YGR011W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR011W / YGR011W

Click on Significant Values for Screen Details ID:SGTC_264|Compound:promethazine|FD-Score:-3.69|P-value:2.46E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.85|P-value:1.10E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.06|P-value:4.28E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.77|P-value:1.87E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:3.74|P-value:2.24E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:-4.30|P-value:1.10E-6 ID:SGTC_656|Compound:4090-1979|FD-Score:4.98|P-value:2.54E-8 ID:SGTC_714|Compound:4296-0578|FD-Score:3.38|P-value:1.12E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.02|P-value:4.30E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:2.92|P-value:7.29E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.02|P-value:4.96E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:2.99|P-value:5.46E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-5.53|P-value:5.96E-10 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.59|P-value:3.82E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.12|P-value:3.37E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.41|P-value:1.32E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.31|P-value:1.05E-6 ID:SGTC_1950|Compound:st077106|FD-Score:3.28|P-value:1.69E-4 ID:SGTC_1956|Compound:st077085|FD-Score:2.98|P-value:5.82E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.12|P-value:3.27E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-3.35|P-value:1.13E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.21|P-value:2.33E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-2.81|P-value:9.58E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.03|P-value:4.19E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.54|P-value:3.58E-7 ID:SGTC_2830|Compound:7992007|FD-Score:3.06|P-value:4.28E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.60|P-value:3.71E-5 ID:SGTC_3206|Compound:9114350|FD-Score:3.49|P-value:6.88E-5 ID:SGTC_3229|Compound:9132204|FD-Score:3.05|P-value:4.31E-4 ID:SGTC_3256|Compound:9138902|FD-Score:3.64|P-value:3.59E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.69|P-value:2.46E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.85|P-value:1.10E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.06|P-value:4.28E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.77|P-value:1.87E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:3.74|P-value:2.24E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:-4.30|P-value:1.10E-6 ID:SGTC_656|Compound:4090-1979|FD-Score:4.98|P-value:2.54E-8 ID:SGTC_714|Compound:4296-0578|FD-Score:3.38|P-value:1.12E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.02|P-value:4.30E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:2.92|P-value:7.29E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.02|P-value:4.96E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:2.99|P-value:5.46E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-5.53|P-value:5.96E-10 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.59|P-value:3.82E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.12|P-value:3.37E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.41|P-value:1.32E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.31|P-value:1.05E-6 ID:SGTC_1950|Compound:st077106|FD-Score:3.28|P-value:1.69E-4 ID:SGTC_1956|Compound:st077085|FD-Score:2.98|P-value:5.82E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.12|P-value:3.27E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-3.35|P-value:1.13E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.21|P-value:2.33E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-2.81|P-value:9.58E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.03|P-value:4.19E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.54|P-value:3.58E-7 ID:SGTC_2830|Compound:7992007|FD-Score:3.06|P-value:4.28E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.60|P-value:3.71E-5 ID:SGTC_3206|Compound:9114350|FD-Score:3.49|P-value:6.88E-5 ID:SGTC_3229|Compound:9132204|FD-Score:3.05|P-value:4.31E-4 ID:SGTC_3256|Compound:9138902|FD-Score:3.64|P-value:3.59E-5

Top fitness defect scores for YGR011W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_656 4090-1979 4.98 187.0 µM 2.54E-8 6 3.12E-7
2 SGTC_2802 7925815 4.54 54.5 µM 3.58E-7 26 2.87E-6
3 SGTC_501 nsc-95397 3.77 161.0 µM 1.87E-5 17 8.00E-5
4 SGTC_505 gw-5074 3.74 63.9 µM 2.24E-5 66 9.32E-5
5 SGTC_3256 9138902 3.64 49.5 µM 3.59E-5 PDR1 3 1.39E-4
6 SGTC_3206 9114350 3.49 49.5 µM 6.88E-5 33 2.40E-4
7 SGTC_714 4296-0578 3.38 26.1 µM 1.12E-4 6 3.63E-4
8 SGTC_1950 st077106 3.28 7.2 µM 1.69E-4 RNA processing & uracil transport 55 5.11E-4
9 SGTC_2326 6164455 3.21 177.6 µM 2.33E-4 mitochondrial processes 51 6.72E-4
10 SGTC_1958 st076513 3.12 41.9 µM 3.27E-4 60S ribosome export 73 8.94E-4
11 SGTC_1289 0976-0073 3.12 69.1 µM 3.37E-4 42 9.16E-4
12 SGTC_2830 7992007 3.06 71.4 µM 4.28E-4 55 0.00112
13 SGTC_453 enantio-paf c16 3.06 10.0 µM 4.28E-4 241 0.00112
14 SGTC_3229 9132204 3.05 49.5 µM 4.31E-4 12 0.00113
15 SGTC_1168 k815-0004 3.02 80.5 µM 4.96E-4 DNA damage response 48 0.00127
16 SGTC_1253 0550-0034 2.99 176.0 µM 5.46E-4 65 0.00138
17 SGTC_1956 st077085 2.98 54.0 µM 5.82E-4 63 0.00146
18 SGTC_1130 3454-2858 2.92 15.9 µM 7.29E-4 NEO1 143 0.00176
19 SGTC_543 3844-1095 2.82 191.0 µM 0.00105 ERG2 122 0.00240
20 SGTC_1295 1013-0063 2.79 9.8 µM 0.00117 76 0.00262

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.337 4.37E-90 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.282 1.65E-62 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.281 4.55E-62 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.260 8.33E-53 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.257 1.63E-51 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.253 4.49E-50 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.250 4.18E-49 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.250 4.02E-49 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.244 1.44E-46 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.241 1.77E-45 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.241 1.88E-45 YLR136C TIS11 hom mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.230 1.14E-41 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.227 4.05E-40 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.223 3.57E-39 YMR074C YMR074C hom Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress
0.223 4.11E-39 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies