YGR057C / LST7

Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR057C / LST7

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:4.69|P-value:3.90E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.77|P-value:7.86E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:6.11|P-value:1.16E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:4.26|P-value:1.72E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:6.71|P-value:6.61E-9 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.06|P-value:1.78E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:7.66|P-value:3.98E-11 ID:SGTC_200|Compound:k038-0079|FD-Score:4.97|P-value:1.41E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:4.06|P-value:3.29E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.81|P-value:7.09E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.67|P-value:8.28E-7 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.87|P-value:9.86E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:3.82|P-value:6.82E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.27|P-value:4.30E-16 ID:SGTC_313|Compound:3474-0040|FD-Score:4.04|P-value:3.45E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-4.19|P-value:1.17E-4 ID:SGTC_401|Compound:neomycin|FD-Score:4.34|P-value:1.32E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-4.18|P-value:1.21E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-4.24|P-value:9.60E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:5.31|P-value:3.73E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:4.08|P-value:3.05E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:4.80|P-value:2.62E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:-4.60|P-value:2.70E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.92|P-value:5.01E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:9.60|P-value:1.54E-16 ID:SGTC_712|Compound:r015-0009|FD-Score:4.35|P-value:1.26E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.73|P-value:5.02E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:5.52|P-value:1.55E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.88|P-value:3.13E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:6.06|P-value:1.44E-7 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.91|P-value:2.92E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.14|P-value:2.55E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:4.11|P-value:2.77E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.63|P-value:6.88E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.84|P-value:6.40E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.74|P-value:8.74E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.85|P-value:6.26E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.14|P-value:2.55E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.78|P-value:7.72E-4 ID:SGTC_1712|Compound:st032288|FD-Score:10.60|P-value:8.97E-20 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.64|P-value:6.57E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.84|P-value:3.61E-4 ID:SGTC_1754|Compound:st042065|FD-Score:6.31|P-value:4.66E-8 ID:SGTC_1781|Compound:st038725|FD-Score:4.02|P-value:3.72E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.80|P-value:2.59E-5 ID:SGTC_2005|Compound:4024620|FD-Score:-4.72|P-value:1.77E-5 ID:SGTC_2055|Compound:5235184|FD-Score:4.48|P-value:8.24E-5 ID:SGTC_2183|Compound:6420625|FD-Score:8.54|P-value:1.93E-13 ID:SGTC_2184|Compound:6075246|FD-Score:3.85|P-value:6.27E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.86|P-value:6.12E-4 ID:SGTC_2302|Compound:7771753|FD-Score:6.11|P-value:1.17E-7 ID:SGTC_2333|Compound:9017922|FD-Score:-3.58|P-value:7.85E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.34|P-value:1.31E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.77|P-value:7.97E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.31|P-value:2.82E-10 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.47|P-value:8.43E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:-4.21|P-value:1.07E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.47|P-value:1.88E-6 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:3.80|P-value:7.17E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.17|P-value:2.31E-4 ID:SGTC_2811|Compound:7967822|FD-Score:5.18|P-value:6.18E-6 ID:SGTC_2818|Compound:7996756|FD-Score:4.30|P-value:1.48E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-6.07|P-value:5.83E-8 ID:SGTC_2912|Compound:7964298|FD-Score:7.11|P-value:8.09E-10 ID:SGTC_2933|Compound:9026794|FD-Score:4.02|P-value:3.67E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.12|P-value:2.65E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.75|P-value:4.81E-4 ID:SGTC_3195|Compound:9113082|FD-Score:6.19|P-value:8.03E-8 ID:SGTC_3201|Compound:9113999|FD-Score:-3.86|P-value:3.37E-4 ID:SGTC_3205|Compound:9113483|FD-Score:4.06|P-value:3.29E-4 ID:SGTC_3311|Compound:9131146|FD-Score:5.71|P-value:6.79E-7 ID:SGTC_3319|Compound:9138450|FD-Score:3.98|P-value:4.16E-4 ID:SGTC_3321|Compound:9137793|FD-Score:7.17|P-value:6.05E-10 ID:SGTC_7|Compound:0192-1582|FD-Score:4.69|P-value:3.90E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.77|P-value:7.86E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:6.11|P-value:1.16E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:4.26|P-value:1.72E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:6.71|P-value:6.61E-9 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.06|P-value:1.78E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:7.66|P-value:3.98E-11 ID:SGTC_200|Compound:k038-0079|FD-Score:4.97|P-value:1.41E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:4.06|P-value:3.29E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.81|P-value:7.09E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.67|P-value:8.28E-7 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.87|P-value:9.86E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:3.82|P-value:6.82E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.27|P-value:4.30E-16 ID:SGTC_313|Compound:3474-0040|FD-Score:4.04|P-value:3.45E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-4.19|P-value:1.17E-4 ID:SGTC_401|Compound:neomycin|FD-Score:4.34|P-value:1.32E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-4.18|P-value:1.21E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-4.24|P-value:9.60E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:5.31|P-value:3.73E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:4.08|P-value:3.05E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:4.80|P-value:2.62E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:-4.60|P-value:2.70E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.92|P-value:5.01E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:9.60|P-value:1.54E-16 ID:SGTC_712|Compound:r015-0009|FD-Score:4.35|P-value:1.26E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.73|P-value:5.02E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:5.52|P-value:1.55E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.88|P-value:3.13E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:6.06|P-value:1.44E-7 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.91|P-value:2.92E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.14|P-value:2.55E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:4.11|P-value:2.77E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.63|P-value:6.88E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.84|P-value:6.40E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.74|P-value:8.74E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.85|P-value:6.26E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.14|P-value:2.55E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.78|P-value:7.72E-4 ID:SGTC_1712|Compound:st032288|FD-Score:10.60|P-value:8.97E-20 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.64|P-value:6.57E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.84|P-value:3.61E-4 ID:SGTC_1754|Compound:st042065|FD-Score:6.31|P-value:4.66E-8 ID:SGTC_1781|Compound:st038725|FD-Score:4.02|P-value:3.72E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.80|P-value:2.59E-5 ID:SGTC_2005|Compound:4024620|FD-Score:-4.72|P-value:1.77E-5 ID:SGTC_2055|Compound:5235184|FD-Score:4.48|P-value:8.24E-5 ID:SGTC_2183|Compound:6420625|FD-Score:8.54|P-value:1.93E-13 ID:SGTC_2184|Compound:6075246|FD-Score:3.85|P-value:6.27E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.86|P-value:6.12E-4 ID:SGTC_2302|Compound:7771753|FD-Score:6.11|P-value:1.17E-7 ID:SGTC_2333|Compound:9017922|FD-Score:-3.58|P-value:7.85E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.34|P-value:1.31E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.77|P-value:7.97E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.31|P-value:2.82E-10 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.47|P-value:8.43E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:-4.21|P-value:1.07E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.47|P-value:1.88E-6 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:3.80|P-value:7.17E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.17|P-value:2.31E-4 ID:SGTC_2811|Compound:7967822|FD-Score:5.18|P-value:6.18E-6 ID:SGTC_2818|Compound:7996756|FD-Score:4.30|P-value:1.48E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-6.07|P-value:5.83E-8 ID:SGTC_2912|Compound:7964298|FD-Score:7.11|P-value:8.09E-10 ID:SGTC_2933|Compound:9026794|FD-Score:4.02|P-value:3.67E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.12|P-value:2.65E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.75|P-value:4.81E-4 ID:SGTC_3195|Compound:9113082|FD-Score:6.19|P-value:8.03E-8 ID:SGTC_3201|Compound:9113999|FD-Score:-3.86|P-value:3.37E-4 ID:SGTC_3205|Compound:9113483|FD-Score:4.06|P-value:3.29E-4 ID:SGTC_3311|Compound:9131146|FD-Score:5.71|P-value:6.79E-7 ID:SGTC_3319|Compound:9138450|FD-Score:3.98|P-value:4.16E-4 ID:SGTC_3321|Compound:9137793|FD-Score:7.17|P-value:6.05E-10

Top fitness defect scores for YGR057C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1712 st032288 10.60 53.4 µM 8.97E-20 calcium & mitochondrial duress 21 1.59E-26
2 SGTC_690 glyoxal 9.60 20.3 µM 1.54E-16 18 4.04E-22
3 SGTC_2183 6420625 8.54 130.5 µM 1.93E-13 mitochondrial processes 5 6.67E-18
4 SGTC_138 0850-0259 7.66 40.9 µM 3.98E-11 cell wall 67 9.47E-15
5 SGTC_2582 agaric acid 7.31 100.0 µM 2.82E-10 redox potentiating 118 1.37E-13
6 SGTC_3321 9137793 7.17 26.8 µM 6.05E-10 cell wall 20 3.85E-13
7 SGTC_2912 7964298 7.11 10.9 µM 8.09E-10 cell wall 32 5.73E-13
8 SGTC_87 0100-0052 6.71 35.5 µM 6.61E-9 21 1.00E-11
9 SGTC_1754 st042065 6.31 16.1 µM 4.66E-8 NEO1-PIK1 89 1.43E-10
10 SGTC_3195 9113082 6.19 49.5 µM 8.03E-8 3 3.01E-10
11 SGTC_59 0330-0160 6.11 1.3 µM 1.16E-7 37 4.95E-10
12 SGTC_2302 7771753 6.11 200.0 µM 1.17E-7 12 5.03E-10
13 SGTC_864 0469-0573 6.06 172.0 µM 1.44E-7 3 6.63E-10
14 SGTC_3311 9131146 5.71 2.9 µM 6.79E-7 cell wall 64 5.50E-9
15 SGTC_221 trifluoperazine 5.67 10.3 µM 8.28E-7 NEO1-PIK1 133 7.22E-9
16 SGTC_747 3448-8087 5.52 38.7 µM 1.55E-6 5 1.69E-8
17 SGTC_2688 kanamycin b 5.47 96.7 µM 1.88E-6 calcium & mitochondrial duress 197 2.20E-8
18 SGTC_574 1315-0397 5.31 40.0 µM 3.73E-6 9 5.60E-8
19 SGTC_2811 7967822 5.18 32.5 µM 6.18E-6 7 1.11E-7
20 SGTC_200 k038-0079 4.97 37.5 µM 1.41E-5 ubiquinone biosynthesis & proteasome 39 3.43E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.365 3.18E-106 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.253 4.57E-50 YGL100W SEH1 hom Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1
0.238 1.96E-44 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.210 1.27E-34 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.204 7.82E-33 YNL070W TOM7 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.202 2.65E-32 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.202 3.80E-32 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.199 2.26E-31 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.199 2.92E-31 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.196 1.85E-30 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.193 1.27E-29 YNL079C TPM1 hom Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication
0.191 7.41E-29 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.190 1.30E-28 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.187 7.50E-28 YGR106C VOA1 hom Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval
0.186 1.76E-27 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication