YGR053C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR053C / YGR053C

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:-3.29|P-value:4.62E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-5.24|P-value:6.48E-8 ID:SGTC_166|Compound:k072-0058|FD-Score:5.16|P-value:1.03E-7 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.38|P-value:3.25E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.10|P-value:8.89E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.28|P-value:4.67E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.28|P-value:4.71E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.58|P-value:1.56E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:3.23|P-value:5.69E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.09|P-value:9.40E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.25|P-value:5.26E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.93|P-value:3.81E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:3.85|P-value:5.30E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.24|P-value:5.59E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.75|P-value:7.85E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:4.61|P-value:1.67E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.42|P-value:2.89E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.51|P-value:2.04E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-3.31|P-value:4.26E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.12|P-value:8.40E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.07|P-value:9.96E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.17|P-value:7.13E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.07|P-value:9.92E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.87|P-value:4.74E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.13|P-value:7.96E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.59|P-value:1.52E-4 ID:SGTC_2193|Compound:5925765|FD-Score:-3.07|P-value:9.82E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.10|P-value:1.78E-5 ID:SGTC_2345|Compound:9052315|FD-Score:3.30|P-value:4.42E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.45|P-value:2.52E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.30|P-value:4.49E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.21|P-value:6.14E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.58|P-value:1.94E-6 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:5.39|P-value:2.82E-8 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.17|P-value:1.35E-5 ID:SGTC_2717|Compound:st081029|FD-Score:4.00|P-value:2.84E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.15|P-value:7.57E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.92|P-value:3.64E-7 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.07|P-value:2.05E-5 ID:SGTC_3030|Compound:9087619|FD-Score:4.09|P-value:1.91E-5 ID:SGTC_3033|Compound:9090887|FD-Score:3.29|P-value:4.68E-4 ID:SGTC_3124|Compound:9127567|FD-Score:-3.61|P-value:1.39E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.52|P-value:1.99E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.49|P-value:2.19E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.92|P-value:3.95E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.29|P-value:4.62E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-5.24|P-value:6.48E-8 ID:SGTC_166|Compound:k072-0058|FD-Score:5.16|P-value:1.03E-7 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.38|P-value:3.25E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.10|P-value:8.89E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.28|P-value:4.67E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.28|P-value:4.71E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.58|P-value:1.56E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:3.23|P-value:5.69E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.09|P-value:9.40E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.25|P-value:5.26E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.93|P-value:3.81E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:3.85|P-value:5.30E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.24|P-value:5.59E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.75|P-value:7.85E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:4.61|P-value:1.67E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.42|P-value:2.89E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.51|P-value:2.04E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-3.31|P-value:4.26E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.12|P-value:8.40E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.07|P-value:9.96E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.17|P-value:7.13E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.07|P-value:9.92E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.87|P-value:4.74E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.13|P-value:7.96E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.59|P-value:1.52E-4 ID:SGTC_2193|Compound:5925765|FD-Score:-3.07|P-value:9.82E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.10|P-value:1.78E-5 ID:SGTC_2345|Compound:9052315|FD-Score:3.30|P-value:4.42E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.45|P-value:2.52E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.30|P-value:4.49E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.21|P-value:6.14E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.58|P-value:1.94E-6 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:5.39|P-value:2.82E-8 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.17|P-value:1.35E-5 ID:SGTC_2717|Compound:st081029|FD-Score:4.00|P-value:2.84E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.15|P-value:7.57E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.92|P-value:3.64E-7 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.07|P-value:2.05E-5 ID:SGTC_3030|Compound:9087619|FD-Score:4.09|P-value:1.91E-5 ID:SGTC_3033|Compound:9090887|FD-Score:3.29|P-value:4.68E-4 ID:SGTC_3124|Compound:9127567|FD-Score:-3.61|P-value:1.39E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.52|P-value:1.99E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.49|P-value:2.19E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.92|P-value:3.95E-5

Top fitness defect scores for YGR053C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2626 ethyl orsellinate 5.39 100.0 µM 2.82E-8 9 3.52E-8
2 SGTC_166 k072-0058 5.16 166.4 µM 1.03E-7 DNA intercalators 14 1.26E-7
3 SGTC_1405 3909-7894 4.61 12.0 µM 1.67E-6 60S ribosome export 5 1.97E-6
4 SGTC_2621 lithochol-11-enic acid 4.58 100.0 µM 1.94E-6 10 2.29E-6
5 SGTC_2628 lathosterol 4.17 100.0 µM 1.35E-5 26 1.54E-5
6 SGTC_2274 7947094 4.10 46.1 µM 1.78E-5 34 2.04E-5
7 SGTC_3030 9087619 4.09 49.5 µM 1.91E-5 7 2.18E-5
8 SGTC_2717 st081029 4.00 62.3 µM 2.84E-5 18 3.22E-5
9 SGTC_816 0325-0417 3.93 81.3 µM 3.81E-5 13 4.31E-5
10 SGTC_3348 9149464 3.92 3.5 µM 3.95E-5 13 4.45E-5
11 SGTC_2087 5276107 3.87 200.0 µM 4.74E-5 18 5.34E-5
12 SGTC_823 0417-1665 3.85 178.0 µM 5.30E-5 42 5.95E-5
13 SGTC_939 1165-0479 3.75 45.3 µM 7.85E-5 35 8.77E-5
14 SGTC_2185 6113692 3.59 200.0 µM 1.52E-4 ergosterol biosynthesis 25 1.68E-4
15 SGTC_673 1082-0474 3.58 110.0 µM 1.56E-4 RSC complex & mRNA processing 79 1.73E-4
16 SGTC_3185 9108267 3.52 49.5 µM 1.99E-4 60S ribosome export 33 2.19E-4
17 SGTC_3340 9146634 3.49 11.1 µM 2.19E-4 25 2.42E-4
18 SGTC_2349 9023730 3.45 187.1 µM 2.52E-4 52 2.77E-4
19 SGTC_1463 k081-0032 3.42 34.1 µM 2.89E-4 13 3.18E-4
20 SGTC_2345 9052315 3.30 157.4 µM 4.42E-4 45 4.83E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.78E-10 YDR169C-A_p YDR169C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.092 1.11E-7 YEL056W HAT2 hom Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
0.083 1.30E-6 YBL032W HEK2 hom RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K
0.081 2.66E-6 YAR027W UIP3 hom Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
0.080 3.44E-6 YBR196C-B_p YBR196C-B_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.080 3.47E-6 YHL008C_p YHL008C_p hom Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.080 3.69E-6 YIL130W ASG1 hom Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance
0.079 4.06E-6 YER047C SAP1 hom Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system
0.079 4.81E-6 YOR028C CIN5 hom Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication
0.078 6.71E-6 YOR367W SCP1 hom Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin
0.076 1.07E-5 YGR028W MSP1 hom Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase
0.072 2.82E-5 YER087C-B SBH1 hom Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p
0.071 4.02E-5 YPL198W RPL7B hom Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication
0.070 4.44E-5 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.070 5.32E-5 YMR120C ADE17 hom Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine