YGR068C / ART5

Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR068C / ART5

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:5.76|P-value:4.40E-9 ID:SGTC_67|Compound:0335-0847|FD-Score:3.57|P-value:1.89E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.47|P-value:3.64E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.31|P-value:7.66E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:-5.65|P-value:7.19E-9 ID:SGTC_77|Compound:0828-0286|FD-Score:6.83|P-value:4.59E-12 ID:SGTC_165|Compound:k038-0023|FD-Score:3.31|P-value:4.86E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.20|P-value:7.16E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.47|P-value:2.68E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.33|P-value:4.58E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.12|P-value:9.28E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.95|P-value:4.14E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:4.41|P-value:5.45E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:4.44|P-value:4.69E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.78|P-value:7.28E-5 ID:SGTC_980|Compound:1473-0395|FD-Score:3.43|P-value:3.09E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.35|P-value:7.24E-6 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.57|P-value:2.57E-6 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.79|P-value:7.83E-5 ID:SGTC_1754|Compound:st042065|FD-Score:3.80|P-value:7.39E-5 ID:SGTC_1838|Compound:st055369|FD-Score:3.37|P-value:3.87E-4 ID:SGTC_1843|Compound:st055809|FD-Score:5.02|P-value:2.68E-7 ID:SGTC_1853|Compound:st056710|FD-Score:-3.53|P-value:1.98E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.48|P-value:2.59E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.23|P-value:6.36E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-4.13|P-value:1.73E-5 ID:SGTC_2070|Compound:5230947|FD-Score:3.21|P-value:6.91E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.05|P-value:2.70E-5 ID:SGTC_2366|Compound:9070441|FD-Score:3.26|P-value:5.73E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-3.08|P-value:9.76E-4 ID:SGTC_2434|Compound:5670830|FD-Score:4.93|P-value:4.40E-7 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.88|P-value:5.35E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.06|P-value:2.51E-5 ID:SGTC_2570|Compound:licareol|FD-Score:5.59|P-value:1.19E-8 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.12|P-value:1.97E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.11|P-value:8.81E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.24|P-value:1.16E-5 ID:SGTC_3081|Compound:9117243|FD-Score:-3.65|P-value:1.24E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.18|P-value:7.59E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.10|P-value:2.16E-5 ID:SGTC_3190|Compound:9110366|FD-Score:3.57|P-value:1.85E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-4.80|P-value:7.24E-7 ID:SGTC_3238|Compound:9133470|FD-Score:-3.31|P-value:4.50E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-4.23|P-value:1.10E-5 ID:SGTC_3346|Compound:9158254|FD-Score:3.25|P-value:6.08E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.19|P-value:7.42E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:5.76|P-value:4.40E-9 ID:SGTC_67|Compound:0335-0847|FD-Score:3.57|P-value:1.89E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.47|P-value:3.64E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.31|P-value:7.66E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:-5.65|P-value:7.19E-9 ID:SGTC_77|Compound:0828-0286|FD-Score:6.83|P-value:4.59E-12 ID:SGTC_165|Compound:k038-0023|FD-Score:3.31|P-value:4.86E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.20|P-value:7.16E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.47|P-value:2.68E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.33|P-value:4.58E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.12|P-value:9.28E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.95|P-value:4.14E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:4.41|P-value:5.45E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:4.44|P-value:4.69E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.78|P-value:7.28E-5 ID:SGTC_980|Compound:1473-0395|FD-Score:3.43|P-value:3.09E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.35|P-value:7.24E-6 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.57|P-value:2.57E-6 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.79|P-value:7.83E-5 ID:SGTC_1754|Compound:st042065|FD-Score:3.80|P-value:7.39E-5 ID:SGTC_1838|Compound:st055369|FD-Score:3.37|P-value:3.87E-4 ID:SGTC_1843|Compound:st055809|FD-Score:5.02|P-value:2.68E-7 ID:SGTC_1853|Compound:st056710|FD-Score:-3.53|P-value:1.98E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.48|P-value:2.59E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.23|P-value:6.36E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-4.13|P-value:1.73E-5 ID:SGTC_2070|Compound:5230947|FD-Score:3.21|P-value:6.91E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.05|P-value:2.70E-5 ID:SGTC_2366|Compound:9070441|FD-Score:3.26|P-value:5.73E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-3.08|P-value:9.76E-4 ID:SGTC_2434|Compound:5670830|FD-Score:4.93|P-value:4.40E-7 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.88|P-value:5.35E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.06|P-value:2.51E-5 ID:SGTC_2570|Compound:licareol|FD-Score:5.59|P-value:1.19E-8 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.12|P-value:1.97E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.11|P-value:8.81E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.24|P-value:1.16E-5 ID:SGTC_3081|Compound:9117243|FD-Score:-3.65|P-value:1.24E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.18|P-value:7.59E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.10|P-value:2.16E-5 ID:SGTC_3190|Compound:9110366|FD-Score:3.57|P-value:1.85E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-4.80|P-value:7.24E-7 ID:SGTC_3238|Compound:9133470|FD-Score:-3.31|P-value:4.50E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-4.23|P-value:1.10E-5 ID:SGTC_3346|Compound:9158254|FD-Score:3.25|P-value:6.08E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.19|P-value:7.42E-4

Top fitness defect scores for YGR068C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_77 0828-0286 6.83 12.5 µM 4.59E-12 TSC3-RPN4 2 4.33E-12
2 SGTC_8 0354-0001 5.76 70.0 µM 4.40E-9 28 4.18E-9
3 SGTC_2570 licareol 5.59 100.0 µM 1.19E-8 7 1.13E-8
4 SGTC_1843 st055809 5.02 45.5 µM 2.68E-7 4 2.55E-7
5 SGTC_2434 5670830 4.93 169.9 µM 4.40E-7 11 4.19E-7
6 SGTC_1116 jasmonic acid 4.57 1.6 µM 2.57E-6 10 2.46E-6
7 SGTC_777 1315-0167 4.44 517.0 µM 4.69E-6 Golgi 21 4.49E-6
8 SGTC_774 k060-0086 4.41 136.0 µM 5.45E-6 13 5.22E-6
9 SGTC_1114 scopoletin 4.35 1.7 µM 7.24E-6 16 6.93E-6
10 SGTC_3037 9091026 4.24 49.5 µM 1.16E-5 NEO1-PIK1 109 1.11E-5
11 SGTC_2638 epoxomicin 4.12 18.0 µM 1.97E-5 30 1.89E-5
12 SGTC_3189 9110682 4.10 49.5 µM 2.16E-5 31 2.07E-5
13 SGTC_2569 tetrandrine 4.06 100.0 µM 2.51E-5 19 2.40E-5
14 SGTC_2342 7990637 4.05 118.9 µM 2.70E-5 RNA processing & uracil transport 32 2.59E-5
15 SGTC_752 1896-0090 3.95 130.0 µM 4.14E-5 TSC3-RPN4 18 3.97E-5
16 SGTC_2512 diallyl trisulfide 3.88 49.2 µM 5.35E-5 8 5.14E-5
17 SGTC_1754 st042065 3.80 16.1 µM 7.39E-5 NEO1-PIK1 190 7.10E-5
18 SGTC_1171 0368-0077 3.79 21.4 µM 7.83E-5 24 7.52E-5
19 SGTC_3190 9110366 3.57 49.5 µM 1.85E-4 15 1.77E-4
20 SGTC_67 0335-0847 3.57 266.0 µM 1.89E-4 ubiquinone biosynthesis & proteasome 141 1.81E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 9.74E-10 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.097 1.78E-8 YGR246C BRF1 het TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
0.095 2.99E-8 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.092 1.06E-7 YDL065C PEX19 hom Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning
0.091 1.30E-7 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.091 1.45E-7 YOL032W OPI10 hom Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress
0.085 8.48E-7 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.083 1.31E-6 YJR025C BNA1 hom 3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.080 3.20E-6 YGR033C TIM21 hom Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity
0.080 3.28E-6 YDR469W SDC1 hom Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30
0.080 3.63E-6 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.078 5.69E-6 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.078 6.01E-6 YKL182W FAS1 het Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
0.078 6.85E-6 YDR141C DOP1 het Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies
0.077 8.81E-6 YNR012W URK1 hom Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP