YGR062C / COX18

Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR062C / COX18

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:6.41|P-value:1.32E-10 ID:SGTC_59|Compound:0330-0160|FD-Score:5.72|P-value:8.65E-9 ID:SGTC_108|Compound:0509-0257|FD-Score:3.50|P-value:2.73E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:13.20|P-value:5.81E-39 ID:SGTC_168|Compound:3970-0862|FD-Score:5.97|P-value:2.01E-9 ID:SGTC_183|Compound:3914-0051|FD-Score:3.79|P-value:9.03E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.44|P-value:3.42E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.08|P-value:2.00E-19 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.48|P-value:4.87E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:6.86|P-value:6.95E-12 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.65|P-value:1.77E-4 ID:SGTC_462|Compound:ag-879|FD-Score:4.01|P-value:3.83E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.41|P-value:4.25E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.37|P-value:4.87E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.91|P-value:5.74E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:6.34|P-value:2.08E-10 ID:SGTC_651|Compound:3253-0966|FD-Score:6.32|P-value:2.35E-10 ID:SGTC_675|Compound:1309-0189|FD-Score:4.58|P-value:3.19E-6 ID:SGTC_685|Compound:1278-0033|FD-Score:3.17|P-value:8.55E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.31|P-value:5.39E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.32|P-value:5.16E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:-3.55|P-value:2.59E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.27|P-value:6.22E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-3.56|P-value:2.49E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.65|P-value:2.22E-6 ID:SGTC_1408|Compound:3909-7976|FD-Score:4.17|P-value:1.94E-5 ID:SGTC_1635|Compound:st007035|FD-Score:7.37|P-value:2.01E-13 ID:SGTC_1768|Compound:st044301|FD-Score:3.47|P-value:3.03E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-3.20|P-value:8.80E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.41|P-value:3.80E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.88|P-value:6.32E-5 ID:SGTC_1969|Compound:st069479|FD-Score:4.44|P-value:6.03E-6 ID:SGTC_1989|Compound:st071868|FD-Score:5.07|P-value:2.92E-7 ID:SGTC_2028|Compound:5153890|FD-Score:3.24|P-value:6.94E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.45|P-value:3.28E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.22|P-value:7.32E-4 ID:SGTC_2118|Compound:5526350|FD-Score:-5.66|P-value:1.47E-8 ID:SGTC_2123|Compound:5259487|FD-Score:5.81|P-value:5.27E-9 ID:SGTC_2177|Compound:5811945|FD-Score:4.28|P-value:1.21E-5 ID:SGTC_2254|Compound:7938975|FD-Score:-3.41|P-value:4.28E-4 ID:SGTC_2288|Compound:7946289|FD-Score:5.51|P-value:2.86E-8 ID:SGTC_2296|Compound:7971656|FD-Score:4.15|P-value:2.13E-5 ID:SGTC_2308|Compound:7584454|FD-Score:4.03|P-value:3.50E-5 ID:SGTC_2314|Compound:7727897|FD-Score:3.13|P-value:9.88E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.54|P-value:2.69E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.86|P-value:6.89E-5 ID:SGTC_2395|Compound:5646831|FD-Score:5.61|P-value:1.57E-8 ID:SGTC_2397|Compound:5161689|FD-Score:4.00|P-value:3.87E-5 ID:SGTC_2421|Compound:5690543|FD-Score:5.86|P-value:3.79E-9 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.57|P-value:2.13E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.86|P-value:7.06E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.37|P-value:4.37E-4 ID:SGTC_2696|Compound:st077691|FD-Score:-4.65|P-value:2.64E-6 ID:SGTC_2718|Compound:lomofungin|FD-Score:-3.26|P-value:7.10E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.15|P-value:9.21E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.58|P-value:2.06E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.20|P-value:7.80E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.23|P-value:8.00E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.61|P-value:2.11E-4 ID:SGTC_2916|Compound:7875993|FD-Score:-3.86|P-value:8.04E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.74|P-value:1.11E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.61|P-value:1.80E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.16|P-value:8.89E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:6.41|P-value:1.32E-10 ID:SGTC_59|Compound:0330-0160|FD-Score:5.72|P-value:8.65E-9 ID:SGTC_108|Compound:0509-0257|FD-Score:3.50|P-value:2.73E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:13.20|P-value:5.81E-39 ID:SGTC_168|Compound:3970-0862|FD-Score:5.97|P-value:2.01E-9 ID:SGTC_183|Compound:3914-0051|FD-Score:3.79|P-value:9.03E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.44|P-value:3.42E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.08|P-value:2.00E-19 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.48|P-value:4.87E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:6.86|P-value:6.95E-12 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.65|P-value:1.77E-4 ID:SGTC_462|Compound:ag-879|FD-Score:4.01|P-value:3.83E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.41|P-value:4.25E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.37|P-value:4.87E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.91|P-value:5.74E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:6.34|P-value:2.08E-10 ID:SGTC_651|Compound:3253-0966|FD-Score:6.32|P-value:2.35E-10 ID:SGTC_675|Compound:1309-0189|FD-Score:4.58|P-value:3.19E-6 ID:SGTC_685|Compound:1278-0033|FD-Score:3.17|P-value:8.55E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.31|P-value:5.39E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.32|P-value:5.16E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:-3.55|P-value:2.59E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.27|P-value:6.22E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-3.56|P-value:2.49E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.65|P-value:2.22E-6 ID:SGTC_1408|Compound:3909-7976|FD-Score:4.17|P-value:1.94E-5 ID:SGTC_1635|Compound:st007035|FD-Score:7.37|P-value:2.01E-13 ID:SGTC_1768|Compound:st044301|FD-Score:3.47|P-value:3.03E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-3.20|P-value:8.80E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.41|P-value:3.80E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.88|P-value:6.32E-5 ID:SGTC_1969|Compound:st069479|FD-Score:4.44|P-value:6.03E-6 ID:SGTC_1989|Compound:st071868|FD-Score:5.07|P-value:2.92E-7 ID:SGTC_2028|Compound:5153890|FD-Score:3.24|P-value:6.94E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.45|P-value:3.28E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.22|P-value:7.32E-4 ID:SGTC_2118|Compound:5526350|FD-Score:-5.66|P-value:1.47E-8 ID:SGTC_2123|Compound:5259487|FD-Score:5.81|P-value:5.27E-9 ID:SGTC_2177|Compound:5811945|FD-Score:4.28|P-value:1.21E-5 ID:SGTC_2254|Compound:7938975|FD-Score:-3.41|P-value:4.28E-4 ID:SGTC_2288|Compound:7946289|FD-Score:5.51|P-value:2.86E-8 ID:SGTC_2296|Compound:7971656|FD-Score:4.15|P-value:2.13E-5 ID:SGTC_2308|Compound:7584454|FD-Score:4.03|P-value:3.50E-5 ID:SGTC_2314|Compound:7727897|FD-Score:3.13|P-value:9.88E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.54|P-value:2.69E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.86|P-value:6.89E-5 ID:SGTC_2395|Compound:5646831|FD-Score:5.61|P-value:1.57E-8 ID:SGTC_2397|Compound:5161689|FD-Score:4.00|P-value:3.87E-5 ID:SGTC_2421|Compound:5690543|FD-Score:5.86|P-value:3.79E-9 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.57|P-value:2.13E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.86|P-value:7.06E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.37|P-value:4.37E-4 ID:SGTC_2696|Compound:st077691|FD-Score:-4.65|P-value:2.64E-6 ID:SGTC_2718|Compound:lomofungin|FD-Score:-3.26|P-value:7.10E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.15|P-value:9.21E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.58|P-value:2.06E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.20|P-value:7.80E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.23|P-value:8.00E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.61|P-value:2.11E-4 ID:SGTC_2916|Compound:7875993|FD-Score:-3.86|P-value:8.04E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.74|P-value:1.11E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.61|P-value:1.80E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.16|P-value:8.89E-4

Top fitness defect scores for YGR062C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_134 0269-0018 13.20 6.9 µM 5.81E-39 27 3.46E-40
2 SGTC_236 1509-0011 9.08 5.3 µM 2.00E-19 216 5.51E-20
3 SGTC_1635 st007035 7.37 42.4 µM 2.01E-13 108 8.74E-14
4 SGTC_386 1509-0011 6.86 3.1 µM 6.95E-12 80 3.40E-12
5 SGTC_52 0329-0193 6.41 875.0 nM 1.32E-10 TSC3-RPN4 9 7.08E-11
6 SGTC_529 4076-0302 6.34 30.3 µM 2.08E-10 mitochondrial processes 2 1.13E-10
7 SGTC_651 3253-0966 6.32 34.4 µM 2.35E-10 calcium & mitochondrial duress 6 1.29E-10
8 SGTC_168 3970-0862 5.97 530.5 µM 2.01E-9 43 1.18E-9
9 SGTC_2421 5690543 5.86 90.7 µM 3.79E-9 4 2.27E-9
10 SGTC_2123 5259487 5.81 200.0 µM 5.27E-9 2 3.20E-9
11 SGTC_59 0330-0160 5.72 1.3 µM 8.65E-9 42 5.33E-9
12 SGTC_2395 5646831 5.61 180.2 µM 1.57E-8 9 9.85E-9
13 SGTC_2288 7946289 5.51 167.3 µM 2.86E-8 8 1.83E-8
14 SGTC_1989 st071868 5.07 50.2 µM 2.92E-7 3 2.01E-7
15 SGTC_1341 1486-1360 4.65 280.0 µM 2.22E-6 9 1.63E-6
16 SGTC_675 1309-0189 4.58 238.0 µM 3.19E-6 8 2.37E-6
17 SGTC_275 trichlorophene 4.48 5.7 µM 4.87E-6 mitochondrial stress 201 3.66E-6
18 SGTC_1969 st069479 4.44 40.1 µM 6.03E-6 6 4.56E-6
19 SGTC_2177 5811945 4.28 192.0 µM 1.21E-5 21 9.39E-6
20 SGTC_1408 3909-7976 4.17 48.8 µM 1.94E-5 Golgi 17 1.52E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.465 4.86E-180 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.439 5.89E-158 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.438 1.04E-157 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.430 4.13E-151 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.412 1.54E-137 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.404 1.19E-131 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.399 5.60E-128 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.396 1.11E-126 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.387 5.22E-120 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.380 1.60E-115 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.379 2.67E-115 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.376 7.87E-113 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.374 4.79E-112 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.374 8.32E-112 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.372 2.08E-110 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs