YGR035W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR035W-A / YGR035W-A

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.45|P-value:1.14E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.14|P-value:3.95E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.34|P-value:1.63E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.65|P-value:2.83E-7 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.14|P-value:3.94E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.64|P-value:5.09E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.12|P-value:3.89E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.14|P-value:3.60E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.70|P-value:3.43E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:3.85|P-value:1.72E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:3.88|P-value:1.50E-5 ID:SGTC_844|Compound:0330-0132|FD-Score:3.26|P-value:2.20E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.01|P-value:6.53E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.25|P-value:2.35E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.24|P-value:2.37E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.27|P-value:2.13E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.45|P-value:1.03E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:2.90|P-value:8.91E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-2.93|P-value:8.78E-4 ID:SGTC_1523|Compound:st012844|FD-Score:4.26|P-value:2.23E-6 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.19|P-value:2.98E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.89|P-value:9.35E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.61|P-value:5.10E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:4.96|P-value:4.88E-8 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-2.93|P-value:8.64E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.16|P-value:3.74E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.19|P-value:3.00E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.79|P-value:2.25E-5 ID:SGTC_1848|Compound:st056003|FD-Score:-4.91|P-value:7.50E-8 ID:SGTC_1849|Compound:st056239|FD-Score:-2.94|P-value:8.43E-4 ID:SGTC_1851|Compound:st056236|FD-Score:6.56|P-value:8.93E-13 ID:SGTC_1935|Compound:st074532|FD-Score:-3.30|P-value:2.09E-4 ID:SGTC_1937|Compound:st074714|FD-Score:-4.04|P-value:7.95E-6 ID:SGTC_1941|Compound:st076221|FD-Score:3.20|P-value:2.82E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.25|P-value:2.29E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.58|P-value:5.89E-5 ID:SGTC_2326|Compound:6164455|FD-Score:3.01|P-value:5.97E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-2.94|P-value:8.30E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.02|P-value:5.70E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.88|P-value:1.47E-5 ID:SGTC_2355|Compound:9061122|FD-Score:3.67|P-value:3.80E-5 ID:SGTC_2375|Compound:9072683|FD-Score:3.80|P-value:2.12E-5 ID:SGTC_2400|Compound:5203494|FD-Score:-4.71|P-value:2.37E-7 ID:SGTC_2403|Compound:6032726|FD-Score:-3.71|P-value:3.60E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.30|P-value:2.16E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.22|P-value:2.66E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.30|P-value:1.85E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.06|P-value:5.44E-4 ID:SGTC_2602|Compound:kawain|FD-Score:2.95|P-value:7.29E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.37|P-value:1.43E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.94|P-value:5.29E-8 ID:SGTC_2707|Compound:st078556|FD-Score:3.37|P-value:1.40E-4 ID:SGTC_2712|Compound:st079126|FD-Score:4.63|P-value:3.14E-7 ID:SGTC_2717|Compound:st081029|FD-Score:3.03|P-value:5.56E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.04|P-value:3.02E-8 ID:SGTC_2820|Compound:7989630|FD-Score:3.57|P-value:6.06E-5 ID:SGTC_2827|Compound:7993847|FD-Score:3.43|P-value:1.11E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-2.90|P-value:9.62E-4 ID:SGTC_2919|Compound:7978188|FD-Score:4.12|P-value:4.67E-6 ID:SGTC_2955|Compound:9076254|FD-Score:4.47|P-value:7.72E-7 ID:SGTC_2956|Compound:9076196|FD-Score:-4.14|P-value:4.69E-6 ID:SGTC_3210|Compound:9128157|FD-Score:9.03|P-value:1.50E-22 ID:SGTC_3211|Compound:9128781|FD-Score:-4.29|P-value:2.25E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.45|P-value:1.14E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.14|P-value:3.95E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.34|P-value:1.63E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.65|P-value:2.83E-7 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.14|P-value:3.94E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.64|P-value:5.09E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.12|P-value:3.89E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.14|P-value:3.60E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.70|P-value:3.43E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:3.85|P-value:1.72E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:3.88|P-value:1.50E-5 ID:SGTC_844|Compound:0330-0132|FD-Score:3.26|P-value:2.20E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.01|P-value:6.53E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.25|P-value:2.35E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.24|P-value:2.37E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.27|P-value:2.13E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.45|P-value:1.03E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:2.90|P-value:8.91E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-2.93|P-value:8.78E-4 ID:SGTC_1523|Compound:st012844|FD-Score:4.26|P-value:2.23E-6 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.19|P-value:2.98E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.89|P-value:9.35E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.61|P-value:5.10E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:4.96|P-value:4.88E-8 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-2.93|P-value:8.64E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.16|P-value:3.74E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.19|P-value:3.00E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.79|P-value:2.25E-5 ID:SGTC_1848|Compound:st056003|FD-Score:-4.91|P-value:7.50E-8 ID:SGTC_1849|Compound:st056239|FD-Score:-2.94|P-value:8.43E-4 ID:SGTC_1851|Compound:st056236|FD-Score:6.56|P-value:8.93E-13 ID:SGTC_1935|Compound:st074532|FD-Score:-3.30|P-value:2.09E-4 ID:SGTC_1937|Compound:st074714|FD-Score:-4.04|P-value:7.95E-6 ID:SGTC_1941|Compound:st076221|FD-Score:3.20|P-value:2.82E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.25|P-value:2.29E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.58|P-value:5.89E-5 ID:SGTC_2326|Compound:6164455|FD-Score:3.01|P-value:5.97E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-2.94|P-value:8.30E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.02|P-value:5.70E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.88|P-value:1.47E-5 ID:SGTC_2355|Compound:9061122|FD-Score:3.67|P-value:3.80E-5 ID:SGTC_2375|Compound:9072683|FD-Score:3.80|P-value:2.12E-5 ID:SGTC_2400|Compound:5203494|FD-Score:-4.71|P-value:2.37E-7 ID:SGTC_2403|Compound:6032726|FD-Score:-3.71|P-value:3.60E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.30|P-value:2.16E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.22|P-value:2.66E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.30|P-value:1.85E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.06|P-value:5.44E-4 ID:SGTC_2602|Compound:kawain|FD-Score:2.95|P-value:7.29E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.37|P-value:1.43E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.94|P-value:5.29E-8 ID:SGTC_2707|Compound:st078556|FD-Score:3.37|P-value:1.40E-4 ID:SGTC_2712|Compound:st079126|FD-Score:4.63|P-value:3.14E-7 ID:SGTC_2717|Compound:st081029|FD-Score:3.03|P-value:5.56E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.04|P-value:3.02E-8 ID:SGTC_2820|Compound:7989630|FD-Score:3.57|P-value:6.06E-5 ID:SGTC_2827|Compound:7993847|FD-Score:3.43|P-value:1.11E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-2.90|P-value:9.62E-4 ID:SGTC_2919|Compound:7978188|FD-Score:4.12|P-value:4.67E-6 ID:SGTC_2955|Compound:9076254|FD-Score:4.47|P-value:7.72E-7 ID:SGTC_2956|Compound:9076196|FD-Score:-4.14|P-value:4.69E-6 ID:SGTC_3210|Compound:9128157|FD-Score:9.03|P-value:1.50E-22 ID:SGTC_3211|Compound:9128781|FD-Score:-4.29|P-value:2.25E-6

Top fitness defect scores for YGR035W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3210 9128157 9.03 49.5 µM 1.50E-22 3 8.75E-20
2 SGTC_1851 st056236 6.56 18.9 µM 8.93E-13 1 2.73E-11
3 SGTC_2752 diclazuril 5.04 33.1 µM 3.02E-8 75 2.38E-7
4 SGTC_1592 4',5'-dihydroxyflavone 4.96 8.8 µM 4.88E-8 60S ribosome export 2 3.61E-7
5 SGTC_2638 epoxomicin 4.94 18.0 µM 5.29E-8 12 3.87E-7
6 SGTC_236 1509-0011 4.65 5.3 µM 2.83E-7 347 1.67E-6
7 SGTC_2712 st079126 4.63 47.7 µM 3.14E-7 6 1.82E-6
8 SGTC_2955 9076254 4.47 12.2 µM 7.72E-7 9 3.99E-6
9 SGTC_1523 st012844 4.26 44.7 µM 2.23E-6 60S ribosome export 12 1.01E-5
10 SGTC_2919 7978188 4.12 46.4 µM 4.67E-6 15 1.92E-5
11 SGTC_2354 9060492 3.88 162.0 µM 1.47E-5 20 5.22E-5
12 SGTC_779 1360-0071 3.88 233.0 µM 1.50E-5 fatty acid desaturase (OLE1) 26 5.29E-5
13 SGTC_771 0250-0039 3.85 27.3 µM 1.72E-5 16 5.99E-5
14 SGTC_2375 9072683 3.80 200.0 µM 2.12E-5 mitochondrial processes 23 7.18E-5
15 SGTC_1720 st037298 3.79 9.5 µM 2.25E-5 36 7.56E-5
16 SGTC_769 0302-0231 3.70 76.0 µM 3.43E-5 50 1.09E-4
17 SGTC_2355 9061122 3.67 103.1 µM 3.80E-5 16 1.19E-4
18 SGTC_1589 2',5'-dimethoxyflavone 3.61 47.2 µM 5.10E-5 29 1.54E-4
19 SGTC_2126 5251174 3.58 33.9 µM 5.89E-5 54 1.75E-4
20 SGTC_2820 7989630 3.57 71.4 µM 6.06E-5 ERG2 36 1.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.64E-15 YBR052C RFS1 hom Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication
0.133 8.68E-15 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.128 1.24E-13 YLL006W-A_p YLL006W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.124 5.44E-13 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.123 9.61E-13 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.123 1.06E-12 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.121 2.07E-12 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.121 2.21E-12 YOR161C-C_p YOR161C-C_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.120 2.57E-12 YJL127C-B_p YJL127C-B_p hom Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii
0.120 2.53E-12 YLL017W YLL017W hom Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.120 2.95E-12 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.118 5.81E-12 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.118 8.31E-12 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.117 9.06E-12 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.117 9.29E-12 YLR361C-A_p YLR361C-A_p hom Putative protein of unknown function