YGR038W / ORM1

Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR038W / ORM1

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:4.22|P-value:1.29E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.60|P-value:8.72E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.88|P-value:3.90E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:-3.69|P-value:6.71E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-6.33|P-value:2.00E-8 ID:SGTC_469|Compound:w7|FD-Score:4.66|P-value:2.72E-5 ID:SGTC_489|Compound:paxilline|FD-Score:-4.27|P-value:1.05E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:4.37|P-value:7.78E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:4.19|P-value:1.45E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:4.38|P-value:7.44E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:6.22|P-value:3.69E-8 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.24|P-value:2.90E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.87|P-value:3.91E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:10.50|P-value:6.25E-20 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.76|P-value:5.68E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:4.55|P-value:4.06E-5 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-3.89|P-value:3.67E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.59|P-value:9.12E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-4.06|P-value:2.13E-4 ID:SGTC_1768|Compound:st044301|FD-Score:-3.64|P-value:7.80E-4 ID:SGTC_1796|Compound:st049173|FD-Score:3.86|P-value:4.21E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.80|P-value:5.00E-4 ID:SGTC_2011|Compound:4012611|FD-Score:4.19|P-value:1.45E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.59|P-value:9.48E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.89|P-value:3.87E-4 ID:SGTC_2119|Compound:5528445|FD-Score:-3.90|P-value:3.56E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.69|P-value:6.76E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-5.12|P-value:4.33E-6 ID:SGTC_2273|Compound:7815444|FD-Score:3.99|P-value:2.77E-4 ID:SGTC_2297|Compound:7971671|FD-Score:4.54|P-value:4.29E-5 ID:SGTC_2351|Compound:9026858|FD-Score:3.80|P-value:4.99E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.94|P-value:3.23E-4 ID:SGTC_2354|Compound:9060492|FD-Score:4.73|P-value:2.10E-5 ID:SGTC_2396|Compound:5342950|FD-Score:4.49|P-value:5.20E-5 ID:SGTC_2477|Compound:5967686|FD-Score:6.16|P-value:4.91E-8 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.59|P-value:9.58E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:4.04|P-value:2.36E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:4.27|P-value:1.08E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.65|P-value:8.06E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.86|P-value:4.24E-4 ID:SGTC_2943|Compound:9068529|FD-Score:5.11|P-value:4.77E-6 ID:SGTC_2982|Compound:9019404|FD-Score:3.83|P-value:4.62E-4 ID:SGTC_3031|Compound:9088762|FD-Score:5.82|P-value:2.34E-7 ID:SGTC_3041|Compound:9091929|FD-Score:-3.82|P-value:4.46E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-3.65|P-value:7.70E-4 ID:SGTC_3083|Compound:9117465|FD-Score:4.93|P-value:9.73E-6 ID:SGTC_3139|Compound:9095020|FD-Score:6.01|P-value:9.93E-8 ID:SGTC_3145|Compound:9085516|FD-Score:-4.04|P-value:2.24E-4 ID:SGTC_3158|Compound:9100007|FD-Score:3.69|P-value:7.00E-4 ID:SGTC_3208|Compound:9114115|FD-Score:7.16|P-value:2.83E-10 ID:SGTC_3216|Compound:9129716|FD-Score:-4.52|P-value:4.39E-5 ID:SGTC_3259|Compound:9138485|FD-Score:-3.87|P-value:3.86E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.90|P-value:3.67E-4 ID:SGTC_3294|Compound:9122953|FD-Score:5.82|P-value:2.37E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:4.22|P-value:1.29E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.60|P-value:8.72E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.88|P-value:3.90E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:-3.69|P-value:6.71E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-6.33|P-value:2.00E-8 ID:SGTC_469|Compound:w7|FD-Score:4.66|P-value:2.72E-5 ID:SGTC_489|Compound:paxilline|FD-Score:-4.27|P-value:1.05E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:4.37|P-value:7.78E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:4.19|P-value:1.45E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:4.38|P-value:7.44E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:6.22|P-value:3.69E-8 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.24|P-value:2.90E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.87|P-value:3.91E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:10.50|P-value:6.25E-20 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.76|P-value:5.68E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:4.55|P-value:4.06E-5 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-3.89|P-value:3.67E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.59|P-value:9.12E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-4.06|P-value:2.13E-4 ID:SGTC_1768|Compound:st044301|FD-Score:-3.64|P-value:7.80E-4 ID:SGTC_1796|Compound:st049173|FD-Score:3.86|P-value:4.21E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.80|P-value:5.00E-4 ID:SGTC_2011|Compound:4012611|FD-Score:4.19|P-value:1.45E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.59|P-value:9.48E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.89|P-value:3.87E-4 ID:SGTC_2119|Compound:5528445|FD-Score:-3.90|P-value:3.56E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.69|P-value:6.76E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-5.12|P-value:4.33E-6 ID:SGTC_2273|Compound:7815444|FD-Score:3.99|P-value:2.77E-4 ID:SGTC_2297|Compound:7971671|FD-Score:4.54|P-value:4.29E-5 ID:SGTC_2351|Compound:9026858|FD-Score:3.80|P-value:4.99E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.94|P-value:3.23E-4 ID:SGTC_2354|Compound:9060492|FD-Score:4.73|P-value:2.10E-5 ID:SGTC_2396|Compound:5342950|FD-Score:4.49|P-value:5.20E-5 ID:SGTC_2477|Compound:5967686|FD-Score:6.16|P-value:4.91E-8 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.59|P-value:9.58E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:4.04|P-value:2.36E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:4.27|P-value:1.08E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.65|P-value:8.06E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.86|P-value:4.24E-4 ID:SGTC_2943|Compound:9068529|FD-Score:5.11|P-value:4.77E-6 ID:SGTC_2982|Compound:9019404|FD-Score:3.83|P-value:4.62E-4 ID:SGTC_3031|Compound:9088762|FD-Score:5.82|P-value:2.34E-7 ID:SGTC_3041|Compound:9091929|FD-Score:-3.82|P-value:4.46E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-3.65|P-value:7.70E-4 ID:SGTC_3083|Compound:9117465|FD-Score:4.93|P-value:9.73E-6 ID:SGTC_3139|Compound:9095020|FD-Score:6.01|P-value:9.93E-8 ID:SGTC_3145|Compound:9085516|FD-Score:-4.04|P-value:2.24E-4 ID:SGTC_3158|Compound:9100007|FD-Score:3.69|P-value:7.00E-4 ID:SGTC_3208|Compound:9114115|FD-Score:7.16|P-value:2.83E-10 ID:SGTC_3216|Compound:9129716|FD-Score:-4.52|P-value:4.39E-5 ID:SGTC_3259|Compound:9138485|FD-Score:-3.87|P-value:3.86E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.90|P-value:3.67E-4 ID:SGTC_3294|Compound:9122953|FD-Score:5.82|P-value:2.37E-7

Top fitness defect scores for YGR038W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1124 fisetin 10.50 1.2 µM 6.25E-20 1 6.27E-26
2 SGTC_3208 9114115 7.16 49.5 µM 2.83E-10 7 4.04E-13
3 SGTC_1035 k081-0041 6.22 55.2 µM 3.69E-8 Golgi 3 2.55E-10
4 SGTC_2477 5967686 6.16 25.2 µM 4.91E-8 6 3.72E-10
5 SGTC_3139 9095020 6.01 49.5 µM 9.93E-8 1 9.44E-10
6 SGTC_3031 9088762 5.82 49.5 µM 2.34E-7 1 2.93E-9
7 SGTC_3294 9122953 5.82 26.3 µM 2.37E-7 tubulin folding & SWR complex 10 2.98E-9
8 SGTC_1082 camptothecin 5.24 424.9 nM 2.90E-6 DNA damage response 29 8.12E-8
9 SGTC_2943 9068529 5.11 45.3 µM 4.77E-6 7 1.57E-7
10 SGTC_3083 9117465 4.93 49.5 µM 9.73E-6 5 4.01E-7
11 SGTC_2354 9060492 4.73 162.0 µM 2.10E-5 7 1.11E-6
12 SGTC_469 w7 4.66 172.0 µM 2.72E-5 ERG2 5 1.55E-6
13 SGTC_1324 1418-0026 4.55 34.4 µM 4.06E-5 6 2.63E-6
14 SGTC_2297 7971671 4.54 152.3 µM 4.29E-5 RNA processing & uracil transport 14 2.83E-6
15 SGTC_2396 5342950 4.49 42.8 µM 5.20E-5 RSC complex & mRNA processing 29 3.64E-6
16 SGTC_824 1304-0008 4.38 100.0 µM 7.44E-5 DNA damage response 28 5.84E-6
17 SGTC_553 k007-0256 4.37 45.7 µM 7.78E-5 heme biosynthesis & mitochondrial translocase 13 6.19E-6
18 SGTC_2769 toremifene 4.27 3.7 µM 1.08E-4 16 9.59E-6
19 SGTC_67 0335-0847 4.22 266.0 µM 1.29E-4 ubiquinone biosynthesis & proteasome 101 1.21E-5
20 SGTC_2011 4012611 4.19 177.0 µM 1.45E-4 mitochondrial processes 24 1.40E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 8.04E-9 YOR378W_p YOR378W_p hom Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
0.097 1.78E-8 YLR177W_p YLR177W_p hom Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication
0.095 3.87E-8 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.093 7.73E-8 YOR026W BUB3 hom Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
0.093 7.88E-8 YDR279W RNH202 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome
0.092 1.12E-7 YGL190C CDC55 hom Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion
0.090 1.59E-7 YPL230W USV1 hom Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication
0.088 3.06E-7 YGL098W USE1 het Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
0.087 4.26E-7 YOR172W YRM1 hom Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes
0.087 4.58E-7 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.086 7.09E-7 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.084 1.01E-6 YKR055W RHO4 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity
0.084 1.16E-6 YGL209W MIG2 hom Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication
0.076 9.87E-6 YPR201W ARR3 hom Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite
0.072 3.45E-5 YBL070C_d YBL070C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data