YGR033C / TIM21

Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR033C / TIM21

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:-4.53|P-value:9.00E-7 ID:SGTC_72|Compound:0744-0168|FD-Score:-4.31|P-value:2.67E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.39|P-value:1.75E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.22|P-value:3.54E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.01|P-value:7.76E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.69|P-value:5.20E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.09|P-value:8.22E-6 ID:SGTC_430|Compound:0958-0115|FD-Score:2.98|P-value:8.46E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.17|P-value:4.12E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.96|P-value:1.55E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.47|P-value:1.24E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.14|P-value:4.66E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.12|P-value:5.09E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:5.04|P-value:5.51E-8 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.91|P-value:1.85E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:5.32|P-value:1.04E-8 ID:SGTC_809|Compound:3998-0021|FD-Score:4.12|P-value:7.10E-6 ID:SGTC_877|Compound:0771-0151|FD-Score:3.16|P-value:4.40E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.18|P-value:4.12E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-5.29|P-value:1.22E-8 ID:SGTC_1336|Compound:1486-0901|FD-Score:-2.99|P-value:8.03E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.35|P-value:2.14E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.14|P-value:6.61E-6 ID:SGTC_2005|Compound:4024620|FD-Score:-2.96|P-value:8.81E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.11|P-value:5.25E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-3.59|P-value:7.69E-5 ID:SGTC_2160|Compound:5660466|FD-Score:4.28|P-value:3.31E-6 ID:SGTC_2214|Compound:7179297|FD-Score:3.08|P-value:5.89E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.79|P-value:3.36E-5 ID:SGTC_2300|Compound:7976697|FD-Score:4.26|P-value:3.57E-6 ID:SGTC_2301|Compound:7769476|FD-Score:3.00|P-value:7.85E-4 ID:SGTC_2333|Compound:9017922|FD-Score:4.21|P-value:4.69E-6 ID:SGTC_2334|Compound:9017922|FD-Score:3.51|P-value:1.10E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.23|P-value:3.33E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.10|P-value:5.42E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.01|P-value:7.34E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.74|P-value:4.05E-5 ID:SGTC_2537|Compound:larixol|FD-Score:3.39|P-value:1.82E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.01|P-value:1.24E-10 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.26|P-value:2.88E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.21|P-value:3.58E-4 ID:SGTC_2967|Compound:9089538|FD-Score:-3.15|P-value:4.48E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.36|P-value:2.00E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.08|P-value:5.85E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.18|P-value:3.99E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.27|P-value:2.75E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-3.08|P-value:5.69E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-3.00|P-value:7.87E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.53|P-value:9.00E-7 ID:SGTC_72|Compound:0744-0168|FD-Score:-4.31|P-value:2.67E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.39|P-value:1.75E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.22|P-value:3.54E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.01|P-value:7.76E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.69|P-value:5.20E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.09|P-value:8.22E-6 ID:SGTC_430|Compound:0958-0115|FD-Score:2.98|P-value:8.46E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.17|P-value:4.12E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.96|P-value:1.55E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.47|P-value:1.24E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.14|P-value:4.66E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.12|P-value:5.09E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:5.04|P-value:5.51E-8 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.91|P-value:1.85E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:5.32|P-value:1.04E-8 ID:SGTC_809|Compound:3998-0021|FD-Score:4.12|P-value:7.10E-6 ID:SGTC_877|Compound:0771-0151|FD-Score:3.16|P-value:4.40E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.18|P-value:4.12E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-5.29|P-value:1.22E-8 ID:SGTC_1336|Compound:1486-0901|FD-Score:-2.99|P-value:8.03E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.35|P-value:2.14E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.14|P-value:6.61E-6 ID:SGTC_2005|Compound:4024620|FD-Score:-2.96|P-value:8.81E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.11|P-value:5.25E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-3.59|P-value:7.69E-5 ID:SGTC_2160|Compound:5660466|FD-Score:4.28|P-value:3.31E-6 ID:SGTC_2214|Compound:7179297|FD-Score:3.08|P-value:5.89E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.79|P-value:3.36E-5 ID:SGTC_2300|Compound:7976697|FD-Score:4.26|P-value:3.57E-6 ID:SGTC_2301|Compound:7769476|FD-Score:3.00|P-value:7.85E-4 ID:SGTC_2333|Compound:9017922|FD-Score:4.21|P-value:4.69E-6 ID:SGTC_2334|Compound:9017922|FD-Score:3.51|P-value:1.10E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.23|P-value:3.33E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.10|P-value:5.42E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.01|P-value:7.34E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.74|P-value:4.05E-5 ID:SGTC_2537|Compound:larixol|FD-Score:3.39|P-value:1.82E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.01|P-value:1.24E-10 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.26|P-value:2.88E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.21|P-value:3.58E-4 ID:SGTC_2967|Compound:9089538|FD-Score:-3.15|P-value:4.48E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.36|P-value:2.00E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.08|P-value:5.85E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.18|P-value:3.99E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.27|P-value:2.75E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-3.08|P-value:5.69E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-3.00|P-value:7.87E-4

Top fitness defect scores for YGR033C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2583 asiatic acid 6.01 100.0 µM 1.24E-10 13 9.48E-10
2 SGTC_801 0866-0028 5.32 10.1 µM 1.04E-8 8 5.16E-8
3 SGTC_765 1319-0117 5.04 244.0 µM 5.51E-8 60S ribosome export 1 2.33E-7
4 SGTC_2160 5660466 4.28 132.9 µM 3.31E-6 60S ribosome export 9 9.44E-6
5 SGTC_2300 7976697 4.26 71.6 µM 3.57E-6 ERG2 25 1.01E-5
6 SGTC_2333 9017922 4.21 200.0 µM 4.69E-6 20 1.29E-5
7 SGTC_2004 4023728 4.14 41.9 µM 6.61E-6 24 1.76E-5
8 SGTC_809 3998-0021 4.12 90.0 µM 7.10E-6 RNA processing & uracil transport 13 1.88E-5
9 SGTC_387 norethindrone acetate 4.09 66.7 µM 8.22E-6 11 2.15E-5
10 SGTC_549 1661-1316 3.96 519.0 µM 1.55E-5 19 3.81E-5
11 SGTC_2297 7971671 3.79 152.3 µM 3.36E-5 RNA processing & uracil transport 32 7.68E-5
12 SGTC_366 0181-0206 3.69 4.3 µM 5.20E-5 Golgi 51 1.14E-4
13 SGTC_2334 9017922 3.51 200.0 µM 1.10E-4 37 2.24E-4
14 SGTC_2537 larixol 3.39 68.9 µM 1.82E-4 47 3.55E-4
15 SGTC_2974 9094440 3.36 9.7 µM 2.00E-4 ergosterol biosynthesis 64 3.88E-4
16 SGTC_1510 1123-0200 3.35 71.5 µM 2.14E-4 69 4.11E-4
17 SGTC_2338 7999974 3.23 200.0 µM 3.33E-4 55 6.14E-4
18 SGTC_87 0100-0052 3.22 35.5 µM 3.54E-4 186 6.50E-4
19 SGTC_3124 9127567 3.18 49.5 µM 3.99E-4 DNA damage response 40 7.25E-4
20 SGTC_1064 honokiol 3.18 6.8 µM 4.12E-4 50 7.45E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 6.63E-18 YMR305C SCW10 hom Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
0.128 1.07E-13 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.127 1.69E-13 YDR379W RGA2 hom GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p
0.116 1.61E-11 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.116 1.82E-11 YJL041W NSP1 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress
0.115 2.32E-11 YGL227W VID30 hom Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm
0.114 3.88E-11 YDL078C MDH3 hom Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
0.108 3.34E-10 YOR083W WHI5 hom Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
0.106 6.89E-10 YBR261C TAE1 hom AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm
0.104 1.56E-9 YIL058W_d YIL058W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102 2.89E-9 YDR208W MSS4 het Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
0.095 3.44E-8 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.090 1.62E-7 YGL217C_d YGL217C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W
0.090 1.92E-7 YIL130W ASG1 hom Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance
0.089 2.41E-7 YDL039C PRM7 hom Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements