YGR013W / SNU71

Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR013W / SNU71

Click on Significant Values for Screen Details ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.65|P-value:7.77E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.81|P-value:3.87E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:3.32|P-value:2.84E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.49|P-value:1.45E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.94|P-value:1.43E-7 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.46|P-value:1.81E-6 ID:SGTC_1034|Compound:k072-0165|FD-Score:6.12|P-value:1.04E-10 ID:SGTC_1043|Compound:0916-0009|FD-Score:-4.82|P-value:2.46E-7 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.36|P-value:2.45E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.90|P-value:1.77E-7 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.07|P-value:7.27E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.08|P-value:1.13E-5 ID:SGTC_1675|Compound:st018485|FD-Score:3.21|P-value:4.29E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.20|P-value:4.55E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-4.86|P-value:2.04E-7 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-5.18|P-value:3.25E-8 ID:SGTC_1830|Compound:st055982|FD-Score:2.99|P-value:9.65E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.20|P-value:6.66E-6 ID:SGTC_2011|Compound:4012611|FD-Score:5.02|P-value:9.32E-8 ID:SGTC_2108|Compound:5365811|FD-Score:-3.18|P-value:4.50E-4 ID:SGTC_2162|Compound:5663267|FD-Score:5.36|P-value:1.33E-8 ID:SGTC_2307|Compound:7538926|FD-Score:-4.70|P-value:4.73E-7 ID:SGTC_2312|Compound:7706453|FD-Score:-3.94|P-value:1.96E-5 ID:SGTC_2315|Compound:7733312|FD-Score:-3.07|P-value:6.89E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.46|P-value:1.85E-6 ID:SGTC_2432|Compound:5630864|FD-Score:4.92|P-value:1.65E-7 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.42|P-value:1.79E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-3.95|P-value:1.93E-5 ID:SGTC_2838|Compound:9002687|FD-Score:3.05|P-value:7.77E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.38|P-value:2.09E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.57|P-value:1.06E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.96|P-value:1.27E-7 ID:SGTC_2998|Compound:9066762|FD-Score:3.32|P-value:2.87E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.40|P-value:2.08E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-3.31|P-value:2.72E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.27|P-value:3.47E-4 ID:SGTC_3335|Compound:9143315|FD-Score:3.05|P-value:7.88E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.65|P-value:7.77E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.81|P-value:3.87E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:3.32|P-value:2.84E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.49|P-value:1.45E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.94|P-value:1.43E-7 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.46|P-value:1.81E-6 ID:SGTC_1034|Compound:k072-0165|FD-Score:6.12|P-value:1.04E-10 ID:SGTC_1043|Compound:0916-0009|FD-Score:-4.82|P-value:2.46E-7 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.36|P-value:2.45E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.90|P-value:1.77E-7 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.07|P-value:7.27E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.08|P-value:1.13E-5 ID:SGTC_1675|Compound:st018485|FD-Score:3.21|P-value:4.29E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.20|P-value:4.55E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-4.86|P-value:2.04E-7 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-5.18|P-value:3.25E-8 ID:SGTC_1830|Compound:st055982|FD-Score:2.99|P-value:9.65E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.20|P-value:6.66E-6 ID:SGTC_2011|Compound:4012611|FD-Score:5.02|P-value:9.32E-8 ID:SGTC_2108|Compound:5365811|FD-Score:-3.18|P-value:4.50E-4 ID:SGTC_2162|Compound:5663267|FD-Score:5.36|P-value:1.33E-8 ID:SGTC_2307|Compound:7538926|FD-Score:-4.70|P-value:4.73E-7 ID:SGTC_2312|Compound:7706453|FD-Score:-3.94|P-value:1.96E-5 ID:SGTC_2315|Compound:7733312|FD-Score:-3.07|P-value:6.89E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.46|P-value:1.85E-6 ID:SGTC_2432|Compound:5630864|FD-Score:4.92|P-value:1.65E-7 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.42|P-value:1.79E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-3.95|P-value:1.93E-5 ID:SGTC_2838|Compound:9002687|FD-Score:3.05|P-value:7.77E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.38|P-value:2.09E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.57|P-value:1.06E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.96|P-value:1.27E-7 ID:SGTC_2998|Compound:9066762|FD-Score:3.32|P-value:2.87E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.40|P-value:2.08E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-3.31|P-value:2.72E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.27|P-value:3.47E-4 ID:SGTC_3335|Compound:9143315|FD-Score:3.05|P-value:7.88E-4

Top fitness defect scores for YGR013W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1034 k072-0165 6.12 12.7 µM 1.04E-10 Golgi 2 4.72E-10 1.39
2 SGTC_2162 5663267 5.36 200.0 µM 1.33E-8 4 4.26E-8 0.77
3 SGTC_2011 4012611 5.02 177.0 µM 9.32E-8 mitochondrial processes 5 2.59E-7 0.13
4 SGTC_2980 9014342 4.96 25.3 µM 1.27E-7 11 3.44E-7 0.20
5 SGTC_996 3970-0799 4.94 1.8 µM 1.43E-7 14 3.84E-7 0.04
6 SGTC_2432 5630864 4.92 12.2 µM 1.65E-7 2 4.40E-7 0.55
7 SGTC_1331 1472-0049 4.90 76.2 µM 1.77E-7 1 4.68E-7 0.36
8 SGTC_1032 k061-1018 4.46 98.7 µM 1.81E-6 2 4.07E-6 0.41
9 SGTC_2344 7990960 4.46 77.0 µM 1.85E-6 30 4.15E-6 0.06
10 SGTC_1964 st076914 4.20 61.0 µM 6.66E-6 RPP1 & pyrimidine depletion 6 1.36E-5 0.35
11 SGTC_1627 st003713 4.08 25.6 µM 1.13E-5 calcium & mitochondrial duress 5 2.23E-5 0.16
12 SGTC_764 1951-2361 3.81 146.0 µM 3.87E-5 17 7.00E-5 0.06
13 SGTC_102 gallobenzophenone 3.65 83.6 µM 7.77E-5 redox potentiating 5 1.34E-4 0.12
14 SGTC_2978 9011784 3.57 43.0 µM 1.06E-4 7 1.79E-4 0.17
15 SGTC_867 0518-0118 3.49 155.0 µM 1.45E-4 DNA intercalators 17 2.39E-4 0.18
16 SGTC_3028 9087778 3.40 49.5 µM 2.08E-4 4 3.34E-4 0.38
17 SGTC_1153 4055-0057 3.36 267.0 µM 2.45E-4 12 3.88E-4 0.17
18 SGTC_818 4072-2707 3.32 53.5 µM 2.84E-4 16 4.46E-4 0.09
19 SGTC_2998 9066762 3.32 71.4 µM 2.87E-4 RPP1 & pyrimidine depletion 17 4.50E-4 0.28
20 SGTC_3215 9129942 3.27 49.5 µM 3.47E-4 13 5.37E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.197 1.12E-30 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.161 6.84E-21 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.146 1.74E-17 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.140 3.98E-16 YJL087C TRL1 het tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes
0.120 3.14E-12 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.119 4.83E-12 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.118 6.81E-12 YGR009C SEC9 het t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog
0.117 1.31E-11 YGR046W TAM41 het Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition
0.116 1.35E-11 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.112 7.19E-11 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.110 1.43E-10 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.110 1.81E-10 YHR109W CTM1 hom Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
0.106 7.94E-10 YGR029W ERV1 het Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)
0.103 2.21E-9 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.102 2.97E-9 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene