YGR030C / POP6

Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR030C / POP6

Click on Significant Values for Screen Details ID:SGTC_32|Compound:0928-0142|FD-Score:3.23|P-value:7.47E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.48|P-value:3.15E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-6.58|P-value:5.75E-11 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.53|P-value:2.82E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.62|P-value:2.01E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:6.57|P-value:5.35E-11 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.37|P-value:4.52E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-3.96|P-value:5.43E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.86|P-value:7.53E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.54|P-value:2.46E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.48|P-value:3.36E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.78|P-value:1.00E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.84|P-value:7.90E-5 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.60|P-value:2.01E-4 ID:SGTC_1720|Compound:st037298|FD-Score:4.71|P-value:1.87E-6 ID:SGTC_1777|Compound:st045864|FD-Score:4.03|P-value:3.79E-5 ID:SGTC_1802|Compound:st050112|FD-Score:-3.17|P-value:9.81E-4 ID:SGTC_1809|Compound:st050081|FD-Score:4.96|P-value:5.40E-7 ID:SGTC_1814|Compound:st052110|FD-Score:3.38|P-value:4.50E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.16|P-value:9.42E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.43|P-value:3.73E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.15|P-value:9.67E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.32|P-value:5.57E-4 ID:SGTC_2480|Compound:5767542|FD-Score:5.00|P-value:4.55E-7 ID:SGTC_2505|Compound:galangin|FD-Score:-3.37|P-value:4.87E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-8.59|P-value:1.93E-17 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.31|P-value:6.05E-4 ID:SGTC_2842|Compound:9000675|FD-Score:4.35|P-value:9.50E-6 ID:SGTC_2884|Compound:9058502|FD-Score:-3.71|P-value:1.40E-4 ID:SGTC_2917|Compound:7979103|FD-Score:5.22|P-value:1.48E-7 ID:SGTC_2938|Compound:9059746|FD-Score:3.34|P-value:5.07E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.51|P-value:4.61E-6 ID:SGTC_3025|Compound:9087895|FD-Score:4.17|P-value:2.10E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-4.31|P-value:1.22E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-3.86|P-value:7.88E-5 ID:SGTC_3264|Compound:9137442|FD-Score:4.07|P-value:3.10E-5 ID:SGTC_3266|Compound:9136860|FD-Score:3.21|P-value:8.10E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.26|P-value:6.78E-4 ID:SGTC_3285|Compound:9112818|FD-Score:4.28|P-value:1.32E-5 ID:SGTC_3330|Compound:9141424|FD-Score:-3.18|P-value:9.23E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.62|P-value:1.85E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:3.23|P-value:7.47E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.48|P-value:3.15E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-6.58|P-value:5.75E-11 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.53|P-value:2.82E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.62|P-value:2.01E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:6.57|P-value:5.35E-11 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.37|P-value:4.52E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-3.96|P-value:5.43E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.86|P-value:7.53E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.54|P-value:2.46E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.48|P-value:3.36E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.78|P-value:1.00E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.84|P-value:7.90E-5 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.60|P-value:2.01E-4 ID:SGTC_1720|Compound:st037298|FD-Score:4.71|P-value:1.87E-6 ID:SGTC_1777|Compound:st045864|FD-Score:4.03|P-value:3.79E-5 ID:SGTC_1802|Compound:st050112|FD-Score:-3.17|P-value:9.81E-4 ID:SGTC_1809|Compound:st050081|FD-Score:4.96|P-value:5.40E-7 ID:SGTC_1814|Compound:st052110|FD-Score:3.38|P-value:4.50E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.16|P-value:9.42E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.43|P-value:3.73E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.15|P-value:9.67E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.32|P-value:5.57E-4 ID:SGTC_2480|Compound:5767542|FD-Score:5.00|P-value:4.55E-7 ID:SGTC_2505|Compound:galangin|FD-Score:-3.37|P-value:4.87E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-8.59|P-value:1.93E-17 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.31|P-value:6.05E-4 ID:SGTC_2842|Compound:9000675|FD-Score:4.35|P-value:9.50E-6 ID:SGTC_2884|Compound:9058502|FD-Score:-3.71|P-value:1.40E-4 ID:SGTC_2917|Compound:7979103|FD-Score:5.22|P-value:1.48E-7 ID:SGTC_2938|Compound:9059746|FD-Score:3.34|P-value:5.07E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.51|P-value:4.61E-6 ID:SGTC_3025|Compound:9087895|FD-Score:4.17|P-value:2.10E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-4.31|P-value:1.22E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-3.86|P-value:7.88E-5 ID:SGTC_3264|Compound:9137442|FD-Score:4.07|P-value:3.10E-5 ID:SGTC_3266|Compound:9136860|FD-Score:3.21|P-value:8.10E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.26|P-value:6.78E-4 ID:SGTC_3285|Compound:9112818|FD-Score:4.28|P-value:1.32E-5 ID:SGTC_3330|Compound:9141424|FD-Score:-3.18|P-value:9.23E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.62|P-value:1.85E-4

Top fitness defect scores for YGR030C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1029 k015-0030 6.57 64.7 µM 5.35E-11 1 2.44E-11 1.26
2 SGTC_2917 7979103 5.22 53.8 µM 1.48E-7 3 9.04E-8 0.38
3 SGTC_2480 5767542 5.00 37.2 µM 4.55E-7 3 2.90E-7 0.90
4 SGTC_1809 st050081 4.96 57.6 µM 5.40E-7 2 3.46E-7 0.48
5 SGTC_1720 st037298 4.71 9.5 µM 1.87E-6 5 1.26E-6 0.14
6 SGTC_2976 9009005 4.51 19.5 µM 4.61E-6 6 3.20E-6 0.65
7 SGTC_2842 9000675 4.35 19.5 µM 9.50E-6 8 6.77E-6 0.12
8 SGTC_3285 9112818 4.28 20.9 µM 1.32E-5 cell wall 12 9.53E-6 0.15
9 SGTC_3025 9087895 4.17 49.5 µM 2.10E-5 PDR1 4 1.54E-5 0.43
10 SGTC_3264 9137442 4.07 49.5 µM 3.10E-5 5 2.30E-5 0.03
11 SGTC_1777 st045864 4.03 34.8 µM 3.79E-5 2 2.84E-5 0.36
12 SGTC_1194 1488-0194 3.86 225.0 µM 7.53E-5 3 5.77E-5 0.17
13 SGTC_1376 2910-0861 3.84 41.3 µM 7.90E-5 4 6.07E-5 0.29
14 SGTC_1364 1653-0028 3.78 37.6 µM 1.00E-4 4 7.77E-5 0.13
15 SGTC_3333 9141820 3.62 12.1 µM 1.85E-4 8 1.46E-4 0.09
16 SGTC_1439 4092-1168 3.60 46.0 µM 2.01E-4 2 1.60E-4 0.07
17 SGTC_1281 0884-0031 3.54 11.8 µM 2.46E-4 fatty acid desaturase (OLE1) 5 1.96E-4 0.10
18 SGTC_79 0052-0007 3.48 94.1 µM 3.15E-4 3 2.54E-4 0.06
19 SGTC_2040 5100729 3.43 123.0 µM 3.73E-4 8 3.02E-4 0.11
20 SGTC_1814 st052110 3.38 31.5 µM 4.50E-4 RNA processing & uracil transport 17 3.67E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.215 1.43E-36 YFR012W DCV1 hom Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication
0.144 5.34E-17 YKL095W YJU2 het Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing
0.124 5.72E-13 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.112 8.48E-11 YLR090W XDJ1 hom Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.108 3.23E-10 YNL163C RIA1 het Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
0.100 5.77E-9 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.098 1.47E-8 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.096 2.90E-8 YKL152C GPM1 het Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.095 3.34E-8 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.095 3.69E-8 YLR298C YHC1 het Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
0.094 5.30E-8 YDR234W LYS4 hom Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
0.092 8.29E-8 YOR353C SOG2 het Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis
0.089 2.15E-7 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.087 3.96E-7 YMR081C ISF1 hom Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
0.087 4.66E-7 YKL127W PGM1 hom Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism