YGR050C_p

Protein of unknown function; mRNA identified as translated by ribosome profiling data

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR050C / YGR050C

Click on Significant Values for Screen Details ID:SGTC_223|Compound:busulfan|FD-Score:3.76|P-value:5.41E-5 ID:SGTC_252|Compound:miconazole|FD-Score:3.25|P-value:3.96E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.20|P-value:4.77E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.55|P-value:1.29E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.68|P-value:1.21E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.35|P-value:4.26E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.76|P-value:5.53E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:6.47|P-value:1.85E-11 ID:SGTC_1010|Compound:4112-3296|FD-Score:-3.39|P-value:3.62E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.08|P-value:7.30E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.49|P-value:1.61E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.04|P-value:8.52E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.05|P-value:8.19E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.27|P-value:3.79E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-3.59|P-value:1.73E-4 ID:SGTC_1930|Compound:st074634|FD-Score:4.72|P-value:6.39E-7 ID:SGTC_1935|Compound:st074532|FD-Score:-3.32|P-value:4.64E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.06|P-value:8.00E-4 ID:SGTC_2134|Compound:5324836|FD-Score:4.02|P-value:1.82E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-3.64|P-value:1.42E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.65|P-value:8.48E-5 ID:SGTC_2337|Compound:9009472|FD-Score:8.76|P-value:1.99E-19 ID:SGTC_2338|Compound:7999974|FD-Score:7.25|P-value:6.36E-14 ID:SGTC_2349|Compound:9023730|FD-Score:3.69|P-value:7.18E-5 ID:SGTC_2457|Compound:5731572|FD-Score:3.37|P-value:2.58E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.62|P-value:1.50E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.08|P-value:7.45E-4 ID:SGTC_2828|Compound:7998861|FD-Score:-4.92|P-value:4.19E-7 ID:SGTC_2841|Compound:9004761|FD-Score:3.64|P-value:9.04E-5 ID:SGTC_2909|Compound:7941780|FD-Score:3.44|P-value:1.97E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.18|P-value:5.09E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.97|P-value:2.19E-5 ID:SGTC_3072|Compound:9116419|FD-Score:3.74|P-value:6.02E-5 ID:SGTC_3088|Compound:9117578|FD-Score:5.37|P-value:1.91E-8 ID:SGTC_3096|Compound:9117468|FD-Score:-3.38|P-value:3.76E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.67|P-value:1.23E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.68|P-value:7.50E-5 ID:SGTC_3308|Compound:9128332|FD-Score:-5.02|P-value:2.40E-7 ID:SGTC_3316|Compound:9136639|FD-Score:3.44|P-value:1.95E-4 ID:SGTC_3333|Compound:9141820|FD-Score:5.64|P-value:3.81E-9 ID:SGTC_223|Compound:busulfan|FD-Score:3.76|P-value:5.41E-5 ID:SGTC_252|Compound:miconazole|FD-Score:3.25|P-value:3.96E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.20|P-value:4.77E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.55|P-value:1.29E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.68|P-value:1.21E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.35|P-value:4.26E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.76|P-value:5.53E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:6.47|P-value:1.85E-11 ID:SGTC_1010|Compound:4112-3296|FD-Score:-3.39|P-value:3.62E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.08|P-value:7.30E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.49|P-value:1.61E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.04|P-value:8.52E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.05|P-value:8.19E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.27|P-value:3.79E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-3.59|P-value:1.73E-4 ID:SGTC_1930|Compound:st074634|FD-Score:4.72|P-value:6.39E-7 ID:SGTC_1935|Compound:st074532|FD-Score:-3.32|P-value:4.64E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.06|P-value:8.00E-4 ID:SGTC_2134|Compound:5324836|FD-Score:4.02|P-value:1.82E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-3.64|P-value:1.42E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.65|P-value:8.48E-5 ID:SGTC_2337|Compound:9009472|FD-Score:8.76|P-value:1.99E-19 ID:SGTC_2338|Compound:7999974|FD-Score:7.25|P-value:6.36E-14 ID:SGTC_2349|Compound:9023730|FD-Score:3.69|P-value:7.18E-5 ID:SGTC_2457|Compound:5731572|FD-Score:3.37|P-value:2.58E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.62|P-value:1.50E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.08|P-value:7.45E-4 ID:SGTC_2828|Compound:7998861|FD-Score:-4.92|P-value:4.19E-7 ID:SGTC_2841|Compound:9004761|FD-Score:3.64|P-value:9.04E-5 ID:SGTC_2909|Compound:7941780|FD-Score:3.44|P-value:1.97E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.18|P-value:5.09E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.97|P-value:2.19E-5 ID:SGTC_3072|Compound:9116419|FD-Score:3.74|P-value:6.02E-5 ID:SGTC_3088|Compound:9117578|FD-Score:5.37|P-value:1.91E-8 ID:SGTC_3096|Compound:9117468|FD-Score:-3.38|P-value:3.76E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.67|P-value:1.23E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.68|P-value:7.50E-5 ID:SGTC_3308|Compound:9128332|FD-Score:-5.02|P-value:2.40E-7 ID:SGTC_3316|Compound:9136639|FD-Score:3.44|P-value:1.95E-4 ID:SGTC_3333|Compound:9141820|FD-Score:5.64|P-value:3.81E-9

Top fitness defect scores for YGR050C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2337 9009472 8.76 200.0 µM 1.99E-19 1 9.85E-19
2 SGTC_2338 7999974 7.25 200.0 µM 6.36E-14 1 2.06E-13
3 SGTC_996 3970-0799 6.47 1.8 µM 1.85E-11 29 4.93E-11
4 SGTC_3333 9141820 5.64 12.1 µM 3.81E-9 5 8.43E-9
5 SGTC_3088 9117578 5.37 49.5 µM 1.91E-8 amide catabolism 3 4.00E-8
6 SGTC_1930 st074634 4.72 34.3 µM 6.39E-7 RNA pol III & RNase P/MRP 21 1.17E-6
7 SGTC_2134 5324836 4.02 1.5 µM 1.82E-5 14 2.95E-5
8 SGTC_3052 9092717 3.97 49.5 µM 2.19E-5 26 3.53E-5
9 SGTC_223 busulfan 3.76 5.0 mM 5.41E-5 10 8.42E-5
10 SGTC_891 0929-0073 3.76 133.0 µM 5.53E-5 29 8.59E-5
11 SGTC_3072 9116419 3.74 49.5 µM 6.02E-5 ERG2 23 9.33E-5
12 SGTC_2349 9023730 3.69 187.1 µM 7.18E-5 34 1.10E-4
13 SGTC_3250 9135583 3.68 49.5 µM 7.50E-5 14 1.15E-4
14 SGTC_2334 9017922 3.65 200.0 µM 8.48E-5 32 1.30E-4
15 SGTC_2841 9004761 3.64 39.0 µM 9.04E-5 amide catabolism 41 1.38E-4
16 SGTC_792 4534-1957 3.55 155.0 µM 1.29E-4 54 1.94E-4
17 SGTC_1108 betulinic acid 3.49 729.1 nM 1.61E-4 25 2.41E-4
18 SGTC_3316 9136639 3.44 10.6 µM 1.95E-4 24 2.88E-4
19 SGTC_2909 7941780 3.44 10.5 µM 1.97E-4 38 2.91E-4
20 SGTC_2457 5731572 3.37 11.7 µM 2.58E-4 25 3.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.234 4.37E-43 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.210 6.48E-35 YHR109W CTM1 hom Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
0.201 4.62E-32 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.191 7.56E-29 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.181 4.13E-26 YML087C AIM33 hom Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
0.158 3.07E-20 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.150 1.82E-18 YJR131W MNS1 hom Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation
0.150 2.00E-18 YKR090W PXL1 hom Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.146 1.81E-17 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.145 3.06E-17 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.141 1.77E-16 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.137 2.10E-15 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.123 7.94E-13 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.122 1.11E-12 YIL058W_d YIL058W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.121 2.25E-12 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C