YGR017W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR017W / YGR017W

Click on Significant Values for Screen Details ID:SGTC_223|Compound:busulfan|FD-Score:2.62|P-value:9.90E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-2.90|P-value:2.87E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.20|P-value:7.79E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:-2.68|P-value:7.38E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:2.84|P-value:4.09E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.50|P-value:1.77E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:3.23|P-value:6.93E-5 ID:SGTC_433|Compound:pimozide|FD-Score:-2.72|P-value:6.24E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:4.83|P-value:5.99E-9 ID:SGTC_694|Compound:1315-0438|FD-Score:-2.62|P-value:9.23E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.44|P-value:2.22E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.00|P-value:1.84E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.67|P-value:7.42E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:2.93|P-value:2.70E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.01|P-value:1.73E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.86|P-value:2.60E-6 ID:SGTC_1198|Compound:1612-1005|FD-Score:2.97|P-value:2.27E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:2.93|P-value:2.79E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:2.87|P-value:3.61E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-2.68|P-value:7.25E-4 ID:SGTC_1817|Compound:st052116|FD-Score:2.63|P-value:9.76E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.63|P-value:8.27E-6 ID:SGTC_1914|Compound:st062367|FD-Score:-2.88|P-value:3.13E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-2.60|P-value:9.85E-4 ID:SGTC_1934|Compound:st074720|FD-Score:2.76|P-value:5.56E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.21|P-value:7.49E-5 ID:SGTC_1979|Compound:st071809|FD-Score:2.80|P-value:4.77E-4 ID:SGTC_2016|Compound:5121758|FD-Score:2.78|P-value:5.19E-4 ID:SGTC_2018|Compound:5133068|FD-Score:2.63|P-value:9.74E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-5.52|P-value:2.99E-11 ID:SGTC_2020|Compound:4017018|FD-Score:-3.00|P-value:1.87E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-2.66|P-value:7.81E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-2.85|P-value:3.55E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-4.19|P-value:3.36E-7 ID:SGTC_2290|Compound:7904846|FD-Score:-2.63|P-value:9.05E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.08|P-value:1.37E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.38|P-value:3.36E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-3.15|P-value:9.17E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.33|P-value:1.40E-7 ID:SGTC_2575|Compound:plumbagin|FD-Score:-7.98|P-value:1.53E-21 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-5.98|P-value:6.73E-13 ID:SGTC_2581|Compound:avocatin a|FD-Score:8.08|P-value:6.61E-22 ID:SGTC_2584|Compound:androsterone|FD-Score:6.84|P-value:3.24E-16 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.49|P-value:5.69E-8 ID:SGTC_3152|Compound:9099253|FD-Score:3.14|P-value:1.06E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.97|P-value:1.20E-6 ID:SGTC_3173|Compound:9105693|FD-Score:3.19|P-value:8.30E-5 ID:SGTC_3174|Compound:9107204|FD-Score:2.91|P-value:3.02E-4 ID:SGTC_3182|Compound:9108849|FD-Score:2.86|P-value:3.73E-4 ID:SGTC_3295|Compound:9122362|FD-Score:-2.67|P-value:7.54E-4 ID:SGTC_223|Compound:busulfan|FD-Score:2.62|P-value:9.90E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-2.90|P-value:2.87E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.20|P-value:7.79E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:-2.68|P-value:7.38E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:2.84|P-value:4.09E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.50|P-value:1.77E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:3.23|P-value:6.93E-5 ID:SGTC_433|Compound:pimozide|FD-Score:-2.72|P-value:6.24E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:4.83|P-value:5.99E-9 ID:SGTC_694|Compound:1315-0438|FD-Score:-2.62|P-value:9.23E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.44|P-value:2.22E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.00|P-value:1.84E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.67|P-value:7.42E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:2.93|P-value:2.70E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.01|P-value:1.73E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.86|P-value:2.60E-6 ID:SGTC_1198|Compound:1612-1005|FD-Score:2.97|P-value:2.27E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:2.93|P-value:2.79E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:2.87|P-value:3.61E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-2.68|P-value:7.25E-4 ID:SGTC_1817|Compound:st052116|FD-Score:2.63|P-value:9.76E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.63|P-value:8.27E-6 ID:SGTC_1914|Compound:st062367|FD-Score:-2.88|P-value:3.13E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-2.60|P-value:9.85E-4 ID:SGTC_1934|Compound:st074720|FD-Score:2.76|P-value:5.56E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.21|P-value:7.49E-5 ID:SGTC_1979|Compound:st071809|FD-Score:2.80|P-value:4.77E-4 ID:SGTC_2016|Compound:5121758|FD-Score:2.78|P-value:5.19E-4 ID:SGTC_2018|Compound:5133068|FD-Score:2.63|P-value:9.74E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-5.52|P-value:2.99E-11 ID:SGTC_2020|Compound:4017018|FD-Score:-3.00|P-value:1.87E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-2.66|P-value:7.81E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-2.85|P-value:3.55E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-4.19|P-value:3.36E-7 ID:SGTC_2290|Compound:7904846|FD-Score:-2.63|P-value:9.05E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.08|P-value:1.37E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.38|P-value:3.36E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-3.15|P-value:9.17E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.33|P-value:1.40E-7 ID:SGTC_2575|Compound:plumbagin|FD-Score:-7.98|P-value:1.53E-21 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-5.98|P-value:6.73E-13 ID:SGTC_2581|Compound:avocatin a|FD-Score:8.08|P-value:6.61E-22 ID:SGTC_2584|Compound:androsterone|FD-Score:6.84|P-value:3.24E-16 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.49|P-value:5.69E-8 ID:SGTC_3152|Compound:9099253|FD-Score:3.14|P-value:1.06E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.97|P-value:1.20E-6 ID:SGTC_3173|Compound:9105693|FD-Score:3.19|P-value:8.30E-5 ID:SGTC_3174|Compound:9107204|FD-Score:2.91|P-value:3.02E-4 ID:SGTC_3182|Compound:9108849|FD-Score:2.86|P-value:3.73E-4 ID:SGTC_3295|Compound:9122362|FD-Score:-2.67|P-value:7.54E-4

Top fitness defect scores for YGR017W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2581 avocatin a 8.08 64.0 µM 6.61E-22 sphingolipid biosynthesis & PDR1 5 3.34E-16
2 SGTC_2584 androsterone 6.84 48.7 µM 3.24E-16 cell wall 43 4.07E-12
3 SGTC_650 1328-0195 4.83 38.0 µM 5.99E-9 7 6.99E-7
4 SGTC_2588 indole-3-carbinol 4.49 100.0 µM 5.69E-8 25 3.56E-6
5 SGTC_1122 capsaicin 3.86 818.6 nM 2.60E-6 32 5.68E-5
6 SGTC_774 k060-0086 3.67 136.0 µM 7.42E-6 24 1.22E-4
7 SGTC_382 3229-0966 3.50 23.2 µM 1.77E-5 37 2.29E-4
8 SGTC_2419 paclitaxel 3.38 166.5 µM 3.36E-5 78 3.66E-4
9 SGTC_425 3825-7017 3.23 13.1 µM 6.93E-5 54 6.20E-4
10 SGTC_1950 st077106 3.21 7.2 µM 7.49E-5 RNA processing & uracil transport 59 6.57E-4
11 SGTC_329 k048-0121 3.20 21.3 µM 7.79E-5 RSC & ERG11 34 6.76E-4
12 SGTC_3173 9105693 3.19 49.5 µM 8.30E-5 52 7.08E-4
13 SGTC_3152 9099253 3.14 49.5 µM 1.06E-4 NEO1-PIK1 191 8.44E-4
14 SGTC_2316 5844804 3.08 197.4 µM 1.37E-4 85 0.00102
15 SGTC_1198 1612-1005 2.97 86.7 µM 2.27E-4 52 0.00148
16 SGTC_951 1171-0579 2.93 82.7 µM 2.70E-4 cell wall 153 0.00168
17 SGTC_1490 4089-0339 2.93 670.0 nM 2.79E-4 31 0.00172
18 SGTC_3174 9107204 2.91 49.5 µM 3.02E-4 ERG2 86 0.00182
19 SGTC_1501 4491-0275 2.87 38.4 µM 3.61E-4 44 0.00208
20 SGTC_3182 9108849 2.86 49.5 µM 3.73E-4 RPP1 & pyrimidine depletion 52 0.00213

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.171 2.11E-23 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.154 3.01E-19 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.146 2.41E-17 YGL122C NAB2 het Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
0.145 3.22E-17 YIL121W QDR2 hom Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper
0.140 4.96E-16 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.135 4.49E-15 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.129 6.73E-14 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.123 9.31E-13 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.120 2.67E-12 YMR244W_p YMR244W_p hom Putative protein of unknown function
0.117 1.04E-11 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
0.117 1.26E-11 YGR045C_d YGR045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.114 3.35E-11 YBL081W_p YBL081W_p hom Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport
0.113 4.92E-11 YCL049C_p YCL049C_p hom Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene
0.112 6.99E-11 YGL164C YRB30 hom RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes
0.109 3.03E-10 YGR023W MTL1 hom Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p