-6 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.29|P-value:1.39E-6 ID:SGTC_2646|Compound:retinol|FD-Score:3.17|P-value:2.76E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:2.91|P-value:7.35E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.40|P-value:9.95E-5 ID:SGTC_2876|Compound:9059903|FD-Score:2.89|P-value:8.02E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-2.84|P-value:9.53E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.18|P-value:2.59E-4 ID:SGTC_3233|Compound:9132340|FD-Score:2.95|P-value:6.52E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.43|P-value:9.24E-5 ID:SGTC_3318|Compound:9139014|FD-Score:-5.54|P-value:7.22E-10 ID:SGTC_3334|Compound:9142812|FD-Score:4.76|P-value:1.00E-7 ID:SGTC_3352|Compound:9151559|FD-Score:-2.90|P-value:7.56E-4 ID:SGTC_3356|Compound:9151811|FD-Score:-4.48|P-value:4.94E-7

Top fitness defect scores for YGR009C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2162 5663267 6.99 200.0 µM 1.17E-14 2 1.38E-12 1.62
2 SGTC_910 3454-3003 5.20 490.0 µM 7.01E-9 2 1.02E-7 1.15
3 SGTC_3334 9142812 4.76 21.9 µM 1.00E-7 4 9.58E-7 0.54
4 SGTC_2427 5545055 4.36 42.8 µM 9.74E-7 5 6.53E-6 0.24
5 SGTC_2568 diosmetin 4.29 100.0 µM 1.39E-6 5 8.79E-6 0.14
6 SGTC_1675 st018485 4.20 24.5 µM 2.28E-6 60S ribosome export 6 1.34E-5 0.07
7 SGTC_736 0958-0254 4.09 92.6 µM 3.95E-6 Golgi 4 2.13E-5 0.14
8 SGTC_2514 salinomycin 3.92 42.7 µM 9.20E-6 3 4.35E-5 0.28
9 SGTC_493 zm226600 3.91 134.0 µM 9.98E-6 mitochondrial processes 4 4.66E-5 0.14
10 SGTC_2386 9075165 3.90 157.4 µM 1.01E-5 2 4.73E-5 0.33
11 SGTC_389 tpck 3.87 16.7 µM 1.22E-5 9 5.51E-5 0.03
12 SGTC_2086 5274770 3.83 176.6 µM 1.44E-5 12 6.36E-5 0.16
13 SGTC_2356 9061756 3.69 189.0 µM 2.77E-5 3 1.11E-4 0.07
14 SGTC_917 harmaline 3.58 728.1 nM 4.61E-5 ergosterol biosynthesis 11 1.70E-4 0.23
15 SGTC_344 k064-0035 3.53 6.4 µM 5.89E-5 60S ribosome export 8 2.09E-4 0.01
16 SGTC_2002 4023503 3.49 131.0 µM 6.85E-5 mitochondrial processes 16 2.38E-4 0.12
17 SGTC_2468 5987765 3.49 72.9 µM 6.85E-5 7 2.38E-4 0.07
18 SGTC_3257 9139206 3.43 33.0 µM 9.24E-5 10 3.07E-4 0.05
19 SGTC_1743 st037606 3.37 46.4 µM 1.17E-4 14 3.75E-4 0.04
20 SGTC_1756 st041558 3.31 35.5 µM 1.50E-4 7 4.62E-4 0.41

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.30E-12 YLR363C NMD4 hom Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.118 6.81E-12 YGR013W SNU71 het Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart
0.108 3.55E-10 YLR147C SMD3 het Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3
0.105 9.50E-10 YGR019W UGA1 hom Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress
0.102 2.94E-9 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.100 6.99E-9 YKL030W_d YKL030W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
0.097 2.03E-8 YGL082W_p YGL082W_p hom Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene
0.096 2.78E-8 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.089 2.51E-7 YML066C SMA2 hom Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation
0.085 7.51E-7 YLR196W PWP1 het Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
0.085 8.17E-7 YJR133W XPT1 hom Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
0.084 1.08E-6 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
0.083 1.37E-6 YLR311C_d YLR311C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.083 1.53E-6 YGL149W_d YGL149W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
0.081 2.34E-6 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c