YGR039W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR039W / YGR039W

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:3.38|P-value:2.08E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.22|P-value:3.88E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.41|P-value:1.15E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:2.97|P-value:9.82E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:-3.07|P-value:4.42E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:-4.45|P-value:8.22E-7 ID:SGTC_560|Compound:2332-1943|FD-Score:3.25|P-value:3.48E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:3.63|P-value:7.37E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:3.30|P-value:2.86E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.01|P-value:8.36E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-2.93|P-value:7.30E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.90|P-value:1.27E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.15|P-value:5.01E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-2.93|P-value:7.28E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.63|P-value:7.33E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.57|P-value:8.19E-7 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.40|P-value:1.90E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.45|P-value:1.55E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.10|P-value:6.17E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.46|P-value:1.49E-4 ID:SGTC_1971|Compound:st069429|FD-Score:4.25|P-value:4.19E-6 ID:SGTC_2054|Compound:5233173|FD-Score:4.31|P-value:3.14E-6 ID:SGTC_2058|Compound:5236698|FD-Score:3.37|P-value:2.14E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-4.05|P-value:6.27E-6 ID:SGTC_2414|Compound:st077232|FD-Score:-3.22|P-value:2.49E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.56|P-value:8.58E-7 ID:SGTC_2419|Compound:paclitaxel|FD-Score:8.74|P-value:1.37E-20 ID:SGTC_2537|Compound:larixol|FD-Score:3.44|P-value:1.64E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.30|P-value:3.20E-6 ID:SGTC_2602|Compound:kawain|FD-Score:3.01|P-value:8.39E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.10|P-value:8.69E-6 ID:SGTC_3008|Compound:9078912|FD-Score:-3.85|P-value:1.61E-5 ID:SGTC_3259|Compound:9138485|FD-Score:-3.04|P-value:4.95E-4 ID:SGTC_3298|Compound:9116858|FD-Score:-3.76|P-value:2.38E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:3.38|P-value:2.08E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.22|P-value:3.88E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.41|P-value:1.15E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:2.97|P-value:9.82E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:-3.07|P-value:4.42E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:-4.45|P-value:8.22E-7 ID:SGTC_560|Compound:2332-1943|FD-Score:3.25|P-value:3.48E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:3.63|P-value:7.37E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:3.30|P-value:2.86E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.01|P-value:8.36E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-2.93|P-value:7.30E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.90|P-value:1.27E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.15|P-value:5.01E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-2.93|P-value:7.28E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.63|P-value:7.33E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.57|P-value:8.19E-7 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.40|P-value:1.90E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.45|P-value:1.55E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.10|P-value:6.17E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.46|P-value:1.49E-4 ID:SGTC_1971|Compound:st069429|FD-Score:4.25|P-value:4.19E-6 ID:SGTC_2054|Compound:5233173|FD-Score:4.31|P-value:3.14E-6 ID:SGTC_2058|Compound:5236698|FD-Score:3.37|P-value:2.14E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-4.05|P-value:6.27E-6 ID:SGTC_2414|Compound:st077232|FD-Score:-3.22|P-value:2.49E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.56|P-value:8.58E-7 ID:SGTC_2419|Compound:paclitaxel|FD-Score:8.74|P-value:1.37E-20 ID:SGTC_2537|Compound:larixol|FD-Score:3.44|P-value:1.64E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.30|P-value:3.20E-6 ID:SGTC_2602|Compound:kawain|FD-Score:3.01|P-value:8.39E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.10|P-value:8.69E-6 ID:SGTC_3008|Compound:9078912|FD-Score:-3.85|P-value:1.61E-5 ID:SGTC_3259|Compound:9138485|FD-Score:-3.04|P-value:4.95E-4 ID:SGTC_3298|Compound:9116858|FD-Score:-3.76|P-value:2.38E-5

Top fitness defect scores for YGR039W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2419 paclitaxel 8.74 166.5 µM 1.37E-20 1 1.21E-18
2 SGTC_1300 1094-0077 4.57 113.0 µM 8.19E-7 6 2.49E-6
3 SGTC_2417 cerulenin 4.56 830.0 nM 8.58E-7 18 2.59E-6
4 SGTC_2054 5233173 4.31 129.0 µM 3.14E-6 mitochondrial response to ROS 45 8.33E-6
5 SGTC_2595 hexamethylquercetagetin 4.30 100.0 µM 3.20E-6 17 8.47E-6
6 SGTC_1971 st069429 4.25 63.5 µM 4.19E-6 60S ribosome export 8 1.08E-5
7 SGTC_2934 9036370 4.10 36.9 µM 8.69E-6 30 2.08E-5
8 SGTC_1297 1068-0111 3.63 14.1 µM 7.33E-5 17 1.42E-4
9 SGTC_854 0422-0053 3.63 192.0 µM 7.37E-5 PDR1 21 1.43E-4
10 SGTC_1549 4'-methoxyflavonol 3.46 74.6 µM 1.49E-4 14 2.70E-4
11 SGTC_1477 0139-0234 3.45 16.0 µM 1.55E-4 18 2.81E-4
12 SGTC_2537 larixol 3.44 68.9 µM 1.64E-4 41 2.94E-4
13 SGTC_1391 3442-0225 3.40 151.0 µM 1.90E-4 30 3.37E-4
14 SGTC_61 0978-8327 3.38 98.6 µM 2.08E-4 ergosterol biosynthesis 47 3.65E-4
15 SGTC_2058 5236698 3.37 133.0 µM 2.14E-4 44 3.75E-4
16 SGTC_893 0958-0369 3.30 48.9 µM 2.86E-4 52 4.88E-4
17 SGTC_560 2332-1943 3.25 155.0 µM 3.48E-4 30 5.82E-4
18 SGTC_94 0334-0113 3.22 514.8 µM 3.88E-4 43 6.43E-4
19 SGTC_1125 tnp00248 3.15 1.3 µM 5.01E-4 86 8.10E-4
20 SGTC_1548 st061468 3.10 90.8 µM 6.17E-4 30 9.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 9.33E-22 YIL099W SGA1 hom Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
0.150 2.60E-18 YGR049W SCM4 hom Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation
0.134 7.11E-15 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.132 1.52E-14 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.126 2.58E-13 YKR059W TIF1 hom Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication
0.124 5.93E-13 YDR234W LYS4 hom Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
0.123 1.02E-12 YDL048C STP4 hom Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; predicted to be a transcription factor; relative distribution to the nucleus increases upon DNA replication stress
0.119 5.43E-12 YGR043C NQM1 hom Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift
0.117 9.41E-12 YNR013C PHO91 hom Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
0.114 3.31E-11 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.112 9.49E-11 YDR096W GIS1 hom Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication
0.108 4.16E-10 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.106 8.60E-10 YPR030W CSR2 hom Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication
0.104 1.30E-9 YGR201C_p YGR201C_p hom Putative protein of unknown function
0.103 1.92E-9 YCL057W PRD1 hom Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress