YGR037C / ACB1

Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR037C / ACB1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:4.45|P-value:6.52E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.66|P-value:6.71E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:12.60|P-value:2.01E-20 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.21|P-value:9.02E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:11.50|P-value:2.15E-17 ID:SGTC_115|Compound:0527-0192|FD-Score:5.70|P-value:1.82E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:9.38|P-value:4.55E-12 ID:SGTC_160|Compound:3453-0671|FD-Score:7.28|P-value:6.40E-8 ID:SGTC_169|Compound:k015-0017|FD-Score:5.38|P-value:4.96E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:-4.49|P-value:4.50E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:-4.26|P-value:8.11E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:10.40|P-value:2.09E-14 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.18|P-value:9.19E-8 ID:SGTC_294|Compound:k038-0071|FD-Score:4.34|P-value:8.68E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:4.74|P-value:3.03E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:5.23|P-value:7.64E-5 ID:SGTC_398|Compound:bronopol|FD-Score:4.72|P-value:3.20E-4 ID:SGTC_470|Compound:aa-861|FD-Score:6.00|P-value:6.85E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:8.02|P-value:2.80E-9 ID:SGTC_523|Compound:1934-0222|FD-Score:4.32|P-value:8.96E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:7.41|P-value:3.75E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:4.50|P-value:5.72E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:5.28|P-value:6.56E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:11.40|P-value:4.42E-17 ID:SGTC_664|Compound:1222-0054|FD-Score:5.97|P-value:7.51E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:5.84|P-value:1.17E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:5.90|P-value:9.38E-6 ID:SGTC_724|Compound:3910-0327|FD-Score:5.42|P-value:4.34E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:4.53|P-value:5.34E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:5.44|P-value:4.04E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:11.10|P-value:3.22E-16 ID:SGTC_794|Compound:k038-0031|FD-Score:4.67|P-value:3.72E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:6.16|P-value:4.03E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:5.72|P-value:1.69E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:5.12|P-value:1.06E-4 ID:SGTC_918|Compound:glabranin|FD-Score:5.02|P-value:1.42E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:23.10|P-value:3.46E-64 ID:SGTC_955|Compound:1216-0110|FD-Score:4.30|P-value:9.53E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:6.60|P-value:8.35E-7 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.95|P-value:1.73E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:6.37|P-value:1.89E-6 ID:SGTC_1363|Compound:1636-0063|FD-Score:7.70|P-value:1.13E-8 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.79|P-value:2.68E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:6.56|P-value:9.88E-7 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.36|P-value:8.20E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:7.46|P-value:3.05E-8 ID:SGTC_1573|Compound:oleylamine|FD-Score:5.63|P-value:2.27E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:4.56|P-value:4.88E-4 ID:SGTC_1672|Compound:st016598|FD-Score:5.48|P-value:3.58E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.85|P-value:1.12E-5 ID:SGTC_1687|Compound:st020778|FD-Score:6.02|P-value:6.33E-6 ID:SGTC_1697|Compound:st025554|FD-Score:4.83|P-value:2.36E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.90|P-value:1.98E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.53|P-value:5.26E-4 ID:SGTC_1792|Compound:st045773|FD-Score:4.55|P-value:4.98E-4 ID:SGTC_1808|Compound:st050063|FD-Score:4.65|P-value:3.89E-4 ID:SGTC_1814|Compound:st052110|FD-Score:6.21|P-value:3.38E-6 ID:SGTC_1815|Compound:st051655|FD-Score:5.15|P-value:9.71E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.58|P-value:4.63E-4 ID:SGTC_1922|Compound:5578187|FD-Score:6.82|P-value:3.74E-7 ID:SGTC_1941|Compound:st076221|FD-Score:4.53|P-value:5.33E-4 ID:SGTC_2078|Compound:5212016|FD-Score:4.63|P-value:4.08E-4 ID:SGTC_2082|Compound:5219693|FD-Score:7.03|P-value:1.66E-7 ID:SGTC_2090|Compound:5301565|FD-Score:5.42|P-value:4.40E-5 ID:SGTC_2092|Compound:5303694|FD-Score:5.32|P-value:5.83E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.96|P-value:1.68E-4 ID:SGTC_2123|Compound:5259487|FD-Score:5.22|P-value:7.96E-5 ID:SGTC_2192|Compound:5915882|FD-Score:4.36|P-value:8.11E-4 ID:SGTC_2217|Compound:6934799|FD-Score:4.55|P-value:5.03E-4 ID:SGTC_2248|Compound:tofa|FD-Score:19.40|P-value:1.23E-45 ID:SGTC_2276|Compound:7947513|FD-Score:4.38|P-value:7.69E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-4.59|P-value:3.45E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-4.24|P-value:8.50E-4 ID:SGTC_2315|Compound:7733312|FD-Score:7.27|P-value:6.53E-8 ID:SGTC_2349|Compound:9023730|FD-Score:4.71|P-value:3.33E-4 ID:SGTC_2384|Compound:9036245|FD-Score:5.51|P-value:3.33E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:6.70|P-value:5.95E-7 ID:SGTC_2416|Compound:tofa|FD-Score:28.90|P-value:4.40E-99 ID:SGTC_2441|Compound:5730946|FD-Score:6.40|P-value:1.75E-6 ID:SGTC_2447|Compound:5741742|FD-Score:6.55|P-value:1.00E-6 ID:SGTC_2463|Compound:5473429|FD-Score:-4.77|P-value:2.12E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-4.30|P-value:7.25E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.56|P-value:2.81E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:7.14|P-value:1.10E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.69|P-value:3.50E-4 ID:SGTC_2701|Compound:st077767|FD-Score:4.55|P-value:4.98E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:6.56|P-value:9.66E-7 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.81|P-value:2.50E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.35|P-value:5.29E-5 ID:SGTC_2905|Compound:7799065|FD-Score:5.20|P-value:8.28E-5 ID:SGTC_2912|Compound:7964298|FD-Score:5.78|P-value:1.43E-5 ID:SGTC_3016|Compound:9080866|FD-Score:8.50|P-value:3.25E-10 ID:SGTC_3237|Compound:9133362|FD-Score:5.31|P-value:6.06E-5 ID:SGTC_3266|Compound:9136860|FD-Score:8.93|P-value:4.24E-11 ID:SGTC_3281|Compound:9140613|FD-Score:5.35|P-value:5.44E-5 ID:SGTC_3311|Compound:9131146|FD-Score:8.38|P-value:5.61E-10 ID:SGTC_3321|Compound:9137793|FD-Score:5.87|P-value:1.05E-5 ID:SGTC_3341|Compound:9147222|FD-Score:4.48|P-value:6.09E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:4.45|P-value:6.52E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.66|P-value:6.71E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:12.60|P-value:2.01E-20 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.21|P-value:9.02E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:11.50|P-value:2.15E-17 ID:SGTC_115|Compound:0527-0192|FD-Score:5.70|P-value:1.82E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:9.38|P-value:4.55E-12 ID:SGTC_160|Compound:3453-0671|FD-Score:7.28|P-value:6.40E-8 ID:SGTC_169|Compound:k015-0017|FD-Score:5.38|P-value:4.96E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:-4.49|P-value:4.50E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:-4.26|P-value:8.11E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:10.40|P-value:2.09E-14 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.18|P-value:9.19E-8 ID:SGTC_294|Compound:k038-0071|FD-Score:4.34|P-value:8.68E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:4.74|P-value:3.03E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:5.23|P-value:7.64E-5 ID:SGTC_398|Compound:bronopol|FD-Score:4.72|P-value:3.20E-4 ID:SGTC_470|Compound:aa-861|FD-Score:6.00|P-value:6.85E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:8.02|P-value:2.80E-9 ID:SGTC_523|Compound:1934-0222|FD-Score:4.32|P-value:8.96E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:7.41|P-value:3.75E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:4.50|P-value:5.72E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:5.28|P-value:6.56E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:11.40|P-value:4.42E-17 ID:SGTC_664|Compound:1222-0054|FD-Score:5.97|P-value:7.51E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:5.84|P-value:1.17E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:5.90|P-value:9.38E-6 ID:SGTC_724|Compound:3910-0327|FD-Score:5.42|P-value:4.34E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:4.53|P-value:5.34E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:5.44|P-value:4.04E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:11.10|P-value:3.22E-16 ID:SGTC_794|Compound:k038-0031|FD-Score:4.67|P-value:3.72E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:6.16|P-value:4.03E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:5.72|P-value:1.69E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:5.12|P-value:1.06E-4 ID:SGTC_918|Compound:glabranin|FD-Score:5.02|P-value:1.42E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:23.10|P-value:3.46E-64 ID:SGTC_955|Compound:1216-0110|FD-Score:4.30|P-value:9.53E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:6.60|P-value:8.35E-7 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.95|P-value:1.73E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:6.37|P-value:1.89E-6 ID:SGTC_1363|Compound:1636-0063|FD-Score:7.70|P-value:1.13E-8 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.79|P-value:2.68E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:6.56|P-value:9.88E-7 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.36|P-value:8.20E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:7.46|P-value:3.05E-8 ID:SGTC_1573|Compound:oleylamine|FD-Score:5.63|P-value:2.27E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:4.56|P-value:4.88E-4 ID:SGTC_1672|Compound:st016598|FD-Score:5.48|P-value:3.58E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.85|P-value:1.12E-5 ID:SGTC_1687|Compound:st020778|FD-Score:6.02|P-value:6.33E-6 ID:SGTC_1697|Compound:st025554|FD-Score:4.83|P-value:2.36E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.90|P-value:1.98E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.53|P-value:5.26E-4 ID:SGTC_1792|Compound:st045773|FD-Score:4.55|P-value:4.98E-4 ID:SGTC_1808|Compound:st050063|FD-Score:4.65|P-value:3.89E-4 ID:SGTC_1814|Compound:st052110|FD-Score:6.21|P-value:3.38E-6 ID:SGTC_1815|Compound:st051655|FD-Score:5.15|P-value:9.71E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.58|P-value:4.63E-4 ID:SGTC_1922|Compound:5578187|FD-Score:6.82|P-value:3.74E-7 ID:SGTC_1941|Compound:st076221|FD-Score:4.53|P-value:5.33E-4 ID:SGTC_2078|Compound:5212016|FD-Score:4.63|P-value:4.08E-4 ID:SGTC_2082|Compound:5219693|FD-Score:7.03|P-value:1.66E-7 ID:SGTC_2090|Compound:5301565|FD-Score:5.42|P-value:4.40E-5 ID:SGTC_2092|Compound:5303694|FD-Score:5.32|P-value:5.83E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.96|P-value:1.68E-4 ID:SGTC_2123|Compound:5259487|FD-Score:5.22|P-value:7.96E-5 ID:SGTC_2192|Compound:5915882|FD-Score:4.36|P-value:8.11E-4 ID:SGTC_2217|Compound:6934799|FD-Score:4.55|P-value:5.03E-4 ID:SGTC_2248|Compound:tofa|FD-Score:19.40|P-value:1.23E-45 ID:SGTC_2276|Compound:7947513|FD-Score:4.38|P-value:7.69E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-4.59|P-value:3.45E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-4.24|P-value:8.50E-4 ID:SGTC_2315|Compound:7733312|FD-Score:7.27|P-value:6.53E-8 ID:SGTC_2349|Compound:9023730|FD-Score:4.71|P-value:3.33E-4 ID:SGTC_2384|Compound:9036245|FD-Score:5.51|P-value:3.33E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:6.70|P-value:5.95E-7 ID:SGTC_2416|Compound:tofa|FD-Score:28.90|P-value:4.40E-99 ID:SGTC_2441|Compound:5730946|FD-Score:6.40|P-value:1.75E-6 ID:SGTC_2447|Compound:5741742|FD-Score:6.55|P-value:1.00E-6 ID:SGTC_2463|Compound:5473429|FD-Score:-4.77|P-value:2.12E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-4.30|P-value:7.25E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.56|P-value:2.81E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:7.14|P-value:1.10E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.69|P-value:3.50E-4 ID:SGTC_2701|Compound:st077767|FD-Score:4.55|P-value:4.98E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:6.56|P-value:9.66E-7 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.81|P-value:2.50E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.35|P-value:5.29E-5 ID:SGTC_2905|Compound:7799065|FD-Score:5.20|P-value:8.28E-5 ID:SGTC_2912|Compound:7964298|FD-Score:5.78|P-value:1.43E-5 ID:SGTC_3016|Compound:9080866|FD-Score:8.50|P-value:3.25E-10 ID:SGTC_3237|Compound:9133362|FD-Score:5.31|P-value:6.06E-5 ID:SGTC_3266|Compound:9136860|FD-Score:8.93|P-value:4.24E-11 ID:SGTC_3281|Compound:9140613|FD-Score:5.35|P-value:5.44E-5 ID:SGTC_3311|Compound:9131146|FD-Score:8.38|P-value:5.61E-10 ID:SGTC_3321|Compound:9137793|FD-Score:5.87|P-value:1.05E-5 ID:SGTC_3341|Compound:9147222|FD-Score:4.48|P-value:6.09E-4

Top fitness defect scores for YGR037C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2416 tofa 28.90 880.0 nM 4.40E-99 sphingolipid biosynthesis & PDR1 2 5.74E-184
2 SGTC_951 1171-0579 23.10 82.7 µM 3.46E-64 cell wall 1 1.17E-118
3 SGTC_2248 tofa 19.40 1.1 µM 1.23E-45 sphingolipid biosynthesis & PDR1 2 5.99E-84
4 SGTC_70 0141-0289 12.60 43.3 µM 2.01E-20 mitochondrial stress 13 8.45E-37
5 SGTC_75 0159-0059 11.50 199.0 µM 2.15E-17 fatty acid desaturase (OLE1) 1 3.87E-31
6 SGTC_662 k832-1615 11.40 104.0 µM 4.42E-17 2 1.48E-30
7 SGTC_767 0929-0023 11.10 86.0 µM 3.22E-16 TRP & mitochondrial translation 3 6.01E-29
8 SGTC_266 formosanin C 10.40 406.0 nM 2.09E-14 sphingolipid biosynthesis & PDR1 13 1.45E-25
9 SGTC_138 0850-0259 9.38 40.9 µM 4.55E-12 cell wall 49 3.31E-21
10 SGTC_3266 9136860 8.93 49.5 µM 4.24E-11 cell wall 10 2.11E-19
11 SGTC_3016 9080866 8.50 49.5 µM 3.25E-10 1 9.38E-18
12 SGTC_3311 9131146 8.38 2.9 µM 5.61E-10 cell wall 27 2.59E-17
13 SGTC_513 4245-1575 8.02 41.7 µM 2.80E-9 unfolded protein response 27 5.15E-16
14 SGTC_1363 1636-0063 7.70 10.4 µM 1.13E-8 Golgi 4 6.91E-15
15 SGTC_1568 digitonin 7.46 820.0 nM 3.05E-8 sphingolipid biosynthesis & PDR1 8 4.35E-14
16 SGTC_527 4476-4215 7.41 268.0 µM 3.75E-8 PDR1 7 6.39E-14
17 SGTC_160 3453-0671 7.28 289.7 µM 6.40E-8 6 1.72E-13
18 SGTC_2315 7733312 7.27 200.0 µM 6.53E-8 3 1.79E-13
19 SGTC_275 trichlorophene 7.18 5.7 µM 9.19E-8 mitochondrial stress 90 3.36E-13
20 SGTC_2576 guaiol 7.14 23.1 µM 1.10E-7 3 4.73E-13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.345 2.45E-94 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.256 3.49E-51 YJR059W PTK2 hom Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
0.251 2.09E-49 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.245 2.97E-47 YLR420W URA4 hom Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
0.231 5.07E-42 YIL036W CST6 hom Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication
0.216 1.02E-36 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.206 1.65E-33 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.206 1.71E-33 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.205 2.43E-33 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.202 2.46E-32 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.202 2.72E-32 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.200 1.11E-31 YKL216W URA1 hom Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
0.198 4.57E-31 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.198 7.13E-31 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.197 1.33E-30 YMR242C RPL20A hom Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication