YGR029W / ERV1

Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR029W / ERV1

Click on Significant Values for Screen Details ID:SGTC_109|Compound:0132-0036|FD-Score:3.35|P-value:7.88E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:-3.51|P-value:4.21E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:-4.29|P-value:2.27E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:-3.31|P-value:8.20E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.87|P-value:1.29E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.29|P-value:9.55E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:5.30|P-value:2.65E-7 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.30|P-value:2.46E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.84|P-value:1.45E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:6.37|P-value:8.60E-10 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.66|P-value:2.72E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.41|P-value:1.56E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.94|P-value:9.95E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.14|P-value:4.58E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:6.00|P-value:7.11E-9 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.53|P-value:8.37E-8 ID:SGTC_1375|Compound:2910-0797|FD-Score:-5.81|P-value:1.70E-8 ID:SGTC_1380|Compound:2291-0730|FD-Score:-4.05|P-value:5.97E-5 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.86|P-value:1.34E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-3.32|P-value:7.98E-4 ID:SGTC_1704|Compound:st028805|FD-Score:-3.28|P-value:8.98E-4 ID:SGTC_2118|Compound:5526350|FD-Score:4.71|P-value:4.34E-6 ID:SGTC_2120|Compound:5538279|FD-Score:3.52|P-value:4.50E-4 ID:SGTC_2139|Compound:5578692|FD-Score:7.08|P-value:1.09E-11 ID:SGTC_2152|Compound:5568786|FD-Score:3.43|P-value:5.98E-4 ID:SGTC_2153|Compound:5569715|FD-Score:3.44|P-value:5.89E-4 ID:SGTC_2155|Compound:5570423|FD-Score:4.08|P-value:5.86E-5 ID:SGTC_2159|Compound:5658611|FD-Score:5.09|P-value:7.51E-7 ID:SGTC_2162|Compound:5663267|FD-Score:4.15|P-value:4.46E-5 ID:SGTC_2225|Compound:6654152|FD-Score:22.10|P-value:2.44E-97 ID:SGTC_2233|Compound:sulbentine|FD-Score:6.30|P-value:1.27E-9 ID:SGTC_2344|Compound:7990960|FD-Score:15.70|P-value:2.84E-50 ID:SGTC_2388|Compound:9080168|FD-Score:3.44|P-value:5.82E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.57|P-value:7.81E-6 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:4.27|P-value:2.68E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.08|P-value:5.68E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.44|P-value:1.22E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.33|P-value:7.76E-4 ID:SGTC_2708|Compound:st078559|FD-Score:-5.52|P-value:8.14E-8 ID:SGTC_2743|Compound:auranofin|FD-Score:12.10|P-value:1.78E-30 ID:SGTC_2799|Compound:7812892|FD-Score:4.00|P-value:8.00E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.64|P-value:2.97E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.36|P-value:7.51E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.42|P-value:6.27E-4 ID:SGTC_3062|Compound:9077494|FD-Score:4.05|P-value:6.44E-5 ID:SGTC_3268|Compound:9137683|FD-Score:3.41|P-value:6.50E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.66|P-value:2.75E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:3.35|P-value:7.88E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:-3.51|P-value:4.21E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:-4.29|P-value:2.27E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:-3.31|P-value:8.20E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.87|P-value:1.29E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.29|P-value:9.55E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:5.30|P-value:2.65E-7 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.30|P-value:2.46E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.84|P-value:1.45E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:6.37|P-value:8.60E-10 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.66|P-value:2.72E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.41|P-value:1.56E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.94|P-value:9.95E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.14|P-value:4.58E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:6.00|P-value:7.11E-9 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.53|P-value:8.37E-8 ID:SGTC_1375|Compound:2910-0797|FD-Score:-5.81|P-value:1.70E-8 ID:SGTC_1380|Compound:2291-0730|FD-Score:-4.05|P-value:5.97E-5 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.86|P-value:1.34E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-3.32|P-value:7.98E-4 ID:SGTC_1704|Compound:st028805|FD-Score:-3.28|P-value:8.98E-4 ID:SGTC_2118|Compound:5526350|FD-Score:4.71|P-value:4.34E-6 ID:SGTC_2120|Compound:5538279|FD-Score:3.52|P-value:4.50E-4 ID:SGTC_2139|Compound:5578692|FD-Score:7.08|P-value:1.09E-11 ID:SGTC_2152|Compound:5568786|FD-Score:3.43|P-value:5.98E-4 ID:SGTC_2153|Compound:5569715|FD-Score:3.44|P-value:5.89E-4 ID:SGTC_2155|Compound:5570423|FD-Score:4.08|P-value:5.86E-5 ID:SGTC_2159|Compound:5658611|FD-Score:5.09|P-value:7.51E-7 ID:SGTC_2162|Compound:5663267|FD-Score:4.15|P-value:4.46E-5 ID:SGTC_2225|Compound:6654152|FD-Score:22.10|P-value:2.44E-97 ID:SGTC_2233|Compound:sulbentine|FD-Score:6.30|P-value:1.27E-9 ID:SGTC_2344|Compound:7990960|FD-Score:15.70|P-value:2.84E-50 ID:SGTC_2388|Compound:9080168|FD-Score:3.44|P-value:5.82E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.57|P-value:7.81E-6 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:4.27|P-value:2.68E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.08|P-value:5.68E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.44|P-value:1.22E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.33|P-value:7.76E-4 ID:SGTC_2708|Compound:st078559|FD-Score:-5.52|P-value:8.14E-8 ID:SGTC_2743|Compound:auranofin|FD-Score:12.10|P-value:1.78E-30 ID:SGTC_2799|Compound:7812892|FD-Score:4.00|P-value:8.00E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.64|P-value:2.97E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.36|P-value:7.51E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.42|P-value:6.27E-4 ID:SGTC_3062|Compound:9077494|FD-Score:4.05|P-value:6.44E-5 ID:SGTC_3268|Compound:9137683|FD-Score:3.41|P-value:6.50E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.66|P-value:2.75E-4

Top fitness defect scores for YGR029W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2225 6654152 22.10 15.4 µM 2.44E-97 1 2.93E-108 7.74
2 SGTC_2344 7990960 15.70 77.0 µM 2.84E-50 1 7.89E-56 1.50
3 SGTC_2743 auranofin 12.10 4.3 µM 1.78E-30 RPP1 & pyrimidine depletion 1 8.93E-34 3.03
4 SGTC_2139 5578692 7.08 56.5 µM 1.09E-11 superoxide 5 7.45E-13 0.20
5 SGTC_1212 0520-0165 6.37 585.0 µM 8.60E-10 2 9.64E-11 1.65
6 SGTC_2233 sulbentine 6.30 40.4 µM 1.27E-9 22 1.49E-10 0.26
7 SGTC_1369 1866-0067 6.00 208.0 µM 7.11E-9 RPP1 & pyrimidine depletion 3 1.01E-9 0.56
8 SGTC_1371 2421-0008 5.53 32.7 µM 8.37E-8 mitochondrial processes 11 1.57E-8 0.21
9 SGTC_1027 k015-0025 5.30 8.7 µM 2.65E-7 2 5.67E-8 1.15
10 SGTC_2159 5658611 5.09 73.8 µM 7.51E-7 3 1.80E-7 0.89
11 SGTC_2118 5526350 4.71 200.0 µM 4.34E-6 3 1.27E-6 0.44
12 SGTC_2408 sulbentine 4.57 18.4 µM 7.81E-6 26 2.44E-6 0.06
13 SGTC_1310 1188-0297 4.41 994.0 nM 1.56E-5 azole & statin 11 5.26E-6 0.12
14 SGTC_1071 trifluoperazine 4.30 6.3 µM 2.46E-5 4 8.71E-6 0.01
15 SGTC_2503 beta-caryophyllene alcohol 4.27 24.7 µM 2.68E-5 1 9.58E-6 0.41
16 SGTC_2162 5663267 4.15 200.0 µM 4.46E-5 8 1.69E-5 0.13
17 SGTC_1365 1672-3266 4.14 55.4 µM 4.58E-5 4 1.74E-5 0.21
18 SGTC_2566 crystal violet carbinol 4.08 226.0 nM 5.68E-5 16 2.21E-5 0.03
19 SGTC_2155 5570423 4.08 76.0 µM 5.86E-5 ergosterol biosynthesis 4 2.28E-5 0.16
20 SGTC_3062 9077494 4.05 49.5 µM 6.44E-5 mitochondrial response to ROS 7 2.54E-5 0.20

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.267 6.43E-56 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.199 2.23E-31 YDR016C DAD1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.198 7.36E-31 YLR147C SMD3 het Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3
0.189 2.51E-28 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.170 4.76E-23 YKR008W RSC4 het Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p
0.155 1.92E-19 YJR043C POL32 hom Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
0.149 4.01E-18 YMR274C RCE1 hom Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone
0.147 8.77E-18 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.145 3.53E-17 YMR131C RRB1 het Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
0.141 1.88E-16 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.141 2.03E-16 YBR002C RER2 het Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
0.140 3.26E-16 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.135 3.49E-15 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.131 3.60E-14 YDR303C RSC3 het Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p
0.121 1.78E-12 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda