YGR047C / TFC4

One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR047C / TFC4

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.13|P-value:3.45E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.33|P-value:1.80E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.63|P-value:4.20E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:-3.06|P-value:4.64E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.23|P-value:2.30E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.45|P-value:1.09E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.67|P-value:3.59E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:-5.19|P-value:1.02E-8 ID:SGTC_582|Compound:0987-0078|FD-Score:2.94|P-value:8.17E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:-2.87|P-value:9.51E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-5.21|P-value:9.06E-9 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.81|P-value:1.90E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.87|P-value:9.31E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.31|P-value:1.90E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.29|P-value:2.12E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:2.97|P-value:7.37E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.05|P-value:5.39E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.80|P-value:2.31E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:5.17|P-value:1.38E-8 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.55|P-value:7.01E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.97|P-value:6.34E-4 ID:SGTC_1816|Compound:st051957|FD-Score:-3.13|P-value:3.44E-4 ID:SGTC_1826|Compound:st055655|FD-Score:-3.27|P-value:2.00E-4 ID:SGTC_1850|Compound:st056238|FD-Score:-2.97|P-value:6.49E-4 ID:SGTC_1969|Compound:st069479|FD-Score:2.90|P-value:9.34E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-5.46|P-value:1.78E-9 ID:SGTC_2055|Compound:5235184|FD-Score:-3.20|P-value:2.67E-4 ID:SGTC_2215|Compound:7188065|FD-Score:-3.01|P-value:5.47E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.25|P-value:2.19E-4 ID:SGTC_2267|Compound:7931562|FD-Score:2.96|P-value:7.56E-4 ID:SGTC_2321|Compound:7390090|FD-Score:4.14|P-value:4.43E-6 ID:SGTC_2345|Compound:9052315|FD-Score:-3.29|P-value:1.81E-4 ID:SGTC_2366|Compound:9070441|FD-Score:2.92|P-value:8.72E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.65|P-value:4.48E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.27|P-value:2.28E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:-4.19|P-value:2.85E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:2.89|P-value:9.89E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.02|P-value:6.10E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:2.94|P-value:8.08E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:6.03|P-value:4.56E-11 ID:SGTC_2800|Compound:7887935|FD-Score:7.07|P-value:1.47E-14 ID:SGTC_2835|Compound:9006588|FD-Score:-2.87|P-value:9.29E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-3.13|P-value:3.55E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.17|P-value:3.37E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.21|P-value:2.51E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.34|P-value:1.67E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.95|P-value:9.47E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-3.36|P-value:1.38E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.24|P-value:2.53E-4 ID:SGTC_3270|Compound:9137563|FD-Score:3.15|P-value:3.59E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.18|P-value:3.24E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.07|P-value:4.96E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.13|P-value:3.45E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.33|P-value:1.80E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.63|P-value:4.20E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:-3.06|P-value:4.64E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.23|P-value:2.30E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.45|P-value:1.09E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.67|P-value:3.59E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:-5.19|P-value:1.02E-8 ID:SGTC_582|Compound:0987-0078|FD-Score:2.94|P-value:8.17E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:-2.87|P-value:9.51E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-5.21|P-value:9.06E-9 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.81|P-value:1.90E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.87|P-value:9.31E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.31|P-value:1.90E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.29|P-value:2.12E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:2.97|P-value:7.37E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.05|P-value:5.39E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.80|P-value:2.31E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:5.17|P-value:1.38E-8 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.55|P-value:7.01E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.97|P-value:6.34E-4 ID:SGTC_1816|Compound:st051957|FD-Score:-3.13|P-value:3.44E-4 ID:SGTC_1826|Compound:st055655|FD-Score:-3.27|P-value:2.00E-4 ID:SGTC_1850|Compound:st056238|FD-Score:-2.97|P-value:6.49E-4 ID:SGTC_1969|Compound:st069479|FD-Score:2.90|P-value:9.34E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-5.46|P-value:1.78E-9 ID:SGTC_2055|Compound:5235184|FD-Score:-3.20|P-value:2.67E-4 ID:SGTC_2215|Compound:7188065|FD-Score:-3.01|P-value:5.47E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.25|P-value:2.19E-4 ID:SGTC_2267|Compound:7931562|FD-Score:2.96|P-value:7.56E-4 ID:SGTC_2321|Compound:7390090|FD-Score:4.14|P-value:4.43E-6 ID:SGTC_2345|Compound:9052315|FD-Score:-3.29|P-value:1.81E-4 ID:SGTC_2366|Compound:9070441|FD-Score:2.92|P-value:8.72E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.65|P-value:4.48E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.27|P-value:2.28E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:-4.19|P-value:2.85E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:2.89|P-value:9.89E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.02|P-value:6.10E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:2.94|P-value:8.08E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:6.03|P-value:4.56E-11 ID:SGTC_2800|Compound:7887935|FD-Score:7.07|P-value:1.47E-14 ID:SGTC_2835|Compound:9006588|FD-Score:-2.87|P-value:9.29E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-3.13|P-value:3.55E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.17|P-value:3.37E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.21|P-value:2.51E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.34|P-value:1.67E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.95|P-value:9.47E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-3.36|P-value:1.38E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.24|P-value:2.53E-4 ID:SGTC_3270|Compound:9137563|FD-Score:3.15|P-value:3.59E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.18|P-value:3.24E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.07|P-value:4.96E-4

Top fitness defect scores for YGR047C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2800 7887935 7.07 81.8 µM 1.47E-14 RPP1 & pyrimidine depletion 2 7.88E-13 0.89
2 SGTC_2774 tamoxifen 6.03 10.9 µM 4.56E-11 2 8.26E-10 0.88
3 SGTC_1198 1612-1005 5.17 86.7 µM 1.38E-8 1 1.16E-7 0.89
4 SGTC_2321 7390090 4.14 138.8 µM 4.43E-6 4 1.75E-5 0.06
5 SGTC_1193 1488-0126 3.80 41.5 µM 2.31E-5 4 7.36E-5 0.18
6 SGTC_2478 5763493 3.65 32.3 µM 4.48E-5 7 1.31E-4 0.34
7 SGTC_1273 0849-0096 3.55 14.1 µM 7.01E-5 RPP1 & pyrimidine depletion 10 1.93E-4 0.08
8 SGTC_554 4483-2211 3.45 187.0 µM 1.09E-4 4 2.85E-4 0.15
9 SGTC_3054 9094397 3.34 49.5 µM 1.67E-4 fatty acid desaturase (OLE1) 14 4.13E-4 0.00
10 SGTC_128 0906-2981 3.33 13.4 µM 1.80E-4 18 4.40E-4 0.12
11 SGTC_996 3970-0799 3.31 1.8 µM 1.90E-4 26 4.63E-4 0.03
12 SGTC_1165 k072-0275 3.29 30.3 µM 2.12E-4 16 5.08E-4 0.01
13 SGTC_2533 agelasine 3.27 13.7 µM 2.28E-4 ERG2 24 5.42E-4 0.04
14 SGTC_3216 9129716 3.24 49.5 µM 2.53E-4 RPP1 & pyrimidine depletion 9 5.92E-4 0.05
15 SGTC_3309 9129340 3.18 25.8 µM 3.24E-4 5 7.35E-4 0.14
16 SGTC_2957 9076800 3.17 11.5 µM 3.37E-4 12 7.62E-4 0.07
17 SGTC_3270 9137563 3.15 49.5 µM 3.59E-4 RPP1 & pyrimidine depletion 4 8.04E-4 0.08
18 SGTC_3315 9136395 3.07 68.5 µM 4.96E-4 16 0.00107 0.03
19 SGTC_1189 1431-2119 3.05 7.3 µM 5.39E-4 16 0.00115 0.05
20 SGTC_2736 butenafine 3.02 14.7 µM 6.10E-4 16 0.00128 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.70E-13 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.123 7.48E-13 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.114 3.68E-11 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.110 1.55E-10 YJL151C SNA3 hom Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles
0.108 3.19E-10 YMR298W LIP1 het Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis
0.102 3.21E-9 YGR048W UFD1 het Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)
0.101 4.69E-9 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.100 5.60E-9 YGL226W MTC3 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1
0.099 9.93E-9 YMR251W-A HOR7 hom Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication
0.098 1.34E-8 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.098 1.45E-8 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.096 2.61E-8 YBL020W RFT1 het Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein
0.095 3.09E-8 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.094 4.44E-8 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.093 7.78E-8 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly