YGR034W / RPL26B

Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR034W / RPL26B

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:4.40|P-value:2.63E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:7.75|P-value:5.10E-13 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.85|P-value:4.18E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:4.30|P-value:3.84E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:4.31|P-value:3.76E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:4.64|P-value:1.00E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.82|P-value:2.19E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.10|P-value:8.25E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:4.17|P-value:6.41E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.21|P-value:5.33E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.94|P-value:1.49E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.51|P-value:1.68E-5 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.40|P-value:9.00E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.91|P-value:1.65E-4 ID:SGTC_1843|Compound:st055809|FD-Score:4.09|P-value:8.50E-5 ID:SGTC_1891|Compound:st059073|FD-Score:-4.06|P-value:9.37E-5 ID:SGTC_1905|Compound:st060207|FD-Score:3.83|P-value:2.15E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.44|P-value:2.25E-5 ID:SGTC_1958|Compound:st076513|FD-Score:4.24|P-value:4.80E-5 ID:SGTC_2481|Compound:5478948|FD-Score:-3.40|P-value:8.93E-4 ID:SGTC_2488|Compound:5268135|FD-Score:-4.40|P-value:2.62E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.19|P-value:5.78E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-3.37|P-value:9.84E-4 ID:SGTC_2832|Compound:7992762|FD-Score:9.30|P-value:6.17E-18 ID:SGTC_2852|Compound:9023854|FD-Score:-6.27|P-value:4.10E-9 ID:SGTC_2853|Compound:9015042|FD-Score:5.35|P-value:4.33E-7 ID:SGTC_2854|Compound:9024559|FD-Score:3.70|P-value:3.33E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.53|P-value:5.79E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.42|P-value:8.42E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.91|P-value:1.60E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-4.52|P-value:1.64E-5 ID:SGTC_3191|Compound:9110352|FD-Score:3.77|P-value:2.64E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.67|P-value:3.68E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.96|P-value:1.35E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.48|P-value:6.88E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.86|P-value:1.97E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.40|P-value:2.63E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:7.75|P-value:5.10E-13 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.85|P-value:4.18E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:4.30|P-value:3.84E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:4.31|P-value:3.76E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:4.64|P-value:1.00E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.82|P-value:2.19E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.10|P-value:8.25E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:4.17|P-value:6.41E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.21|P-value:5.33E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.94|P-value:1.49E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.51|P-value:1.68E-5 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.40|P-value:9.00E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.91|P-value:1.65E-4 ID:SGTC_1843|Compound:st055809|FD-Score:4.09|P-value:8.50E-5 ID:SGTC_1891|Compound:st059073|FD-Score:-4.06|P-value:9.37E-5 ID:SGTC_1905|Compound:st060207|FD-Score:3.83|P-value:2.15E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.44|P-value:2.25E-5 ID:SGTC_1958|Compound:st076513|FD-Score:4.24|P-value:4.80E-5 ID:SGTC_2481|Compound:5478948|FD-Score:-3.40|P-value:8.93E-4 ID:SGTC_2488|Compound:5268135|FD-Score:-4.40|P-value:2.62E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.19|P-value:5.78E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-3.37|P-value:9.84E-4 ID:SGTC_2832|Compound:7992762|FD-Score:9.30|P-value:6.17E-18 ID:SGTC_2852|Compound:9023854|FD-Score:-6.27|P-value:4.10E-9 ID:SGTC_2853|Compound:9015042|FD-Score:5.35|P-value:4.33E-7 ID:SGTC_2854|Compound:9024559|FD-Score:3.70|P-value:3.33E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.53|P-value:5.79E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.42|P-value:8.42E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.91|P-value:1.60E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-4.52|P-value:1.64E-5 ID:SGTC_3191|Compound:9110352|FD-Score:3.77|P-value:2.64E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.67|P-value:3.68E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.96|P-value:1.35E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.48|P-value:6.88E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.86|P-value:1.97E-4

Top fitness defect scores for YGR034W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2832 7992762 9.30 52.0 µM 6.17E-18 3 7.01E-21
2 SGTC_71 0417-1750 7.75 47.8 µM 5.10E-13 Golgi 9 4.47E-15
3 SGTC_2853 9015042 5.35 58.4 µM 4.33E-7 10 4.36E-8
4 SGTC_378 3970-0959 4.64 8.3 µM 1.00E-5 10 1.75E-6
5 SGTC_1445 4239-0156 4.51 97.7 µM 1.68E-5 18 3.21E-6
6 SGTC_1911 st060208 4.44 74.3 µM 2.25E-5 23 4.54E-6
7 SGTC_59 0330-0160 4.40 1.3 µM 2.63E-5 88 5.45E-6
8 SGTC_123 0083-0120 4.31 66.7 µM 3.76E-5 40 8.29E-6
9 SGTC_78 0336-0123 4.30 156.8 µM 3.84E-5 18 8.51E-6
10 SGTC_1958 st076513 4.24 41.9 µM 4.80E-5 60S ribosome export 22 1.10E-5
11 SGTC_1129 3453-1384 4.21 223.0 µM 5.33E-5 31 1.25E-5
12 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.19 3.7 µM 5.78E-5 71 1.37E-5
13 SGTC_1073 triclabendazole 4.17 3.1 µM 6.41E-5 20 1.55E-5
14 SGTC_1016 4226-1401 4.10 38.0 µM 8.25E-5 RNA pol III & RNase P/MRP 18 2.08E-5
15 SGTC_1843 st055809 4.09 45.5 µM 8.50E-5 13 2.16E-5
16 SGTC_3123 9126162 3.91 49.5 µM 1.60E-4 18 4.55E-5
17 SGTC_1834 st055981 3.91 52.8 µM 1.65E-4 RPP1 & pyrimidine depletion 34 4.71E-5
18 SGTC_1905 st060207 3.83 84.5 µM 2.15E-4 15 6.42E-5
19 SGTC_550 4123-0385 3.82 25.7 µM 2.19E-4 TSC3-RPN4 29 6.56E-5
20 SGTC_3191 9110352 3.77 49.5 µM 2.64E-4 13 8.17E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.93E-15 YDR439W LRS4 hom Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.125 4.34E-13 YKR004C ECM9 het Non-essential protein of unknown function
0.116 1.86E-11 YER176W ECM32 hom DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.112 8.71E-11 YJR035W RAD26 hom Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
0.105 8.99E-10 YKR059W TIF1 hom Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication
0.102 3.36E-9 YBR074W_p YBR074W_p hom Putative metalloprotease
0.100 5.69E-9 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.092 9.49E-8 YPL066W RGL1 hom Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
0.084 1.01E-6 YOR259C RPT4 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization
0.081 3.02E-6 YOL061W PRS5 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
0.079 4.98E-6 YGR111W_p YGR111W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.078 5.34E-6 YLR328W NMA1 hom Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication
0.078 5.65E-6 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.078 6.06E-6 YKL150W MCR1 hom Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis
0.078 6.92E-6 YDR083W RRP8 hom Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1