YGR031W / IMO32

Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR031W / IMO32

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:6.40|P-value:7.77E-13 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:2.87|P-value:8.21E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:3.81|P-value:1.37E-5 ID:SGTC_34|Compound:0469-0683|FD-Score:3.01|P-value:4.88E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.74|P-value:1.95E-5 ID:SGTC_91|Compound:0417-1751|FD-Score:-2.74|P-value:9.92E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.34|P-value:1.22E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.19|P-value:1.30E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:3.10|P-value:3.34E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:2.91|P-value:7.00E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:-3.26|P-value:1.23E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:4.17|P-value:2.23E-6 ID:SGTC_264|Compound:promethazine|FD-Score:4.16|P-value:2.29E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:3.02|P-value:4.70E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.41|P-value:9.17E-5 ID:SGTC_508|Compound:roscovitine|FD-Score:3.51|P-value:5.74E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:3.17|P-value:2.54E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.17|P-value:2.53E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.67|P-value:2.79E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.70|P-value:2.38E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.73|P-value:2.09E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.86|P-value:1.07E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:2.83|P-value:9.63E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.16|P-value:2.58E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:2.95|P-value:6.20E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.65|P-value:3.06E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.36|P-value:1.13E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.12|P-value:2.93E-6 ID:SGTC_1656|Compound:st012921|FD-Score:3.25|P-value:1.84E-4 ID:SGTC_1659|Compound:st012954|FD-Score:4.30|P-value:1.09E-6 ID:SGTC_1758|Compound:st042942|FD-Score:3.34|P-value:1.22E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.60|P-value:3.85E-5 ID:SGTC_1840|Compound:st055363|FD-Score:3.63|P-value:3.36E-5 ID:SGTC_1959|Compound:st077091|FD-Score:2.91|P-value:7.23E-4 ID:SGTC_2226|Compound:7298446|FD-Score:2.93|P-value:6.51E-4 ID:SGTC_2293|Compound:7624732|FD-Score:4.17|P-value:2.27E-6 ID:SGTC_2295|Compound:7971645|FD-Score:-3.62|P-value:2.37E-5 ID:SGTC_2296|Compound:7971656|FD-Score:-5.03|P-value:9.13E-9 ID:SGTC_2298|Compound:7976326|FD-Score:-2.88|P-value:5.89E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-2.83|P-value:7.09E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.33|P-value:8.97E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.52|P-value:5.45E-5 ID:SGTC_2431|Compound:5490079|FD-Score:-3.08|P-value:2.64E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.06|P-value:3.97E-4 ID:SGTC_2534|Compound:helenine|FD-Score:2.92|P-value:6.98E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:2.82|P-value:9.90E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.73|P-value:2.09E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:2.90|P-value:7.47E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.84|P-value:7.02E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.58|P-value:2.27E-7 ID:SGTC_2850|Compound:9015429|FD-Score:2.86|P-value:8.61E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.02|P-value:4.60E-4 ID:SGTC_3111|Compound:9122088|FD-Score:3.24|P-value:1.87E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.11|P-value:3.18E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.16|P-value:2.58E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:6.40|P-value:7.77E-13 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:2.87|P-value:8.21E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:3.81|P-value:1.37E-5 ID:SGTC_34|Compound:0469-0683|FD-Score:3.01|P-value:4.88E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.74|P-value:1.95E-5 ID:SGTC_91|Compound:0417-1751|FD-Score:-2.74|P-value:9.92E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.34|P-value:1.22E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.19|P-value:1.30E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:3.10|P-value:3.34E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:2.91|P-value:7.00E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:-3.26|P-value:1.23E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:4.17|P-value:2.23E-6 ID:SGTC_264|Compound:promethazine|FD-Score:4.16|P-value:2.29E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:3.02|P-value:4.70E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.41|P-value:9.17E-5 ID:SGTC_508|Compound:roscovitine|FD-Score:3.51|P-value:5.74E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:3.17|P-value:2.54E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.17|P-value:2.53E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.67|P-value:2.79E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.70|P-value:2.38E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.73|P-value:2.09E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.86|P-value:1.07E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:2.83|P-value:9.63E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.16|P-value:2.58E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:2.95|P-value:6.20E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.65|P-value:3.06E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.36|P-value:1.13E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.12|P-value:2.93E-6 ID:SGTC_1656|Compound:st012921|FD-Score:3.25|P-value:1.84E-4 ID:SGTC_1659|Compound:st012954|FD-Score:4.30|P-value:1.09E-6 ID:SGTC_1758|Compound:st042942|FD-Score:3.34|P-value:1.22E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.60|P-value:3.85E-5 ID:SGTC_1840|Compound:st055363|FD-Score:3.63|P-value:3.36E-5 ID:SGTC_1959|Compound:st077091|FD-Score:2.91|P-value:7.23E-4 ID:SGTC_2226|Compound:7298446|FD-Score:2.93|P-value:6.51E-4 ID:SGTC_2293|Compound:7624732|FD-Score:4.17|P-value:2.27E-6 ID:SGTC_2295|Compound:7971645|FD-Score:-3.62|P-value:2.37E-5 ID:SGTC_2296|Compound:7971656|FD-Score:-5.03|P-value:9.13E-9 ID:SGTC_2298|Compound:7976326|FD-Score:-2.88|P-value:5.89E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-2.83|P-value:7.09E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.33|P-value:8.97E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.52|P-value:5.45E-5 ID:SGTC_2431|Compound:5490079|FD-Score:-3.08|P-value:2.64E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.06|P-value:3.97E-4 ID:SGTC_2534|Compound:helenine|FD-Score:2.92|P-value:6.98E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:2.82|P-value:9.90E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.73|P-value:2.09E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:2.90|P-value:7.47E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.84|P-value:7.02E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.58|P-value:2.27E-7 ID:SGTC_2850|Compound:9015429|FD-Score:2.86|P-value:8.61E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.02|P-value:4.60E-4 ID:SGTC_3111|Compound:9122088|FD-Score:3.24|P-value:1.87E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.11|P-value:3.18E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.16|P-value:2.58E-4

Top fitness defect scores for YGR031W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_8 0354-0001 6.40 70.0 µM 7.77E-13 23 7.65E-11
2 SGTC_2594 a-mangostin 4.58 100.0 µM 2.27E-7 17 2.33E-6
3 SGTC_1659 st012954 4.30 42.1 µM 1.09E-6 6 8.46E-6
4 SGTC_253 dyclonine 4.17 31.2 µM 2.23E-6 amide catabolism 17 1.53E-5
5 SGTC_2293 7624732 4.17 200.0 µM 2.27E-6 21 1.55E-5
6 SGTC_264 promethazine 4.16 12.5 mM 2.29E-6 DNA intercalators 45 1.56E-5
7 SGTC_1500 4488-1866 4.12 171.0 µM 2.93E-6 RPP1 & pyrimidine depletion 14 1.91E-5
8 SGTC_1151 3909-8316 3.86 15.3 µM 1.07E-5 19 5.57E-5
9 SGTC_31 0508-1974 3.81 57.2 µM 1.37E-5 30 6.82E-5
10 SGTC_87 0100-0052 3.74 35.5 µM 1.95E-5 124 9.14E-5
11 SGTC_1082 camptothecin 3.73 424.9 nM 2.09E-5 DNA damage response 49 9.67E-5
12 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 3.73 19.9 µM 2.09E-5 redox potentiating 12 9.68E-5
13 SGTC_1014 4130-3005 3.70 69.3 µM 2.38E-5 26 1.08E-4
14 SGTC_1008 4106-0037 3.67 6.0 µM 2.79E-5 PDR1 27 1.23E-4
15 SGTC_1335 1486-0900 3.65 202.0 µM 3.06E-5 35 1.33E-4
16 SGTC_1840 st055363 3.63 71.0 µM 3.36E-5 19 1.43E-4
17 SGTC_1811 st050069 3.60 61.5 µM 3.85E-5 6 1.60E-4
18 SGTC_2365 9042475 3.52 200.0 µM 5.45E-5 54 2.14E-4
19 SGTC_508 roscovitine 3.51 141.0 µM 5.74E-5 12 2.23E-4
20 SGTC_507 nimesulide 3.41 162.0 µM 9.17E-5 33 3.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.69E-16 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.137 1.81E-15 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.132 2.00E-14 YCR095C_p OCA4_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.121 1.98E-12 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.114 3.26E-11 YNL056W OCA2 hom Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.113 5.72E-11 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.110 1.44E-10 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation
0.102 3.75E-9 YLR176C RFX1 hom Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins
0.101 4.11E-9 YPR153W YPR153W hom Putative protein of unknown function
0.098 1.50E-8 YGL234W ADE5,7 hom Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
0.096 2.39E-8 YOL075C_p YOL075C_p hom Putative ABC transporter
0.096 2.84E-8 YDR151C CTH1 hom Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis
0.094 4.56E-8 YDR465C RMT2 hom Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress
0.092 9.66E-8 YNL001W DOM34 hom Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
0.088 3.63E-7 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress