YGR049W / SCM4

Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR049W / SCM4

Click on Significant Values for Screen Details ID:SGTC_432|Compound:NS 1619|FD-Score:-4.52|P-value:5.16E-6 ID:SGTC_509|Compound:pifithrin|FD-Score:4.71|P-value:2.28E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:3.38|P-value:5.17E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.49|P-value:3.42E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.44|P-value:4.21E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.14|P-value:2.85E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.30|P-value:6.70E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:-3.58|P-value:2.31E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.29|P-value:6.88E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:-3.66|P-value:1.73E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-4.65|P-value:2.76E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:9.11|P-value:3.84E-19 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.59|P-value:2.63E-8 ID:SGTC_2416|Compound:tofa|FD-Score:3.48|P-value:3.54E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.74|P-value:1.99E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.57|P-value:2.94E-8 ID:SGTC_2607|Compound:solasodine|FD-Score:4.43|P-value:8.38E-6 ID:SGTC_2807|Compound:7945238|FD-Score:-3.32|P-value:5.87E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.82|P-value:9.55E-5 ID:SGTC_3323|Compound:9138564|FD-Score:-3.87|P-value:7.72E-5 ID:SGTC_3327|Compound:9140648|FD-Score:-4.41|P-value:8.25E-6 ID:SGTC_3334|Compound:9142812|FD-Score:-3.73|P-value:1.33E-4 ID:SGTC_3335|Compound:9143315|FD-Score:4.23|P-value:1.97E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:-4.52|P-value:5.16E-6 ID:SGTC_509|Compound:pifithrin|FD-Score:4.71|P-value:2.28E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:3.38|P-value:5.17E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.49|P-value:3.42E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.44|P-value:4.21E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.14|P-value:2.85E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.30|P-value:6.70E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:-3.58|P-value:2.31E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.29|P-value:6.88E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:-3.66|P-value:1.73E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-4.65|P-value:2.76E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:9.11|P-value:3.84E-19 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.59|P-value:2.63E-8 ID:SGTC_2416|Compound:tofa|FD-Score:3.48|P-value:3.54E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.74|P-value:1.99E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.57|P-value:2.94E-8 ID:SGTC_2607|Compound:solasodine|FD-Score:4.43|P-value:8.38E-6 ID:SGTC_2807|Compound:7945238|FD-Score:-3.32|P-value:5.87E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.82|P-value:9.55E-5 ID:SGTC_3323|Compound:9138564|FD-Score:-3.87|P-value:7.72E-5 ID:SGTC_3327|Compound:9140648|FD-Score:-4.41|P-value:8.25E-6 ID:SGTC_3334|Compound:9142812|FD-Score:-3.73|P-value:1.33E-4 ID:SGTC_3335|Compound:9143315|FD-Score:4.23|P-value:1.97E-5

Top fitness defect scores for YGR049W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2408 sulbentine 9.11 18.4 µM 3.84E-19 8 4.21E-20
2 SGTC_2409 alverine citrate 5.59 64.0 µM 2.63E-8 28 1.10E-8
3 SGTC_2419 paclitaxel 5.57 166.5 µM 2.94E-8 7 1.24E-8
4 SGTC_2417 cerulenin 4.74 830.0 nM 1.99E-6 14 1.05E-6
5 SGTC_509 pifithrin 4.71 175.0 µM 2.28E-6 mitochondrial processes 2 1.21E-6
6 SGTC_2607 solasodine 4.43 47.4 µM 8.38E-6 44 4.78E-6
7 SGTC_3335 9143315 4.23 29.6 µM 1.97E-5 fatty acid desaturase (OLE1) 9 1.17E-5
8 SGTC_1021 4476-0760 4.14 85.3 µM 2.85E-5 19 1.74E-5
9 SGTC_787 4152-0075 3.49 138.0 µM 3.42E-4 37 2.38E-4
10 SGTC_2416 tofa 3.48 880.0 nM 3.54E-4 sphingolipid biosynthesis & PDR1 68 2.46E-4
11 SGTC_993 3909-8757 3.44 62.7 µM 4.21E-4 39 2.96E-4
12 SGTC_536 3852-0578 3.38 10.6 µM 5.17E-4 48 3.67E-4
13 SGTC_1087 pterostilbene 3.30 9.1 µM 6.70E-4 52 4.82E-4
14 SGTC_1310 1188-0297 3.29 994.0 nM 6.88E-4 azole & statin 54 4.95E-4
15 SGTC_2810 7959871 3.17 45.5 µM 0.00104 copper-dependent oxidative stress 76 7.68E-4
16 SGTC_1690 st023502 3.13 41.2 µM 0.00118 calcium & mitochondrial duress 33 8.71E-4
17 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.04 3.7 µM 0.00159 199 0.00120
18 SGTC_2364 9055074 3.02 200.0 µM 0.00167 55 0.00126
19 SGTC_2795 7780010 3.02 54.5 µM 0.00168 77 0.00127
20 SGTC_995 3931-2021 2.97 34.6 µM 0.00197 RPP1 & pyrimidine depletion 61 0.00150

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.197 1.31E-30 YDL069C CBS1 hom Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.166 2.98E-22 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.164 9.21E-22 YHR043C DOG2 hom 2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, paralogous to DOG1, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed
0.162 4.23E-21 YNL024C_p YNL024C_p hom Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern
0.150 2.60E-18 YGR039W_d YGR039W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
0.137 1.33E-15 YKR059W TIF1 hom Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication
0.135 3.55E-15 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.134 6.37E-15 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.133 1.03E-14 YKL030W_d YKL030W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
0.125 4.27E-13 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.123 1.00E-12 YLR421C RPN13 hom Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.117 1.39E-11 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.115 2.37E-11 YDR498C SEC20 het Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p
0.109 2.27E-10 YNL071W LAT1 hom Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
0.108 3.36E-10 YGL068W MNP1 het Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth