YGR028W / MSP1

Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR028W / MSP1

Click on Significant Values for Screen Details ID:SGTC_178|Compound:4092-0806|FD-Score:-3.35|P-value:1.32E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:-2.85|P-value:9.58E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.42|P-value:1.03E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-2.84|P-value:9.89E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:2.93|P-value:7.33E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.04|P-value:4.57E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.07|P-value:4.81E-6 ID:SGTC_522|Compound:1273-0010|FD-Score:5.12|P-value:1.33E-8 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.04|P-value:4.56E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.59|P-value:4.77E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.55|P-value:5.84E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:3.69|P-value:3.10E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.30|P-value:1.70E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:2.91|P-value:7.83E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.03|P-value:4.91E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.11|P-value:4.04E-6 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.15|P-value:3.10E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.83|P-value:1.60E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.43|P-value:9.93E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.18|P-value:2.78E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.07|P-value:4.05E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.49|P-value:7.45E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:2.93|P-value:7.45E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.39|P-value:1.10E-4 ID:SGTC_1696|Compound:st025591|FD-Score:-2.85|P-value:9.37E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.25|P-value:2.04E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.80|P-value:1.82E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:2.96|P-value:6.54E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.07|P-value:4.10E-4 ID:SGTC_2173|Compound:5763948|FD-Score:-3.34|P-value:1.36E-4 ID:SGTC_2308|Compound:7584454|FD-Score:2.89|P-value:8.56E-4 ID:SGTC_2338|Compound:7999974|FD-Score:2.99|P-value:5.93E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.18|P-value:2.68E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-3.46|P-value:8.11E-5 ID:SGTC_2693|Compound:st077581|FD-Score:2.90|P-value:8.05E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.19|P-value:2.77E-15 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.35|P-value:1.32E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:-2.85|P-value:9.58E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.42|P-value:1.03E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-2.84|P-value:9.89E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:2.93|P-value:7.33E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.04|P-value:4.57E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.07|P-value:4.81E-6 ID:SGTC_522|Compound:1273-0010|FD-Score:5.12|P-value:1.33E-8 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.04|P-value:4.56E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.59|P-value:4.77E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.55|P-value:5.84E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:3.69|P-value:3.10E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.30|P-value:1.70E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:2.91|P-value:7.83E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.03|P-value:4.91E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.11|P-value:4.04E-6 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.15|P-value:3.10E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.83|P-value:1.60E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.43|P-value:9.93E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.18|P-value:2.78E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.07|P-value:4.05E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.49|P-value:7.45E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:2.93|P-value:7.45E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.39|P-value:1.10E-4 ID:SGTC_1696|Compound:st025591|FD-Score:-2.85|P-value:9.37E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.25|P-value:2.04E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.80|P-value:1.82E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:2.96|P-value:6.54E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.07|P-value:4.10E-4 ID:SGTC_2173|Compound:5763948|FD-Score:-3.34|P-value:1.36E-4 ID:SGTC_2308|Compound:7584454|FD-Score:2.89|P-value:8.56E-4 ID:SGTC_2338|Compound:7999974|FD-Score:2.99|P-value:5.93E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.18|P-value:2.68E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-3.46|P-value:8.11E-5 ID:SGTC_2693|Compound:st077581|FD-Score:2.90|P-value:8.05E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.19|P-value:2.77E-15

Top fitness defect scores for YGR028W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2752 diclazuril 7.19 33.1 µM 2.77E-15 45 3.29E-13
2 SGTC_522 1273-0010 5.12 11.6 µM 1.33E-8 60S ribosome export 9 1.54E-7
3 SGTC_1066 ketoconazole 4.11 628.0 nM 4.04E-6 15 2.00E-5
4 SGTC_513 4245-1575 4.07 41.7 µM 4.81E-6 unfolded protein response 108 2.31E-5
5 SGTC_1086 cerivastatin 3.83 2.2 µM 1.60E-5 azole & statin 17 6.44E-5
6 SGTC_2108 5365811 3.80 200.0 µM 1.82E-5 15 7.21E-5
7 SGTC_767 0929-0023 3.69 86.0 µM 3.10E-5 TRP & mitochondrial translation 94 1.14E-4
8 SGTC_635 k038-0028 3.59 24.7 µM 4.77E-5 ubiquinone biosynthesis & proteasome 57 1.64E-4
9 SGTC_669 0108-0021 3.55 26.2 µM 5.84E-5 fatty acid desaturase (OLE1) 109 1.95E-4
10 SGTC_1139 k015-0024 3.49 46.9 µM 7.45E-5 PDR1 18 2.40E-4
11 SGTC_1091 telmisartan 3.43 47.6 µM 9.93E-5 33 3.07E-4
12 SGTC_345 1362-0200 3.42 395.0 µM 1.03E-4 34 3.16E-4
13 SGTC_769 0302-0231 3.30 76.0 µM 1.70E-4 84 4.86E-4
14 SGTC_2006 4011487 3.25 200.0 µM 2.04E-4 endomembrane recycling 117 5.68E-4
15 SGTC_1114 scopoletin 3.18 1.7 µM 2.78E-4 38 7.38E-4
16 SGTC_1073 triclabendazole 3.15 3.1 µM 3.10E-4 76 8.11E-4
17 SGTC_1050 3232-1156 3.03 69.3 µM 4.91E-4 RSC complex & mRNA processing 54 0.00120
18 SGTC_2338 7999974 2.99 200.0 µM 5.93E-4 65 0.00141
19 SGTC_2115 tiliquinol 2.96 12.8 µM 6.54E-4 37 0.00154
20 SGTC_445 e6 berbamine 2.93 66.0 µM 7.33E-4 NEO1-PIK1 198 0.00170

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.167 2.17E-22 YDR034W-B_p YDR034W-B_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.149 3.75E-18 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.136 2.91E-15 YDR257C RKM4 hom Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein
0.121 1.62E-12 YNL023C FAP1 hom Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1
0.120 2.99E-12 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.120 3.41E-12 YBR221W-A_p YBR221W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.118 6.05E-12 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.117 1.12E-11 YKR106W GEX2 hom Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway
0.117 1.16E-11 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.115 2.05E-11 YBR299W MAL32 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.113 4.55E-11 YNL235C_d YNL235C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex
0.113 6.06E-11 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.110 1.98E-10 YNL277W-A_p YNL277W-A_p hom Putative protein of unknown function
0.109 2.54E-10 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.108 3.62E-10 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p