YGR040W / KSS1

Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR040W / KSS1

Click on Significant Values for Screen Details ID:SGTC_162|Compound:k030-0015|FD-Score:3.07|P-value:4.67E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:3.20|P-value:2.68E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.31|P-value:1.73E-4 ID:SGTC_460|Compound:trequinsin|FD-Score:3.80|P-value:1.96E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:3.35|P-value:1.43E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:-4.24|P-value:1.18E-6 ID:SGTC_642|Compound:0335-0876|FD-Score:3.52|P-value:6.83E-5 ID:SGTC_647|Compound:0140-0236|FD-Score:3.14|P-value:3.54E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:3.19|P-value:2.83E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-5.96|P-value:1.80E-11 ID:SGTC_962|Compound:1254-0300|FD-Score:9.28|P-value:1.84E-24 ID:SGTC_963|Compound:1269-2853|FD-Score:4.43|P-value:7.43E-7 ID:SGTC_966|Compound:1300-0360|FD-Score:3.03|P-value:5.36E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:-6.55|P-value:1.93E-13 ID:SGTC_1023|Compound:4482-3888|FD-Score:2.88|P-value:9.44E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-2.79|P-value:8.84E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.87|P-value:1.40E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:-4.02|P-value:3.64E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.66|P-value:3.74E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.36|P-value:1.42E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.92|P-value:1.09E-5 ID:SGTC_1714|Compound:st033236|FD-Score:6.22|P-value:5.93E-12 ID:SGTC_1715|Compound:st032160|FD-Score:4.28|P-value:1.67E-6 ID:SGTC_1720|Compound:st037298|FD-Score:4.08|P-value:4.92E-6 ID:SGTC_1739|Compound:st037196|FD-Score:-4.25|P-value:1.09E-6 ID:SGTC_1748|Compound:st037455|FD-Score:3.93|P-value:1.02E-5 ID:SGTC_1866|Compound:st057638|FD-Score:-3.46|P-value:5.60E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.30|P-value:1.78E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.98|P-value:8.16E-6 ID:SGTC_2412|Compound:st077135|FD-Score:-3.47|P-value:5.32E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.30|P-value:1.49E-6 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.20|P-value:2.71E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.12|P-value:3.80E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:5.47|P-value:1.27E-9 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-2.81|P-value:8.12E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.38|P-value:7.74E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.06|P-value:3.10E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.13|P-value:3.59E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:3.02|P-value:5.48E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.27|P-value:1.28E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.28|P-value:1.93E-4 ID:SGTC_2858|Compound:9025781|FD-Score:2.98|P-value:6.58E-4 ID:SGTC_2872|Compound:9044037|FD-Score:3.73|P-value:2.66E-5 ID:SGTC_2875|Compound:9039966|FD-Score:3.34|P-value:1.52E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-4.13|P-value:2.06E-6 ID:SGTC_2902|Compound:5787006|FD-Score:-4.06|P-value:2.98E-6 ID:SGTC_2908|Compound:7930301|FD-Score:-4.22|P-value:1.30E-6 ID:SGTC_2914|Compound:7968218|FD-Score:-2.90|P-value:5.71E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.07|P-value:2.93E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.62|P-value:2.63E-7 ID:SGTC_2944|Compound:9067346|FD-Score:-2.86|P-value:6.62E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.48|P-value:4.98E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.45|P-value:9.68E-5 ID:SGTC_3134|Compound:9127454|FD-Score:3.02|P-value:5.58E-4 ID:SGTC_3331|Compound:9141060|FD-Score:2.90|P-value:8.82E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.07|P-value:4.67E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:3.20|P-value:2.68E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.31|P-value:1.73E-4 ID:SGTC_460|Compound:trequinsin|FD-Score:3.80|P-value:1.96E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:3.35|P-value:1.43E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:-4.24|P-value:1.18E-6 ID:SGTC_642|Compound:0335-0876|FD-Score:3.52|P-value:6.83E-5 ID:SGTC_647|Compound:0140-0236|FD-Score:3.14|P-value:3.54E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:3.19|P-value:2.83E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-5.96|P-value:1.80E-11 ID:SGTC_962|Compound:1254-0300|FD-Score:9.28|P-value:1.84E-24 ID:SGTC_963|Compound:1269-2853|FD-Score:4.43|P-value:7.43E-7 ID:SGTC_966|Compound:1300-0360|FD-Score:3.03|P-value:5.36E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:-6.55|P-value:1.93E-13 ID:SGTC_1023|Compound:4482-3888|FD-Score:2.88|P-value:9.44E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-2.79|P-value:8.84E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.87|P-value:1.40E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:-4.02|P-value:3.64E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.66|P-value:3.74E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.36|P-value:1.42E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.92|P-value:1.09E-5 ID:SGTC_1714|Compound:st033236|FD-Score:6.22|P-value:5.93E-12 ID:SGTC_1715|Compound:st032160|FD-Score:4.28|P-value:1.67E-6 ID:SGTC_1720|Compound:st037298|FD-Score:4.08|P-value:4.92E-6 ID:SGTC_1739|Compound:st037196|FD-Score:-4.25|P-value:1.09E-6 ID:SGTC_1748|Compound:st037455|FD-Score:3.93|P-value:1.02E-5 ID:SGTC_1866|Compound:st057638|FD-Score:-3.46|P-value:5.60E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.30|P-value:1.78E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.98|P-value:8.16E-6 ID:SGTC_2412|Compound:st077135|FD-Score:-3.47|P-value:5.32E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.30|P-value:1.49E-6 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.20|P-value:2.71E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.12|P-value:3.80E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:5.47|P-value:1.27E-9 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-2.81|P-value:8.12E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.38|P-value:7.74E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.06|P-value:3.10E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.13|P-value:3.59E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:3.02|P-value:5.48E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.27|P-value:1.28E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.28|P-value:1.93E-4 ID:SGTC_2858|Compound:9025781|FD-Score:2.98|P-value:6.58E-4 ID:SGTC_2872|Compound:9044037|FD-Score:3.73|P-value:2.66E-5 ID:SGTC_2875|Compound:9039966|FD-Score:3.34|P-value:1.52E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-4.13|P-value:2.06E-6 ID:SGTC_2902|Compound:5787006|FD-Score:-4.06|P-value:2.98E-6 ID:SGTC_2908|Compound:7930301|FD-Score:-4.22|P-value:1.30E-6 ID:SGTC_2914|Compound:7968218|FD-Score:-2.90|P-value:5.71E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.07|P-value:2.93E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.62|P-value:2.63E-7 ID:SGTC_2944|Compound:9067346|FD-Score:-2.86|P-value:6.62E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.48|P-value:4.98E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.45|P-value:9.68E-5 ID:SGTC_3134|Compound:9127454|FD-Score:3.02|P-value:5.58E-4 ID:SGTC_3331|Compound:9141060|FD-Score:2.90|P-value:8.82E-4

Top fitness defect scores for YGR040W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_962 1254-0300 9.28 21.5 µM 1.84E-24 1 8.74E-21
2 SGTC_1714 st033236 6.22 13.6 µM 5.93E-12 4 2.44E-10
3 SGTC_2549 cedrol 5.47 20.9 µM 1.27E-9 4 2.19E-8
4 SGTC_2937 9044753 4.62 11.3 µM 2.63E-7 60S ribosome export 21 1.94E-6
5 SGTC_963 1269-2853 4.43 151.0 µM 7.43E-7 19 4.65E-6
6 SGTC_2419 paclitaxel 4.30 166.5 µM 1.49E-6 30 8.38E-6
7 SGTC_1715 st032160 4.28 10.2 µM 1.67E-6 37 9.21E-6
8 SGTC_1720 st037298 4.08 9.5 µM 4.92E-6 32 2.29E-5
9 SGTC_2002 4023503 3.98 131.0 µM 8.16E-6 mitochondrial processes 30 3.51E-5
10 SGTC_1748 st037455 3.93 53.6 µM 1.02E-5 32 4.25E-5
11 SGTC_1702 st027038 3.92 51.0 µM 1.09E-5 11 4.48E-5
12 SGTC_1241 0364-0022 3.87 50.8 µM 1.40E-5 ERG2 31 5.53E-5
13 SGTC_460 trequinsin 3.80 123.0 µM 1.96E-5 4 7.38E-5
14 SGTC_2872 9044037 3.73 26.0 µM 2.66E-5 9 9.55E-5
15 SGTC_1266 0828-0227 3.66 32.9 µM 3.74E-5 25 1.27E-4
16 SGTC_642 0335-0876 3.52 158.0 µM 6.83E-5 ubiquinone biosynthesis & proteasome 54 2.12E-4
17 SGTC_3067 9117431 3.45 49.5 µM 9.68E-5 28 2.85E-4
18 SGTC_1335 1486-0900 3.36 202.0 µM 1.42E-4 54 3.94E-4
19 SGTC_626 0214-0009 3.35 33.0 µM 1.43E-4 copper-dependent oxidative stress 40 3.97E-4
20 SGTC_2875 9039966 3.34 71.4 µM 1.52E-4 20 4.17E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 5.81E-21 YGR012W YGR012W hom Putative cysteine synthase, localized to the mitochondrial outer membrane
0.150 3.02E-18 YMR004W MVP1 hom Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress
0.127 1.75E-13 YDR105C TMS1 hom Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
0.119 4.20E-12 YKL215C OXP1 hom 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.093 5.92E-8 YCL074W YCL074W hom Pseudogene: encodes fragment of Ty Pol protein
0.090 1.65E-7 YMR209C_p YMR209C_p hom Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene
0.090 1.92E-7 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.081 2.58E-6 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.081 2.74E-6 YOR283W YOR283W hom Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene
0.080 3.44E-6 YPR044C_d OPI11_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO
0.080 4.01E-6 YJR061W_p YJR061W_p hom Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication
0.079 4.10E-6 YGR066C_p YGR066C_p hom Putative protein of unknown function
0.079 4.67E-6 YOR148C SPP2 het Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction
0.079 5.16E-6 YKR039W GAP1 hom General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth
0.077 8.34E-6 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters