YGR046W / TAM41

Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR046W / TAM41

Click on Significant Values for Screen Details ID:SGTC_363|Compound:0455-0021|FD-Score:4.65|P-value:1.49E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-6.28|P-value:6.74E-9 ID:SGTC_525|Compound:k781-2675|FD-Score:4.46|P-value:3.08E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:4.58|P-value:1.98E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:3.54|P-value:7.57E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.48|P-value:8.92E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.50|P-value:8.46E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:-4.11|P-value:9.71E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:-3.51|P-value:7.38E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:6.20|P-value:1.24E-8 ID:SGTC_921|Compound:1561-0023|FD-Score:6.35|P-value:5.57E-9 ID:SGTC_996|Compound:3970-0799|FD-Score:3.55|P-value:7.22E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.62|P-value:5.73E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.71|P-value:4.41E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.46|P-value:9.61E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.85|P-value:2.74E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-4.24|P-value:6.25E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.45|P-value:9.84E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.77|P-value:3.19E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.53|P-value:7.63E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.86|P-value:2.67E-4 ID:SGTC_1616|Compound:st002734|FD-Score:4.11|P-value:1.13E-4 ID:SGTC_1700|Compound:st030840|FD-Score:-4.37|P-value:3.84E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.63|P-value:4.94E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.81|P-value:3.17E-4 ID:SGTC_2048|Compound:5246248|FD-Score:-3.46|P-value:8.56E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-3.91|P-value:2.00E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:5.12|P-value:2.08E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.94|P-value:1.82E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.74|P-value:3.99E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-5.24|P-value:1.05E-6 ID:SGTC_2978|Compound:9011784|FD-Score:6.54|P-value:2.02E-9 ID:SGTC_2980|Compound:9014342|FD-Score:8.93|P-value:4.58E-16 ID:SGTC_3053|Compound:9095903|FD-Score:3.62|P-value:5.82E-4 ID:SGTC_3062|Compound:9077494|FD-Score:5.14|P-value:1.95E-6 ID:SGTC_3087|Compound:9117406|FD-Score:3.50|P-value:8.38E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.59|P-value:6.39E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.91|P-value:2.23E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.71|P-value:3.84E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.65|P-value:1.49E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-6.28|P-value:6.74E-9 ID:SGTC_525|Compound:k781-2675|FD-Score:4.46|P-value:3.08E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:4.58|P-value:1.98E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:3.54|P-value:7.57E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.48|P-value:8.92E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.50|P-value:8.46E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:-4.11|P-value:9.71E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:-3.51|P-value:7.38E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:6.20|P-value:1.24E-8 ID:SGTC_921|Compound:1561-0023|FD-Score:6.35|P-value:5.57E-9 ID:SGTC_996|Compound:3970-0799|FD-Score:3.55|P-value:7.22E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.62|P-value:5.73E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.71|P-value:4.41E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.46|P-value:9.61E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.85|P-value:2.74E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-4.24|P-value:6.25E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.45|P-value:9.84E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.77|P-value:3.19E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.53|P-value:7.63E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.86|P-value:2.67E-4 ID:SGTC_1616|Compound:st002734|FD-Score:4.11|P-value:1.13E-4 ID:SGTC_1700|Compound:st030840|FD-Score:-4.37|P-value:3.84E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.63|P-value:4.94E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.81|P-value:3.17E-4 ID:SGTC_2048|Compound:5246248|FD-Score:-3.46|P-value:8.56E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-3.91|P-value:2.00E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:5.12|P-value:2.08E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.94|P-value:1.82E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.74|P-value:3.99E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-5.24|P-value:1.05E-6 ID:SGTC_2978|Compound:9011784|FD-Score:6.54|P-value:2.02E-9 ID:SGTC_2980|Compound:9014342|FD-Score:8.93|P-value:4.58E-16 ID:SGTC_3053|Compound:9095903|FD-Score:3.62|P-value:5.82E-4 ID:SGTC_3062|Compound:9077494|FD-Score:5.14|P-value:1.95E-6 ID:SGTC_3087|Compound:9117406|FD-Score:3.50|P-value:8.38E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.59|P-value:6.39E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.91|P-value:2.23E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.71|P-value:3.84E-4

Top fitness defect scores for YGR046W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2980 9014342 8.93 25.3 µM 4.58E-16 3 2.09E-19 0.67
2 SGTC_2978 9011784 6.54 43.0 µM 2.02E-9 1 3.03E-11 0.96
3 SGTC_921 1561-0023 6.35 372.0 µM 5.57E-9 2 1.06E-10 1.02
4 SGTC_903 1134-0042 6.20 114.0 µM 1.24E-8 2 2.82E-10 1.01
5 SGTC_3062 9077494 5.14 49.5 µM 1.95E-6 mitochondrial response to ROS 1 1.39E-7 0.55
6 SGTC_2408 sulbentine 5.12 18.4 µM 2.08E-6 21 1.50E-7 0.08
7 SGTC_363 0455-0021 4.65 3.1 µM 1.49E-5 azole & statin 14 1.68E-6 0.11
8 SGTC_743 1275-0778 4.58 158.0 µM 1.98E-5 excess fatty acid 10 2.37E-6 0.23
9 SGTC_525 k781-2675 4.46 26.7 µM 3.08E-5 redox potentiating 35 4.06E-6 0.11
10 SGTC_1616 st002734 4.11 56.1 µM 1.13E-4 5 1.99E-5 0.11
11 SGTC_3134 9127454 3.91 49.5 µM 2.23E-4 2 4.56E-5 0.52
12 SGTC_1455 4262-0120 3.86 131.0 µM 2.67E-4 plasma membrane duress 4 5.70E-5 0.06
13 SGTC_1376 2910-0861 3.85 41.3 µM 2.74E-4 3 5.89E-5 0.29
14 SGTC_2016 5121758 3.81 140.0 µM 3.17E-4 redox potentiating 18 7.03E-5 0.00
15 SGTC_2786 7743617 3.74 45.5 µM 3.99E-4 10 9.32E-5 0.29
16 SGTC_1093 fluphenazine 3.71 8.0 µM 4.41E-4 6 1.05E-4 0.09
17 SGTC_1027 k015-0025 3.62 8.7 µM 5.73E-4 6 1.45E-4 6.08E-5
18 SGTC_3053 9095903 3.62 49.5 µM 5.82E-4 Golgi 1 1.48E-4 0.21
19 SGTC_3124 9127567 3.59 49.5 µM 6.39E-4 DNA damage response 8 1.65E-4 0.01
20 SGTC_996 3970-0799 3.55 1.8 µM 7.22E-4 24 1.92E-4 0.22

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 9.68E-20 YNL274C GOR1 hom Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.136 3.52E-15 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.127 1.48E-13 YLR345W_p YLR345W_p hom Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
0.121 2.47E-12 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.119 4.47E-12 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.117 1.31E-11 YGR013W SNU71 het Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart
0.107 5.83E-10 YDL217C TIM22 het Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
0.103 1.86E-9 YDR515W SLF1 hom RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.102 3.84E-9 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.101 4.17E-9 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.101 5.37E-9 YDL069C CBS1 hom Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.099 1.04E-8 YMR203W TOM40 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.095 3.04E-8 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.093 6.13E-8 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.093 7.54E-8 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine