YGR056W / RSC1

Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR056W / RSC1

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:5.51|P-value:1.28E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:7.54|P-value:3.65E-9 ID:SGTC_121|Compound:0557-0495|FD-Score:7.19|P-value:1.81E-8 ID:SGTC_138|Compound:0850-0259|FD-Score:6.66|P-value:1.67E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:4.98|P-value:7.11E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:4.13|P-value:8.33E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.99|P-value:6.99E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:4.14|P-value:7.92E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:4.06|P-value:9.90E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:5.03|P-value:6.18E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.06|P-value:7.49E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.23|P-value:4.66E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:5.99|P-value:2.25E-6 ID:SGTC_642|Compound:0335-0876|FD-Score:4.62|P-value:2.09E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:6.97|P-value:4.66E-8 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.99|P-value:2.27E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:4.41|P-value:3.86E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:4.30|P-value:5.18E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.75|P-value:1.43E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:5.88|P-value:3.46E-6 ID:SGTC_872|Compound:0588-0139|FD-Score:4.28|P-value:5.57E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:6.34|P-value:5.93E-7 ID:SGTC_925|Compound:2064-1272|FD-Score:-4.05|P-value:7.59E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:5.11|P-value:4.77E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:11.30|P-value:2.41E-18 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.24|P-value:6.07E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:7.78|P-value:1.20E-9 ID:SGTC_1519|Compound:esterone|FD-Score:4.92|P-value:8.59E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.38|P-value:4.18E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.88|P-value:9.83E-5 ID:SGTC_1781|Compound:st038725|FD-Score:6.46|P-value:3.84E-7 ID:SGTC_1836|Compound:st055642|FD-Score:4.81|P-value:1.20E-4 ID:SGTC_1933|Compound:st074711|FD-Score:6.02|P-value:2.04E-6 ID:SGTC_2148|Compound:5546263|FD-Score:4.98|P-value:7.19E-5 ID:SGTC_2189|Compound:6047310|FD-Score:4.30|P-value:5.20E-4 ID:SGTC_2192|Compound:5915882|FD-Score:5.74|P-value:5.59E-6 ID:SGTC_2213|Compound:7173844|FD-Score:4.19|P-value:6.93E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.14|P-value:8.02E-4 ID:SGTC_2319|Compound:6033012|FD-Score:5.25|P-value:3.04E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-4.50|P-value:2.21E-4 ID:SGTC_2334|Compound:9017922|FD-Score:5.77|P-value:5.14E-6 ID:SGTC_2338|Compound:7999974|FD-Score:-5.22|P-value:2.31E-5 ID:SGTC_2367|Compound:9070478|FD-Score:5.04|P-value:5.95E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:6.03|P-value:1.95E-6 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:6.00|P-value:2.22E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:5.18|P-value:3.81E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:5.25|P-value:3.02E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:8.70|P-value:1.21E-11 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-4.19|P-value:5.19E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.26|P-value:5.74E-4 ID:SGTC_3016|Compound:9080866|FD-Score:5.15|P-value:4.18E-5 ID:SGTC_3025|Compound:9087895|FD-Score:4.60|P-value:2.24E-4 ID:SGTC_3074|Compound:9116018|FD-Score:9.52|P-value:1.36E-13 ID:SGTC_3114|Compound:9122766|FD-Score:4.81|P-value:1.19E-4 ID:SGTC_3118|Compound:9124250|FD-Score:5.02|P-value:6.26E-5 ID:SGTC_3120|Compound:9124077|FD-Score:5.81|P-value:4.44E-6 ID:SGTC_3167|Compound:9103034|FD-Score:4.66|P-value:1.86E-4 ID:SGTC_3285|Compound:9112818|FD-Score:9.43|P-value:2.20E-13 ID:SGTC_3311|Compound:9131146|FD-Score:11.40|P-value:9.75E-19 ID:SGTC_3321|Compound:9137793|FD-Score:6.16|P-value:1.21E-6 ID:SGTC_3322|Compound:9139058|FD-Score:10.10|P-value:3.47E-15 ID:SGTC_3331|Compound:9141060|FD-Score:5.31|P-value:2.47E-5 ID:SGTC_3350|Compound:9150499|FD-Score:8.73|P-value:1.02E-11 ID:SGTC_3351|Compound:9150312|FD-Score:4.59|P-value:2.33E-4 ID:SGTC_3356|Compound:9151811|FD-Score:6.79|P-value:9.86E-8 ID:SGTC_54|Compound:0159-0055|FD-Score:5.51|P-value:1.28E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:7.54|P-value:3.65E-9 ID:SGTC_121|Compound:0557-0495|FD-Score:7.19|P-value:1.81E-8 ID:SGTC_138|Compound:0850-0259|FD-Score:6.66|P-value:1.67E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:4.98|P-value:7.11E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:4.13|P-value:8.33E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.99|P-value:6.99E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:4.14|P-value:7.92E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:4.06|P-value:9.90E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:5.03|P-value:6.18E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.06|P-value:7.49E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.23|P-value:4.66E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:5.99|P-value:2.25E-6 ID:SGTC_642|Compound:0335-0876|FD-Score:4.62|P-value:2.09E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:6.97|P-value:4.66E-8 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.99|P-value:2.27E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:4.41|P-value:3.86E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:4.30|P-value:5.18E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.75|P-value:1.43E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:5.88|P-value:3.46E-6 ID:SGTC_872|Compound:0588-0139|FD-Score:4.28|P-value:5.57E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:6.34|P-value:5.93E-7 ID:SGTC_925|Compound:2064-1272|FD-Score:-4.05|P-value:7.59E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:5.11|P-value:4.77E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:11.30|P-value:2.41E-18 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.24|P-value:6.07E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:7.78|P-value:1.20E-9 ID:SGTC_1519|Compound:esterone|FD-Score:4.92|P-value:8.59E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.38|P-value:4.18E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.88|P-value:9.83E-5 ID:SGTC_1781|Compound:st038725|FD-Score:6.46|P-value:3.84E-7 ID:SGTC_1836|Compound:st055642|FD-Score:4.81|P-value:1.20E-4 ID:SGTC_1933|Compound:st074711|FD-Score:6.02|P-value:2.04E-6 ID:SGTC_2148|Compound:5546263|FD-Score:4.98|P-value:7.19E-5 ID:SGTC_2189|Compound:6047310|FD-Score:4.30|P-value:5.20E-4 ID:SGTC_2192|Compound:5915882|FD-Score:5.74|P-value:5.59E-6 ID:SGTC_2213|Compound:7173844|FD-Score:4.19|P-value:6.93E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.14|P-value:8.02E-4 ID:SGTC_2319|Compound:6033012|FD-Score:5.25|P-value:3.04E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-4.50|P-value:2.21E-4 ID:SGTC_2334|Compound:9017922|FD-Score:5.77|P-value:5.14E-6 ID:SGTC_2338|Compound:7999974|FD-Score:-5.22|P-value:2.31E-5 ID:SGTC_2367|Compound:9070478|FD-Score:5.04|P-value:5.95E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:6.03|P-value:1.95E-6 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:6.00|P-value:2.22E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:5.18|P-value:3.81E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:5.25|P-value:3.02E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:8.70|P-value:1.21E-11 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-4.19|P-value:5.19E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.26|P-value:5.74E-4 ID:SGTC_3016|Compound:9080866|FD-Score:5.15|P-value:4.18E-5 ID:SGTC_3025|Compound:9087895|FD-Score:4.60|P-value:2.24E-4 ID:SGTC_3074|Compound:9116018|FD-Score:9.52|P-value:1.36E-13 ID:SGTC_3114|Compound:9122766|FD-Score:4.81|P-value:1.19E-4 ID:SGTC_3118|Compound:9124250|FD-Score:5.02|P-value:6.26E-5 ID:SGTC_3120|Compound:9124077|FD-Score:5.81|P-value:4.44E-6 ID:SGTC_3167|Compound:9103034|FD-Score:4.66|P-value:1.86E-4 ID:SGTC_3285|Compound:9112818|FD-Score:9.43|P-value:2.20E-13 ID:SGTC_3311|Compound:9131146|FD-Score:11.40|P-value:9.75E-19 ID:SGTC_3321|Compound:9137793|FD-Score:6.16|P-value:1.21E-6 ID:SGTC_3322|Compound:9139058|FD-Score:10.10|P-value:3.47E-15 ID:SGTC_3331|Compound:9141060|FD-Score:5.31|P-value:2.47E-5 ID:SGTC_3350|Compound:9150499|FD-Score:8.73|P-value:1.02E-11 ID:SGTC_3351|Compound:9150312|FD-Score:4.59|P-value:2.33E-4 ID:SGTC_3356|Compound:9151811|FD-Score:6.79|P-value:9.86E-8

Top fitness defect scores for YGR056W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3311 9131146 11.40 2.9 µM 9.75E-19 cell wall 12 2.14E-30
2 SGTC_951 1171-0579 11.30 82.7 µM 2.41E-18 cell wall 7 9.71E-30
3 SGTC_3322 9139058 10.10 2.1 µM 3.47E-15 cell wall 2 1.91E-24
4 SGTC_3074 9116018 9.52 49.5 µM 1.36E-13 RNA processing & uracil transport 2 8.91E-22
5 SGTC_3285 9112818 9.43 20.9 µM 2.20E-13 cell wall 2 2.00E-21
6 SGTC_3350 9150499 8.73 3.6 µM 1.02E-11 cell wall 5 1.23E-18
7 SGTC_2619 obliquin 8.70 87.9 µM 1.21E-11 cell wall 35 1.64E-18
8 SGTC_1247 0448-0043 7.78 5.8 µM 1.20E-9 ERG2 2 3.56E-15
9 SGTC_58 0957-0393 7.54 9.0 µM 3.65E-9 cell wall 142 2.28E-14
10 SGTC_121 0557-0495 7.19 61.3 µM 1.81E-8 calcium & mitochondrial duress 11 3.30E-13
11 SGTC_666 0272-0154 6.97 136.0 µM 4.66E-8 cell wall 14 1.60E-12
12 SGTC_3356 9151811 6.79 4.5 µM 9.86E-8 cell wall 5 5.59E-12
13 SGTC_138 0850-0259 6.66 40.9 µM 1.67E-7 cell wall 85 1.35E-11
14 SGTC_1781 st038725 6.46 66.3 µM 3.84E-7 NEO1 50 5.39E-11
15 SGTC_923 1900-2434 6.34 73.3 µM 5.93E-7 RNA processing & uracil transport 8 1.11E-10
16 SGTC_3321 9137793 6.16 26.8 µM 1.21E-6 cell wall 28 3.63E-10
17 SGTC_2489 cantharidin 6.03 73.4 µM 1.95E-6 cell wall signaling 10 8.07E-10
18 SGTC_1933 st074711 6.02 15.9 µM 2.04E-6 12 8.74E-10
19 SGTC_2500 5-alpha-androstan-3,17-dione 6.00 61.4 µM 2.22E-6 12 1.00E-9
20 SGTC_620 0109-0052 5.99 432.0 µM 2.25E-6 3 1.03E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.468 6.27E-182 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.422 3.91E-145 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.316 7.48E-79 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
0.312 2.65E-76 YDR293C SSD1 hom Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function
0.305 2.67E-73 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.292 7.16E-67 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.282 1.54E-62 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.282 2.06E-62 YOR258W HNT3 hom DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress
0.280 2.29E-61 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.278 1.26E-60 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.273 1.89E-58 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.271 1.22E-57 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.262 7.13E-54 YKL114C APN1 hom Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
0.262 1.05E-53 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.260 9.32E-53 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly