YGR021W_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR021W / YGR021W

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:3.58|P-value:2.85E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.35|P-value:5.91E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.34|P-value:6.20E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-4.01|P-value:5.22E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:-7.90|P-value:1.07E-14 ID:SGTC_448|Compound:monastrol|FD-Score:4.25|P-value:2.06E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.26|P-value:1.97E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:5.36|P-value:1.18E-7 ID:SGTC_797|Compound:k781-0471|FD-Score:-4.59|P-value:4.38E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.22|P-value:8.99E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.60|P-value:2.61E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.48|P-value:4.06E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-4.07|P-value:4.07E-5 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.79|P-value:1.28E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:4.15|P-value:3.14E-5 ID:SGTC_1726|Compound:st035556|FD-Score:3.57|P-value:2.86E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.48|P-value:3.96E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-4.36|P-value:1.22E-5 ID:SGTC_1843|Compound:st055809|FD-Score:3.31|P-value:7.18E-4 ID:SGTC_1940|Compound:st075990|FD-Score:4.00|P-value:5.71E-5 ID:SGTC_2052|Compound:5265182|FD-Score:-4.13|P-value:3.24E-5 ID:SGTC_2057|Compound:5236571|FD-Score:-3.48|P-value:3.76E-4 ID:SGTC_2110|Compound:5483698|FD-Score:5.15|P-value:3.41E-7 ID:SGTC_2227|Compound:7312221|FD-Score:3.78|P-value:1.37E-4 ID:SGTC_2383|Compound:9036125|FD-Score:4.08|P-value:4.14E-5 ID:SGTC_2386|Compound:9075165|FD-Score:3.31|P-value:7.14E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.59|P-value:2.67E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.11|P-value:3.79E-5 ID:SGTC_2534|Compound:helenine|FD-Score:3.22|P-value:9.47E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.51|P-value:3.64E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.79|P-value:1.30E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:3.58|P-value:2.85E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.35|P-value:5.91E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.34|P-value:6.20E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-4.01|P-value:5.22E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:-7.90|P-value:1.07E-14 ID:SGTC_448|Compound:monastrol|FD-Score:4.25|P-value:2.06E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.26|P-value:1.97E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:5.36|P-value:1.18E-7 ID:SGTC_797|Compound:k781-0471|FD-Score:-4.59|P-value:4.38E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.22|P-value:8.99E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.60|P-value:2.61E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.48|P-value:4.06E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-4.07|P-value:4.07E-5 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.79|P-value:1.28E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:4.15|P-value:3.14E-5 ID:SGTC_1726|Compound:st035556|FD-Score:3.57|P-value:2.86E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.48|P-value:3.96E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-4.36|P-value:1.22E-5 ID:SGTC_1843|Compound:st055809|FD-Score:3.31|P-value:7.18E-4 ID:SGTC_1940|Compound:st075990|FD-Score:4.00|P-value:5.71E-5 ID:SGTC_2052|Compound:5265182|FD-Score:-4.13|P-value:3.24E-5 ID:SGTC_2057|Compound:5236571|FD-Score:-3.48|P-value:3.76E-4 ID:SGTC_2110|Compound:5483698|FD-Score:5.15|P-value:3.41E-7 ID:SGTC_2227|Compound:7312221|FD-Score:3.78|P-value:1.37E-4 ID:SGTC_2383|Compound:9036125|FD-Score:4.08|P-value:4.14E-5 ID:SGTC_2386|Compound:9075165|FD-Score:3.31|P-value:7.14E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.59|P-value:2.67E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.11|P-value:3.79E-5 ID:SGTC_2534|Compound:helenine|FD-Score:3.22|P-value:9.47E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.51|P-value:3.64E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.79|P-value:1.30E-4

Top fitness defect scores for YGR021W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_796 1234-0020 5.36 70.7 µM 1.18E-7 SWF1 & branched chain AA biosynthesis 9 4.18E-8
2 SGTC_2110 5483698 5.15 200.0 µM 3.41E-7 TSC3-RPN4 10 1.30E-7
3 SGTC_669 0108-0021 4.26 26.2 µM 1.97E-5 fatty acid desaturase (OLE1) 63 1.00E-5
4 SGTC_448 monastrol 4.25 171.0 µM 2.06E-5 7 1.05E-5
5 SGTC_1546 5-methoxyflavanone 4.15 78.7 µM 3.14E-5 9 1.65E-5
6 SGTC_2419 paclitaxel 4.11 166.5 µM 3.79E-5 32 2.01E-5
7 SGTC_2383 9036125 4.08 200.0 µM 4.14E-5 5 2.22E-5
8 SGTC_1940 st075990 4.00 51.1 µM 5.71E-5 60S ribosome export 20 3.13E-5
9 SGTC_1439 4092-1168 3.79 46.0 µM 1.28E-4 13 7.43E-5
10 SGTC_2889 9059656 3.79 52.0 µM 1.30E-4 12 7.57E-5
11 SGTC_2227 7312221 3.78 64.1 µM 1.37E-4 4 7.97E-5
12 SGTC_942 3253-1115 3.60 227.0 µM 2.61E-4 40 1.59E-4
13 SGTC_2404 5161160 3.59 200.0 µM 2.67E-4 28 1.63E-4
14 SGTC_82 0054-0107 3.58 293.8 µM 2.85E-4 16 1.75E-4
15 SGTC_1726 st035556 3.57 14.6 µM 2.86E-4 49 1.76E-4
16 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 3.51 100.0 µM 3.64E-4 36 2.27E-4
17 SGTC_1753 st043925 3.48 64.0 µM 3.96E-4 16 2.48E-4
18 SGTC_1027 k015-0025 3.48 8.7 µM 4.06E-4 41 2.55E-4
19 SGTC_2386 9075165 3.31 157.4 µM 7.14E-4 20 4.67E-4
20 SGTC_1843 st055809 3.31 45.5 µM 7.18E-4 38 4.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.82E-18 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.142 1.68E-16 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.131 2.59E-14 YOR169C_d YOR169C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W
0.128 1.06E-13 YDL009C_p YDL009C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene
0.124 5.63E-13 YNR013C PHO91 hom Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
0.123 9.52E-13 YIL099W SGA1 hom Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
0.118 7.28E-12 YKL120W OAC1 hom Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family
0.109 2.14E-10 YDR503C LPP1 hom Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA
0.109 2.45E-10 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.108 3.15E-10 YNL180C RHO5 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
0.106 7.98E-10 YGR026W_p YGR026W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.102 3.25E-9 YDR222W_p YDR222W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.102 3.53E-9 YPR006C ICL2 hom 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
0.098 1.11E-8 YMR122C_d YMR122C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.098 1.37E-8 YNL024C_p YNL024C_p hom Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern