YGR020C / VMA7

Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR020C / VMA7

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:4.58|P-value:1.06E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.08|P-value:4.52E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:5.75|P-value:1.64E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:4.16|P-value:3.90E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.10|P-value:4.59E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-5.97|P-value:6.08E-7 ID:SGTC_167|Compound:3672-0051|FD-Score:8.46|P-value:3.62E-12 ID:SGTC_171|Compound:k064-0041|FD-Score:-4.27|P-value:2.55E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.91|P-value:7.92E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.63|P-value:8.48E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:4.15|P-value:3.91E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:5.07|P-value:2.03E-5 ID:SGTC_252|Compound:miconazole|FD-Score:-4.73|P-value:6.01E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.67|P-value:8.05E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.68|P-value:7.13E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.87|P-value:8.13E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.17|P-value:3.79E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:5.24|P-value:1.10E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:8.43|P-value:4.39E-12 ID:SGTC_551|Compound:k048-0028|FD-Score:-4.94|P-value:3.00E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:5.62|P-value:2.75E-6 ID:SGTC_868|Compound:0527-0199|FD-Score:5.09|P-value:1.92E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:-3.94|P-value:6.79E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:4.00|P-value:6.19E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:6.79|P-value:1.98E-8 ID:SGTC_944|Compound:3370-0224|FD-Score:4.14|P-value:4.13E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:6.02|P-value:5.60E-7 ID:SGTC_1080|Compound:nisoldipine|FD-Score:6.21|P-value:2.51E-7 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.83|P-value:9.74E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:5.16|P-value:1.48E-5 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.02|P-value:5.73E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.12|P-value:4.39E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.62|P-value:9.35E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:5.81|P-value:1.31E-6 ID:SGTC_1500|Compound:4488-1866|FD-Score:6.59|P-value:4.91E-8 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.97|P-value:2.89E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.90|P-value:3.76E-5 ID:SGTC_1740|Compound:st038286|FD-Score:-8.66|P-value:1.02E-12 ID:SGTC_1742|Compound:st038235|FD-Score:-8.34|P-value:6.36E-12 ID:SGTC_1745|Compound:st081495|FD-Score:-4.00|P-value:5.66E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-4.25|P-value:2.74E-4 ID:SGTC_1750|Compound:st081859|FD-Score:6.40|P-value:1.10E-7 ID:SGTC_1772|Compound:st048439|FD-Score:7.27|P-value:1.98E-9 ID:SGTC_1774|Compound:st048371|FD-Score:-3.89|P-value:7.75E-4 ID:SGTC_1791|Compound:st048313|FD-Score:-6.91|P-value:1.01E-8 ID:SGTC_2015|Compound:5119600|FD-Score:6.83|P-value:1.65E-8 ID:SGTC_2029|Compound:5175081|FD-Score:-4.10|P-value:4.22E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.91|P-value:7.91E-4 ID:SGTC_2054|Compound:5233173|FD-Score:4.73|P-value:6.61E-5 ID:SGTC_2105|Compound:5350118|FD-Score:3.87|P-value:8.84E-4 ID:SGTC_2205|Compound:7238770|FD-Score:4.94|P-value:3.22E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.83|P-value:9.82E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.96|P-value:6.89E-4 ID:SGTC_2396|Compound:5342950|FD-Score:6.61|P-value:4.39E-8 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.38|P-value:2.00E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-4.88|P-value:3.68E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:6.64|P-value:3.82E-8 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.84|P-value:4.61E-5 ID:SGTC_2428|Compound:5615643|FD-Score:-4.35|P-value:2.03E-4 ID:SGTC_2435|Compound:5706476|FD-Score:7.65|P-value:2.92E-10 ID:SGTC_2456|Compound:5770359|FD-Score:5.11|P-value:1.82E-5 ID:SGTC_2462|Compound:5162487|FD-Score:4.01|P-value:5.87E-4 ID:SGTC_2474|Compound:5321570|FD-Score:4.44|P-value:1.65E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.51|P-value:1.32E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:4.04|P-value:5.49E-4 ID:SGTC_2681|Compound:menadione|FD-Score:5.29|P-value:9.50E-6 ID:SGTC_2686|Compound:alizarin|FD-Score:4.28|P-value:2.69E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:7.48|P-value:7.08E-10 ID:SGTC_2862|Compound:9027634|FD-Score:4.06|P-value:5.10E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.11|P-value:4.45E-4 ID:SGTC_3057|Compound:9095946|FD-Score:4.03|P-value:5.70E-4 ID:SGTC_3065|Compound:9113888|FD-Score:4.26|P-value:2.88E-4 ID:SGTC_3155|Compound:9099265|FD-Score:5.01|P-value:2.53E-5 ID:SGTC_3237|Compound:9133362|FD-Score:3.89|P-value:8.41E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:4.58|P-value:1.06E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.08|P-value:4.52E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:5.75|P-value:1.64E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:4.16|P-value:3.90E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.10|P-value:4.59E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-5.97|P-value:6.08E-7 ID:SGTC_167|Compound:3672-0051|FD-Score:8.46|P-value:3.62E-12 ID:SGTC_171|Compound:k064-0041|FD-Score:-4.27|P-value:2.55E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.91|P-value:7.92E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.63|P-value:8.48E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:4.15|P-value:3.91E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:5.07|P-value:2.03E-5 ID:SGTC_252|Compound:miconazole|FD-Score:-4.73|P-value:6.01E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.67|P-value:8.05E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.68|P-value:7.13E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.87|P-value:8.13E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.17|P-value:3.79E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:5.24|P-value:1.10E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:8.43|P-value:4.39E-12 ID:SGTC_551|Compound:k048-0028|FD-Score:-4.94|P-value:3.00E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:5.62|P-value:2.75E-6 ID:SGTC_868|Compound:0527-0199|FD-Score:5.09|P-value:1.92E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:-3.94|P-value:6.79E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:4.00|P-value:6.19E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:6.79|P-value:1.98E-8 ID:SGTC_944|Compound:3370-0224|FD-Score:4.14|P-value:4.13E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:6.02|P-value:5.60E-7 ID:SGTC_1080|Compound:nisoldipine|FD-Score:6.21|P-value:2.51E-7 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.83|P-value:9.74E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:5.16|P-value:1.48E-5 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.02|P-value:5.73E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.12|P-value:4.39E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.62|P-value:9.35E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:5.81|P-value:1.31E-6 ID:SGTC_1500|Compound:4488-1866|FD-Score:6.59|P-value:4.91E-8 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.97|P-value:2.89E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.90|P-value:3.76E-5 ID:SGTC_1740|Compound:st038286|FD-Score:-8.66|P-value:1.02E-12 ID:SGTC_1742|Compound:st038235|FD-Score:-8.34|P-value:6.36E-12 ID:SGTC_1745|Compound:st081495|FD-Score:-4.00|P-value:5.66E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-4.25|P-value:2.74E-4 ID:SGTC_1750|Compound:st081859|FD-Score:6.40|P-value:1.10E-7 ID:SGTC_1772|Compound:st048439|FD-Score:7.27|P-value:1.98E-9 ID:SGTC_1774|Compound:st048371|FD-Score:-3.89|P-value:7.75E-4 ID:SGTC_1791|Compound:st048313|FD-Score:-6.91|P-value:1.01E-8 ID:SGTC_2015|Compound:5119600|FD-Score:6.83|P-value:1.65E-8 ID:SGTC_2029|Compound:5175081|FD-Score:-4.10|P-value:4.22E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.91|P-value:7.91E-4 ID:SGTC_2054|Compound:5233173|FD-Score:4.73|P-value:6.61E-5 ID:SGTC_2105|Compound:5350118|FD-Score:3.87|P-value:8.84E-4 ID:SGTC_2205|Compound:7238770|FD-Score:4.94|P-value:3.22E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.83|P-value:9.82E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.96|P-value:6.89E-4 ID:SGTC_2396|Compound:5342950|FD-Score:6.61|P-value:4.39E-8 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.38|P-value:2.00E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-4.88|P-value:3.68E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:6.64|P-value:3.82E-8 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.84|P-value:4.61E-5 ID:SGTC_2428|Compound:5615643|FD-Score:-4.35|P-value:2.03E-4 ID:SGTC_2435|Compound:5706476|FD-Score:7.65|P-value:2.92E-10 ID:SGTC_2456|Compound:5770359|FD-Score:5.11|P-value:1.82E-5 ID:SGTC_2462|Compound:5162487|FD-Score:4.01|P-value:5.87E-4 ID:SGTC_2474|Compound:5321570|FD-Score:4.44|P-value:1.65E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.51|P-value:1.32E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:4.04|P-value:5.49E-4 ID:SGTC_2681|Compound:menadione|FD-Score:5.29|P-value:9.50E-6 ID:SGTC_2686|Compound:alizarin|FD-Score:4.28|P-value:2.69E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:7.48|P-value:7.08E-10 ID:SGTC_2862|Compound:9027634|FD-Score:4.06|P-value:5.10E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.11|P-value:4.45E-4 ID:SGTC_3057|Compound:9095946|FD-Score:4.03|P-value:5.70E-4 ID:SGTC_3065|Compound:9113888|FD-Score:4.26|P-value:2.88E-4 ID:SGTC_3155|Compound:9099265|FD-Score:5.01|P-value:2.53E-5 ID:SGTC_3237|Compound:9133362|FD-Score:3.89|P-value:8.41E-4

Top fitness defect scores for YGR020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_167 3672-0051 8.46 66.2 µM 3.62E-12 5 1.29E-17
2 SGTC_534 k292-0788 8.43 63.4 µM 4.39E-12 mitochondrial processes 1 1.73E-17
3 SGTC_2435 5706476 7.65 10.6 µM 2.92E-10 1 9.89E-15
4 SGTC_2689 tacrolimus 7.48 100.0 µM 7.08E-10 6 3.76E-14
5 SGTC_1772 st048439 7.27 82.2 µM 1.98E-9 3 1.78E-13
6 SGTC_2015 5119600 6.83 184.0 µM 1.65E-8 7 4.37E-12
7 SGTC_935 2996-0153 6.79 430.0 µM 1.98E-8 PDR1 4 5.77E-12
8 SGTC_2418 pentamidine 6.64 31.7 µM 3.82E-8 mitochondrial processes 11 1.55E-11
9 SGTC_2396 5342950 6.61 42.8 µM 4.39E-8 RSC complex & mRNA processing 11 1.91E-11
10 SGTC_1500 4488-1866 6.59 171.0 µM 4.91E-8 RPP1 & pyrimidine depletion 3 2.26E-11
11 SGTC_1750 st081859 6.40 2.4 µM 1.10E-7 endomembrane recycling 99 7.64E-11
12 SGTC_1080 nisoldipine 6.21 24.4 µM 2.51E-7 TSC3-RPN4 4 2.65E-10
13 SGTC_1053 3366-3204 6.02 134.0 µM 5.60E-7 cell wall 9 8.84E-10
14 SGTC_1368 1852-0141 5.81 284.0 µM 1.31E-6 ERG2 13 3.17E-9
15 SGTC_100 0086-0128 5.75 49.6 µM 1.64E-6 copper-dependent oxidative stress 16 4.44E-9
16 SGTC_790 1575-0012 5.62 79.1 µM 2.75E-6 TSC3-RPN4 7 9.66E-9
17 SGTC_2681 menadione 5.29 3.2 µM 9.50E-6 superoxide 17 6.23E-8
18 SGTC_529 4076-0302 5.24 30.3 µM 1.10E-5 mitochondrial processes 4 7.82E-8
19 SGTC_1112 tnp00069 5.16 1.2 µM 1.48E-5 8 1.21E-7
20 SGTC_2456 5770359 5.11 74.5 µM 1.82E-5 5 1.65E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.51E-21 YDL185W VMA1 hom Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
0.142 1.34E-16 YPR036W VMA13 hom Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase
0.136 3.04E-15 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.115 2.57E-11 YGL071W AFT1 hom Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.102 3.22E-9 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.097 1.62E-8 YPL174C NIP100 hom Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)
0.097 2.12E-8 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.094 4.91E-8 YKL118W_d YKL118W_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2
0.094 5.38E-8 YHR026W VMA16 hom Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
0.092 1.02E-7 YPL263C KEL3 hom Cytoplasmic protein of unknown function
0.091 1.23E-7 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.089 2.35E-7 YNL256W FOL1 het Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
0.085 8.10E-7 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.084 1.04E-6 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.084 1.07E-6 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport