YGR064W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR064W / YGR064W

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:4.45|P-value:2.35E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:4.34|P-value:3.26E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:6.44|P-value:1.50E-7 ID:SGTC_49|Compound:0717-0965|FD-Score:4.03|P-value:8.00E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.08|P-value:6.82E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:6.74|P-value:3.91E-8 ID:SGTC_127|Compound:0180-0333|FD-Score:6.72|P-value:4.42E-8 ID:SGTC_129|Compound:0088-0017|FD-Score:6.86|P-value:2.33E-8 ID:SGTC_134|Compound:0269-0018|FD-Score:6.44|P-value:1.46E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:5.08|P-value:2.96E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:4.16|P-value:5.49E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-4.35|P-value:1.17E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:-4.57|P-value:5.57E-5 ID:SGTC_263|Compound:alizarin|FD-Score:-4.14|P-value:2.25E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:-4.67|P-value:3.98E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-5.33|P-value:3.67E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.74|P-value:3.15E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:5.31|P-value:1.32E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.66|P-value:3.63E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.74|P-value:7.19E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.07|P-value:7.10E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:9.59|P-value:7.26E-15 ID:SGTC_562|Compound:3772-2733|FD-Score:10.30|P-value:4.94E-17 ID:SGTC_614|Compound:0462-0418|FD-Score:4.69|P-value:1.08E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:4.14|P-value:5.78E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.29|P-value:3.79E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.27|P-value:4.04E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:6.54|P-value:9.47E-8 ID:SGTC_848|Compound:0368-0089|FD-Score:-3.78|P-value:6.57E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:4.47|P-value:2.20E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.07|P-value:2.78E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.77|P-value:3.39E-8 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.48|P-value:2.13E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:4.05|P-value:7.62E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.84|P-value:5.53E-4 ID:SGTC_1604|Compound:st002052|FD-Score:4.66|P-value:1.22E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.85|P-value:6.48E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-4.04|P-value:3.08E-4 ID:SGTC_1909|Compound:st060837|FD-Score:4.71|P-value:1.03E-4 ID:SGTC_1934|Compound:st074720|FD-Score:7.62|P-value:5.68E-10 ID:SGTC_1947|Compound:st076332|FD-Score:4.57|P-value:1.59E-4 ID:SGTC_2175|Compound:5807670|FD-Score:4.20|P-value:4.96E-4 ID:SGTC_2181|Compound:6316240|FD-Score:4.14|P-value:5.91E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-4.34|P-value:1.20E-4 ID:SGTC_2296|Compound:7971656|FD-Score:6.72|P-value:4.25E-8 ID:SGTC_2300|Compound:7976697|FD-Score:-4.89|P-value:1.88E-5 ID:SGTC_2413|Compound:inermin|FD-Score:9.42|P-value:2.07E-14 ID:SGTC_2417|Compound:cerulenin|FD-Score:8.77|P-value:1.09E-12 ID:SGTC_2594|Compound:a-mangostin|FD-Score:5.23|P-value:1.78E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:6.48|P-value:1.24E-7 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.17|P-value:5.28E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.47|P-value:2.20E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:5.62|P-value:4.26E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.00|P-value:9.47E-7 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-4.67|P-value:4.05E-5 ID:SGTC_2810|Compound:7959871|FD-Score:5.30|P-value:1.36E-5 ID:SGTC_2813|Compound:7971799|FD-Score:-5.58|P-value:1.41E-6 ID:SGTC_2814|Compound:7977482|FD-Score:5.42|P-value:8.87E-6 ID:SGTC_2878|Compound:9043973|FD-Score:4.31|P-value:3.51E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.11|P-value:6.37E-4 ID:SGTC_2932|Compound:9016711|FD-Score:5.70|P-value:3.05E-6 ID:SGTC_2964|Compound:9083345|FD-Score:4.39|P-value:2.77E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.05|P-value:7.54E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.80|P-value:7.72E-5 ID:SGTC_3008|Compound:9078912|FD-Score:4.10|P-value:6.47E-4 ID:SGTC_3011|Compound:9081274|FD-Score:5.05|P-value:3.29E-5 ID:SGTC_3016|Compound:9080866|FD-Score:4.36|P-value:3.03E-4 ID:SGTC_3137|Compound:9097352|FD-Score:5.58|P-value:4.83E-6 ID:SGTC_3264|Compound:9137442|FD-Score:-3.65|P-value:9.25E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-7.23|P-value:8.16E-10 ID:SGTC_3281|Compound:9140613|FD-Score:4.68|P-value:1.13E-4 ID:SGTC_3338|Compound:9144300|FD-Score:4.49|P-value:2.06E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:4.45|P-value:2.35E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:4.34|P-value:3.26E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:6.44|P-value:1.50E-7 ID:SGTC_49|Compound:0717-0965|FD-Score:4.03|P-value:8.00E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.08|P-value:6.82E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:6.74|P-value:3.91E-8 ID:SGTC_127|Compound:0180-0333|FD-Score:6.72|P-value:4.42E-8 ID:SGTC_129|Compound:0088-0017|FD-Score:6.86|P-value:2.33E-8 ID:SGTC_134|Compound:0269-0018|FD-Score:6.44|P-value:1.46E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:5.08|P-value:2.96E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:4.16|P-value:5.49E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-4.35|P-value:1.17E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:-4.57|P-value:5.57E-5 ID:SGTC_263|Compound:alizarin|FD-Score:-4.14|P-value:2.25E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:-4.67|P-value:3.98E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-5.33|P-value:3.67E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.74|P-value:3.15E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:5.31|P-value:1.32E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.66|P-value:3.63E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.74|P-value:7.19E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.07|P-value:7.10E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:9.59|P-value:7.26E-15 ID:SGTC_562|Compound:3772-2733|FD-Score:10.30|P-value:4.94E-17 ID:SGTC_614|Compound:0462-0418|FD-Score:4.69|P-value:1.08E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:4.14|P-value:5.78E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.29|P-value:3.79E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.27|P-value:4.04E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:6.54|P-value:9.47E-8 ID:SGTC_848|Compound:0368-0089|FD-Score:-3.78|P-value:6.57E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:4.47|P-value:2.20E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.07|P-value:2.78E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.77|P-value:3.39E-8 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.48|P-value:2.13E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:4.05|P-value:7.62E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.84|P-value:5.53E-4 ID:SGTC_1604|Compound:st002052|FD-Score:4.66|P-value:1.22E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.85|P-value:6.48E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-4.04|P-value:3.08E-4 ID:SGTC_1909|Compound:st060837|FD-Score:4.71|P-value:1.03E-4 ID:SGTC_1934|Compound:st074720|FD-Score:7.62|P-value:5.68E-10 ID:SGTC_1947|Compound:st076332|FD-Score:4.57|P-value:1.59E-4 ID:SGTC_2175|Compound:5807670|FD-Score:4.20|P-value:4.96E-4 ID:SGTC_2181|Compound:6316240|FD-Score:4.14|P-value:5.91E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-4.34|P-value:1.20E-4 ID:SGTC_2296|Compound:7971656|FD-Score:6.72|P-value:4.25E-8 ID:SGTC_2300|Compound:7976697|FD-Score:-4.89|P-value:1.88E-5 ID:SGTC_2413|Compound:inermin|FD-Score:9.42|P-value:2.07E-14 ID:SGTC_2417|Compound:cerulenin|FD-Score:8.77|P-value:1.09E-12 ID:SGTC_2594|Compound:a-mangostin|FD-Score:5.23|P-value:1.78E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:6.48|P-value:1.24E-7 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.17|P-value:5.28E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.47|P-value:2.20E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:5.62|P-value:4.26E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.00|P-value:9.47E-7 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-4.67|P-value:4.05E-5 ID:SGTC_2810|Compound:7959871|FD-Score:5.30|P-value:1.36E-5 ID:SGTC_2813|Compound:7971799|FD-Score:-5.58|P-value:1.41E-6 ID:SGTC_2814|Compound:7977482|FD-Score:5.42|P-value:8.87E-6 ID:SGTC_2878|Compound:9043973|FD-Score:4.31|P-value:3.51E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.11|P-value:6.37E-4 ID:SGTC_2932|Compound:9016711|FD-Score:5.70|P-value:3.05E-6 ID:SGTC_2964|Compound:9083345|FD-Score:4.39|P-value:2.77E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.05|P-value:7.54E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.80|P-value:7.72E-5 ID:SGTC_3008|Compound:9078912|FD-Score:4.10|P-value:6.47E-4 ID:SGTC_3011|Compound:9081274|FD-Score:5.05|P-value:3.29E-5 ID:SGTC_3016|Compound:9080866|FD-Score:4.36|P-value:3.03E-4 ID:SGTC_3137|Compound:9097352|FD-Score:5.58|P-value:4.83E-6 ID:SGTC_3264|Compound:9137442|FD-Score:-3.65|P-value:9.25E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-7.23|P-value:8.16E-10 ID:SGTC_3281|Compound:9140613|FD-Score:4.68|P-value:1.13E-4 ID:SGTC_3338|Compound:9144300|FD-Score:4.49|P-value:2.06E-4

Top fitness defect scores for YGR064W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_562 3772-2733 10.30 112.0 µM 4.94E-17 ERG2 9 2.35E-25
2 SGTC_543 3844-1095 9.59 191.0 µM 7.26E-15 ERG2 4 4.58E-22
3 SGTC_2413 inermin 9.42 26.1 µM 2.07E-14 5 2.25E-21
4 SGTC_2417 cerulenin 8.77 830.0 nM 1.09E-12 2 9.23E-19
5 SGTC_1934 st074720 7.62 32.6 µM 5.68E-10 9 1.25E-14
6 SGTC_129 0088-0017 6.86 176.6 µM 2.33E-8 24 3.53E-12
7 SGTC_1304 1165-0502 6.77 251.0 µM 3.39E-8 23 6.26E-12
8 SGTC_109 0132-0036 6.74 33.7 µM 3.91E-8 6 7.78E-12
9 SGTC_2296 7971656 6.72 126.5 µM 4.25E-8 7 8.83E-12
10 SGTC_127 0180-0333 6.72 59.1 µM 4.42E-8 mitochondrial response to ROS 6 9.37E-12
11 SGTC_725 1497-0963 6.54 19.0 µM 9.47E-8 copper-dependent oxidative stress 4 2.99E-11
12 SGTC_2595 hexamethylquercetagetin 6.48 100.0 µM 1.24E-7 4 4.48E-11
13 SGTC_134 0269-0018 6.44 6.9 µM 1.46E-7 76 5.80E-11
14 SGTC_43 0570-0105 6.44 72.5 µM 1.50E-7 ERG2 27 6.03E-11
15 SGTC_2651 1327-0036 6.00 5.0 µM 9.47E-7 73 9.93E-10
16 SGTC_2932 9016711 5.70 44.5 µM 3.05E-6 15 5.89E-9
17 SGTC_453 enantio-paf c16 5.66 10.0 µM 3.63E-6 64 7.66E-9
18 SGTC_2618 avocadyne 5.62 43.4 µM 4.26E-6 21 9.77E-9
19 SGTC_3137 9097352 5.58 49.5 µM 4.83E-6 10 1.18E-8
20 SGTC_2814 7977482 5.42 43.0 µM 8.87E-6 12 2.98E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.277 2.52E-60 YGR063C SPT4 hom Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions
0.276 9.67E-60 YOL051W GAL11 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator
0.252 8.80E-50 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.213 1.02E-35 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.212 2.65E-35 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.198 6.42E-31 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.193 2.58E-29 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
0.182 2.48E-26 YHR167W THP2 hom Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
0.173 7.45E-24 YML122C_d YML122C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.172 9.76E-24 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.155 1.62E-19 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.143 9.77E-17 YNL236W SIN4 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
0.141 2.17E-16 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.138 9.35E-16 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.131 2.51E-14 YIR023W DAL81 hom Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism